Melatonin Research最新文献_第4页

Serotonin, melatonin and their precursors and metabolites and vitamin D₃ derivatives in honey. 蜂蜜中的血清素，褪黑素及其前体和代谢物以及维生素D3衍生物。

Melatonin Research Pub Date : 2022-10-03 DOI: 10.32794/mr112500137

Tae-Kang Kim, Adrian Fabisiak, Pawel Brzeminski, Russel J Reiter, Andrzej T Slominski

引用次数: 5

The pleiotropic role of melatonin against chromium-induced cardiovascular infirmities: a mechanistic insight 褪黑素对铬诱导的心血管疾病的多效性作用:一个机制的见解

Melatonin Research Pub Date : 2022-09-30 DOI: 10.32794/mr112500130

P. Ghosh, T. Dey, D. Bandyopadhyay

{"title":"The pleiotropic role of melatonin against chromium-induced cardiovascular infirmities: a mechanistic insight","authors":"P. Ghosh, T. Dey, D. Bandyopadhyay","doi":"10.32794/mr112500130","DOIUrl":"https://doi.org/10.32794/mr112500130","url":null,"abstract":"Currently, cardiovascular diseases are still the number one killer in the world. These include hypertension, coronary heart disease, ischemic heart disease, myocardial infarction, congestive heart failure, cardiac arrhythmias, etc. One of the risk factors for cardiovascular diseases is environmental heavy metal pollution which makes the victims more vulnerable to sudden cardiac death. Chromium (Cr) is one of the metals. Cr(VI) is the most hazardous one among its variants. It is readily across the plasma membrane to cause oxidative damage to intracellular molecules including LDL, proteins, and DNA; therefore, promotes endothelial dysfunction and Ca2+ overload in the heart. As to its molecular mechanism, Cr(VI) downregulates the expressions of SIRTUINS, FOXOs, PGC-1α, and AMPK and upregulates the P53, Akt, and NF-κβ, causing alteration in metabolic pathways, inhibiting mitochondrial biogenesis, inducing autophagy and apoptosis. In addition, Cr(VI) alters the expressions of Th1 cytokines (IL-1β, IL-2, IL-12, TNF-α, and IFN-γ) as well as Th2 cytokines (IL-4, IL-5, and IL-10) to induce myocardial inflammation. Melatonin, a potent antioxidant, and an efficient metal chelator can neutralize almost all the alterations caused by Cr(VI). Thus, melatonin can be a selected molecule to protect against Cr(VI)-induced cardiovascular toxicity. This review highlights the etiology of Cr(VI) associated heart diseases and the potentiality of melatonin to prevent Cr(VI)-mediated cardiac oxidative stress, apoptosis and inflammation.","PeriodicalId":18604,"journal":{"name":"Melatonin Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83029357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Autoxidation of melatonin at excited state: mechanism proposal for formation of N1-acetyl-N2-formyl-5-methoxykynuramine 激发态褪黑素的自氧化:n1 -乙酰- n2 -甲酰基-5-甲氧基氨基形成的机制建议

Melatonin Research Pub Date : 2022-09-30 DOI: 10.32794/mr112500135

M. R. Peres, V. R. Miranda, A. D. de Souza, N. Morgon, V. Ximenes

{"title":"Autoxidation of melatonin at excited state: mechanism proposal for formation of N1-acetyl-N2-formyl-5-methoxykynuramine","authors":"M. R. Peres, V. R. Miranda, A. D. de Souza, N. Morgon, V. Ximenes","doi":"10.32794/mr112500135","DOIUrl":"https://doi.org/10.32794/mr112500135","url":null,"abstract":"N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) is one of the primary oxidation products of melatonin. There is growing evidence of its beneficial biological properties, including antioxidant features and modulators of cytokines and enzymes involved in the inflammatory process. Here, the autoxidation of melatonin mediated by UVC was studied regarding the formation of AFMK and the reaction mechanism. The parameters evaluated were irradiation, pH, dissolved oxygen, superoxide radical anion, and hydroxyl radical. We found that the AFMK yield is directly correlated with UVC irradiation. The AFMK concentration decreased 95% when a 280 nm cutoff filter blocked the irradiation. By removing the dissolved oxygen from the medium, the decrease was 90%. Superoxide dismutase, acting as a scavenger of superoxide radical anion, caused a 64% reduction. At pH 7.0, the AFMK yield was just 14% of those obtained at pH 10. These findings are consistent with a typical autoxidation reaction. In addition, the low yield of AFMK in the absence of UVC irradiation suggested that electronically excited melatonin is the species involved in the initial electron transfer. Density Functional Theory (DFT) calculations were performed to strengthen the proposal. Corroborant with the experimental results, the theoretical analyses revealed that electron transfer from melatonin to molecular oxygen is only energetically feasible in the excited state. In conclusion, the direct autoxidation of melatonin at excited state in alkaline pH is a straightforward approach to producing AFMK.","PeriodicalId":18604,"journal":{"name":"Melatonin Research","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81027804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Transient responses of melatonin to stress 褪黑素对应激的短暂反应

Melatonin Research Pub Date : 2022-09-30 DOI: 10.32794/mr112500133

S. Zimmerman, R. Reiter

{"title":"Transient responses of melatonin to stress","authors":"S. Zimmerman, R. Reiter","doi":"10.32794/mr112500133","DOIUrl":"https://doi.org/10.32794/mr112500133","url":null,"abstract":"Melatonin and its metabolites are ubiquitous antioxidants that are produced \u0000in response to reactive oxygen species (ROS) in virtually all cells of the \u0000body. The highest reported melatonin values in plasma and sweat occur during \u0000heavy exercise both indoors and outdoors during the day. The advent of sweat \u0000biosensors with sufficient melatonin sensitivity provides pseudo real-time \u0000evidence that melatonin is produced throughout the body not just in the pineal \u0000gland. The role of the pineal gland appears to be to provide cyclic production \u0000of melatonin for the regulation of circadian rhythms as well as supplemental melatonin \u0000during periods of low cellular activity. \u0000Melatonin from the pineal gland represents only a small fraction of the \u0000body’s production capacity. Greater than 5 pg/ml min ramp rates for plasma and \u0000sweat melatonin have been reported during strenuous exercise in sunlight as \u0000compared to 0.15 pg/ml min ramp rates for plasma melatonin under dim light \u0000melatonin onset (DLMO) conditions. Sunlight \u0000and exercise, like fever, generates transient elevated levels of ROS in tissues \u0000with time constants measured in minutes or even seconds making this systemic \u0000antioxidant response potentially protective. Based on a simple accounting of \u0000ROS generated by sunlight, ROS we breathe, ROS we drink, and exercise, it \u0000appears that the body maintains a heightened basal level of ROS as part of its \u0000pathogen defense mechanisms. Current \u0000human lifestyles and modern enclosed spaces have substantially eliminated over \u000090% of the ROS which undermines one of the body’s primary defenses. With \u0000advanced age, the inability to maintain this protective barrier appears to make \u0000us more susceptible to disease. ","PeriodicalId":18604,"journal":{"name":"Melatonin Research","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80198418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A geographical approach to the development of hypotheses relating to Covid-19 death rates 用地理方法提出与Covid-19死亡率有关的假设

Melatonin Research Pub Date : 2022-09-30 DOI: 10.32794/mr112500132

M. Skutsch, R. Seheult, Jaime Loya

{"title":"A geographical approach to the development of hypotheses relating to Covid-19 death rates","authors":"M. Skutsch, R. Seheult, Jaime Loya","doi":"10.32794/mr112500132","DOIUrl":"https://doi.org/10.32794/mr112500132","url":null,"abstract":"Covid-19 deaths per million vary greatly between continents, with countries in South America having higher death rates even than Europe and North America, while Asia, Africa and Oceania have death rates which are only a fifth of those in South America. By analysing national level data on body weight, diet and latitude, we hypothesise and demonstrate that difference in the percentage of people with overweight (BMI > 25) may be the major factor that explains these differences in Covid-19 death rates. Meanwhile, within the group of countries where adult overweight is prevalent (i.e., where more than 50% of the population has BMI > 25), we hypothesise and demonstrate that latitude plays a role, with relatively lower death rates occurring in countries at lower latitudes. We further suggest that these relationships may be explained by two possible medical hypotheses relating to solar radiation: (1) In overweight people there is less penetration to important organs of near-infrared radiation (NIR) which stimulates production of subcellular melatonin, a strong anti-oxidizing factor and (2) In overweight people, fatty tissue holds much of the body´s 25(OH)D3 leaving less circulating in the blood stream. Several pathways have been proposed by other researchers to explain the link between Vitamin D deficiency and severity of Covid-19, but the possible link of Covid-19 outcome with NIR has not been explored. Latitude, of course, determines the amount of incoming NIR and as well as UV-B, which is the main stimulant for the body´s production of Vitamin D. It may well be that these two physiological processes operate simultaneously. ","PeriodicalId":18604,"journal":{"name":"Melatonin Research","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74774045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin and redox homeostasis 褪黑素和氧化还原稳态

Melatonin Research Pub Date : 2022-09-30 DOI: 10.32794/mr112500134

S. Süzen, M. C. Atayik, Hanif Sirinzade, Bita Entezari, H. Gurer-Orhan, U. Çakatay

{"title":"Melatonin and redox homeostasis","authors":"S. Süzen, M. C. Atayik, Hanif Sirinzade, Bita Entezari, H. Gurer-Orhan, U. Çakatay","doi":"10.32794/mr112500134","DOIUrl":"https://doi.org/10.32794/mr112500134","url":null,"abstract":"Redox homeostasis and redox signaling are constituents of preservation of a normal physiological state. Whereas the equilibrium between oxidants and nucleophiles is conserved in redox homeostasis, oxidative stress promotes the formation of a radically altered redox state. It is known that modification of circadian clock may lead to severe alteration in redox balance. Melatonin [N-acetyl-5-methoxytryptamine, (MLT)] regulates numerous physiological functions including circadian rhythm, sleep-wake cycle, gonadal activity, redox homeostasis, neuroprotection, immune-modulation, and anticancer activity in organisms. Insufficient MLT production is closely related to development of aging process, tumorigenesis, visceral adiposity, neurodegenerative disorders, etc. Reactive oxygen species (ROS) are not intrinsically harmful or beneficial in cellular redox metabolism. Redox homeostasis is an integrative status for both of the hormetic response to ROS overproduction and subsequent redox signaling. MLT and its derivatives are traditionally classified as hormone-like substances. Their redox sensitive regulatory activity and direct interaction with intracellular ROS serve as second messenger in cell signaling. This review involves the role of redox homeostasis in the pathogenesis of age-related disorders and its relationship with MLT, therefore, targeting the circadian rhythm may propose new therapeutic approach for these disorders.","PeriodicalId":18604,"journal":{"name":"Melatonin Research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81989683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A comparative overview on the role of melatonin and vitamins as potential antioxidants against oxidative stress induced degenerative infirmities: An emerging concept 褪黑激素和维生素作为抗氧化应激诱导的退行性疾病的潜在抗氧化剂的作用的比较概述:一个新兴的概念

Melatonin Research Pub Date : 2022-09-30 DOI: 10.32794/mr112500131

Manisha Mukhopadhyay, R. Majumder, Adrita Banerjee, D. Bandyopadhyay

{"title":"A comparative overview on the role of melatonin and vitamins as potential antioxidants against oxidative stress induced degenerative infirmities: An emerging concept","authors":"Manisha Mukhopadhyay, R. Majumder, Adrita Banerjee, D. Bandyopadhyay","doi":"10.32794/mr112500131","DOIUrl":"https://doi.org/10.32794/mr112500131","url":null,"abstract":"Oxidative stress is a biological phenomenon described by decreased ability of the antioxidative system to neutralize excess reactive oxygen species (ROS). At low or moderate concentrations, ROS creates harmony in physiological functions but over production of ROS in long term can predisposes several chronic and neurodegenerative diseases such as coronary diseases, atherosclerosis, diabetes mellitus, hemolytic anemia, pulmonary diseases, neurodegenerative disorders, etc. The therapeutic use of antioxidants to control oxidative damage is a well-established phenomenon. In these aspects, melatonin and other classical antioxidant vitamins such as carotenoids, α-tocopherol, vitamin D, and ascorbic acid have gained enormous attention in the modern research area. In this review, we will discuss the comparative as well as the synergistic role of melatonin and other vitamins against stress-mediated disorders. Noteworthy, based on research evidence mentioned here we can recommend the combined use of melatonin and vitamins to alleviate the stress-induced toxicity in the broad spectrum.","PeriodicalId":18604,"journal":{"name":"Melatonin Research","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82953370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial dynamics in myocardial ischemia/reperfusion injury: Effects of melatonin 心肌缺血/再灌注损伤中的线粒体动力学:褪黑素的影响

Melatonin Research Pub Date : 2022-09-30 DOI: 10.32794/mr112500136

A. Lochner, M. Blignaut

{"title":"Mitochondrial dynamics in myocardial ischemia/reperfusion injury: Effects of melatonin","authors":"A. Lochner, M. Blignaut","doi":"10.32794/mr112500136","DOIUrl":"https://doi.org/10.32794/mr112500136","url":null,"abstract":"Timely reperfusion during myocardial infarction paradoxically leads to ischemia/reperfusion (I/R) injury. Mitochondrial quality control has emerged as a key participant in regulation of this process. The aims of this review are to briefly summarize current evidence for the role of mitochondrial quality control in I/R injury and to evaluate whether the cardioprotective actions of melatonin, a potent free radical scavenger and antioxidant, can be attributed to its effects on these processes. Using a variety of experimental models, in vivo and in vitro, melatonin-induced cardioprotection has been demonstrated to be associated with attenuation or reversal of the harmful effects of I/R on parameters of mitochondrial quality control as evidenced by (i) upregulation of mitochondrial fusion and inhibition of fission, particularly Drp1 expression and translocation from the cytosol to the mitochondria; (ii) changes in both the conventional and alternative mitophagy pathways. Melatonin significantly upregulates mitochondrial biogenesis and the expression of sirtuins 1, 3 and 6 and has a beneficial effect on mitochondrial-endoplasmic reticulum interaction in I/R. A novel observation is the ability of melatonin to stimulate intercellular transfer of mitochondria between damaged cells, although this has not yet been demonstrated in myocardial I/R. Melatonin treatment has profound effects on the diabetic heart: it reverses the significant reduction in function and inhibits the progression of diabetic cardiomyopathy which was associated with a significant effect on mitochondrial quality control, as evidenced by a reduction in fission. In summary, available evidence supports a major role for mitochondrial quality control in the beneficial actions of melatonin in the I/R heart.","PeriodicalId":18604,"journal":{"name":"Melatonin Research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86324298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin as a protective adjunct to the renin angiotensin system imbalance induced cardiovascular pathogenesis: A review 褪黑素作为肾素-血管紧张素系统失衡引起的心血管发病机制的保护性辅助剂:综述

Melatonin Research Pub Date : 2022-06-30 DOI: 10.32794/mr112500126

M. Datta, R. Majumder, A. Chattopadhyay, D. Bandyopadhyay

引用次数: 0

Molecular interactions of melatonin with lipid rafts 褪黑素与脂筏的分子相互作用

Melatonin Research Pub Date : 2022-06-30 DOI: 10.32794/mr112500123

D. Bolmatov, M. Lavrentovich, R. Reiter

引用次数: 3