Minerva medicaPub Date : 2024-02-01Epub Date: 2021-02-08DOI: 10.23736/S0026-4806.21.07359-6
Marco Zuin, Gianluca Rigatelli, Giovanni Zuliani, Loris Roncon
{"title":"COVID-19 restrictive measures are changing the flu season in Italy.","authors":"Marco Zuin, Gianluca Rigatelli, Giovanni Zuliani, Loris Roncon","doi":"10.23736/S0026-4806.21.07359-6","DOIUrl":"10.23736/S0026-4806.21.07359-6","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"86-88"},"PeriodicalIF":4.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25346162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2024-02-01Epub Date: 2023-08-03DOI: 10.23736/S0026-4806.23.08677-9
Gianni Belcaro, Maria R Cesarone, Andrea Ledda, Claudia Scipione, Valeria Scipione, Marcello Corsi, David Cox, Roberto Cotellese, Beatrice Feragalli
{"title":"Altitude trekking and Robuvit®: fatigue prevention and recovery.","authors":"Gianni Belcaro, Maria R Cesarone, Andrea Ledda, Claudia Scipione, Valeria Scipione, Marcello Corsi, David Cox, Roberto Cotellese, Beatrice Feragalli","doi":"10.23736/S0026-4806.23.08677-9","DOIUrl":"10.23736/S0026-4806.23.08677-9","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"83-84"},"PeriodicalIF":4.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10284211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2024-02-01Epub Date: 2023-03-29DOI: 10.23736/S0026-4806.23.08575-0
Tommaso Semino, Gian M Rosa, Fiammetta Monacelli, Rinaldo Pellicano, Gianni Testino, Italo Porto
{"title":"Right ventricle: current knowledge of echocardiographic evaluation of this \"forgotten\" chamber.","authors":"Tommaso Semino, Gian M Rosa, Fiammetta Monacelli, Rinaldo Pellicano, Gianni Testino, Italo Porto","doi":"10.23736/S0026-4806.23.08575-0","DOIUrl":"10.23736/S0026-4806.23.08575-0","url":null,"abstract":"<p><p>In the past the right ventricle (RV) has been traditionally regarded as a simple conduit between the venous system and the pulmonary circulation and it has aroused little interest in both clinical and echocardiographic cardiologists to such an extent that it has been defined as the \"forgotten chamber.\" Subsequently it was clearly shown that the right heart (RH) plays an important physiologic role in cardiac activity, and that congenital or acquired alterations in its structure and function have an important prognostic value. Aim of this review is to shed the light on the echocardiographic approach to this cardiac chamber. In this narrative review we critically explored the most recent literature on this topic using PubMed and Medline and examining the most recent guidelines on the echocardiographic approach to the RV. Echocardiographic approach to RV presents some technical difficulties, which stem from the position of the RV inside the thorax and around the LV and from its particular anatomy, which precludes geometric assumptions. However, RV may now be evaluated quantitatively and qualitatively in many ways, and some new methods can partially overcome some of the limits imposed by its complex anatomy, thereby yielding a quantitative evaluation. Furthermore, due to the wide range of pathologies which may involve the RV a disease-oriented approach should be considered in the echocardiographic investigation of right heart disease.</p>","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"45-60"},"PeriodicalIF":4.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9193029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2024-02-01Epub Date: 2023-04-06DOI: 10.23736/S0026-4806.22.08266-0
Davide Piloni, Stefania Ottaviani, Laura Saderi, Luciano Corda, Paolo Baderna, Valentina Barzon, Alice M Balderacchi, Christine Seebacher, Bruno Balbi, Federica Albicini, Alessandra Corino, Maria C Mennitti, Claudio Tirelli, Fabio Spreafico, Matteo Bosio, Francesca Mariani, Giovanni Sotgiu, Angelo G Corsico, Ilaria Ferrarotti
{"title":"Comparison among populations with severe and intermediate alpha1-antitrypsin deficiency and chronic obstructive pulmonary disease.","authors":"Davide Piloni, Stefania Ottaviani, Laura Saderi, Luciano Corda, Paolo Baderna, Valentina Barzon, Alice M Balderacchi, Christine Seebacher, Bruno Balbi, Federica Albicini, Alessandra Corino, Maria C Mennitti, Claudio Tirelli, Fabio Spreafico, Matteo Bosio, Francesca Mariani, Giovanni Sotgiu, Angelo G Corsico, Ilaria Ferrarotti","doi":"10.23736/S0026-4806.22.08266-0","DOIUrl":"10.23736/S0026-4806.22.08266-0","url":null,"abstract":"<p><strong>Background: </strong>Severe alpha1-antitrypsin (AAT) deficiency (AATD) is associated with a high risk of airflow obstruction and emphysema. The risk of lung disease in those with intermediate AAT deficiency is unclear. Our aims were to compare pulmonary function, time of onset of symptoms, and indicators of quality of life among patients with severe AATD (PI*ZZ), patients with intermediate AATD (PI*MZ) from the Italian Registry of AATD with a chronic obstructive pulmonary disease (COPD) cohort of patients without AATD (PI*MM).</p><p><strong>Methods: </strong>We considered a total of 613 patients: 330 with the PI*ZZ genotype, 183 with the PI*MZ genotype and 100 with the PI*MM genotype. Radiological exams, pulmonary function test, and measurement of quality of life have been performed on all cohorts of patients.</p><p><strong>Results: </strong>The three populations differ significantly in terms of age at COPD/AATD diagnosis (P=0.00001), respiratory function (FEV1, FVC, DLCO P<0.001), quality of life (P=0.0001) and smoking history (P<0.0001). PI*ZZ genotype had 24.9 times a higher likelihood of developing airflow obstruction. The MZ genotype is not associated with a significant early risk of airflow obstruction.</p><p><strong>Conclusions: </strong>The comparison of populations with PI*ZZ, MZ and MM genotypes allows to delineate the role of alpha1-antitrypsin deficiency on respiratory function and on the impact on quality of life, in relation to other risk factors. These results highlight the crucial role of primary and secondary prevention on smoking habits in PI*MZ subjects and the importance of an early diagnosis.</p>","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"23-31"},"PeriodicalIF":4.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9621970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2024-02-01Epub Date: 2020-04-01DOI: 10.23736/S0026-4806.20.06527-1
Zhen Liu, Xing Hua
{"title":"Primary retroperitoneal renal cell carcinoma associated with transcription EB gene fusion.","authors":"Zhen Liu, Xing Hua","doi":"10.23736/S0026-4806.20.06527-1","DOIUrl":"10.23736/S0026-4806.20.06527-1","url":null,"abstract":"<p><strong>Background: </strong>Renal cell carcinoma (RCC) with the distinct type of t(6;11) (p21;q12) translocation (transcription factor EB, TFEB) is a rare neoplasm. It is even less when talks about primary retroperitoneal TFEB RCCs. To our knowledge, no previous literature has been reported about this kind of RCCs. In this article, we report a case of primary retroperitoneal renal cell carcinoma associated with transcription EB gene fusion.</p><p><strong>Methods: </strong>A 73-year-old male patient presented with a retroperitoneal mass for more than one month.</p><p><strong>Results: </strong>Pathologically, the mass was soft and colorful, tumor cells showed a biphasic morphology characterized by nests of larger epithelioid cells surrounding intraluminal collections of smaller cells clustered around basement membrane materia. These tumor cells were positive for Pax-8, EMA, TFEB, CK, P504S, Vimentin and CD10 on immunohistochemical stain, and positive for TFEB on fluorescence in situ hybridization assay.</p><p><strong>Conclusions: </strong>We reported the first case of primary retroperitoneal renal cell carcinoma associated with transcription EB gene fusion. The pathological feature of the case we reported was very typical. The best treatment at presentation is the total resection. Long-term follow-up study is needed in order to acquire better diagonitic quality and fulfill diagnostic requirements.</p>","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"32-36"},"PeriodicalIF":4.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37794925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2023-12-01Epub Date: 2023-05-25DOI: 10.23736/S0026-4806.23.08628-7
Lan Hu, Yan Mi, Jing Wang, Jun Shi, Wen Jiang, Mengxiao Song
{"title":"The impact of extended nursing and home care on the disease of diabetic patients.","authors":"Lan Hu, Yan Mi, Jing Wang, Jun Shi, Wen Jiang, Mengxiao Song","doi":"10.23736/S0026-4806.23.08628-7","DOIUrl":"10.23736/S0026-4806.23.08628-7","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"897-900"},"PeriodicalIF":4.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9522544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva medicaPub Date : 2023-12-01Epub Date: 2023-04-06DOI: 10.23736/S0026-4806.22.08397-5
Moreno Tresoldi, Alberto Zangrillo, Alessandro Belletti, Giuseppe A Ramirez, Enrica Bozzolo, Francesca Guzzo, Alessandro Marinosci, Evgeny V Fominskiy, Valentina DA Prat, Marilena Marmiere, Diego Palumbo, Lidia Del Prete, Filippo D'Amico, Chiara Bellino, Deodata Morando, Marco Saracino, Alessandro Ortalda, Elena Castelli, Margherita Rocchi, Martina Baiardo Redaelli, Raffaella Scotti, Gaetano DI Terlizzi, Maria L Azzolini, Giulia Guaschino, Emma Avitabile, Giovanni Borghi, Daniele Soddu, Lorenzo Dagna, Giovanni Landoni, Francesco DE Cobelli
{"title":"Two-year multidisciplinary follow-up of COVID-19 patients requiring invasive and noninvasive respiratory support.","authors":"Moreno Tresoldi, Alberto Zangrillo, Alessandro Belletti, Giuseppe A Ramirez, Enrica Bozzolo, Francesca Guzzo, Alessandro Marinosci, Evgeny V Fominskiy, Valentina DA Prat, Marilena Marmiere, Diego Palumbo, Lidia Del Prete, Filippo D'Amico, Chiara Bellino, Deodata Morando, Marco Saracino, Alessandro Ortalda, Elena Castelli, Margherita Rocchi, Martina Baiardo Redaelli, Raffaella Scotti, Gaetano DI Terlizzi, Maria L Azzolini, Giulia Guaschino, Emma Avitabile, Giovanni Borghi, Daniele Soddu, Lorenzo Dagna, Giovanni Landoni, Francesco DE Cobelli","doi":"10.23736/S0026-4806.22.08397-5","DOIUrl":"10.23736/S0026-4806.22.08397-5","url":null,"abstract":"<p><strong>Background: </strong>COVID-19 patients frequently develop respiratory failure requiring mechanical ventilation. Data on long-term survival of patients who had severe COVID-19 are insufficient. We assessed and compared two-year survival, CT imaging, quality of life, and functional recovery of COVID-19 ARDS patients requiring respiratory support with invasive (IMV) versus noninvasive ventilation (NIV).</p><p><strong>Methods: </strong>Patients with COVID-19 pneumonia admitted up to May 28<sup>th</sup>, 2020, who required IMV or NIV, and survived to hospital discharge were enrolled. Patients were contacted two years after discharge to assess vital status, functional, psychological, and cognitive outcomes using validated scales. Patients with persistent respiratory symptoms or high burden of residual lung damage at previous CT scan received a two-year chest CT scan.</p><p><strong>Results: </strong>Out of 61 IMV survivors, 98% were alive at two-year follow-up, and 52 completed the questionnaire. Out of 82 survivors receiving NIV only, 94% were alive at two years, and 47 completed the questionnaire. We found no major differences between invasively and noninvasively ventilated patients, with overall acceptable functional recovery. Among the 99 patients completing the questionnaire, 23 have more than moderate exertional dyspnea. Chest CT scans showed that 4 patients (all received IMV) had fibrotic-like changes.</p><p><strong>Conclusions: </strong>Patients who received mechanical ventilation due to COVID-19 and were discharged from hospital had a 96% survival rate at the two-year follow-up. There was no difference in overall recovery and quality of life between patients who did and did not require IMV, although respiratory morbidity remains high.</p>","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"773-784"},"PeriodicalIF":4.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9607452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}