Monatshefte Fur Chemie最新文献_第2页

Synthesis and characterization of cobalt SCS pincer complexes. 钴 SCS 钳子复合物的合成与表征。

IF 1.7 4区化学

Monatshefte Fur Chemie Pub Date : 2022-01-01 Epub Date: 2022-07-16 DOI: 10.1007/s00706-022-02949-1

Jan Pecak, Matthias Käfer, Sarah Fleissner, Werner Artner, Karl Kirchner

引用次数: 0

Synthesis, structural characterization, and evaluation of new peptidomimetic Schiff bases as potential antithrombotic agents. 新的拟肽希夫碱的合成、结构表征和评价作为潜在的抗血栓药物。

IF 1.8 4区化学

Monatshefte Fur Chemie Pub Date : 2022-01-01 Epub Date: 2022-07-14 DOI: 10.1007/s00706-022-02936-6

Satheesh Chikkanahalli Eranna, Raghavendra Kumar Panchangam, Jayanna Kengaiah, Suchetan Parameshwar Adimule, Sabine Foro, Devaraju Sannagangaiah

{"title":"Synthesis, structural characterization, and evaluation of new peptidomimetic Schiff bases as potential antithrombotic agents.","authors":"Satheesh Chikkanahalli Eranna, Raghavendra Kumar Panchangam, Jayanna Kengaiah, Suchetan Parameshwar Adimule, Sabine Foro, Devaraju Sannagangaiah","doi":"10.1007/s00706-022-02936-6","DOIUrl":"https://doi.org/10.1007/s00706-022-02936-6","url":null,"abstract":"New Schiff bases functionalized with amide and phenolic groups synthesized by the condensation of 2-hydroxybenzaldehyde and 2-hydroxyacetophenone with amino acid amides which in turn were prepared in two steps from N-Boc-amino acids and homoveraltrylamine through intermediate compounds N-Boc-amino acids amides. The compounds were characterized by elemental analysis, FT-IR, UV-Vis, and NMR spectroscopy. The crystal structures of three Schiff bases were determined by single crystal X-ray diffraction. There exists O-H <math><mo>⋯</mo></math> N, N-H <math><mo>⋯</mo></math> O, and C-H <math><mo>⋯</mo></math> O types of hydrogen bonds and C-H <math><mrow><mo>⋯</mo> <mi>π</mi></mrow> </math> secondary bonding interactions in these crystalline solids. The Schiff bases have been screened for anticoagulant and antiplatelet aggregation activities. All the compounds showed procoagulant activity which shortens the clotting time of citrated human plasma in both platelet-rich plasma and platelet-poor plasma except the derivatives of L-methionine which showed anticoagulant activity by prolonging the clotting time. In addition, the compounds derived from benzyl cysteine and phenylalanine showed adenosine diphosphate induced antiplatelet aggregation activity, whereas others did not show any role. Moreover, all these compounds revealed non-hemolytic activity with red blood cells.Graphical abstract: Supplementary information: The online version contains supplementary material available at 10.1007/s00706-022-02936-6.","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"153 7-8","pages":"635-650"},"PeriodicalIF":1.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40537995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Liquid chromatography and capillary electrophoresis in glycomic and glycoproteomic analysis. 糖组学和糖蛋白组学分析的液相色谱和毛细管电泳。

IF 1.8 4区化学

Monatshefte Fur Chemie Pub Date : 2022-01-01 Epub Date: 2022-06-21 DOI: 10.1007/s00706-022-02938-4

Katarina Molnarova, Katerina Cokrtova, Alice Tomnikova, Tomas Krizek, Petr Kozlik

引用次数: 2

Chemophobia and passion: why chemists should desire Marcel Proust. 化学恐惧症和激情:为什么化学家应该渴望马塞尔·普鲁斯特。

IF 1.8 4区化学

Monatshefte Fur Chemie Pub Date : 2022-01-01 Epub Date: 2022-07-14 DOI: 10.1007/s00706-022-02945-5

Radek Chalupa, Karel Nesměrák

引用次数: 1

Liposomes: preparation and characterization with a special focus on the application of capillary electrophoresis. 脂质体:制备和表征，特别关注毛细管电泳的应用。

IF 1.8 4区化学

Monatshefte Fur Chemie Pub Date : 2022-01-01 Epub Date: 2022-08-09 DOI: 10.1007/s00706-022-02966-0

Alice Tomnikova, Andrea Orgonikova, Tomas Krizek

{"title":"Liposomes: preparation and characterization with a special focus on the application of capillary electrophoresis.","authors":"Alice Tomnikova, Andrea Orgonikova, Tomas Krizek","doi":"10.1007/s00706-022-02966-0","DOIUrl":"https://doi.org/10.1007/s00706-022-02966-0","url":null,"abstract":"Liposomes are nowadays a matter of tremendous interest. Due to their amphiphilic character, various substances with different properties can be incorporated into them and they are especially suitable as a model system for controlled transport of bioactive substances and drugs to the final destination in the body; for example, COVID-19 vaccines use liposomes as a carrier of mRNA. Liposomes mimicking composition of various biological membranes can be prepared with a proper choice of the lipids used, which proved to be important tool in the early drug development. This review deals with commonly used methods for the preparation and characterization of liposomes which is essential for their later use. The alternative capillary electrophoresis methods for physico-chemical characterization such as determination of membrane permeability of liposome, its size and charge, and encapsulation efficiency are included. Two different layouts using liposomes to yield more efficient separation of various analytes are also presented, capillary electrochromatography, and liposomal electrokinetic chromatography.Graphical abstract: ","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"153 9","pages":"687-695"},"PeriodicalIF":1.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40698401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Antimalarial and anticancer properties of artesunate and other artemisinins: current development. 青蒿琥酯和其他青蒿素类药物的抗疟和抗癌特性：目前的发展情况。

IF 1.7 4区化学

Monatshefte Fur Chemie Pub Date : 2021-01-01 Epub Date: 2021-03-30 DOI: 10.1007/s00706-021-02759-x

Pitambar Khanal

{"title":"Antimalarial and anticancer properties of artesunate and other artemisinins: current development.","authors":"Pitambar Khanal","doi":"10.1007/s00706-021-02759-x","DOIUrl":"10.1007/s00706-021-02759-x","url":null,"abstract":"This review provides a recent perspective of artesunate and other artemisinins as antimalarial drugs and their uses in cancer therapy. Artesunate is an artemisinin derivative. Artemisinin is extracted from the plant Artemisia annua. Artemisinin and its derivatives have been the most useful drug for malarial treatment in human history. The artesunate has an advantage of a hydrophilic group over other artemisinins which makes it a more potent drug. On the industrial scale, artemisinins are synthesized in semisynthetic ways. The 1,2,4-endoperoxide bridge of artemisinins is responsible for the drug's antimalarial activity. There is the emergence of artemisinin resistance on Plasmodium falciparum and pieces of evidence suggest that it is mainly due to the mutation at Kelch13 protein of P. falciparum. Clinical trial data show that the artesunate is more favorable than quinine and other artemisinins to treat patients with severe malaria. Pieces of evidence indicate that artemisinins can be developed as anticancer drugs. The mechanism of actions on how artemisinins act as an anticancer drug involves oxidative stress, DNA damage and repair, and various types of cell deaths.Graphic abstract: ","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"152 4","pages":"387-400"},"PeriodicalIF":1.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25573083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of chiral separations of pharmaceutically active substances by HPLC (2018-2020). 高效液相色谱法手性分离药物活性物质概述（2018-2020 年）。

IF 1.7 4区化学

Monatshefte Fur Chemie Pub Date : 2021-01-01 Epub Date: 2021-08-24 DOI: 10.1007/s00706-021-02832-5

Sofiya Grybinik, Zuzana Bosakova

引用次数: 0

Enzyme prodrug therapy: cytotoxic potential of paracetamol turnover with recombinant horseradish peroxidase. 酶原药疗法：重组辣根过氧化物酶转化扑热息痛的细胞毒性潜力。

IF 1.7 4区化学

Monatshefte Fur Chemie Pub Date : 2021-01-01 Epub Date: 2021-10-05 DOI: 10.1007/s00706-021-02848-x

Diana Humer, Oliver Spadiut

{"title":"Enzyme prodrug therapy: cytotoxic potential of paracetamol turnover with recombinant horseradish peroxidase.","authors":"Diana Humer, Oliver Spadiut","doi":"10.1007/s00706-021-02848-x","DOIUrl":"10.1007/s00706-021-02848-x","url":null,"abstract":"Targeted cancer treatment is a promising, less invasive alternative to chemotherapy as it is precisely directed against tumor cells whilst leaving healthy tissue unaffected. The plant-derived enzyme horseradish peroxidase (HRP) can be used for enzyme prodrug cancer therapy with indole-3-acetic acid or the analgesic paracetamol (acetaminophen). Oxidation of paracetamol by HRP in the presence of hydrogen peroxide leads to N-acetyl-p-benzoquinone imine and polymer formation via a radical reaction mechanism. N-acetyl-p-benzoquinone imine binds to DNA and proteins, resulting in severe cytotoxicity. However, plant HRP is not suitable for this application since the foreign glycosylation pattern is recognized by the human immune system, causing rapid clearance from the body. Furthermore, plant-derived HRP is a mixture of isoenzymes with a heterogeneous composition. Here, we investigated the reaction of paracetamol with defined recombinant HRP variants produced in E. coli, as well as plant HRP, and found that they are equally effective in paracetamol oxidation at a concentration ≥ 400 µM. At low paracetamol concentrations, however, recombinant HRP seems to be more efficient in paracetamol oxidation. Yet upon treatment of HCT-116 colon carcinoma and FaDu squamous carcinoma cells with HRP-paracetamol no cytotoxic effect was observed, neither in the presence nor absence of hydrogen peroxide.Supplementary information: The online version contains supplementary material available at 10.1007/s00706-021-02848-x.","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"152 11","pages":"1389-1397"},"PeriodicalIF":1.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10255306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemophobia cured by chemists: chemists as children of the Sun. 化学家治愈的化学恐惧症：化学家是太阳的孩子。

IF 1.7 4区化学

Monatshefte Fur Chemie Pub Date : 2021-01-01 Epub Date: 2021-08-11 DOI: 10.1007/s00706-021-02814-7

Radek Chalupa, Karel Nesměrák

引用次数: 0

A trigonal coordination of Au(I) phosphane complexes stabilized by O-H ^⋯ X (X = Cl^-, Br^-, I^-) interactions. 通过 O-H ⋯ X（X = Cl-、Br-、I-）相互作用稳定的 Au（I）膦烷配合物的三方配位。

IF 1.8 4区化学

Monatshefte Fur Chemie Pub Date : 2021-01-01 Epub Date: 2021-09-15 DOI: 10.1007/s00706-021-02843-2

Petra Gründlinger, Cezarina Cela Mardare, Thorsten Wagner, Uwe Monkowius

引用次数: 0