Metal ions in life sciences最新文献_第5页

Metallointercalators and Metalloinsertors: Structural Requirements for DNA Recognition and Anticancer Activity. 金属插入物和金属插入物:DNA识别和抗癌活性的结构要求。

Metal ions in life sciences Pub Date : 2018-02-05 DOI: 10.1515/9783110470734-020

Ulrich Schatzschneider

引用次数: 5

Health Benefits of Vanadium and Its Potential as an Anticancer Agent. 钒的健康益处及其抗癌潜力。

Metal ions in life sciences Pub Date : 2018-02-05 DOI: 10.1515/9783110470734-015

Debbie C Crans, Lining Yang, Allison Haase, Xiaogai Yang

{"title":"Health Benefits of Vanadium and Its Potential as an Anticancer Agent.","authors":"Debbie C Crans, Lining Yang, Allison Haase, Xiaogai Yang","doi":"10.1515/9783110470734-015","DOIUrl":"https://doi.org/10.1515/9783110470734-015","url":null,"abstract":"Vanadium compounds have been known to have beneficial therapeutic properties since the turn of the century, but it was not until 1965 when it was discovered that those effects could be extended to treating cancer. Some vanadium compounds can combat common markers of cancer, which include metabolic processes that are important to initiating and developing the phenotypes of cancer. It is appropriate to consider vanadium as a treatment option due to the similarities in some of the metabolic pathways utilized by both diabetes and cancer and therefore is among the few drugs that are effective against more than one disease. The development of vanadium compounds as protein phosphatase inhibitors for the treatment of diabetes may be useful for potential applications as an anticancer agent. Furthermore, the ability of vanadium to redox cycle is also important for biological properties and is involved in the pathways of reactive oxygen species. Early agents including vanadocene and peroxovanadium compounds have been investigated in detail, and the results can be used to gain a better understanding of how some vanadium compounds are modifying the metabolic pathways potentially developing cancer. Considering the importance of coordination chemistry to biological responses, it is likely that proper consideration of compound formulation will improve the efficacy of the drug. Future development of vanadium-based drugs should include consideration of drug formulation at earlier stages of drug development.","PeriodicalId":18698,"journal":{"name":"Metal ions in life sciences","volume":"18 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/9783110470734-015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35789027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 54

Cisplatin and Oxaliplatin: Our Current Understanding of Their Actions. 顺铂和奥沙利铂:我们目前对其作用的理解。

Metal ions in life sciences Pub Date : 2018-02-05 DOI: 10.1515/9783110470734-007

Imogen A Riddell

{"title":"Cisplatin and Oxaliplatin: Our Current Understanding of Their Actions.","authors":"Imogen A Riddell","doi":"10.1515/9783110470734-007","DOIUrl":"https://doi.org/10.1515/9783110470734-007","url":null,"abstract":"Following the serendipitous discovery of the anticancer activity of cisplatin over 50 years ago, a deep understanding of the chemical and biochemical transformations giving rise to its medicinal properties has developed allowing for improved treatment regimens and rational design of second and third generation drugs. This chapter begins with a brief historical review detailing initial results that led to the worldwide clinical approval of cisplatin and development of the field of metal anticancer agents. Later sections summarize our understanding of key mechanistic features including drug uptake, formation of covalent adducts with DNA, recognition and repair of Pt-DNA adducts, and the DNA damage response, with respect to cisplatin and oxaliplatin. The final section highlights known shortcomings of classical platinum anticancer agents, including problems with toxicity and mutagenicity, and the development of resistance and enrichment of cancer stem cells brought about through treatment. Instances where specific differences in the response or mechanism of action of cisplatin versus oxaliplatin have been demonstrated are discussed in the text. In this manner the chapter provides a broad overview of our current understanding of the mechanism of action of platinum anticancer agents, providing a framework for improving the rational design of better Pt-based anticancer agents.","PeriodicalId":18698,"journal":{"name":"Metal ions in life sciences","volume":"18 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/9783110470734-007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35789098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 119

The Role of Lead(II) in Nucleic Acids. 铅(II)在核酸中的作用。

Metal ions in life sciences Pub Date : 2017-04-10 DOI: 10.1515/9783110434330-012

Joana Palou-Mir, Miquel Barceló-Oliver, Roland K O Sigel

{"title":"The Role of Lead(II) in Nucleic Acids.","authors":"Joana Palou-Mir, Miquel Barceló-Oliver, Roland K O Sigel","doi":"10.1515/9783110434330-012","DOIUrl":"https://doi.org/10.1515/9783110434330-012","url":null,"abstract":"Although lead(II) is naturally not associated with nucleic acids, this metal ions has been applied with DNA and RNA in various contexts. Pb2+ is an excellent hydrolytic metal ion for nucleic acids, which is why it is mainly used as probing agent for secondary structure and to determine metal ion binding sites both in vitro and in vivo. A further application of lead(II) is in structural studies, i.e., NMR, but also in X-ray crystallography, mostly using this heavy metal to solve the phase problem in the latter method. The structures of tRNAPhe, RNase P, HIV-1 DIS, and the leadzyme are discussed here in detail. A major part of this review is devoted to the cleavage properties of lead(II) with RNA because of its excellence in catalyzing phosphodiester cleavage. Metal ion binding sites in large naturally occurring ribozymes are regularly determined by Pb2+ cleavage, and also in the in vitro selected socalled leadzyme, this metal ion is the decisive key to backbone cleavage at a specific site. Lead(II) was used in the first in vitro selection that yielded a catalytic DNA, i.e., the DNAzyme named GR5. Next to the GR5, the so-called 8-17E is the second most prominent DNAzyme today. Derivatives of these two lead(II)-dependent DNAzymes, as well as the G-quadruplex forming PS2.M have been applied to detect lead(II) in the lower nanomolar range not only in the test tube but also in body fluids. Due to the toxicity of lead(II) for living beings, this is a highly active research field. Finally, further applications of lead(II)-dependent DNAzymes, e.g., in the construction of nanocomputers, are also discussed.","PeriodicalId":18698,"journal":{"name":"Metal ions in life sciences","volume":"17 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/9783110434330-012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35188332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Historical View on Lead: Guidelines and Regulations. 铅的历史观点:指南和法规。

Metal ions in life sciences Pub Date : 2017-04-10 DOI: 10.1515/9783110434330-013

Hana R Pohl, Susan Z Ingber, Henry G Abadin

{"title":"Historical View on Lead: Guidelines and Regulations.","authors":"Hana R Pohl, Susan Z Ingber, Henry G Abadin","doi":"10.1515/9783110434330-013","DOIUrl":"https://doi.org/10.1515/9783110434330-013","url":null,"abstract":"Lead has been used in many commodities for centuries. As a result, human exposure has occurred through the production and use of these lead-containing products. For example, leaded gasoline, lead-based paint, and lead solder/pipes in water distribution systems have been important in terms of exposure potential to the general population. Worker exposures occur in various industrial activities such as lead smelting and refining, battery manufacturing, steel welding or cutting operations, printing, and construction. Some industrial locations have also been a source of exposure to the surrounding communities. While the toxicity of relatively high lead exposures has been recognized for centuries, modern scientific studies have shown adverse health effects at very low doses, particularly in the developing nervous system of fetuses and children. This chapter reflects on historical and current views on lead toxicity. It also addresses the development and evolution of exposure prevention policies. As discussed here, these lead policies target a variety of potential exposure routes and sources. The changes reflect our better understanding of lead toxicity. The chapter provides lead-related guidelines and regulations currently valid in the U. S. and in many countries around the world. The reader will learn about the significant progress that has been made through regulations and guidelines to reduce exposure and prevent lead toxicity.","PeriodicalId":18698,"journal":{"name":"Metal ions in life sciences","volume":"17 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/9783110434330-013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35188333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Lead(II) Binding in Metallothioneins. 铅(II)在金属硫蛋白中的结合。

Metal ions in life sciences Pub Date : 2017-04-10 DOI: 10.1515/9783110434330-009

Daisy L Wong, Maureen E Merrifield-MacRae, Martin J Stillman

{"title":"Lead(II) Binding in Metallothioneins.","authors":"Daisy L Wong, Maureen E Merrifield-MacRae, Martin J Stillman","doi":"10.1515/9783110434330-009","DOIUrl":"https://doi.org/10.1515/9783110434330-009","url":null,"abstract":"Heavy metal exposure has long been associated with metallothionein (MT) regulation and its functions. MT is a ubiquitous, cysteine-rich protein that is involved in homeostatic metal response for the essential metals zinc and copper, as well as detoxification of heavy metals; the most commonly proposed being cadmium. MT binds in vivo to a number of metals in addition to zinc, cadmium and copper, such as bismuth. In vitro, metallation with a wide range of metals (especially mercury, arsenic, and lead) has been reported using a variety of analytical methods. To fully understand MT and its role with lead metabolism, we will describe how MT interacts with a wide variety of metals that bind in vitro. In general, affinity to the metal-binding cysteine residues of MT follows that of metal binding to thiols: Zn(II) < Pb(II) < Cd (II) < Cu(I) < Ag(I) < Hg(II) < Bi(III). To introduce the metal binding properties that we feel directly relate to the metallation of metallothionein by Pb(II), we will explore MT's interactions with metals long known as toxic, particularly, Cd(II), Hg(II), and As(III), along with xenobiotic metals, and how these metal-binding studies complement those of lead binding. Lead's effects on an organism's physiological functions are not fully understood, but it is known that chronic exposure inflicts amongst other factors pernicious anemia and developmental issues in the brain, especially in children who are more vulnerable to its toxic effects. Understanding the interaction of lead with metallothioneins throughout the biosphere, from bacteria, to algae, to fish, to humans, is important in determining pathways for lead to enter and damage physiologically significant protein function, and thereby its toxicity.","PeriodicalId":18698,"journal":{"name":"Metal ions in life sciences","volume":"17 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/9783110434330-009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35188432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Biogeochemistry of Lead. Its Release to the Environment and Chemical Speciation. 铅的生物地球化学。其释放到环境和化学形态。

Metal ions in life sciences Pub Date : 2017-04-10 DOI: 10.1515/9783110434330-002

Jay T Cullen, Jason McAlister

{"title":"Biogeochemistry of Lead. Its Release to the Environment and Chemical Speciation.","authors":"Jay T Cullen, Jason McAlister","doi":"10.1515/9783110434330-002","DOIUrl":"https://doi.org/10.1515/9783110434330-002","url":null,"abstract":"Lead (Pb) is a metal that is not essential for life processes and proves acutely toxic to most organisms. Compared to other metals Pb is rather immobile in the environment but still its biogeochemical cycling is greatly perturbed by human activities. In this review we present a summary of information describing the physical and chemical properties of Pb, its distribution in crustal materials, and the processes, both natural and anthropogenic, that contribute to the metal's mobilization in the biosphere. The relatively high volatility of Pb metal, low melting point, its large ionic radius, and its chemical speciation in aquatic systems contributes to its redistribution by anthropogenic and natural processes. The biogeochemical cycle of Pb is significantly altered by anthropogenic inputs. This alteration began in antiquity but accelerated during the industrial revolution, which sparked increases in both mining activities and fossil fuel combustion. Estimates of the flux of Pb to the atmosphere, its deposition and processing in soils and freshwater systems are presented. Finally, the basin scale distribution of dissolved Pb in the ocean is interpreted in light of the chemical speciation and association with inorganic and organic particulate matter. The utility of stable radiogenic Pb isotopes, as a complement to concentration data, to trace inputs to the ocean, better understand the biogeochemical cycling of Pb and track water mass circulation in the ocean is discussed. An ongoing international survey of trace elements and their isotopes in seawater will undoubtedly increase our understanding of the deposition, biogeochemical cycling and fate of this infamous toxic metal.","PeriodicalId":18698,"journal":{"name":"Metal ions in life sciences","volume":"17 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/9783110434330-002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35188425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Lead(II) Binding in Natural and Artificial Proteins. 铅(II)在天然和人工蛋白质中的结合。

Metal ions in life sciences Pub Date : 2017-04-10 DOI: 10.1515/9783110434330-010

Virginia Cangelosi, Leela Ruckthong, Vincent L Pecoraro

{"title":"Lead(II) Binding in Natural and Artificial Proteins.","authors":"Virginia Cangelosi, Leela Ruckthong, Vincent L Pecoraro","doi":"10.1515/9783110434330-010","DOIUrl":"10.1515/9783110434330-010","url":null,"abstract":"This article describes recent attempts to understand the biological chemistry of lead using a synthetic biology approach. Lead binds to a variety of different biomolecules ranging from enzymes to regulatory and signaling proteins to bone matrix. We have focused on the interactions of this element in thiolate-rich sites that are found in metalloregulatory proteins such as Pbr, Znt, and CadC and in enzymes such as δ-aminolevulinic acid dehydratase (ALAD). In these proteins, Pb(II) is often found as a homoleptic and hemidirectic Pb(II)(SR)3- complex. Using first principles of biophysics, we have developed relatively short peptides that can associate into three-stranded coiled coils (3SCCs), in which a cysteine group is incorporated into the hydrophobic core to generate a (cysteine)3 binding site. We describe how lead may be sequestered into these sites, the characteristic spectral features may be observed for such systems and we provide crystallographic insight on metal binding. The Pb(II)(SR)3- that is revealed within these α-helical assemblies forms a trigonal pyramidal structure (having an endo orientation) with distinct conformations than are also found in natural proteins (having an exo conformation). This structural insight, combined with 207Pb NMR spectroscopy, suggests that while Pb(II) prefers hemidirected Pb(II)(SR)3- scaffolds regardless of the protein fold, the way this is achieved within α-helical systems is different than in β-sheet or loop regions of proteins. These interactions between metal coordination preference and protein structural preference undoubtedly are exploited in natural systems to allow for protein conformation changes that define function. Thus, using a design approach that separates the numerous factors that lead to stable natural proteins allows us to extract fundamental concepts on how metals behave in biological systems.","PeriodicalId":18698,"journal":{"name":"Metal ions in life sciences","volume":"17 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/9783110434330-010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35188331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Smart Capsules for Lead Removal from Industrial Wastewater. 用于工业废水中铅去除的智能胶囊。

Metal ions in life sciences Pub Date : 2017-04-10 DOI: 10.1515/9783110434330-004

Bartosz Tylkowski, Renata Jastrząb

{"title":"Smart Capsules for Lead Removal from Industrial Wastewater.","authors":"Bartosz Tylkowski, Renata Jastrząb","doi":"10.1515/9783110434330-004","DOIUrl":"https://doi.org/10.1515/9783110434330-004","url":null,"abstract":"Ground and especially drinking water could be contaminated by heavy metal ions such as lead and chromium, or the metalloid arsenic, discarded from industrial wastewater. These heavy metal ions are regarded as highly toxic pollutants which could cause a wide range of health problems in case of a long-term accumulation in the body. Thus, there have been many efforts to reduce the concentration of lead ions in effluent wastewater. They have included the establishment of stringent permissible discharge levels and management policies, the application of various pollution-control technologies, and the development of adsorbent materials for lead reduction. According to Science [1] encapsulation, developed approximately 65 years ago, has been defined as a major interdisciplinary research technology. Encapsulation has been used to deliver almost everything from advanced drugs to unique consumer sensory experiences. In this chapter we review the art of encapsulation technology as a potential breakthrough solution for a recyclable removal system for lead ions. Moreover, in order to provide the readers with a comprehensive and in-depth understanding of recent developments and innovative applications in this field, we highlight some remarkable advantages of encapsulation for heavy metal remove, such as simplicity of preparation, applicability for a wide range of selective extractants, large special interfacial area, ability for concentration of metal ions from dilute solutions, and less leakage of harmful components to the environment.","PeriodicalId":18698,"journal":{"name":"Metal ions in life sciences","volume":"17 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/9783110434330-004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35188427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Solid State Structures of Lead Complexes with Relevance for Biological Systems. 与生物系统相关的铅配合物的固态结构。

Metal ions in life sciences Pub Date : 2017-04-10 DOI: 10.1515/9783110434330-007

Katsuyuki Aoki, Kazutaka Murayama, Ning-Hai Hu

引用次数: 1