Molecular and clinical oncology最新文献

{"title":"Reconstruction of the lateral collateral ligament using the plantaris tendon after wide excision of soft tissue sarcoma of the knee: A case report.","authors":"Yuichi Tsuha,&nbsp;Hiromichi Oshiro,&nbsp;Kohei Mizuta,&nbsp;Tomoko Tamaki,&nbsp;Yasunori Tome,&nbsp;Naoki Wada,&nbsp;Kotaro Nishida","doi":"10.3892/mco.2023.2619","DOIUrl":"https://doi.org/10.3892/mco.2023.2619","url":null,"abstract":"<p><p>An 83-year-old woman presented with a 1-year history of a growing mass on the lateral surface of the right knee. Magnetic resonance imaging revealed a large soft tissue tumor in the subcutis of the right knee. The mass in the right knee rapidly increased, due to hemorrhage from the tumor. A needle biopsy revealed that the diagnosis was synovial sarcoma. The patient underwent wide excision and lateral collateral ligament reconstruction using the plantaris tendon. The patient had a Musculoskeletal Tumor Society Score of 86% at the lateset follow-up. In conclusion, reconstruction of the lateral collateral ligament using the plantaris tendon may be useful for preserving the function of the knee joint after resection of the soft tissue due to sarcoma of the knee.</p>","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"18 3","pages":"23"},"PeriodicalIF":1.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a7/44/mco-18-03-02619.PMC9944641.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10799373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AXL upregulates c‑Myc expression through AKT and ERK signaling pathways in breast cancers.","authors":"Xiaobai Sun,&nbsp;Hong Chen,&nbsp;Shuling You,&nbsp;Zhikang Tian,&nbsp;Zhaoyu Wang,&nbsp;Fulin Liu,&nbsp;Wenyi Hu,&nbsp;Hao Zhang,&nbsp;Guoan Zhang,&nbsp;Hongli Zhao,&nbsp;Qingwei Guo","doi":"10.3892/mco.2023.2618","DOIUrl":"https://doi.org/10.3892/mco.2023.2618","url":null,"abstract":"<p><p>Breast cancer (BC) is common worldwide. c-Myc and AXL are both overexpressed in BC, promoting its progression. The present study aimed to investigate the role of AXL in c-Myc expression in BC. Overexpression of AXL increased c-Myc expression while knockdown of AXL decreased c-Myc expression as determined by western blot analysis. Pharmaceutical inhibition of AXL also suppressed c-Myc expression. AKT and ERK inhibitor LY294002 and U0126 suppressed c-Myc expression, respectively. AXL overexpression which activates AKT and ERK signaling, upregulates c-Myc expression, while kinase-dead AXL which cannot activate AKT and ERK signaling, does not upregulate c-Myc expression, emphasizing the important role of these two signaling pathways in c-Myc upregulation. Finally, expression data of BC tissues from The Cancer Proteome Atlas displayed an association between AXL and c-Myc. Taken together, the present study revealed that AXL upregulates c-Myc expression through AKT and ERK signaling pathways in BC.</p>","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"18 3","pages":"22"},"PeriodicalIF":1.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944620/pdf/mco-18-03-02618.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10792394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"t(1;7;22)(p13;q21;q13) is a novel 3-way variant of t(1;22)(p13;q13) neonatal acute megakaryoblastic leukemia: A case report.","authors":"Julie Messiaen,&nbsp;Anne Uyttebroeck,&nbsp;Lucienne Michaux,&nbsp;Peter Vandenberghe,&nbsp;Nancy Boeckx,&nbsp;Sandra A Jacobs","doi":"10.3892/mco.2023.2614","DOIUrl":"https://doi.org/10.3892/mco.2023.2614","url":null,"abstract":"<p><p>Acute megakaryoblastic leukemia (AMKL) is a rare disease, occurring mostly in infants and young children. The chromosomal translocation t(1;22)(p13;q13), resulting in the RBM15-MKL1 fusion gene, is a recurrent and diagnostic translocation in infants with AMKL. The present case report describes a case of a newborn girl, without Down's syndrome, with congenital AMKL. At birth, the infant had hepatosplenomegaly and the peripheral blood count revealed anemia, thrombopenia and leukocytosis, with 28% blasts. Immunophenotyping demonstrated blasts positive for CD34, CD61 and CD42b. Karyotyping of these blasts (R-banding) showed a hitherto unreported chromosomal translocation, t(1;7;22)(p13;q21;q13), a 3-way variant of the t(1;22)(p13;q13) variant. Fluorescent <i>in situ</i> hybridization analysis confirmed the presence of the RBM15-MKL1 fusion gene.</p>","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"18 3","pages":"18"},"PeriodicalIF":1.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b2/fe/mco-18-03-02614.PMC9926329.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10731200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous microwave ablation‑induced hepatic artery‑pulmonary artery fistula: A rare case report.","authors":"Bin Li,&nbsp;Xiao-Guang Li","doi":"10.3892/mco.2023.2616","DOIUrl":"https://doi.org/10.3892/mco.2023.2616","url":null,"abstract":"<p><p>Microwave ablation (MWA) is safe and effective for patients with unresectable primary and secondary hepatic tumors, but it also has a series of complications. The present study reported on the case of a 60-year-old male patient with progression of solitary liver metastasis who underwent multiple courses and lines of chemotherapy. Hepatic artery-pulmonary artery fistula due to thermal damage may occur after MWA for hepatic tumor adjacent to the diaphragm. Symptomatic improvement was achieved by trans-arterial embolization and hepatic arteriography indicated complete occlusion of the fistula. The postoperative course was uneventful and the patient was discharged three days later. This rare complication should be taken into consideration in clinical treatment.</p>","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"18 3","pages":"20"},"PeriodicalIF":1.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/e7/mco-18-03-02616.PMC9926041.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10742792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epstein‑Barr virus‑associated lymphoepithelial carcinoma arising in the parotid gland: A case report and literature review.","authors":"Akinobu Kubota,&nbsp;Nobuyuki Bandoh,&nbsp;Takashi Goto,&nbsp;Ken-Ichi Matsumoto,&nbsp;Tomomi Yamaguchi-Ishochi,&nbsp;Yasutaka Kato,&nbsp;Hiroshi Nishihara,&nbsp;Hidehiro Takei","doi":"10.3892/mco.2023.2620","DOIUrl":"https://doi.org/10.3892/mco.2023.2620","url":null,"abstract":"<p><p>A 60-year-old woman presented with a 3-year history of a slow-growing, painless mass in their left parotid gland. Ultrasonography revealed a well-circumscribed, lobulated, hypoechoic mass measuring 19x12x10 mm in the left parotid gland. Computed tomography revealed a well-circumscribed, solid mass with homogeneous enhancement. Fluorodeoxyglucose-positron emission tomography revealed uptake by the tumor but no uptake in other organs, including the nasopharynx. The patient underwent superficial parotidectomy with adequate safety margins and selective neck dissection followed by radiotherapy. No facial paralysis or recurrence of the tumor had been observed as of 20 months post-operation. Histologically, the tumor was composed of sheets of syncytial cancer cells with prominent nucleoli in a dense lymphoplasmacytic background. Epstein-Barr virus (EBV)-encoded RNA <i>in situ</i> hybridization was diffusely positive in the tumor cells. These findings indicated that the tumor was an EBV-associated lymphoepithelial carcinoma. Metastasis, especially from the nasopharynx, was excluded endoscopically and radiologically. Targeted next-generation sequencing of 160 cancer-related genes using the surgical specimen revealed no mutations, including known significant mutations detected in EBV-associated nasopharyngeal carcinoma.</p>","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"18 3","pages":"24"},"PeriodicalIF":1.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/85/mco-18-03-02620.PMC9944707.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10792396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging findings of NTRK‑rearranged spindle cell neoplasms: A case series.","authors":"Hiroshi Kobayashi,&nbsp;Yasuyo Teramura,&nbsp;Kyoko Yamashita,&nbsp;Naohiro Makise,&nbsp;Keisuke Ae,&nbsp;Sakae Tanaka","doi":"10.3892/mco.2023.2610","DOIUrl":"https://doi.org/10.3892/mco.2023.2610","url":null,"abstract":"<p><p>NTRK-rearranged spindle cell neoplasms (NTRK-RSCNs) are a new category of soft tissue tumors with <i>NTRK</i> gene fusions. The present study aimed to investigate the radiological features of NTRK-RSCNs and their association with histopathological findings. The present study included six patients with NTRK-RSCNs, whose fusion genes were confirmed using next-generation sequencing. All patients underwent surgery, and their diagnosis and clinical outcomes were investigated. In addition, the magnetic resonance imaging (MRI) features of all tumors and histopathological findings of the resected specimens were assessed. The present study included three women and three men, with a mean age of 22 years (range, 2-43 years). The <i>NTRK</i> gene fusions included four <i>NTRK1</i> and two <i>NTRK3</i> fusions. Three patients were preoperatively diagnosed with solitary fibrous tumors. One patient with <i>NTRK3</i> fusion experienced local recurrence and distant metastases, whereas the other five patients had no local recurrence or metastasis. MRI revealed that all tumors were highly vascular with intra- and peritumoral flow voids of differing degrees. Furthermore, a partially ill-defined border, suggesting infiltration of tumors into the surrounding tissues, particularly fat tissue, was observed in five patients, which was confirmed by histopathological findings. In conclusion, NTRK-RSCNs are highly vascular tumors that can infiltrate the surrounding tissues. These findings suggested that NTRK-RSCNs should be considered in the differential diagnosis of highly vascular-rich mesenchymal tumors, including solitary fibrous tumors and alveolar soft part sarcomas. Furthermore, wide resection may be preferred to completely resect this type of tumor, considering its invasive nature.</p>","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"18 3","pages":"14"},"PeriodicalIF":1.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c2/fb/mco-18-03-02610.PMC9926045.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10742793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early variation of inflammatory indexes refines prognostic prediction in patients with hepatocellular carcinoma under systemic treatment.","authors":"Leonardo G Da Fonseca, Lucas Fernando Uratani, Gabriella Fernandes Soares, Paulo Siqueira Do Amaral, Regiane Saraiva De Souza Melo Alencar, Aline Lopes Chagas, Venancio Avancini Ferreira Alves, Flair Jose Carrilho","doi":"10.3892/mco.2023.2625","DOIUrl":"10.3892/mco.2023.2625","url":null,"abstract":"<p><p>Prognostic markers in advanced hepatocellular carcinoma (HCC) are relevant for clinical decisions. Variations in inflammatory indexes, such as neutrophil-to-lymphocyte ratio (NLR) or platelet-to-lymphocyte ratio (PLR), may correlate with outcomes. In the present study, it was aimed to assess the prognostic role of inflammation indexes in patients with HCC and the evolutionary behavior of these variables within the first month of treatment in a cohort of patients treated with sorafenib from 2009-2021. Subgroups were divided based on the median of each variable ('low' or 'high)'. Survival was estimated using the Kaplan-Meier method. Hazard Ratio (HR) with 95% confidence interval (CI) were estimated using Cox regression models. A total of 373 patients were included, most Child-Pugh-A (83.1%) and BCLC-C (74%). Child-Pugh-A (P=0.011), performance status 0 (P<0.001), no ascites (P<0.001) and NLR<2.6 (P<0.001) were independently associated with improved survival. Baseline PLR was not correlated with survival (P=0.137). Patients who maintained low NLR at baseline and at 1 month (reference subgroup) had improved survival (18.6 months, 95% CI:15.4-22.0) compared with the subgroup that maintained high NLR at baseline and at 1 month (4.2 months, 95% CI:3.6-5.9), with HR: 3.80 (95% CI: 2.89-4.96). The subgroup with low NLR at baseline and high NLR at 1 month had a worse prognosis compared with the reference group (HR:1.4, 95% CI: 1.1-2.0), whereas the subgroup with high NLR at baseline and low at 1 month had similar outcome (HR:1.2, 95% CI: 0.8-1.6). It was concluded that evolutionary variation of NLR has a prognostic role in HCC patients under systemic therapy. This finding suggested that systemic inflammation and early modulation of the immune environment during treatment may correlate with outcomes.</p>","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"18 4","pages":"29"},"PeriodicalIF":1.4,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d3/3e/mco-18-04-02625.PMC9995701.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9155697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential dual synergy between electrochemotherapy and sequence of immunotherapies in metastatic melanoma: A case report.","authors":"Francesca Morgese,&nbsp;Francesco De Feudis,&nbsp;Paolo Balercia,&nbsp;Rossana Berardi","doi":"10.3892/mco.2023.2604","DOIUrl":"https://doi.org/10.3892/mco.2023.2604","url":null,"abstract":"<p><p>Immune checkpoint inhibitors have changed the natural history of advanced melanoma. Despite this, a notable proportion of patients immediately relapse or develop resistance during immunotherapy, especially with the appearance of superficial metastases and consequently with a dramatic impact on clinical outcomes. Local treatment by electrochemotherapy (ECT), parallel to regional control with palliative aim, seems to release neoantigens potentially determining a significant systemic anticancer immune reactivation. The present study reported a case of a patient with metastatic melanoma receiving Pembrolizumab, electrochemotherapy and then Ipilimumab for in-transit and finally locoregional lymph nodes and distant bone metastases with experience of clinic-radiological remission. Specifically, the present patient progressed during adjuvant treatment with in-transit metastases on the scalp; he underwent two cycle of ECT obtaining partial and then unexpected and very fast nearly complete response with the Ipilimumab treatment. Concomitantly, he developed grade 4 endocrine adverse events (hypophysitis and diabetes mellitus type I) as immune-related toxicities. At 12 months from ECT the patient is in ECOG Performance Status 0 and he has resumed a regular social life. In our experience, ECT in two administrations increased and accelerated the response of Ipilimumab. The present confirmed its promising contribution in inducing a powerful immune response in order to overcome primary or acquired resistance to immune checkpoint inhibitors such as anti-programmed death antigen-1 drugs.</p>","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"18 2","pages":"8"},"PeriodicalIF":1.2,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905651/pdf/mco-18-02-02604.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10679292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating cervical cancer biomarkers potentially useful in medical attention (Review).","authors":"Ruth Ruiz Esparza Garrido,&nbsp;Mercedes Gutiérrez,&nbsp;Miguel Ángel Velázquez Flores","doi":"10.3892/mco.2023.2609","DOIUrl":"https://doi.org/10.3892/mco.2023.2609","url":null,"abstract":"<p><p>Cervical cancer (CC) is a public health problem worldwide, including Mexico. This type of cancer is the fourth most frequent in women worldwide; in Mexico it is the second most common type in women after breast cancer. The diagnosis of CC is based mainly on Pap smears and colposcopy and the identification of molecular tools that serve as a support for these methods is urgent. Regarding this, differential expressions of specific circulating biomolecules has been detected and, based on this, they have been postulated as potential biomarkers for CC diagnosis, prognosis, and/or to identify the response to treatments. Importantly, the combined analysis of these molecules considerably improves their efficacy as biomarkers and their potential use in the medical attention is promising.</p>","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"18 2","pages":"13"},"PeriodicalIF":1.2,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7f/d1/mco-18-02-02609.PMC9892968.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10679293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal cell carcinoma T staging: Diagnostic accuracy of preoperative contrast-enhanced computed tomography.","authors":"Salah M Fateh,&nbsp;Lusan A Arkawazi,&nbsp;Soran H Tahir,&nbsp;Rezheen J Rashid,&nbsp;Dalshad H Rahman,&nbsp;Ismaeel Aghaways,&nbsp;Fahmi H Kakamad,&nbsp;Abdulwahid M Salih,&nbsp;Rawa Bapir,&nbsp;Saman S Fakhralddin,&nbsp;Fattah H Fattah,&nbsp;Berun A Abdalla,&nbsp;Shvan H Mohammed","doi":"10.3892/mco.2023.2607","DOIUrl":"https://doi.org/10.3892/mco.2023.2607","url":null,"abstract":"<p><p>Renal cell carcinoma (RCC) accounts for 1-2% of all malignancies and is the most common renal tumor in adults. Imaging studies are used for diagnosis and staging. Tumor-Node-Metastasis staging strongly affects prognosis and management, while contrast-enhanced computed tomography (CECT) is regarded as a standard imaging technique for local and distant staging. The present study aimed to evaluate the accuracy of CECT for the preoperative staging of RCC by using surgical and pathological staging as the reference methods. This single-center prospective study was conducted between October 2019 and November 2021. The preoperative abdominal CT scans of patients suspected of having RCC were reviewed. Imaging data were collected, including tumor side and size, and perinephric fat invasion. Intraoperative notes were recorded, including the operation type, perinephric fat invasion, renal vein (RV) or inferior vena cava (IVC) tumor extension, and surrounding organ invasion. pathological data were collected on tumor size, RCC type, presence of clear margins, presence of renal capsule or perinephric fat invasion, renal sinus or pelvicalyceal system (PCS) invasion, segmental or main RV extension, and the involvement of Gerota's fascia and nearby organs. Preoperative CECT revealed that 42 out of 59 tumors had a greater maximum diameter than the pathological specimen, with an overall disparity of 0.25 cm. The specificity of CT for the detection of tumor invasion of the perinephric and renal sinus fat and PCS was 95%, and the sensitivity ranged from 80 to 88%. CT had an 83% sensitivity and a 95 specificity in detecting T4 stage cancer, with a 100% specificity for adrenal invasion. The concordance between radiographic and histological results for RV and IVC involvement was high, with specificities of 94 and 98%, and sensitivities of 80 and 100%, respectively. Overall accuracy for correct T staging was 80%. In conclusion, CECT is accurate in the local T staging of RCC, with high sensitivity and specificity for estimating tumor size and detecting extension to nearby structures and venous invasion.</p>","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"18 2","pages":"11"},"PeriodicalIF":1.2,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/3f/mco-18-02-02607.PMC9892965.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10679291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}