Molekul Pub Date : 2022-11-19 DOI: 10.20884/1.jm.2022.17.3.6285

Arroh matus Syafaqoh, Li’aini, Putu Agus, H. Wibawa, A. Rahayu

{"title":"In vitro Antimicrobial and Antioxidant Activity of Meliaceae Plants Collection of Eka Karya Bali Botanic Garden","authors":"Arroh matus Syafaqoh, Li’aini, Putu Agus, H. Wibawa, A. Rahayu","doi":"10.20884/1.jm.2022.17.3.6285","DOIUrl":"https://doi.org/10.20884/1.jm.2022.17.3.6285","url":null,"abstract":"\u0000 \u0000 \u0000Meliaceae are popularly used to produce terpenoid and limonoid compounds. These compounds have the potential as antioxidants, antimicrobials, insecticides, antipyretics, and anthelmintics. This research aims to determine the antioxidant and antimicrobial activity of Meliaceae leaves extract of Eka Karya Bali Botanic Garden plants collection. The dried leaves of 15 species of Meliaceae were extracted by methanol. In vitro antimicrobial tests were carried out on agar media inoculated by selected microbe. On the other hand, the antioxidant activity was assayed by 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging. As a result, Aphanamixis polystachya against Aspergillus niger (35.21 mm) and Cladosporium sp. (46.21), Toona hexandra against Fusarium solani (37.31 mm), Dysoxylum cauliflorum against Candida albicans (38.19 mm), Chisocheton pentandrus against Salmonella typhimurium (39.53 mm), Sandoricum koetjape against Staphylococcus aureus (50.07 mm), and Toona hexandra against Streptococcus nutans (42.25 mm) exhibited the strongest inhibitory effect. Furthermore, the antioxidant screening showed that Cipadessa baccifera, C. pentandrus, and Sandoricum koetjape exhibited strong antioxidant activity, while T. ciliata showed a very strong antioxidant activity with IC50 33.64 μg/mL. This study reveals an initial screening of the potential of various types of Meliaceae as a source of antioxidants and antibacterials. Furthermore, this information can be used as a new alternative for pharmaceutical companies and the industrial sector in the development of new products. \u0000 \u0000 \u0000","PeriodicalId":18773,"journal":{"name":"Molekul","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45911120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sesquiterpenoids from Stem Bark of Chisocheton lasiocarpus and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell 毛果赤松茎皮倍半萜类化合物及其对MCF-7乳腺癌症细胞的细胞毒性作用

Molekul Pub Date : 2022-11-19 DOI: 10.20884/1.jm.2022.17.3.6425

U. Supratman, Samuel San Parulian, N. Nurlelasari, Al Arofatus Naini, T. Mayanti, Erina Hilmayanti, D. Harneti, Darwati Darwati, R. Maharani, K. Farabi, R. Anwar, S. Fajriah, Muhamad Nurul Azmi, Y. Shiono

{"title":"Sesquiterpenoids from Stem Bark of Chisocheton lasiocarpus and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell","authors":"U. Supratman, Samuel San Parulian, N. Nurlelasari, Al Arofatus Naini, T. Mayanti, Erina Hilmayanti, D. Harneti, Darwati Darwati, R. Maharani, K. Farabi, R. Anwar, S. Fajriah, Muhamad Nurul Azmi, Y. Shiono","doi":"10.20884/1.jm.2022.17.3.6425","DOIUrl":"https://doi.org/10.20884/1.jm.2022.17.3.6425","url":null,"abstract":"Sesquiterpenoids are derivatives of terpenoid compound that have a diverse skeleton and broad spectrum of biological activities, particularly anticancer activity. This research reported the isolation and elucidation structure of sesquiterpenoid from Chisocheton lasiocarpus stem bark, as well as their cytotoxic activity. Four sesquiterpenoid compounds, namely eudesm-4(15)-ene-1β,6β-diol (1), allo-aromadendrane-10α,14-diol (2), allo-aromadendrane-10β,14-diol (3) and guaianediol (4), were isolated for the first time from Chisocheton lasiocarpus stem bark. The chemical structure of all compounds was identified by spectroscopic analysis, including IR, MS, 1H-NMR, 13C-NMR and DEPT, and compared with previous reported spectral data. The cytotoxic activity of the isolated compounds against MCF-7 breast cancer line were examined by using the resazurin method. The results showed compound 1 shown the highest cytotoxic activity with IC50 108.08 ± 0.58 µM.","PeriodicalId":18773,"journal":{"name":"Molekul","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42287039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Anti-inflammatory and immunosuppressant activity of Coprinus comatus ethanol extract in carrageenan-induced rats (Rattus norvegicus) 鸡腿菇乙醇提取物对卡拉胶诱导的大鼠（褐家鼠）的抗炎和免疫抑制活性

Molekul Pub Date : 2022-11-19 DOI: 10.20884/1.jm.2022.17.3.5815

N. Ratnaningtyas, Fajar Husen, S.Si., M.Si., Hernayanti Hernayanti, N. Ekowati, B. H. Budianto

{"title":"Anti-inflammatory and immunosuppressant activity of Coprinus comatus ethanol extract in carrageenan-induced rats (Rattus norvegicus)","authors":"N. Ratnaningtyas, Fajar Husen, S.Si., M.Si., Hernayanti Hernayanti, N. Ekowati, B. H. Budianto","doi":"10.20884/1.jm.2022.17.3.5815","DOIUrl":"https://doi.org/10.20884/1.jm.2022.17.3.5815","url":null,"abstract":"\u0000 \u0000 \u0000oprinus comatus (O.F. Mull.) is an edible mushroom that is used as an anti-inflammatory agent. Therefore, this study aims to determine the effect of inflammation treatment on symptoms alleviating, function maintenance, and inhibiting the process of tissue damage due to an increase in free radicals using drug formulations with high antioxidant compounds. This is a true experiment conducted using a Completely Randomized Design (CRD) with a post-test and a control group. The rats were divided into 6 categories, which include 1 healthy and 5 groups induced with 1% carrageenan. Out of the treatment groups, 3 were treated with ethanol extract of C. comatus fruiting body at doses of 250 (T1), 500 (T2), and 750 mg/kg BW (T3), 1 received diclofenac sodium (PC) and the other as a negative control (NC), were given extract for 14 days and induced with 0.5 mL carrageenan in paw of rats at day 15. The qualitative identification showed the extracts contains flavonoid, polyphenol, alkaloid, triterpenoid, steroids and saponins, and GC-MS analysis showed 10 putative metabolites compound. T2 group significantly decreased the levels of IL-1β (70.63%), IgE (59.04%), total leukocyte count (31.24%), plantar thickness (12.5%), edema volume (33.3%), and increased endothelial NO levels (48.2%). \u0000 \u0000 \u0000","PeriodicalId":18773,"journal":{"name":"Molekul","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47512597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis Glycine-Modulated Metal Organic Framework Cr-PTC-Gly for Synergetic Methylene Blue Adsorption and Photodegradation under Visible Light Irradiation 甘氨酸调节金属有机骨架Cr-PTC-Gly的合成及其在可见光照射下对亚甲基蓝的协同吸附和光降解

Molekul Pub Date : 2022-11-19 DOI: 10.20884/1.jm.2022.17.3.6126

A. Adawiah, Risma Nur Fitria, N. Saridewi, Farhan Maulana Azhar, Muhammad Shofyan Gunawan, Sri Komala

{"title":"Synthesis Glycine-Modulated Metal Organic Framework Cr-PTC-Gly for Synergetic Methylene Blue Adsorption and Photodegradation under Visible Light Irradiation","authors":"A. Adawiah, Risma Nur Fitria, N. Saridewi, Farhan Maulana Azhar, Muhammad Shofyan Gunawan, Sri Komala","doi":"10.20884/1.jm.2022.17.3.6126","DOIUrl":"https://doi.org/10.20884/1.jm.2022.17.3.6126","url":null,"abstract":"\u0000 \u0000 \u0000The glycine-modulated metal-organic framework (MOF) Cr-PTC-Gly was successfully synthesized for methylene blue elimination application. The Fourier Transform Infra-Red (FTIR) characterization showed the stretching vibration N-H at 2034 cm-1. The bands at 1506 and 1406 cm-1 are asymmetric and symmetric stretching vibrations (-COO) bound to Cr3+ ions and 3118 cm-1 of the hydroxyl (OH) functional group of H2O bound to the Cr3+ ion. The band gap energy of MOF Cr- PTC-Gly is 1.9 eV. The XRD analysis showed that MOF Cr-PTC-Gly has good crystallinity with a crystal size of 17.79 nm. MOF Cr-PTC-Gly with 50% glycine gave the most optimum elimination activity with an elimination capacity of 87.95 mg/gram via adsorption and photocatalytic degradation. The adsorption mechanisms were carried out via electrostatic interaction, hydrogen bonding, and π-π interaction. In contrast, photocatalytic degradation was carried out by forming free radical species with hydroxyl radicals (•OH) as a dominant species that contributed to the methylene blue degradation. \u0000 \u0000 \u0000","PeriodicalId":18773,"journal":{"name":"Molekul","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41531442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Preparation of Atorvastatin Calcium-Dipicolinic Acid Multicomponent Solids by Liquid-Assisted Grinding Method to Increase Solubility 液体辅助研磨法制备阿托伐他汀钙-二吡啶酸多组分固体提高溶解度

Molekul Pub Date : 2022-11-19 DOI: 10.20884/1.jm.2022.17.3.5946

Yudi Wicaksono, Shafira Faradiba Tsaniyah, Budipratiwi Wisudyaningsih, Kuni Zu’aimah Barikah, Lusia Oktora Ruma Kumala Sari

{"title":"Preparation of Atorvastatin Calcium-Dipicolinic Acid Multicomponent Solids by Liquid-Assisted Grinding Method to Increase Solubility","authors":"Yudi Wicaksono, Shafira Faradiba Tsaniyah, Budipratiwi Wisudyaningsih, Kuni Zu’aimah Barikah, Lusia Oktora Ruma Kumala Sari","doi":"10.20884/1.jm.2022.17.3.5946","DOIUrl":"https://doi.org/10.20884/1.jm.2022.17.3.5946","url":null,"abstract":"Atorvastatin calcium is a cholesterol-lowering drug that is very potent but difficult to dissolve in water, so its bioavailability is low. In this study, atorvastatin calcium-dipicolinic acid multicomponent solids were prepared using the liquid-assisted grinding method to improve atorvastatin calcium's solubility. Characterization of multicomponent solids was carried out using powder x-ray diffraction (PXRD), differential scanning calorimetry (DSC), fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Solubility test was carried out by shaking method using distilled water media. The results showed that the particles of atorvastatin calcium - dipicolinic acid multicomponent solids had an irregular shape with rough and porous surface topography. The multicomponent solids have a diffractogram with specific peaks of 2θ at 8.8, 9.9, 11.5, 16.7, 19.1, 21.2, 22.4, 23.4, and 27.7°. The DSC thermogram of multicomponent solids showed a sharp endothermic peak at 181.9 °C (∆H=17.69 J/g), indicating its melting point. The FTIR spectra of atorvastatin calcium-dipicolinic acid multicomponent solids indicated an intermolecular interaction that was thought to be a hydrogen bond between the molecules of atorvastatin calcium and dipicolinic acid. The results of the solubility test showed that the atorvastatin calcium-dipicolinic acid multicomponent solids had a significantly increased solubility (p<0.05) compared to the solubility of pure atorvastatin calcium.","PeriodicalId":18773,"journal":{"name":"Molekul","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43568067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kinetic Parameters Investigation for The Esterification of Free Fatty Acid from Coconut Oil Mill Waste using Montmorillonite-Sulfonated Carbon from Glucose Composite Catalyst 蒙脱石磺化碳-葡萄糖复合催化剂酯化椰子油废渣中游离脂肪酸的动力学参数研究

Molekul Pub Date : 2022-11-19 DOI: 10.20884/1.jm.2022.17.3.5925

H. Hasanudin, W. R. Asri, W. Purwaningrum, F. Riyanti, N. Novia, R. Maryana, M. A. Muttaqii

{"title":"Kinetic Parameters Investigation for The Esterification of Free Fatty Acid from Coconut Oil Mill Waste using Montmorillonite-Sulfonated Carbon from Glucose Composite Catalyst","authors":"H. Hasanudin, W. R. Asri, W. Purwaningrum, F. Riyanti, N. Novia, R. Maryana, M. A. Muttaqii","doi":"10.20884/1.jm.2022.17.3.5925","DOIUrl":"https://doi.org/10.20884/1.jm.2022.17.3.5925","url":null,"abstract":"Coconut oil mill waste (CMW) contained high free fatty acid (FFA) content which potentially could be converted into a value-added product such as fatty acid methyl ester (FAME). In this study, a montmorillonite-sulfonated carbon catalyst was used to evaluate the kinetic parameter of FFA conversion from CMW into FAME. The characterization of FTIR and SEM-EDX confirmed that the -SO3H groups were successfully incorporated into montmorillonite- carbon catalyst. The highest catalyst acidity (9.4 mmol/g) was achieved by a ratio of montmorillonite to sulfonated carbon of 1:3 % w/w. The kinetic study using montmorillonite-sulfonated carbon 1:3 % w/w showed that the reaction temperature and molar ratio of methanol to FFA (% v/v) were positively correlated to the reaction rate. The highest rate constant of esterification towards the product (k1), reactant (k2), and equilibrium were 0.1187, 0.0595, and 1.995, achieved by a temperature of 80 ˚C, respectively. The Arrhenius constant and activation energy towards the product were 3.3085×106 and 50.3 J/mole, respectively. The reaction temperature was positively correlated to the equilibrium constant, which indicated that the reaction was endothermic. The kinetic model validation revealed that the predicted value from the model was adequately in accordance with the experimental value, as indicated by a high coefficient of determination.","PeriodicalId":18773,"journal":{"name":"Molekul","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48361870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of pH and Ozone Dosage on Characteristic of Ozonated Rice Bran Oil pH值和臭氧用量对臭氧米糠油特性的影响

Molekul Pub Date : 2022-11-19 DOI: 10.20884/1.jm.2022.17.3.5474

E. Enjarlis, M. Christwardana, S. Handayani, S. Fajriah, S. Bismo, Jehuda Reinhard Rahmani, Muhammad Tama Hazadin

{"title":"Effect of pH and Ozone Dosage on Characteristic of Ozonated Rice Bran Oil","authors":"E. Enjarlis, M. Christwardana, S. Handayani, S. Fajriah, S. Bismo, Jehuda Reinhard Rahmani, Muhammad Tama Hazadin","doi":"10.20884/1.jm.2022.17.3.5474","DOIUrl":"https://doi.org/10.20884/1.jm.2022.17.3.5474","url":null,"abstract":"\u0000 \u0000 \u0000The influence of pH and ozone dose, as well as ascorbic acid addition during the ozonation process, on the properties of Rice Bran Oil (RBO), was examined. The spectroscopic characteristic of RBO before and after ozonation was analysis directly, while the physicochemical property was assessed by density, viscosity, pH, iodine number, peroxide number, and acid number. With an increase in ozone dose, the carbon double bond in the RBO reduced. The primary product of the ozonation process is ozonide, and one of its by-products is 1,2,4-trioxolane, which contains a carbon single bond as a result of the ozonation reaction. According to this study, the pH 4 and ozone dose of 440 mg O3/L are the optimum parameters utilized in the RBO ozonation process. RBO's density and viscosity were 0.918 g/mL and 0.042 cP, respectively, at these conditions. Its iodine number, acid number, and peroxide number were also 3.173 g/g RBO, 2.3 mg NaOH/g RBO, and 55 mgeq/kg, respectively. Analyses of gas chromatography and nuclear magnetic resonance spectroscopy revealed the presence of 1,2,4-trioxolane. Ozone dosage is critical because greater ozone concentrations place RBO in a saturated state, making the 1,2,4-trioxolane unstable and readily destroyed, whereas lower temperatures can avoid this. \u0000 \u0000 \u0000","PeriodicalId":18773,"journal":{"name":"Molekul","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45978276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Indirect Colorimetric Method for Potassium Determination in Soil Using a Paper Device and Smartphone 用纸装置和智能手机间接比色法测定土壤中钾

Molekul Pub Date : 2022-11-19 DOI: 10.20884/1.jm.2022.17.3.6279

Thinikan Thongkam, K. Hemavibool

引用次数: 0

Gas-Liquid Separator Modified on CV-AAS System for Determination of Total Hg in the Industrial Wastewater Samples 改进的气液分离器-原子吸收光谱法测定工业废水样品中总汞

Molekul Pub Date : 2022-11-18 DOI: 10.20884/1.jm.2022.17.3.5039

S. Sujito, S. P. Pasaribu, T. Wirawan, A. S. Panggabean

{"title":"Gas-Liquid Separator Modified on CV-AAS System for Determination of Total Hg in the Industrial Wastewater Samples","authors":"S. Sujito, S. P. Pasaribu, T. Wirawan, A. S. Panggabean","doi":"10.20884/1.jm.2022.17.3.5039","DOIUrl":"https://doi.org/10.20884/1.jm.2022.17.3.5039","url":null,"abstract":"\u0000 \u0000 \u0000The research about the utilization of modified gas-liquid separators in the determination of Hg ions by using the Cold Vapor Atomic Absorption Spectrophotometer (CV-AAS) method has been done. To optimize the measurement results, several parameters that affect the hydride generator have been studied. Some specified essential parameters are the type and concentration of acid, the level of SnCl2 as a reducing agent, sample volume and the analytical performance such as linearity (r), detection limit (LOD) and quantitation limit (LOQ), repeatability (% RSD), and accuracy have been studied. The results of the research showed the gas-liquid separator modified can be used instead of commercial gas- liquid separators. It was showed by the repeatability value as % RSD < 2/3 CV Horwitz values, the LOD was 0.2530 μg/mL, and the LOQ was 0.8432 μg/mL. The accuracy of this method was good shown by a recovery percentage of 101.6%. Based on the result of this research, the modified of gas-liquid separator can be used for the determination of Hg ions by using the CV-AAS method with valid results \u0000 \u0000 \u0000","PeriodicalId":18773,"journal":{"name":"Molekul","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46702590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Derivatization of Inseparable Ursolic and Oleanolic Acids of Fagraea fragrans Fruits to Enhance Their Anticancer Activity 香果中不可分离的熊果酸和齐墩果酸的衍生及其抗癌活性的研究

Molekul Pub Date : 2022-07-21 DOI: 10.20884/1.jm.2022.17.2.5425

D. Basir, M. Miksusanti, S. Susilawati

引用次数: 0

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