Minerva medica最新文献_第5页

Effectiveness and safety of direct-acting antivirals in the therapy of HCV-infected elderly people. 直接作用抗病毒药物治疗感染丙型肝炎病毒的老年人的有效性和安全性。

IF 4.7 4区医学

Minerva medica Pub Date : 2024-04-01 DOI: 10.23736/S0026-4806.24.09238-3

Michał Brzdęk, D. Zarębska-Michaluk, K. Tomasiewicz, M. Tudrujek-Zdunek, Beata Lorenc, W. Mazur, H. Berak, Justyna Janocha-Litwin, Jakub Klapaczyński, Marek Sitko, Ewa Janczewska, D. Dybowska, A. Parfieniuk-Kowerda, A. Piekarska, J. Jaroszewicz, R. Flisiak

{"title":"Effectiveness and safety of direct-acting antivirals in the therapy of HCV-infected elderly people.","authors":"Michał Brzdęk, D. Zarębska-Michaluk, K. Tomasiewicz, M. Tudrujek-Zdunek, Beata Lorenc, W. Mazur, H. Berak, Justyna Janocha-Litwin, Jakub Klapaczyński, Marek Sitko, Ewa Janczewska, D. Dybowska, A. Parfieniuk-Kowerda, A. Piekarska, J. Jaroszewicz, R. Flisiak","doi":"10.23736/S0026-4806.24.09238-3","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09238-3","url":null,"abstract":"BACKGROUND\u0000The introduction of direct-acting antivirals (DAAs) with their effectiveness and safety has revolutionized the approach to treating hepatitis C virus (HCV) infections. Nevertheless, elderly patients have often been excluded from clinical trials, so the results of real-world studies are particularly important in the context of the geriatric population. The study aimed to analyze the effectiveness and safety of antiviral DAA treatment in HCV-infected patients over the age of 65, with notable inclusion of those over the age of 85.\u0000\u0000\u0000METHODS\u0000The analyzed patients were divided by age into three groups: group A (65-74 years), group B (75-84 years) and group C (85 years or older). Patients started DAA based therapy at 22 hepatology centers between July 2015 and December 2022.\u0000\u0000\u0000RESULTS\u0000A total of 3505 elderly patients were included in the analysis, and this group consisted of 2501 patients in group A, 893 in group B, and 111 in group C. The study population, regardless of age, was dominated by women. Patients had a high prevalence of comorbidities (84.9%, 92.2%, and 93.7%, respectively) as well as a high rate of concomitant medications. The sustained virological response was 97.9% in groups A and B and 100% in group C. The therapy was well-tolerated, with a comparable safety profile observed in all analyzed groups.\u0000\u0000\u0000CONCLUSIONS\u0000DAA-based therapies are highly effective and well tolerated by the elderly patients, including those over 85. Age should not be a barrier to treatment, but careful management is necessary.","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":"340 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study on the correlation between remote radical surgical methods for gastric cancer and the risk of postoperative malnutrition in patients. 胃癌远程根治手术方法与患者术后营养不良风险的相关性研究。

IF 4.7 4区医学

Minerva medica Pub Date : 2024-04-01 Epub Date: 2023-05-25 DOI: 10.23736/S0026-4806.23.08640-8

Chuandong Wang, Yi Liu, Xiaojuan Zhang, Bo Hu

引用次数: 0

Effects of isoflurane on rats with cerebral ischemia/reperfusion injury and its potential molecular mechanism. 异氟醚对脑缺血再灌注损伤大鼠的影响及其潜在的分子机制

IF 4.7 4区医学

Minerva medica Pub Date : 2024-04-01 Epub Date: 2021-07-16 DOI: 10.23736/S0026-4806.21.07602-3

Yuanyuan Shao, Zhijun Zhou, Wei Su

引用次数: 0

Nursing management strategy of stress injury based on skin temperature monitoring by infrared thermal imaging in postural management of paraplegic patients. 基于红外热成像皮肤温度监测的应力损伤护理管理策略在截瘫患者体位管理中的应用。

IF 4.7 4区医学

Minerva medica Pub Date : 2024-04-01 Epub Date: 2023-07-13 DOI: 10.23736/S0026-4806.23.08786-4

Aimei Miao, Yali Ni, Xiaoqiong Jiang, Chang Lv, Haohao Huang, Shuangshuang Chen, Xizhen Zhao, Cai Lin

引用次数: 0

The impact analysis of multidisciplinary integrated postabortion care services on contraceptive compliance and fertility preservation in patients undergoing induced abortion. 多学科综合人工流产后护理服务对人工流产患者避孕依从性和生育能力保护的影响分析。

IF 4.7 4区医学

Minerva medica Pub Date : 2024-04-01 DOI: 10.23736/S0026-4806.24.09167-5

Junning Jing, Meng Tong, Jing Tang, Jing Li, Chongli Guan, Xiaoxiong Wen, Yapeng An

引用次数: 0

Effectiveness of grid management in emergency operating room for cancer patients. 癌症患者急诊手术室网格管理的有效性。

IF 4.7 4区医学

Minerva medica Pub Date : 2024-04-01 DOI: 10.23736/S0026-4806.24.09174-2

Yongchao He, Kaili Wang, Jun Chen, Xiaoyu Liu, Yan Zheng

引用次数: 0

Incidence and risk factors for non-cardiac syncope in a cohort of patients addressing an accredited Arterial Hypertension Center: the Innocent Study. 在经认可的动脉高血压中心就诊的一组患者中，非心源性晕厥的发生率和风险因素：无辜者研究。

IF 4.7 4区医学

Minerva medica Pub Date : 2024-04-01 DOI: 10.23736/S0026-4806.24.09200-0

F. Numeroso, Luca Bottaro, Ali Younes, Andrea Ungar, A. Cabassi

{"title":"Incidence and risk factors for non-cardiac syncope in a cohort of patients addressing an accredited Arterial Hypertension Center: the Innocent Study.","authors":"F. Numeroso, Luca Bottaro, Ali Younes, Andrea Ungar, A. Cabassi","doi":"10.23736/S0026-4806.24.09200-0","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09200-0","url":null,"abstract":"BACKGROUND\u0000Hypotensive susceptibility in hypertensive patients could facilitate orthostatic hypotension, syncope and fall. The aim of this study was to identify incidence, clinical form, complications and risk factors for non-cardiac syncope in a cohort of hypertensive patients.\u0000\u0000\u0000METHODS\u0000This is an observational, case-controlled, retrospective study carried out on 168 patients, evaluated at the Hypertension Center of the University Hospital of Parma (Italy). Based on the presence of episodes of syncope during the six months prior to enrolment, we identified cases and controls and then we compared them to personal data, comorbidities, current drug regimens, presence of orthostatic hypotension, office and ambulatory blood pressure monitoring (ABPM) blood pressure (BP) values.\u0000\u0000\u0000RESULTS\u0000In patients with previous syncopal episodes (29.8% of total), we more frequently found female gender, comorbidities associated with autonomic dysfunction, diuretics and non-CV drugs potentially associated with hypotension in their current drug regimen, orthostatic hypotension and lower office and ABPM BP values.\u0000\u0000\u0000CONCLUSIONS\u0000To identify hypertensive patients at higher risk for syncope and falls, physicians should focus on comorbidities and current drug regimens, systematically perform an active standing test to identify orthostatic hypotension, employ ABPM to compare BP values with the pre-established target and highlight systolic BP drops and abnormalities suggesting concomitant autonomic dysfunction. The modulation of antihypertensive therapy is an effective tool to counteract the risk of non-cardiac syncope, with possible trauma or other negative influences.","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":"107 ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140758877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical efficacy of comprehensive rehabilitation therapy for postoperative elbow joint dysfunction in upper limb fracture. 综合康复治疗对上肢骨折术后肘关节功能障碍的临床疗效。

IF 4.7 4区医学

Minerva medica Pub Date : 2024-02-01 Epub Date: 2023-06-29 DOI: 10.23736/S0026-4806.23.08729-3

Yao Pang, Yu Gu, Jianfeng Wang

引用次数: 0

Clinical efficacy and mechanism exploration of Tianma Gouteng decoction in improving gestational hypertension by regulating IL-6, NF-kB, and AngII. 天麻钩藤汤通过调节IL-6、NF-kB和AngII改善妊娠高血压的临床疗效及机制探讨

IF 4.7 4区医学

Minerva medica Pub Date : 2024-02-01 Epub Date: 2023-07-24 DOI: 10.23736/S0026-4806.23.08788-8

Shujun Zhao, Xiao Sun, Rui Xu, Yaqin Wang, Muchen Zhang, Yuchen Sun, Yan Zhang

引用次数: 0

The effect of cognitive behavioral therapy on disease recovery and medication adherence in first-episode schizophrenia patient. 认知行为疗法对首发精神分裂症患者疾病康复和坚持服药的影响。