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An overview of chiral separations of pharmaceutically active substances by HPLC (2018-2020). 高效液相色谱法手性分离药物活性物质概述（2018-2020 年）。
IF 1.7 4区 化学
Monatshefte Fur Chemie Pub Date : 2021-01-01 Epub Date: 2021-08-24 DOI: 10.1007/s00706-021-02832-5
Sofiya Grybinik, Zuzana Bosakova
{"title":"An overview of chiral separations of pharmaceutically active substances by HPLC (2018-2020).","authors":"Sofiya Grybinik, Zuzana Bosakova","doi":"10.1007/s00706-021-02832-5","DOIUrl":"10.1007/s00706-021-02832-5","url":null,"abstract":"<p><p>This review provides a brief survey of chiral separation of pharmaceutically active substances published over the last 3 years (2018-2020). Chiral separation of drugs is an important area of research. The control of enantiomeric purity and determination of individual enantiomeric drug molecules is a necessity especially for clinical, analytical, and regulatory purposes. Among chromatographic resolution methods, high-performance liquid chromatography based on chiral stationary phases remains the most popular and effective method used for chiral separation of various drugs. In this review, attention is paid to several classes of chiral stationary phases that have been the most frequently used for drug enantioseparation during this period.</p><p><strong>Graphic abstract: </strong></p>","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"152 9","pages":"1033-1043"},"PeriodicalIF":1.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9222583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selected contributions of young analytical chemists. 年轻分析化学家的贡献。
IF 1.8 4区 化学
Monatshefte Fur Chemie Pub Date : 2021-01-01 Epub Date: 2021-08-12 DOI: 10.1007/s00706-021-02835-2
Karel Nesměrák, Tomáš Navrátil
{"title":"Selected contributions of young analytical chemists.","authors":"Karel Nesměrák,&nbsp;Tomáš Navrátil","doi":"10.1007/s00706-021-02835-2","DOIUrl":"https://doi.org/10.1007/s00706-021-02835-2","url":null,"abstract":"","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":" ","pages":"1017"},"PeriodicalIF":1.8,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00706-021-02835-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39317621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemophobia cured by chemists: chemists as children of the Sun. 化学家治愈的化学恐惧症：化学家是太阳的孩子。
IF 1.7 4区 化学
Monatshefte Fur Chemie Pub Date : 2021-01-01 Epub Date: 2021-08-11 DOI: 10.1007/s00706-021-02814-7
Radek Chalupa, Karel Nesměrák
{"title":"Chemophobia cured by chemists: chemists as children of the Sun.","authors":"Radek Chalupa, Karel Nesměrák","doi":"10.1007/s00706-021-02814-7","DOIUrl":"10.1007/s00706-021-02814-7","url":null,"abstract":"<p><p>The success of chemists in the fight against COVID-19 provides us with a unique opportunity for strengthening the position of chemistry in society and suppressing chemophobia which has badly affected the image and development of chemistry over several decades. By highlighting the unique merits of chemistry in controlling infections and healing diseases, we propose developing a communication strategy \"Chemists as children of the Sun\". The time is ripe for chemists to take control of the story of chemistry. We believe that chemists must help the public to see chemistry in a whole new light. Only a positive perception of chemistry and the chemical profession will secure a sufficient supply of new talents, ideas, and also financial resources for the development of this unique and irreplaceable science for humanity.</p><p><strong>Graphic abstract: </strong></p>","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"152 9","pages":"1045-1051"},"PeriodicalIF":1.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10275920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enzyme prodrug therapy: cytotoxic potential of paracetamol turnover with recombinant horseradish peroxidase. 酶原药疗法：重组辣根过氧化物酶转化扑热息痛的细胞毒性潜力。
IF 1.7 4区 化学
Monatshefte Fur Chemie Pub Date : 2021-01-01 Epub Date: 2021-10-05 DOI: 10.1007/s00706-021-02848-x
Diana Humer, Oliver Spadiut
{"title":"Enzyme prodrug therapy: cytotoxic potential of paracetamol turnover with recombinant horseradish peroxidase.","authors":"Diana Humer, Oliver Spadiut","doi":"10.1007/s00706-021-02848-x","DOIUrl":"10.1007/s00706-021-02848-x","url":null,"abstract":"<p><p>Targeted cancer treatment is a promising, less invasive alternative to chemotherapy as it is precisely directed against tumor cells whilst leaving healthy tissue unaffected. The plant-derived enzyme horseradish peroxidase (HRP) can be used for enzyme prodrug cancer therapy with indole-3-acetic acid or the analgesic paracetamol (acetaminophen). Oxidation of paracetamol by HRP in the presence of hydrogen peroxide leads to <i>N</i>-acetyl-<i>p</i>-benzoquinone imine and polymer formation via a radical reaction mechanism. <i>N</i>-acetyl-<i>p</i>-benzoquinone imine binds to DNA and proteins, resulting in severe cytotoxicity. However, plant HRP is not suitable for this application since the foreign glycosylation pattern is recognized by the human immune system, causing rapid clearance from the body. Furthermore, plant-derived HRP is a mixture of isoenzymes with a heterogeneous composition. Here, we investigated the reaction of paracetamol with defined recombinant HRP variants produced in <i>E. coli,</i> as well as plant HRP, and found that they are equally effective in paracetamol oxidation at a concentration ≥ 400 µM. At low paracetamol concentrations, however, recombinant HRP seems to be more efficient in paracetamol oxidation. Yet upon treatment of HCT-116 colon carcinoma and FaDu squamous carcinoma cells with HRP-paracetamol no cytotoxic effect was observed, neither in the presence nor absence of hydrogen peroxide.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s00706-021-02848-x.</p>","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"152 11","pages":"1389-1397"},"PeriodicalIF":1.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10255306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Voltammetric determination of heavy metals in honey bee venom using hanging mercury drop electrode and PLA/carbon conductive filament for 3D printer. 用垂汞电极和3D打印机用PLA/碳导电长丝伏安法测定蜂毒中的重金属。
IF 1.8 4区 化学
Monatshefte Fur Chemie Pub Date : 2021-01-01 Epub Date: 2021-01-16 DOI: 10.1007/s00706-020-02725-z
Marta Choinska, Vojtěch Hrdlička, Ivana Šestáková, Tomáš Navrátil
{"title":"Voltammetric determination of heavy metals in honey bee venom using hanging mercury drop electrode and PLA/carbon conductive filament for 3D printer.","authors":"Marta Choinska,&nbsp;Vojtěch Hrdlička,&nbsp;Ivana Šestáková,&nbsp;Tomáš Navrátil","doi":"10.1007/s00706-020-02725-z","DOIUrl":"https://doi.org/10.1007/s00706-020-02725-z","url":null,"abstract":"<p><p>A new method for determination of selected heavy metals (Cd, Pb, Cu, Zn, and Ni) in honey bee venom was developed. Heavy metals are metabolized and incorporated into bee products, including honey and honey bee venom (apitoxin). Their composition reflects contamination of \"bee environment\", providing information about heavy metal contamination in the neighborhood of human dwellings. Moreover, assessment of bee products contamination is relevant for medicine, as they are a tool for promising therapeutic and chemoprophylactic strategies against COVID-19 (SARS-CoV-2). Owing to the complicated matrix, the developed method consists of wet mineralization with sulfuric acid, nitric acid, under increased temperature, and pressure and subsequent repeated boiling with concentrated nitric acid. Determination of the selected metals was carried out by anodic or cathodic stripping voltammetry on two types of electrodes: pen-type hanging mercury drop electrode (HMDE) and PLA filament with carbon conductive admixture (PLA-C) for 3D printer. Contents of lead and cadmium in all analyzed bee venom samples were on the level of mg kg<sup>-1</sup>, of nickel and copper about ten times higher, and of zinc on the level of g kg<sup>-1</sup>. The results achieved using HMDE were recorded with average relative standard deviation (RSD) 5.4% (from 3.2% to 8.6%) and using PLA-C 11.8% (from 6.5% to 18.0%). The results achieved using both electrodes proved to be equivalent with statistical probability higher than 95%.</p><p><strong>Graphic abstract: </strong></p>","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"152 1","pages":"35-41"},"PeriodicalIF":1.8,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00706-020-02725-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38853016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
A trigonal coordination of Au(I) phosphane complexes stabilized by O-H ⋯ X (X = Cl-, Br-, I-) interactions. 通过 O-H ⋯ X（X = Cl-、Br-、I-）相互作用稳定的 Au（I）膦烷配合物的三方配位。
IF 1.7 4区 化学
Monatshefte Fur Chemie Pub Date : 2021-01-01 Epub Date: 2021-09-15 DOI: 10.1007/s00706-021-02843-2
Petra Gründlinger, Cezarina Cela Mardare, Thorsten Wagner, Uwe Monkowius
{"title":"A trigonal coordination of Au(I) phosphane complexes stabilized by O-H <sup><b>⋯</b></sup> X (X = Cl<sup>-</sup>, Br<sup>-</sup>, I<sup>-</sup>) interactions.","authors":"Petra Gründlinger, Cezarina Cela Mardare, Thorsten Wagner, Uwe Monkowius","doi":"10.1007/s00706-021-02843-2","DOIUrl":"10.1007/s00706-021-02843-2","url":null,"abstract":"<p><p>In this work, we show that intramolecular hydrogen bonding can be used to stabilize tri-coordinated phosphane-gold(I) complexes. Two molecular structures of 2-(diphenylphosphino)benzoic acid (L) coordinated to a gold(I) atom were determined by single-crystal X-ray diffraction. The linear L-Au-Br shows a standard linear coordination and dimerizes via hydrogen bonds of the carboxylic acid. Upon addition of two additional phosphane ligands the complex [L<sub>3</sub>Au]X is formed which is stabilized by three intramolecular -C(O)O-H <sup><b>…</b></sup> X hydrogen bonds as proven by the X-ray structure of the respective chlorido-complex. X-ray powder diffractograms suggest the same structure also for X<sup>-</sup> = Br<sup>-</sup> and I<sup>-</sup>.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s00706-021-02843-2.</p>","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"152 10","pages":"1201-1207"},"PeriodicalIF":1.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39578381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tribromoisocyanuric acid as a useful oxidant for the synthesis of 1,3-diynes via Glaser coupling 三溴异氰尿酸在激光偶联法合成1,3-二炔中的氧化剂作用
IF 1.8 4区 化学
Monatshefte Fur Chemie Pub Date : 2020-09-10 DOI: 10.1007/S00706-020-02673-8
Vitor S. C. de Andrade, M. C. D. Mattos
{"title":"Tribromoisocyanuric acid as a useful oxidant for the synthesis of 1,3-diynes via Glaser coupling","authors":"Vitor S. C. de Andrade, M. C. D. Mattos","doi":"10.1007/S00706-020-02673-8","DOIUrl":"https://doi.org/10.1007/S00706-020-02673-8","url":null,"abstract":"","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"428 1","pages":"1-6"},"PeriodicalIF":1.8,"publicationDate":"2020-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76489280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Chemophobia versus the identity of chemists: heroes of chemistry as an effective communication strategy. 化学恐惧症与化学家的身份认同：化学英雄作为一种有效的传播策略。
IF 1.7 4区 化学
Monatshefte Fur Chemie Pub Date : 2020-01-01 Epub Date: 2020-06-08 DOI: 10.1007/s00706-020-02633-2
Radek Chalupa, Karel Nesměrák
{"title":"Chemophobia versus the identity of chemists: heroes of chemistry as an effective communication strategy.","authors":"Radek Chalupa, Karel Nesměrák","doi":"10.1007/s00706-020-02633-2","DOIUrl":"10.1007/s00706-020-02633-2","url":null,"abstract":"<p><strong>Abstract: </strong>Decades of chemophobia are taking a high toll on chemistry. As current surveys suggest, people are displaying an irrational desire to live in a world without chemistry, but at the same time are unable to answer trivial chemistry questions. Constant questioning of the importance of chemistry induced by chemophobia leads to a weakening of the identity of chemists and can have negative consequences on the reproduction of chemistry. The need for the support of a positive perception of the chemical profession and an offer of positive examples for self-identification is the result. Everyday communication thus becomes the background on which the determination of the identity of the chemist takes place. The new communication strategy, which we call \"heroes of chemistry\", aims not only to add a much-needed human touch to chemistry communications, but also to create the conditions for strengthening the identity of the chemist.</p><p><strong>Graphic abstract: </strong></p>","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"151 8","pages":"1193-1201"},"PeriodicalIF":1.7,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38298628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assembling the prenylneoflavone system through a Pechmann condensation/Mitsunobu reaction/Claisen rearrangement/olefin cross-metathesis sequence. 通过Pechmann缩合/Mitsunobu反应/Claisen重排/烯烃交叉复分解序列组装戊烯基新黄酮体系。
IF 1.8 4区 化学
Monatshefte Fur Chemie Pub Date : 2020-01-01 Epub Date: 2020-04-28 DOI: 10.1007/s00706-020-02584-8
Oleg A Lozinski, J Bistodeau, C Bennetau-Pelissero, Vladimir P Khilya, S Shinkaruk
{"title":"Assembling the prenylneoflavone system through a Pechmann condensation/Mitsunobu reaction/Claisen rearrangement/olefin cross-metathesis sequence.","authors":"Oleg A Lozinski,&nbsp;J Bistodeau,&nbsp;C Bennetau-Pelissero,&nbsp;Vladimir P Khilya,&nbsp;S Shinkaruk","doi":"10.1007/s00706-020-02584-8","DOIUrl":"https://doi.org/10.1007/s00706-020-02584-8","url":null,"abstract":"<p><strong>Abstract: </strong>The multistep synthesis of a prenylneoflavone through a sequence of the Mitsunobu reaction/Claisen rearrangement/olefin cross-metathesis reaction has been accomplished in 5% yield over six steps starting from commercially available 3-methoxyacetophenone. The sequence is shown to be compatible with a Pechmann condensation which proved to be a robust and cost-effective method for the assembling of the α-pyrone core. The results open doors to a general approach to the prenylneoflavone system starting from phenol and acetophenone derivatives.</p><p><strong>Graphic abstract: </strong></p>","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"151 4","pages":"605-610"},"PeriodicalIF":1.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00706-020-02584-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37881996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Methyl glycosides via Fischer glycosylation: translation from batch microwave to continuous flow processing. 通过Fischer糖基化的甲基糖苷：从分批微波转化为连续流处理。
IF 1.7 4区 化学
Monatshefte Fur Chemie Pub Date : 2019-01-01 Epub Date: 2018-11-17 DOI: 10.1007/s00706-018-2306-8
Jonas Aronow, Christian Stanetty, Ian R Baxendale, Marko D Mihovilovic
{"title":"Methyl glycosides via Fischer glycosylation: translation from batch microwave to continuous flow processing.","authors":"Jonas Aronow, Christian Stanetty, Ian R Baxendale, Marko D Mihovilovic","doi":"10.1007/s00706-018-2306-8","DOIUrl":"10.1007/s00706-018-2306-8","url":null,"abstract":"<p><strong>Abstract: </strong>A continuous flow procedure for the synthesis of methyl glycosides (Fischer glycosylation) of various monosaccharides using a heterogenous catalyst has been developed. In-depth analysis of the isomeric composition was undertaken and high consistency with corresponding results observed under microwave heating was obtained. Even in cases where addition of water was needed to achieve homogeneity-a prerequisite for the flow experiments-no detrimental effect on the conversion was found. The scalability was demonstrated on a model case (mannose) and as part of the target-oriented synthesis of d-<i>glycero</i>-d-<i>manno</i> heptose, both performed on multigram scale.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"150 1","pages":"11-19"},"PeriodicalIF":1.7,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36879190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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