Molecular Biology Reports最新文献_第7页

Advances on the therapeutic potential of cell receptor activation in glioblastoma.

IF 2.6 4区生物学

Molecular Biology Reports Pub Date : 2025-02-05 DOI: 10.1007/s11033-025-10312-w

Gerson G Contreras-Chávez, Luis A Zapi-Colin, José A Estrada, Irazú Contreras, José A Estrada

引用次数: 0

Fibrinopeptide a promotes the proliferation and migration of vascular smooth muscle cells by regulating the integrin αVβ3/PI3K/AKT signaling pathway.

IF 2.6 4区生物学

Molecular Biology Reports Pub Date : 2025-02-05 DOI: 10.1007/s11033-025-10314-8

Rourou Fang, Qifan Yang, Dongdong Wu, Jing Zhao, Shouzhu Xu

{"title":"Fibrinopeptide a promotes the proliferation and migration of vascular smooth muscle cells by regulating the integrin αVβ3/PI3K/AKT signaling pathway.","authors":"Rourou Fang, Qifan Yang, Dongdong Wu, Jing Zhao, Shouzhu Xu","doi":"10.1007/s11033-025-10314-8","DOIUrl":"https://doi.org/10.1007/s11033-025-10314-8","url":null,"abstract":"Background: Atherosclerosis is characterized by subintimal proliferation and migration of vascular smooth muscle cells (VSMCs) in response to stimuli such as coagulation and inflammatory factors. Fibrinopeptide A (FPA), a biomarker for coagulation system activation, is elevated in patients with ischemic heart disease. However, its role in the pathophysiology of cardiovascular disorders remains unclear. This study aimed to investigate the impact of FPA on VSMCs proliferation and migration and elucidate the underlying molecular mechanisms.Methods and results: Transcriptome sequencing and bioinformatics analysis were employed to elucidate molecular pathways. Scratch wound and Transwell assays were performed to evaluate cell migration capacity. Molecular expression patterns were assessed using immunofluorescence, real-time quantitative PCR, and Western blot assays. The differentially expressed genes (DEGs) in the FPA-treated VSMCs were enriched in the cell cycle and PI3K/AKT signaling pathway. FPA treatment enhanced VSMCs' migratory capacity and upregulated integrin αVβ3, PI3K, P-AKT, AKT, Cyclin D1, and PCNA expression. The integrin αVβ3 inhibitor Cyclo-RGDfk effectively suppressed VSMCs migration and reduced the expression levels of these genes in FPA-stimulated VSMCs.Conclusions: These results suggested that FPA promotes the proliferation and migration of VSMCs by regulating the PI3K/AKT signaling pathway through integrin αVβ3.","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"205"},"PeriodicalIF":2.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of cell-free DNA, micro-RNA 21, and micro-RNA 146a levels with rheumatoid arthritis activity.

IF 2.6 4区生物学

Molecular Biology Reports Pub Date : 2025-02-04 DOI: 10.1007/s11033-025-10266-z

Hend Moness, Reham Ali Ibrahim, Samar A Soliman, Al-Shaimaa M Abdel-Naiem, Shaimaa Moustafa Hafez, Noha M Abdullah

{"title":"Association of cell-free DNA, micro-RNA 21, and micro-RNA 146a levels with rheumatoid arthritis activity.","authors":"Hend Moness, Reham Ali Ibrahim, Samar A Soliman, Al-Shaimaa M Abdel-Naiem, Shaimaa Moustafa Hafez, Noha M Abdullah","doi":"10.1007/s11033-025-10266-z","DOIUrl":"https://doi.org/10.1007/s11033-025-10266-z","url":null,"abstract":"Background: Rheumatoid arthritis (RA) is a progressive systemic autoimmune disease characterized by chronic inflammation of synovial joints and impaired immunological tolerance. It ultimately results in irreversible joint degeneration. This study aimed to measure Cell-Free DNA (cf-DNA), miR-21, and miR-146a and assess their disease activity levels in RA.Methods & results: This case-control trial was conducted on 80 subjects (patients and control groups). Cases were categorised into two groups: Group I: 20 cases with active disease and Group II: 20 cases with inactive disease. Group III (control): 40 healthy subjects with matched age and sex. The DAS-28 score was used to assess the RA disease activity. This study demonstrated that miRNA21, miRNA 146a, and cf-DNA significantly increased in both active and inactive groups compared to controls (P-value < 0.001). In addition, there was a significant increase in the active group compared to the inactive group (P-value < 0.001). In the active group, miRNA 146a and cf-DNA exhibited a significant positive correlation with the DAS-28 score and clinical manifestations, including morning stiffness, joint tenderness, and swelling. The linear regression analysis revealed that the primary predictors of miRNA21, miRNA 146a, and cf-DNA levels are the DAS-28 score, ESR, and disease duration.Conclusions: miRNA 146a can be considered a valuable marker for disease activity in RA patients. Furthermore, cf-DNA is suggested to indicate inflammatory conditions; however, MiR21 did not show a significant association with disease activity.","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"200"},"PeriodicalIF":2.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From heterogeneity to prognosis: understanding the complexity of tertiary lymphoid structures in tumors.

IF 2.6 4区生物学

Molecular Biology Reports Pub Date : 2025-02-04 DOI: 10.1007/s11033-025-10319-3

Yingying Wang, Dongyan Zhang, Xueping Huang, Guohao Wu, Chuanbao Wang, Jun Li, Song Wang, Xinmiao Xian, Bo Fu, Keyi Li

{"title":"From heterogeneity to prognosis: understanding the complexity of tertiary lymphoid structures in tumors.","authors":"Yingying Wang, Dongyan Zhang, Xueping Huang, Guohao Wu, Chuanbao Wang, Jun Li, Song Wang, Xinmiao Xian, Bo Fu, Keyi Li","doi":"10.1007/s11033-025-10319-3","DOIUrl":"https://doi.org/10.1007/s11033-025-10319-3","url":null,"abstract":"Tertiary lymphoid structures (TLSs) are aberrant lymphoid tissues found in persistent inflammatory settings, including malignancies, autoimmune disorders, and transplanted organs. The organization and architecture of TLS closely resemble that of secondary lymphoid organs (SLOs). The formation of TLS is an ongoing process, with varying structural features observed at different stages of maturation. The tumor microenvironment (TME) is a multifaceted milieu comprising cells, molecules, and extracellular matrix components in close proximity to the neoplasm. TLS within the TME have the capacity to actively elicit anti-tumor immune responses. TLSs exhibit tumor-specific and individual-specific characteristics, leading to varying immune responses towards tumor immunity based on their distinct cellular components, maturity levels, and spatial distribution. Cell interaction is the foundational elements of tumor immunity. Despite differences in the cellular composition of TLS, B cells and T cells are the main components of tumor-associated TLS。Recent research has highlighted the significance of diverse subtypes of B cells and T cells within TLSs in influencing the therapeutic outcomes and prognostic indicators of individual tumors. This review elucidates the diversity of TLS in terms of cellular composition, developmental stage, anatomical location, and the influence of cytokines on their initiation and progression. Furthermore, the article examines the involvement of B and T cells within TLS and the significance of TLS in relation to tumor prognosis.","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"197"},"PeriodicalIF":2.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic association of single nucleotide polymorphisms in PLEKHA7 gene with primary angle closure glaucoma (PACG) in a Central-Eastern Punjab cohort of Pakistan.

IF 2.6 4区生物学

Molecular Biology Reports Pub Date : 2025-02-04 DOI: 10.1007/s11033-025-10292-x

Roha Asif, Ammara Khalid, Rasheeda Bashir, Komal Aslam, Khazeema Yousaf, Raazia Waseem

{"title":"Genetic association of single nucleotide polymorphisms in PLEKHA7 gene with primary angle closure glaucoma (PACG) in a Central-Eastern Punjab cohort of Pakistan.","authors":"Roha Asif, Ammara Khalid, Rasheeda Bashir, Komal Aslam, Khazeema Yousaf, Raazia Waseem","doi":"10.1007/s11033-025-10292-x","DOIUrl":"https://doi.org/10.1007/s11033-025-10292-x","url":null,"abstract":"Background: Primary Angle Closure Glaucoma (PACG) is a potentially devastating disease that causes optic nerve injury globally.Methods: The enrollment of patients with PACG and healthy controls came from ophthalmology health centers in different hospitals in Punjab (n = 96 cases and n = 102 controls). PLEKHA7 rs216489 and rs11024102 alleles were genotyped by Tetra ARMS PCR. Binary Logistic Regression was applied to discover the relationship amid risk alleles with PLEKHA7. Genetic models were used to identify the risk of links among a specific inheritance pattern's genotype and phenotype. In silico analysis was performed to analyze the functional consequences and regulatory elements of both these polymorphisms.Results: This study investigated that the patients affected with PACG have IOP and C/D ratio (17.43 ± 9.40 and 0.565 ± 0.5994 respectively) along with other clinical characteristics than healthy controls. The genotype distribution for PLEKHA7 rs216489 revealed no association with PACG. In contrast, in SNP rs11024102, the frequency of genotype AA is noticeably higher in PACG patients compared to controls. For genetic models, the dominant model of rs11024102 (P < 0.02) (OR = 2.335, 95% CI = 1.135-4.804) was discovered to be strongly associated to rise the pathogenicity of PACG. In silico examination predicted that both of the SNPs of the PLEKHA7 gene are causing benign mutations in nature and are less and more likely to be predicted as regulatory variants.Conclusion: This is the first study on PACG genotypes from Pakistan, and results suggest that PLEKHA7 (rs11024102) polymorphism is significantly associated with susceptibility to PACG in Punjab, Pakistan.","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"191"},"PeriodicalIF":2.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TRIM11 modulates sepsis progression by promoting HOXB9 ubiquitination and inducing the NF-κB signaling pathway.

IF 2.6 4区生物学

Molecular Biology Reports Pub Date : 2025-02-04 DOI: 10.1007/s11033-024-10212-5

Jiaqi Gan, Wei Zhang, Fei Pan, Zhiyun Qiu, Xiaobing Chen

{"title":"TRIM11 modulates sepsis progression by promoting HOXB9 ubiquitination and inducing the NF-κB signaling pathway.","authors":"Jiaqi Gan, Wei Zhang, Fei Pan, Zhiyun Qiu, Xiaobing Chen","doi":"10.1007/s11033-024-10212-5","DOIUrl":"https://doi.org/10.1007/s11033-024-10212-5","url":null,"abstract":"Introduction: The purpose of this investigation was to elucidate the functions of TRIM11 and HOXB9 in the pathogenesis of sepsis, focusing on their influence on inflammation, apoptosis, and the NF-κB signaling pathway.Material and methods: Through public databases, TRIM family genes related to sepsis were screened, and TRIM11 was evaluated as a sepsis biomarker through ROC analysis. The UbiBrowser database screened TRIM11 downstream genes and identified HOXB9 as an essential target. THP-1 cells were stimulated by Lipopolysaccharide (LPS) to induce inflammation and simulate sepsis. Flow cytometry, Enzyme-linked immunosorbent assay, and Western blot experiments were used to detect changes in cell apoptosis rate, apoptosis-related proteins, and inflammatory cytokines after TRIM11 and HOXB9 were silenced. Additionally, we investigated the ubiquitination interaction between TRIM11 and HOXB9 and their effects on the NF-κB signaling pathway.Results: Our findings demonstrated that sepsis patient samples had elevated levels of TRIM11 expression and had high clinical diagnostic value. Functional experiments showed that the knockdown of TRIM11 significantly alleviated LPS-induced THP-1 cell apoptosis and inflammation, while the knockdown of HOXB9 did the opposite. The simultaneous downregulation of TRIM11 and HOXB9 balanced these responses, suggesting they play a key role in regulating sepsis-associated inflammation and apoptosis. In addition, TRIM11 regulated the NF-κB signaling pathway by reversing HOXB9-induced activation through ubiquitination, suggesting a novel regulatory mechanism in the pathogenesis of sepsis.Conclusions: Our findings highlight the interaction between TRIM11 and HOXB9 in regulating inflammation and apoptosis pathways, providing new insights into sepsis treatment.","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"194"},"PeriodicalIF":2.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico investigation and expression analysis of two-component regulatory systems in Proteus mirabilis.

IF 2.6 4区生物学

Molecular Biology Reports Pub Date : 2025-02-04 DOI: 10.1007/s11033-025-10268-x

Dawid Gmiter, Aleksandra Omelaniuk, Wanesa Sasal, Leon Petruńko, Klaudia Musiał, Sylwia Nawrot, Ilona Pacak, Wiesław Kaca

{"title":"In silico investigation and expression analysis of two-component regulatory systems in Proteus mirabilis.","authors":"Dawid Gmiter, Aleksandra Omelaniuk, Wanesa Sasal, Leon Petruńko, Klaudia Musiał, Sylwia Nawrot, Ilona Pacak, Wiesław Kaca","doi":"10.1007/s11033-025-10268-x","DOIUrl":"https://doi.org/10.1007/s11033-025-10268-x","url":null,"abstract":"Background: Proteus mirabilis (P. mirabilis), a Gram-negative bacterium from the Morganellaceae family, exists in various habitats, ranging from natural environmental sources to animal and human host. Two-component systems (TCSs) are involved in sensing various types of stimuli present in the environment, including antimicrobial chemotherapeutics. Moreover, TCSs regulate bacterial virulence. The 16 sets of genes encoding TCSs proteins have been identified in genome of P. mirabilis HI4320 reference strain, but their role remains understudied.Methods and results: In the presented work, a comparative in silico analysis of TCSs proteins encoded by the genome sequences of P. mirabilis strains obtained from public databases was performed. Additionally, the expression of genes encoding regulatory proteins in response to polymyxin B and H2O2 was analyzed using RT-qPCR. The obtained results revealed a relative conservatism of TCSs among P. mirabilis isolates, indicating, however, differences that might result in strains phenotypic diversity. Moreover, constitutive expression of genes coding regulatory proteins from studied TCSs was observed under laboratory conditions.Conclusions: Presented study shed light on the role of TCSs in P. mirabilis. Further deepen research in this area might provide more effective means for controlling P. mirabilis infections.","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"192"},"PeriodicalIF":2.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Barcoding the Caatinga biome bees: a practical review.

IF 2.6 4区生物学

Molecular Biology Reports Pub Date : 2025-02-04 DOI: 10.1007/s11033-025-10307-7

Pedro Rodrigues, Cláudia Teixeira, Laura Guimarães, Nuno G C Ferreira

{"title":"Barcoding the Caatinga biome bees: a practical review.","authors":"Pedro Rodrigues, Cláudia Teixeira, Laura Guimarães, Nuno G C Ferreira","doi":"10.1007/s11033-025-10307-7","DOIUrl":"10.1007/s11033-025-10307-7","url":null,"abstract":"Bees play a critical role as pollinators in ecosystem services, contributing significantly to the sexual reproduction and diversity of plants. The Caatinga biome in Brazil, home to around 200 bee species, provides an ideal habitat for these species due to its unique climate conditions. However, this biome faces threats from anthropogenic processes, making it urgent to characterise the local bee populations efficiently. Traditional taxonomic surveys for bee identification are complex due to the lack of suitable keys and expertise required. As a result, molecular barcoding has emerged as a valuable tool, using genome regions to compare and identify bee species. However, little is known about Caatinga bees to develop these molecular tools further. This study addresses this gap, providing an updated list of 262 Caatinga bee species across 86 genera and identifying ~ 40 primer sets to aid in barcoding these species. The findings highlight the ongoing work needed to fully characterise the Caatinga biome's bee distribution and species or subspecies to support more effective monitoring and conservation efforts.","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"196"},"PeriodicalIF":2.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Growth hormone signaling and clinical implications: from molecular to therapeutic perspectives.

IF 2.6 4区生物学

Molecular Biology Reports Pub Date : 2025-02-04 DOI: 10.1007/s11033-025-10304-w

Zahra Sadat Aghili, Golnoosh Khoshnevisan, Rezvan Mostoli, Mehdi Alibaglouei, Sayyed Hamid Zarkesh-Esfahani

{"title":"Growth hormone signaling and clinical implications: from molecular to therapeutic perspectives.","authors":"Zahra Sadat Aghili, Golnoosh Khoshnevisan, Rezvan Mostoli, Mehdi Alibaglouei, Sayyed Hamid Zarkesh-Esfahani","doi":"10.1007/s11033-025-10304-w","DOIUrl":"https://doi.org/10.1007/s11033-025-10304-w","url":null,"abstract":"Growth hormone (GH) is a key polypeptide hormone secreted by somatotroph cells in the anterior pituitary gland, essential for postnatal growth, metabolism, and systemic homeostasis. Its secretion is regulated by hypothalamic neuropeptides, including GH-releasing hormone and somatostatin. GH exerts effects through direct interaction with the growth hormone receptor and indirect pathways mediated by the GH-IGF-I axis. GHR activation triggers signaling pathways, such as JAK-STAT, PI3K/AKT, and MAPK, promoting cellular proliferation, differentiation, and metabolic balance. The GH-IGF-I axis is critical for bone growth, lipid and carbohydrate metabolism, and organ-specific physiological functions. Dysregulation of GH results in diverse disorders. Congenital deficiencies, like isolated GH deficiency and syndromic conditions (e.g., Turner syndrome), stem from genetic mutations. Acquired deficiencies arise from trauma, tumors, infections, or autoimmune damage, while GH overproduction causes gigantism in children and acromegaly in adults, often due to pituitary adenomas. Idiopathic deficiencies, lacking identifiable causes, complicate management further. Advances in therapy have transformed outcomes for GH disorders. Recombinant human growth hormone provides effective replacement therapy for deficiencies. Somatostatin analogs, dopamine receptor agonists, and GH receptor antagonists are pivotal for managing GH excess. Surgical and radiotherapeutic interventions remain essential for pituitary adenomas. However, GH therapy requires close monitoring to prevent side effects like insulin resistance and metabolic complications. This review provides a comprehensive evaluation of the molecular mechanisms underlying GH action, its physiological roles, GH-related disorders, and therapeutic approaches to optimize patient outcomes.","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"202"},"PeriodicalIF":2.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting the cholinergic anti-inflammatory pathway: an innovative strategy for treating diseases.

IF 2.6 4区生物学

Molecular Biology Reports Pub Date : 2025-02-04 DOI: 10.1007/s11033-025-10288-7

Yifan Li, Shufan Ding, Yongjie Wang

{"title":"Targeting the cholinergic anti-inflammatory pathway: an innovative strategy for treating diseases.","authors":"Yifan Li, Shufan Ding, Yongjie Wang","doi":"10.1007/s11033-025-10288-7","DOIUrl":"https://doi.org/10.1007/s11033-025-10288-7","url":null,"abstract":"The cholinergic anti-inflammatory pathway (CAP) is comprised of the vagus nerve, acetylcholine, nicotinic acetylcholine receptors, the spleen, and the splenic nerve. It represents a sophisticated neuroimmune axis that critically regulates the crosstalk between the nervous system and the immune response via the vagus nerve. Here, we provided a nuanced exploration of the CAP's role in curbing inflammatory processes and its broad therapeutic potential across a spectrum of diseases. We meticulously dissect the intricate mechanisms by which the CAP modulates key signaling cascades, including the NF-κB, JAK2/STAT3, MAPK/ERK, PI3K/AKT, COX2/PGE2, and NRF2/HO-1 pathways, which are quintessential in the pathogenesis of various conditions. Additionally, we also summarized the CAP's profound implications in the management of inflammatory diseases, neurodegenerative disorders, metabolic syndromes, and oncological malignancies, elucidating its capacity to mitigate disease severity and progression through sophisticated immune modulation. The modulation of the CAP is suggested as a novel strategy that could potentially transform treatment approaches for a variety of conditions. However, the precise cellular and molecular underpinnings of the CAP's effects, as well as its translatability to clinical settings, remain subjects of ongoing investigation. The review calls for further research to demystify the mechanisms of the CAP and to harness its therapeutic potential fully, with the aim of developing innovative and efficacious treatment modalities that exploit the pathway's unique attributes.","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"199"},"PeriodicalIF":2.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0