Molecular Biology Reports最新文献

{"title":"Isolation and identification of core-genes in barley roots under low phosphorus stress.","authors":"Panrong Ren, Qian Li, Jie Wang, Chunlin Wang, Hong Chen, Yihan Wang","doi":"10.1007/s11033-025-10567-3","DOIUrl":"https://doi.org/10.1007/s11033-025-10567-3","url":null,"abstract":"<p><strong>Background: </strong>Low phosphorus stress significantly limits plant growth and agricultural production. Identifying core genes responsive to low-phosphorus stress and breeding new high-phosphorus-efficient crop varieties are crucial for solving practical production problems. Barley is an important crop with genetic diversity and stress tolerance. In this study, we aimed to explore the core genes in barley roots under low-phosphorus stress.</p><p><strong>Methods and results: </strong>Based on the transcriptome sequencing data of barley root under low phosphorus stress, we used the Weighted Gene Co-expression Network Analysis (WGCNA) method on the high phosphorus-efficient genotype GN121. All expressed genes related to phosphorus content were grouped into 16 co-expression modules. Six highly correlated modules were selected for GO enrichment analysis. Genes in the green module were significantly enriched in \"response to stress\" and \"response to oxidative stress\" signaling pathways, while genes in the turquoise module were significantly enriched in \"cell response to stimulation\" and \"cell response to stress\" pathways. Through further analysis of these two modules, we identified three core genes: endoglucan-1,3-β-glucosidase 3 (HORVU2Hr1G044440) and peroxidase 5 (HORVU1Hr1G023750 and HORVU1Hr1G016820).</p><p><strong>Conclusions: </strong>The identified three core genes above mentioned are involved in the regulation of abiotic stress. These results offer clues for further research on the molecular mechanism of barley's response to low phosphorus stress and genetic resources for breeding high-phosphorus-efficient crop varieties. The findings contribute to understanding how barley adapts to low-phosphorus environments and provide a basis for improving crop phosphorus-use efficiency.</p>","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"463"},"PeriodicalIF":2.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of TCF7L2 gene polymorphisms, rs12255372 and rs7903146, with type 2 diabetes mellitus in the Jordanian population.","authors":"Nour Ghosheh, Randa G Naffa, Safaa Mashal, Sawsan Al-Khalayfa, AbdelKader Hamdi Battah, Bilal Azab","doi":"10.1007/s11033-025-10544-w","DOIUrl":"https://doi.org/10.1007/s11033-025-10544-w","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2D) is one of the biggest health concerns of our time. T2D prevalence is expected to reach 1.9 million Jordanians by 2050. Owing to this sharp increase, Jordanians should understand genetic risk factors for this disease. One of the strongest reported single nucleotide polymorphisms (SNPs) associated with T2D is located in the transcription factor 7-like 2 (TCF7L2) gene, particularly rs12255372 and rs7903146. Despite this, contradictory results suggesting no association with T2D were found across ethnicities. Therefore, this study investigated the association of rs12255372 and rs7903146 with T2D in Jordanians.</p><p><strong>Methods and results: </strong>For this case-control study, 301 non-diabetic healthy controls and 301 patients with T2D were genotyped for rs12255372 and rs7903146 using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). A significant development in T2D was demonstrated in rs12255372 and rs7903146. The risk allele for both single nucleotide polymorphisms is the T allele. The p-value ≤ 0.001 reflects a significant difference between the control group and the T2D group. Moreover, the combined effect of rs12255372 and rs7903146 showed statistical significance with a p-value ≤ 0.001.</p><p><strong>Conclusion: </strong>Our study suggests that TCF7L2 gene polymorphisms (rs12255372 and rs7903146) are predisposing risk factors for T2D in the Jordanian population.</p>","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"461"},"PeriodicalIF":2.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of early relapse in multiple myeloma patients after Autologous hematopoietic stem cell transplantation by miR-21 and miR-181a.","authors":"Meysam Kashiri, Sara Zehtabcheh, Setare Kheyrandish, Mohsen Hamidpour, Mohammad Rafiee, Mohammad Hossein Mohammadi","doi":"10.1007/s11033-025-10515-1","DOIUrl":"https://doi.org/10.1007/s11033-025-10515-1","url":null,"abstract":"<p><strong>Background: </strong>MicroRNAs (miRs) are small non-coding RNAs that have been extensively reported to be involved in multiple myeloma (MM) pathogenesis and progression. While the precise role of miRs in MM remains to be fully elucidated, they have demonstrated significant potential as prognostic markers in various other cancers. This study aimed to investigate the relationship between miR-21, miR-181a, and miR-23b expression before autologous hematopoietic stem cell transplantation (AHSCT) and post-transplant early relapse (ER) incidence in MM patients.</p><p><strong>Methods and results: </strong>Thirty-five diagnosed MM patients who were eligible for AHSCT were included. The relative expression of the miRs was determined in peripheral blood samples collected at the time of apheresis using a quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Patients were stratified into two groups based on whether their miR expressions were above or below the median. Eight of thirty-five patients (22.8%) experienced ER within 12 months (with a median of 8.1 months) after AHSCT. Patients with miR-21 expression levels below 2.1 showed delayed relapse, with no early relapse observed within the first ten months. In contrast, high expression of miR-181a (≥ 3.5) was associated with a relapse rate exceeding 75% by approximately five months.</p><p><strong>Conclusion: </strong>This study highlights the potential of miR-21 and miR-181a as biomarkers for predicting ER in MM patients undergoing AHSCT. Ultimately, these findings facilitate the development of targeted interventions and personalized risk assessments, improving patient outcomes. Further research is needed to validate and expand these promising results, optimizing the use of miR-based tools in clinical practice.</p>","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"460"},"PeriodicalIF":2.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene expression analysis of PvDGK genes in response to Helicoverpa armigera Hübner (Lepidoptera: Noctuidae), wounding and methyl jasmonate treatments in common bean.","authors":"Abdurrahman Sami Koca, Mehmet Zahit Yeken","doi":"10.1007/s11033-025-10560-w","DOIUrl":"https://doi.org/10.1007/s11033-025-10560-w","url":null,"abstract":"<p><p>Plants have evolved complex defense mechanisms against biotic stressors, such as insect pests, involving chemical, physical, and molecular responses. These mechanisms, including producing secondary metabolites and activating specific signaling pathways, help mitigate damage and ensure survival under pest pressure. Many plants defense-related genes that play crucial roles in regulating defense responses have been identified in common bean. Phosphatidic acid (PA) is a vital lipid signaling molecule in plant stress responses, with diacylglycerol kinases (DGKs) play a key role in its production. In this study, we investigated the role of the PvDGK gene family in common bean under control, wounding, methyl jasmonate (MeJA, 100 µM), Helicoverpa armigera infestation, MeJA x wounding interaction and MeJA x H. armigera interaction. The larvae of H. armigera were reared under controlled conditions and used for infestation when they reached the fifth instar (L5). Expression levels of PvDGK1, PvDGK2, PvDGK3, PvDGK5a, PvDGK5b, and PvDGK6 genes were analyzed through qRT-PCR in leaves tissues. All PvDGK genes were upregulated in response to MeJA x H. armigera interaction. Notably, PvDGK2 was the most upregulated gene in the interaction of MeJA x H. armigera interaction, indicating its potential role in defense signaling. These findings provide the first evidence the importance of PvDGK genes in stress adaptation mechanisms in common bean and highlight their potential as targets for improving insect resistance. Future functional studies are crucial to fully elucidating the mechanisms through which these genes contribute to stress resilience and enhance our understanding of lipid signaling pathways in plant defense.</p>","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"462"},"PeriodicalIF":2.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-type lectin-like molecule-1 as a diagnostic, prognostic, and therapeutic marker in leukemia.","authors":"Hamed Soleimani Samarkhazan, Sara Zehtabcheh, Sajjad Peyvasteh, Mohammad Hossein Mohammadi","doi":"10.1007/s11033-025-10527-x","DOIUrl":"https://doi.org/10.1007/s11033-025-10527-x","url":null,"abstract":"<p><p>Leukemia, characterized by a heterogeneous spectrum of malignancies arising from the clonal expansion of hematopoietic progenitor cells, continues to represent a significant challenge within the field of oncology. Notwithstanding advancements in diagnostic techniques, therapeutic strategies, and prognostic tools, the complexities surrounding the pathogenesis of leukemia and its diverse clinical manifestations highlight the imperative need for the identification of novel biomarkers aimed at improving patient outcomes. The C-type lectin-like molecule-1 (CLL-1) has recently gained recognition as a particularly promising and appealing therapeutic target within the realm of leukemia. This cell surface receptor is characterized by an exceptionally high expression level on acute myeloid leukemia (AML) blasts. The consistent presence of CLL-1 on these cells not only emphasizes its prospective utility as a therapeutic target but also positions it as an optimal candidate for the surveillance of minimal residual disease (MRD). Furthermore, CLL-1 showcases innovative potential for the formulation of new immunotherapeutic strategies designed to combat leukemia. This narrative review aims to explore the structure, function, and diverse expression patterns of CLL-1 in relation to leukemia, thereby offering critical insights into its pivotal role in the disease's pathogenesis and its potential ramifications for treatment. The investigation of CLL-1 as a feasible target for diagnostic purposes, MRD monitoring, and the creation of novel immunotherapy strategies heralds the commencement of new and promising pathways for therapeutic approaches employed in the management of leukemia. A comprehensive understanding of the complex interplay between CLL-1 and the pathogenesis of leukemia will undeniably contribute to the design and advancement of more targeted and efficacious therapeutic interventions.</p>","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"464"},"PeriodicalIF":2.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting cholesterol-driven pyroptosis: a promising strategy for the prevention and treatment of atherosclerosis.","authors":"Yuehong Tang, Wenjuan Tong, Yujiao Peng, Shaowei Sun","doi":"10.1007/s11033-025-10554-8","DOIUrl":"https://doi.org/10.1007/s11033-025-10554-8","url":null,"abstract":"<p><p>Funding Pyroptosis is a type of programmed cell death (PCD) pathway distinguished by inflammation. It is activated by specific inflammasomes. Once activated, it causes the physical breakdown of the cell, along with the discharge of pro-inflammatory cytokines, such as interleukin-1β (IL-1β) and interleukin-18 (IL-18). Abundant evidence has demonstrated the existence of pyroptotic cell death within atherosclerotic plaques, which has significance for the development of atherosclerosis (AS). As a result, pyroptosis has become a new and important topic in cardiovascular disease (CVD) research. Cholesterol, it is recognized to have a connection with inflammation, exerts a crucial function in the development process of AS, and has been linked to the initiation of pyroptosis. This review aims to briefly summarize the fundamental aspects of pyroptosis and the influence of cholesterol-related inflammation in AS. Additionally, this review will explore potential therapeutic approaches based on pyroptosis that could be utilized for the prevention and treatment of AS.</p>","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"459"},"PeriodicalIF":2.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional characterization of two distinct classes of NADPH-cytochrome P450 reductases in Senna alexandrina Mill.","authors":"Mushfa Khatoon, Amita Dubey","doi":"10.1007/s11033-025-10566-4","DOIUrl":"10.1007/s11033-025-10566-4","url":null,"abstract":"<p><strong>Background: </strong>Senna alexandrina Mill., an important medicinal plant of Fabaceae family, is famous for its laxative properties which are mainly due to the presence of sennosides (anthraquinone glycosides). However, the complete biosynthetic pathway of sennosides in Senna is not yet fully understood. Cytochrome P450 monooxygenases (CYPs), which are heme-containing enzymes are supposed to play key roles in sennoside biosynthesis. Cytochrome P450 reductases (CPRs) are essential for the activity of CYPs, as they function as their redox partners. However, CPRs in Senna have not yet been characterized in detail.</p><p><strong>Methods and results: </strong>In this study, two different sequences of SaCPRs were retrieved from the publicly available Transcriptome Shotgun Assembly (TSA) database of S. alexandrina at National Center for Biotechnology Information (NCBI). The open reading frames of SaCPR1 and SaCPR2 were found to be 2079 and 2121 bp, encoding 693 and 707 amino acid long polypeptides, respectively. Phylogenetic and 3-D structure analysis predicted that these two SaCPRs (i.e. SaCPR1 and SaCPR2) were grouped with the members of Class I and Class II CPRs, respectively. Analysis of SaCPR1 and SaCPR2 sequences showed that the conserved domains commonly found in CPRs such as FMN- (Flavin adenine mononucleotide), FAD-(Flavin adenine dinucleotide), NADPH-(Nicotinamide adenine dinucleotide phosphate hydrogen) and cytochrome P450 binding region, were also present in SaCPRs. SaCPR1 and SaCPR2 were cloned and expressed in yeast for functional characterization. In cytochrome P450 reductase assay, both SaCPR1 and SaCPR2 reduced cytochrome c in the presence of NADPH as an electron donor, however, SaCPR1 showed higher specific activity than SaCPR2. The real time expression analysis of SaCPRs performed in the leaf, stem and root tissues of Senna showed that SaCPR1 was expressed more in leaf tissue while SaCPR2 expressed more in stem tissue. Furthermore, both the SaCPRs were found to be induced by salicylic acid as well as wound treatment (up to two hr).</p><p><strong>Conclusion: </strong>Two different classes of cytochrome P450 reductases were identified and functionally characterized. SaCPR1 showed higher in vitro activity than SaCPR2 in cytochrome c reduction assay.</p>","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"457"},"PeriodicalIF":2.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginkgetin inhibits the proliferation and migration of lung cancer cells via FAK/STAT3/AKT pathway.","authors":"Longhua Sun, Wen Chen, Wenxin Yuan, Qianwen Huang, Hong Yang, Wei Zhang, Jianjun Tang, Ping Hu","doi":"10.1007/s11033-025-10540-0","DOIUrl":"https://doi.org/10.1007/s11033-025-10540-0","url":null,"abstract":"<p><strong>Purpose: </strong>Lung cancer has become a primary illness that severely endangers human life and health due to its extremely high morbidity and mortality rates. Ginkgetin has been proven to have toxic effects on various tumor cells. Nevertheless, the mechanism of Ginkgetin on lung cancer is uncertain. In the present study, the effect and possible mechanism of Ginkgetin on lung cancer were explored.</p><p><strong>Methods: </strong>The cell counting kit-8 assay and colony formation assay were performed to detect the effect of Ginkgetin on cell proliferation. The wound healing assay was performed to detect the effect of Ginkgetin on cell migration. Additionally, western blot and immunofluorescence assay were performed to detect the expression of proteins.</p><p><strong>Results: </strong>Our results demonstrated that Ginkgetin effectively inhibited the proliferation and migration of A549 and H1299 cells. Mechanistically, Ginkgetin downregulated the phosphorylated expression of focal adhesion kinase (FAK), signal transducer and activator of transcription 3 (STAT3), and protein kinase B (AKT) and blocked the FAK/STAT3/AKT phosphorylation induced by epidermal growth factor (EGF). Furthermore, Ginkgetin suppressed the proliferation and migration of A549 and H1299 cells induced by EGF. Notably, Ginkgetin decreased the Cyclin A2 and Cyclin D1 expression.</p><p><strong>Conclusion: </strong>Collectively, these findings concluded that Ginkgetin may suppress the proliferation and migration of lung cancer cells via the FAK/STAT3/AKT pathway, suggesting that Ginkgetin has potential applications in lung cancer treatment.</p>","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"458"},"PeriodicalIF":2.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-transgenic rodent models of Alzheimer's disease for preclinical research: a review.","authors":"Abhishek Joshi, Shubham Lehene, Ashish Mishra","doi":"10.1007/s11033-025-10549-5","DOIUrl":"https://doi.org/10.1007/s11033-025-10549-5","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by progressive memory loss and cognitive decline. It involves the irreversible destruction of higher brain structures, leading to significant cognitive deficits, personality changes, and aberrant behavior. Key pathological features include the accumulation of amyloid-beta (Aβ) plaques and hyperphosphorylated tau protein neurofibrillary tangles, which disrupt cellular communication and neuron function. Chronic inflammation, vascular abnormalities, and genetic factors like the APOE (apolipoprotein E) ε4 allele also play crucial roles in AD progression. Epidemiological data indicate a substantial global impact, especially among older adults, with women disproportionately affected. Animal models, both transgenic and non-transgenic, are pivotal in researching AD pathophysiology and potential treatments. This review presents a full overview regarding a variety of non-transgenic rodent models of Alzheimer's disease utilized in the preclinical research for treatment approaches in Alzheimer's disease.</p>","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"456"},"PeriodicalIF":2.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrogenic control of matrix metalloproteinases: a perspective on breast tumor invasion and metastasis.","authors":"Ningthoujam Sonia, Snigdha Saikia, Anil Mukund Limaye","doi":"10.1007/s11033-025-10555-7","DOIUrl":"https://doi.org/10.1007/s11033-025-10555-7","url":null,"abstract":"<p><p>Metastasis is the major cause of mortality in breast cancer patients, and presents an invincible therapeutic challenge. It is a complex process of dissemination of tumor epithelial cells, which is associated with disruption of tissue homeostasis, and alterations in the tumor microenvironment through extracellular matrix (ECM) remodeling, stromal alteration, and epithelial-mesenchymal transition. Matrix metalloproteinases (MMPs) constitute a group of more than 25 zinc-dependent endopeptidases. By virtue of their ability to degrade a wide variety of ECM-associated proteins, they enable ECM remodelling during development, and disease. A large body of clinical data, and experimental evidences implicate MMPs in the invasion and metastasis of breast tumors. While MMPs are aberrantly expressed in breast tumors, few appear to have a dual role in disease progression; either promoting or inhibiting metastasis. Given the role of estrogen in breast cancer development, it is natural to ask whether this steroid hormone has any role in breast cancer metastasis. This review is a round-up of the prominent literature that presents estrogenic control of MMPs, which in turn implies its influence on the tumor microenvironment and metastasis.</p>","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"453"},"PeriodicalIF":2.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}