Sesquiterpenoids from Stem Bark of Chisocheton lasiocarpus and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell

Q3 Chemistry

Molekul Pub Date : 2022-11-19 DOI:10.20884/1.jm.2022.17.3.6425

U. Supratman, Samuel San Parulian, N. Nurlelasari, Al Arofatus Naini, T. Mayanti, Erina Hilmayanti, D. Harneti, Darwati Darwati, R. Maharani, K. Farabi, R. Anwar, S. Fajriah, Muhamad Nurul Azmi, Y. Shiono

{"title":"Sesquiterpenoids from Stem Bark of Chisocheton lasiocarpus and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell","authors":"U. Supratman, Samuel San Parulian, N. Nurlelasari, Al Arofatus Naini, T. Mayanti, Erina Hilmayanti, D. Harneti, Darwati Darwati, R. Maharani, K. Farabi, R. Anwar, S. Fajriah, Muhamad Nurul Azmi, Y. Shiono","doi":"10.20884/1.jm.2022.17.3.6425","DOIUrl":null,"url":null,"abstract":"Sesquiterpenoids are derivatives of terpenoid compound that have a diverse skeleton and broad spectrum of biological activities, particularly anticancer activity. This research reported the isolation and elucidation structure of sesquiterpenoid from Chisocheton lasiocarpus stem bark, as well as their cytotoxic activity. Four sesquiterpenoid compounds, namely eudesm-4(15)-ene-1β,6β-diol (1), allo-aromadendrane-10α,14-diol (2), allo-aromadendrane-10β,14-diol (3) and guaianediol (4), were isolated for the first time from Chisocheton lasiocarpus stem bark. The chemical structure of all compounds was identified by spectroscopic analysis, including IR, MS, 1H-NMR, 13C-NMR and DEPT, and compared with previous reported spectral data. The cytotoxic activity of the isolated compounds against MCF-7 breast cancer line were examined by using the resazurin method. The results showed compound 1 shown the highest cytotoxic activity with IC50 108.08 ± 0.58 µM.","PeriodicalId":18773,"journal":{"name":"Molekul","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molekul","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20884/1.jm.2022.17.3.6425","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Chemistry","Score":null,"Total":0}

引用次数: 1

Abstract

Sesquiterpenoids are derivatives of terpenoid compound that have a diverse skeleton and broad spectrum of biological activities, particularly anticancer activity. This research reported the isolation and elucidation structure of sesquiterpenoid from Chisocheton lasiocarpus stem bark, as well as their cytotoxic activity. Four sesquiterpenoid compounds, namely eudesm-4(15)-ene-1β,6β-diol (1), allo-aromadendrane-10α,14-diol (2), allo-aromadendrane-10β,14-diol (3) and guaianediol (4), were isolated for the first time from Chisocheton lasiocarpus stem bark. The chemical structure of all compounds was identified by spectroscopic analysis, including IR, MS, 1H-NMR, 13C-NMR and DEPT, and compared with previous reported spectral data. The cytotoxic activity of the isolated compounds against MCF-7 breast cancer line were examined by using the resazurin method. The results showed compound 1 shown the highest cytotoxic activity with IC50 108.08 ± 0.58 µM.

查看原文本刊更多论文

毛果赤松茎皮倍半萜类化合物及其对MCF-7乳腺癌症细胞的细胞毒性作用

倍半萜类化合物是萜类化合物的衍生物，具有多样的骨架和广泛的生物活性，特别是抗癌活性。本研究报道了赤松茎皮倍半萜类化合物的分离、结构鉴定及其细胞毒活性。首次从赤松茎皮中分离得到四种倍半萜类化合物，即eudesm-4（15）-ene-1β、6β-二醇（1）、异-丙二烯-10α、14二醇（2）、异/丙二烯-10β、14二醇和愈创木二醇（4）。通过光谱分析，包括IR、MS、1H-NMR、13C-NMR和DEPT，鉴定了所有化合物的化学结构，并与先前报道的光谱数据进行了比较。用雷沙苏林法检测分离的化合物对MCF-7乳腺癌症细胞系的细胞毒性。结果显示，化合物1显示出最高的细胞毒性活性，IC50为108.08±0.58µM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊