Mitochondrion最新文献_第6页

Escherichia coli infection induces ferroptosis in bovine mammary epithelial cells by activating the Wnt/β-catenin pathway-mediated mitophagy 大肠埃希氏菌感染通过激活 Wnt/β-catenin 通路介导的有丝分裂，诱导牛乳腺上皮细胞铁变态反应

IF 4.4 3区生物学

Mitochondrion Pub Date : 2024-06-15 DOI: 10.1016/j.mito.2024.101921

Cuicui Zhuang , Yang Liu , Herman W. Barkema , Zhaoju Deng , Jian Gao , John P. Kastelic , Bo Han , Jianhai Zhang

引用次数: 0

Increased expression of SLC25A18 is associated with Alzheimer’s disease and is involved in Aβ42-induced mitochondrial dysfunction and apoptosis in neuronal cells SLC25A18 的表达增加与阿尔茨海默病有关，并参与 Aβ42 诱导的线粒体功能障碍和神经细胞凋亡。

IF 4.4 3区生物学

Mitochondrion Pub Date : 2024-06-12 DOI: 10.1016/j.mito.2024.101918

Jia-Yi Song , Yong Jia , Hao Han , Xue-Han Yang , Jing Zhang , Qiang Zhang , Su-Shan Wang , Chun-Yan Wang , Li Chen , Ming Zhang

{"title":"Increased expression of SLC25A18 is associated with Alzheimer’s disease and is involved in Aβ42-induced mitochondrial dysfunction and apoptosis in neuronal cells","authors":"Jia-Yi Song , Yong Jia , Hao Han , Xue-Han Yang , Jing Zhang , Qiang Zhang , Su-Shan Wang , Chun-Yan Wang , Li Chen , Ming Zhang","doi":"10.1016/j.mito.2024.101918","DOIUrl":"10.1016/j.mito.2024.101918","url":null,"abstract":"<div><p>Alzheimer’s disease (AD) is currently one of the most serious public health concerns in the world. However, the best approach to treat AD has yet to be discovered, implying that we must continue to work hard to find new AD target genes. In this study, we further analysed Gene Expression Omnibus (GEO) data and discovered that the expression of the Mitochondria glutamate carrier SLC25A18 is associated with AD by screening the differentially expressed genes in different regions of the brains of Alzheimer’s disease patients. To verify the expression of SLC25A18 during Alzheimer’s disease development, we analysed animal models (5×FAD transgenic AD animal model, chemically induced AD animal model, natural ageing animal model), and the results showed that the expression of SLC25A18 was increased in animal models of AD. Further investigation of the different regions found that SLC25A18 expression was elevated in the EC, TeA, and CA3, and expressed in neurons. Next, We found that Aβ42 treatment elevated SLC25A18 expression in Neuro 2A cells. Reducing SLC25A18 expression attenuated mitochondrial dysfunction and neuronal apoptosis caused by Aβ42. Overexpression of SLC25A18 increased ATP and intracellular superoxide anions but decreased mitochondrial membrane potential. The results indicate that SLC25A18 affects mitochondrial function and neuronal apoptosis, and is related to AD, which makes it a potential target for treating brain dysfunction.</p></div>","PeriodicalId":18606,"journal":{"name":"Mitochondrion","volume":"78 ","pages":"Article 101918"},"PeriodicalIF":4.4,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S156772492400076X/pdfft?md5=a6d038576477b989162d7b765a2d4446&pid=1-s2.0-S156772492400076X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interplay between mitophagy and mitochondrial ROS in acute lung injury 急性肺损伤中有丝分裂与线粒体 ROS 之间的相互作用

IF 3.9 3区生物学

Mitochondrion Pub Date : 2024-06-12 DOI: 10.1016/j.mito.2024.101920

Yizhi Zhong , Siwei Xia , Gaojian Wang , Qinxue Liu , Fengjie Ma , Yijin Yu , Yaping Zhang , Lu Qian , Li Hu , Junran Xie

引用次数: 0

Thyroid hormone enhances efficacy of cisplatin in lung cancer patients via down-regulating GLUT1 expression and reversing the Warburg effect 甲状腺激素通过下调 GLUT1 表达和逆转沃伯格效应增强顺铂对肺癌患者的疗效。

IF 3.9 3区生物学

Mitochondrion Pub Date : 2024-06-12 DOI: 10.1016/j.mito.2024.101919

Chenchen Fan , Yanbei Ren , Wen Zhang , Jing Wen , Wenjia Zhang , Shumeng Lin , Yidong Bai , Tiansheng Zheng , Baigenzhin Abay , Ming Li , Lihong Fan

{"title":"Thyroid hormone enhances efficacy of cisplatin in lung cancer patients via down-regulating GLUT1 expression and reversing the Warburg effect","authors":"Chenchen Fan , Yanbei Ren , Wen Zhang , Jing Wen , Wenjia Zhang , Shumeng Lin , Yidong Bai , Tiansheng Zheng , Baigenzhin Abay , Ming Li , Lihong Fan","doi":"10.1016/j.mito.2024.101919","DOIUrl":"10.1016/j.mito.2024.101919","url":null,"abstract":"<div><p>Cisplatin (CDDP) is a standard non-small cell lung cancer (NSCLC) chemotherapy, but its efficacy is hampered by resistance, partly due to the Warburg effect. This study investigates how thyroid hormones enhance the Warburg effect, increasing sensitivity to cisplatin in lung cancer. Clinical data from advanced NSCLC patients were analyzed based on thyroid hormone levels, categorizing patients into high and low groups. Cellular experiments involved Control, 10uM CDDP, 10uM CDDP + 0.1uM T3, and 10uM CDDP + 0.1uM T4 categories. Parameters were measured in A549 and PC9 lung cancer cells, including proliferation, apoptosis, mitochondrial membrane potential, ROS production, glycolysis enzyme activity, lactic acid level, and ATP content. Gene and protein expressions were assessed using qPCR and Western Blot. Analysis revealed higher FT3 levels correlated with prolonged progression-free survival before chemotherapy (median PFS: high FT3 group = 12.67 months, low FT3 group = 7.03 months, p = 0.01). Cellular experiments demonstrated that thyroid hormones increase lung cancer cell sensitivity to cisplatin, inhibiting proliferation and enhancing efficacy. The mechanism involves thyroid hormones and cisplatin jointly down-regulating MSI1/AKT/GLUT1 expression, reducing lactic acid and glycolysis. This Warburg effect reversal boosts ATP levels, elevates ROS, and decreases MMP, enhancing cisplatin effectiveness in A549 and PC9 cells. In conclusion, elevated free T3 levels in advanced NSCLC patients correlate with prolonged progression-free survival under cisplatin chemotherapy. Cellular experiments reveal that thyroid hormones enhance lung cancer cell sensitivity to cisplatin by reversing the Warburg effect, providing a mechanistic basis for improved therapeutic outcomes.</p></div>","PeriodicalId":18606,"journal":{"name":"Mitochondrion","volume":"78 ","pages":"Article 101919"},"PeriodicalIF":3.9,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141321215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of mitochondrial genes in ischemia-reperfusion injury: A systematic review of experimental studies 线粒体基因在缺血再灌注损伤中的作用：实验研究的系统回顾。

IF 4.4 3区生物学

Mitochondrion Pub Date : 2024-06-06 DOI: 10.1016/j.mito.2024.101908

Zeyu Chen , Daniel Rayner , Robert Morton , Laura Banfield , Guillaume Paré , Michael Chong

引用次数: 0

Liver mitochondrial coupling efficiency and its relationship to oxidative capacity and adenine nucleotide translocase content: A comparative study among crocodiles, birds and mammals 肝脏线粒体偶联效率及其与氧化能力和腺嘌呤核苷酸转运酶含量的关系：鳄鱼、鸟类和哺乳动物的比较研究。

IF 4.4 3区生物学

Mitochondrion Pub Date : 2024-06-04 DOI: 10.1016/j.mito.2024.101909

Damien Roussel , Nathan Roussel , Yann Voituron , Benjamin Rey

引用次数: 0

Cell-penetrating peptides with nanoparticles hybrid delivery vectors and their uptake pathways 细胞穿透肽与纳米颗粒混合输送载体及其吸收途径

IF 4.4 3区生物学

Mitochondrion Pub Date : 2024-05-24 DOI: 10.1016/j.mito.2024.101906

Moataz Dowaidar

引用次数: 0

ACAD9 treatment with bezafibrate and nicotinamide riboside temporarily stabilizes cardiomyopathy and lactic acidosis 用贝扎贝特和烟酰胺核糖苷治疗 ACAD9 可暂时稳定心肌病和乳酸酸中毒的病情

IF 4.4 3区生物学

Mitochondrion Pub Date : 2024-05-24 DOI: 10.1016/j.mito.2024.101905

Johan L.K. Van Hove , Marisa W. Friederich , Daniella H. Hock , David A. Stroud , Nikeisha J. Caruana , Uwe Christians , Björn Schniedewind , Cole R. Michel , Richard Reisdorph , Edwin D.J. Lopez Gonzalez , Charles Brenner , Tonia E. Donovan , Jessica C. Lee , Kathryn C. Chatfield , Austin A. Larson , Peter R. Baker II , Shawn E. McCandless , Meghan F. Moore Burk

{"title":"ACAD9 treatment with bezafibrate and nicotinamide riboside temporarily stabilizes cardiomyopathy and lactic acidosis","authors":"Johan L.K. Van Hove , Marisa W. Friederich , Daniella H. Hock , David A. Stroud , Nikeisha J. Caruana , Uwe Christians , Björn Schniedewind , Cole R. Michel , Richard Reisdorph , Edwin D.J. Lopez Gonzalez , Charles Brenner , Tonia E. Donovan , Jessica C. Lee , Kathryn C. Chatfield , Austin A. Larson , Peter R. Baker II , Shawn E. McCandless , Meghan F. Moore Burk","doi":"10.1016/j.mito.2024.101905","DOIUrl":"10.1016/j.mito.2024.101905","url":null,"abstract":"<div><p>Pathogenic <em>ACAD9</em> variants cause complex I deficiency. Patients presenting in infancy unresponsive to riboflavin have high mortality. A six-month-old infant presented with riboflavin unresponsive lactic acidosis and life-threatening cardiomyopathy. Treatment with high dose bezafibrate and nicotinamide riboside resulted in marked clinical improvement including reduced lactate and NT-pro-brain type natriuretic peptide levels, with stabilized echocardiographic measures. After a long stable period, the child succumbed from cardiac failure with infection at 10.5 months. Therapy was well tolerated. Peak bezafibrate levels exceeded its EC<sub>50</sub>. The clinical improvement with this treatment illustrates its potential, but weak PPAR agonist activity of bezafibrate limited its efficacy.</p></div>","PeriodicalId":18606,"journal":{"name":"Mitochondrion","volume":"78 ","pages":"Article 101905"},"PeriodicalIF":4.4,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141140945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chelating mitochondrial iron and copper: Recipes, pitfalls and promise 螯合线粒体中的铁和铜：配方、陷阱和前景。

IF 4.4 3区生物学

Mitochondrion Pub Date : 2024-05-21 DOI: 10.1016/j.mito.2024.101903

Lucie J. Lamačová, Jan Trnka

引用次数: 0

The tissue-specific nature of physiological zebrafish mitochondrial bioenergetics 生理斑马鱼线粒体生物能的组织特异性。

IF 4.4 3区生物学

Mitochondrion Pub Date : 2024-05-21 DOI: 10.1016/j.mito.2024.101901

Rafael David Souto de Azevedo , Kivia Vanessa Gomes Falcão , Sinara Monica Vitalino de Almeida , Marlyete Chagas Araújo , Reginaldo Correia Silva-Filho , Maria Bernadete de Souza Maia , Ian Porto Gurgel do Amaral , Ana Catarina Rezende Leite , Ranilson de Souza Bezerra

{"title":"The tissue-specific nature of physiological zebrafish mitochondrial bioenergetics","authors":"Rafael David Souto de Azevedo , Kivia Vanessa Gomes Falcão , Sinara Monica Vitalino de Almeida , Marlyete Chagas Araújo , Reginaldo Correia Silva-Filho , Maria Bernadete de Souza Maia , Ian Porto Gurgel do Amaral , Ana Catarina Rezende Leite , Ranilson de Souza Bezerra","doi":"10.1016/j.mito.2024.101901","DOIUrl":"10.1016/j.mito.2024.101901","url":null,"abstract":"<div><p>Zebrafish are a powerful tool to study a myriad of experimental conditions, including mitochondrial bioenergetics. Considering that mitochondria are different in many aspects depending on the tissue evaluated, in the zebrafish model there is still a lack of this investigation. Especially for juvenile zebrafish. In the present study, we examined whether different tissues from zebrafish juveniles show mitochondrial density- and tissue-specificity comparing brain, liver, heart, and skeletal muscle (SM). The liver and brain complex IV showed the highest O<sub>2</sub> consumption of all ETC in all tissues (10x when compared to other respiratory complexes). The liver showed a higher potential for ROS generation. In this way, the brain and liver showed more susceptibility to O<sub>2</sub><sup><img>−</sup> generation when compared to other tissues. Regarding Ca<sup>2+</sup> transport, the brain showed greater capacity for Ca<sup>2+</sup> uptake and the liver presented low Ca<sup>2+</sup> uptake capacity. The liver and brain were more susceptible to producing <sup><img></sup>NO. The enzymes SOD and Catalase showed high activity in the brain, whereas GPx showed higher activity in the liver and CS in the SM. TEM reveals, as expected, a physiological diverse mitochondrial morphology. The essential differences between zebrafish tissues investigated probably reflect how the mitochondria play a diverse role in systemic homeostasis. This feature may not be limited to normal metabolic functions but also to stress conditions. In summary, mitochondrial bioenergetics in zebrafish juvenile permeabilized tissues showed a tissue-specificity and a useful tool to investigate conditions of redox system imbalance, mainly in the liver and brain.</p></div>","PeriodicalId":18606,"journal":{"name":"Mitochondrion","volume":"77 ","pages":"Article 101901"},"PeriodicalIF":4.4,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0