In vitro Antimicrobial and Antioxidant Activity of Meliaceae Plants Collection of Eka Karya Bali Botanic Garden

Q3 Chemistry

Molekul Pub Date : 2022-11-19 DOI:10.20884/1.jm.2022.17.3.6285

Arroh matus Syafaqoh, Li’aini, Putu Agus, H. Wibawa, A. Rahayu

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Abstract

Meliaceae are popularly used to produce terpenoid and limonoid compounds. These compounds have the potential as antioxidants, antimicrobials, insecticides, antipyretics, and anthelmintics. This research aims to determine the antioxidant and antimicrobial activity of Meliaceae leaves extract of Eka Karya Bali Botanic Garden plants collection. The dried leaves of 15 species of Meliaceae were extracted by methanol. In vitro antimicrobial tests were carried out on agar media inoculated by selected microbe. On the other hand, the antioxidant activity was assayed by 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging. As a result, Aphanamixis polystachya against Aspergillus niger (35.21 mm) and Cladosporium sp. (46.21), Toona hexandra against Fusarium solani (37.31 mm), Dysoxylum cauliflorum against Candida albicans (38.19 mm), Chisocheton pentandrus against Salmonella typhimurium (39.53 mm), Sandoricum koetjape against Staphylococcus aureus (50.07 mm), and Toona hexandra against Streptococcus nutans (42.25 mm) exhibited the strongest inhibitory effect. Furthermore, the antioxidant screening showed that Cipadessa baccifera, C. pentandrus, and Sandoricum koetjape exhibited strong antioxidant activity, while T. ciliata showed a very strong antioxidant activity with IC50 33.64 μg/mL. This study reveals an initial screening of the potential of various types of Meliaceae as a source of antioxidants and antibacterials. Furthermore, this information can be used as a new alternative for pharmaceutical companies and the industrial sector in the development of new products.

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巴厘植物园楝科植物的体外抗菌和抗氧化活性研究

Meliaceae通常用于生产萜类和褐铁矿类化合物。这些化合物具有作为抗氧化剂、抗菌剂、杀虫剂、退烧药和驱虫剂的潜力。本研究旨在测定Eka Karya Bali植物园植物收藏的木犀科叶提取物的抗氧化和抗菌活性。用甲醇提取了15种木犀科植物的干叶。在所选微生物接种的琼脂培养基上进行了体外抗菌试验。另一方面，通过1，1-二苯基-2-苦基肼（DPPH）自由基清除来测定其抗氧化活性。结果，抗黑曲霉（35.21mm）和Cladosporium sp.（46.21）的Aphanamixis polystachia，抗茄镰孢（37.31mm）的Toona hexandra，抗白色念珠菌（38.19mm）的花椰菜脱氧菌，抗鼠伤寒沙门氏菌的Chishocheton penandrus（39.53mm），抗金黄色葡萄球菌的Sandoricum koetjape（50.07mm），香椿对坚果链球菌（42.25mm）的抑制作用最强。此外，抗氧化物筛选表明，Cipadessa baccifera、C.penandrus和Sandoricum koetjape表现出较强的抗氧化活性，而T.cilia表现出非常强的抗氧化活性（IC50为33.64μg/mL）。这项研究揭示了对各种类型的Meliaceae作为抗氧化剂和抗菌药物来源的潜力的初步筛选。此外，这些信息可以作为制药公司和工业部门开发新产品的新选择。

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