Molecular and clinical oncology最新文献

{"title":"Expression and significance analyses of microRNAs in colorectal cancer.","authors":"Jing Zhang, Liwei Sun, Changxiu Yan, Honggang Ran, Kaiyong Qu, Zhijian Chen, Argen Bahet, Chenxi Wang, Xin Cai, Guohong Zhuang, Zeyang Lin","doi":"10.3892/mco.2026.2929","DOIUrl":"10.3892/mco.2026.2929","url":null,"abstract":"<p><p>MicroRNAs (miRNAs or miRs) serve as potential diagnostic and prognostic markers or therapeutic targets. However, their roles in the pathogenesis of colorectal cancer (CRC) is not fully understood. The aim of the present study was to investigate the expression levels and functions of miR-205, miR-376c, and miR-539 in CRC development and prognosis. Multiple GEO databases were used to explore miRNA expression levels and associations in CRC cancer and adjacent/normal tissues. In addition, the associations between the expression of the miRNAs and the clinicopathological features of CRC were analyzed. The clinical data and specimens of 25 patients with CRC were collected, detected and analyzed. Combining bioinformatics analysis and databases, the relationship between the three miRNAs and CRC progression and prognosis was explored. In the GSE41655 dataset, miR-376c, miR-539, and miR-205 were all downregulated in tumor tissues, with miRNA-376c exhibiting the most pronounced downregulation. MiR-376c was closely associated with CRC liver metastasis, especially in the synchronous metastasis condition. Additionally, in the miRDB database, an analysis of the overlapping predicted target genes for miR-205, miR-376c, and miR-539 revealed that these three miRNAs share 53 common predicted target genes. Not only did miR-539 and miR-205 significantly differ according to tumor stage and lymph node metastasis, but also their upregulation was significant in tumor advanced stage and lymph node metastasis according to logistic regression in collected cancer tissues. Furthermore, miR-205 was significantly upregulated in tumor differentiation according to logistic regression. In conclusion, miR-205, miR-376c, and miR-539 were revealed to be involved in the development and prognosis of CRC and may be potential targets for CRC therapy.</p>","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"24 3","pages":"20"},"PeriodicalIF":1.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12933723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147308006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monocyte distribution width in breast cancer: Results from a retrospective exploratory pilot study.","authors":"Giovanni Napolitano, Ruben Napolitano, Raffaella Coppola, Angela Ragone, Sanober Kafeel, Giuseppina Palmiero, Angela Lombardi, Giovanni Casaretta, Rosa Giannatiempo, Michele Caraglia, Silvio Naviglio, Luigi Sapio","doi":"10.3892/mco.2026.2930","DOIUrl":"10.3892/mco.2026.2930","url":null,"abstract":"<p><p>Despite the therapeutic breakthroughs achieved over the years, breast cancer (BC) continues to rank as the deadliest tumor among women worldwide. Therefore, prevention and screening programs remain crucial for the successful recovery of patients with BC. Monocyte distribution width (MDW) is a novel hematological parameter provided along with the complete blood count by DxH haematology analyzers. Variations in MDW have been associated with diagnostic and prognostic significance in sepsis, viral infections and other inflammation-related diseases. However, the potential role of MDW remains largely unknown in malignant disorders, including BC. Using a retrospective approach, patients with BC were included in the present study to examine the MDW levels at diagnosis in relation to controls. MDW was also assessed with respect to the histopathological features of BC. Either Welch's t-test or Brown-Forsythe and Welch ANOVA were used to estimate significance, while receiver operating characteristic curves and the area under the curve were used to evaluate the overall performance of MDW in BC. MDW levels were higher in patients with BC than in controls (P<0.0001), while no changes were recorded in the absolute monocytes count. With respect to the histopathological features, an elevated MDW was typically detected in BC presenting as invasive ductal carcinoma (P=0.0002), and expressing either estrogen (P<0.0001) or progesterone receptors (P<0.0001). Higher MDW levels were also observed in patients with BC scoring as grade III, as well as in those presenting lymph node involvement (N1-3), suggesting a possible association with the progression of BC. Overall, the present retrospective exploratory pilot study proposed MDW as a possible biomarker in BC, indicating future perspectives for the diagnosis, stratification and prognosis of this deadly disease.</p>","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"24 3","pages":"21"},"PeriodicalIF":1.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12933710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147307992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of serum uric acid levels following radiotherapy and chemotherapy in nasopharyngeal carcinoma.","authors":"Xianming He, Qiwei Luo, Yuhao Ding, Jianwu Ding, Ronghuan Hu, Jia-Li Hu, Lei Tao, Jianze Zhang, Zhenxing Huang, Xiaoqiang Chen, Jiayin Wu, Su Deng, Shubin Luo, Lei Zeng, Mengmeng Liu","doi":"10.3892/mco.2026.2924","DOIUrl":"https://doi.org/10.3892/mco.2026.2924","url":null,"abstract":"<p><p>To evaluate the association between serum uric acid (SUA) levels and prognosis in patients with nasopharyngeal carcinoma (NPC) treated with a comprehensive regimen of induction chemotherapy, intensity-modulated radiation therapy (IMRT), and adjuvant chemotherapy. A total of 182 patients with NPC treated at the Second Affiliated Hospital of Nanchang University between 2017 and 2021 were retrospectively analyzed. SUA levels were recorded at four time points: Pre-treatment, post-induction chemotherapy, post-IMRT and post-adjuvant chemotherapy. Based on the median post-adjuvant chemotherapy SUA level (350.48 µmol/l), patients were stratified into high (SUA >350 µmol/l) and low (SUA ≤350 µmol/l) groups. Survival outcomes were compared using Kaplan-Meier analysis and log-rank tests. Cox proportional hazards models were employed to identify independent prognostic factors. Changes in SUA levels over time were assessed using repeated-measures ANOVA. The high SUA group demonstrated improved 3-year overall survival (OS; P=0.037), progression-free survival (PFS; P<0.001), and distant metastasis-free survival (DMFS; P=0.001) compared with the low SUA group. No significant difference in locoregional relapse-free survival (P=0.41) was observed. Post-adjuvant chemotherapy SUA levels were an independent prognostic factor for OS, PFS and DMFS. Repeated-measures ANOVA showed a significant reduction in SUA levels post-IMRT compared with baseline, post-induction chemotherapy, and post-adjuvant chemotherapy (all P<0.001). In conclusion, elevated post-adjuvant chemotherapy SUA levels are associated with improved survival outcomes in patients with advanced-stage NPC. IMRT induces a transient decrease in SUA levels. These findings suggested that SUA levels may serve as a valuable prognostic biomarker for NPC.</p>","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"24 2","pages":"15"},"PeriodicalIF":1.4,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction of seroma by pectoralis fascia dissection using an energy device in total mastectomy for breast cancer: An observational study.","authors":"Hiroaki Shima, Yuta Kondo, Takashi Nakamura, Daisuke Kyuno, Noriko Nishikawa, Satoko Uno, Ai Noda, Kiminori Sato, Asaka Wada, Toru Mizuguchi","doi":"10.3892/mco.2026.2923","DOIUrl":"https://doi.org/10.3892/mco.2026.2923","url":null,"abstract":"<p><p>Seroma formation is one of the unresolved complications of breast cancer surgery. The use of energy devices (EDs) can improve breast cancer surgery outcomes. Dissection of the pectoralis fascia is an important process in total mastectomy, which involves a wide area of the posterior wall of the mammary glands. The current study investigated whether using EDs for this process could lead to a reduction in seroma formation or potentially reduce other complications. In the present observational study, the use of an ED for pectoralis fascia dissection was compared with conventional electrocautery. The main outcomes were the total amount of drainage (total AD), amount of drainage per day and adverse events (AEs) after propensity score matching (PSM). in addition, a univariate analysis of AE occurrence was performed. Overall, 41 and 117 patients were included in the ED and control groups, respectively. PSM was performed for three covariates: Presence or absence of axillary dissection, preoperative chemotherapy and body mass index >25 kg/m². Compared with those in the control group, the total AD post-PSM in the ED group did not decrease (P<i>=</i>0.1778), whereas the amount of drainage per day was markedly decreased on postoperative day 8 in the ED group. In the univariate analysis, only the use of ED was associated with a reduction in AEs requiring intervention; other factors showed no significant association. The frequency of AEs requiring intervention was significantly lower in the ED group than that in the control group post-PSM (P=0.0372). Notably, seroma accounted for most AEs. The results of the present study suggested that pectoralis fascia dissection using an ED may reduce fluid drainage and the incidence of AEs. This simple modification suggests the possibility of improving surgical techniques and is expected to contribute to favorable surgical outcomes.</p>","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"24 2","pages":"14"},"PeriodicalIF":1.4,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of ramucirumab and subsequent nivolumab therapy in patients with advanced gastric cancer: A retrospective study","authors":"Masaaki Saito, Koichi Suzuki, S. Tamaki, Yasuaki Kimura, I. Abe, Y. Endo, F. Watanabe, T. Rikiyama","doi":"10.3892/mco.2024.2715","DOIUrl":"https://doi.org/10.3892/mco.2024.2715","url":null,"abstract":"","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"42 33","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic splenic angiosarcoma presenting with anemia and bone marrow fibrosis mimicking primary myelofibrosis: A case report and literature review","authors":"Meiqing Wu, Zhongqing Li, Lin Luo, Weihua Zhao, Jun Luo","doi":"10.3892/mco.2024.2714","DOIUrl":"https://doi.org/10.3892/mco.2024.2714","url":null,"abstract":"","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"19 2","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139387105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive prognostic prediction of metastatic breast cancer treated with eribulin using blood‑based parameters and ratio","authors":"H. Shimada, A. Fujimoto, Kazuo Matsuura, Shunsuke Kohyama, Asami Nukui, Y. Ichinose, Aya Asano, Masahiro Ohara, Hiroshi Ishiguro, Akihiko Osaki, Toshiaki Saeki","doi":"10.3892/mco.2024.2713","DOIUrl":"https://doi.org/10.3892/mco.2024.2713","url":null,"abstract":"","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"125 17","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139387717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR‑146a‑5p and miR‑191‑5p as novel diagnostic marker candidates for ovarian clear cell carcinoma","authors":"Shigeatsu Takamizawa, J. Kojima, Tomohiro Umezu, Masahiko Kuroda, Shigehiro Hayashi, Takenori Maruta, A. Okamoto, Hirotaka Nishi","doi":"10.3892/mco.2023.2712","DOIUrl":"https://doi.org/10.3892/mco.2023.2712","url":null,"abstract":"","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"24 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Albumin‑bilirubin grade is an independent prognostic factor for small lung cell cancer","authors":"Shicheng Liu, Qingtao Zhao, Zengming Wang, Bin Zhao, Xiaopeng Zhang","doi":"10.3892/mco.2023.2710","DOIUrl":"https://doi.org/10.3892/mco.2023.2710","url":null,"abstract":"","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"104 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138998583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare coexistence of multiple osteochondromas and solitary osteoid osteoma: A case report","authors":"Ryo Katsuki, Hiromichi Oshiro, Yusuke Aoki, Kohei Mizuta, Y. Tome, Kotaro Nishida","doi":"10.3892/mco.2023.2711","DOIUrl":"https://doi.org/10.3892/mco.2023.2711","url":null,"abstract":"","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"32 2","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139000157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}