{"title":"Development and In vitro Assessment of Topical Microemulsion Based Pluronic-Lecithin Organogel for the Management of Arthritic Pain","authors":"Abhishek Yadav, Vikas Jhawat, Rahul Pratap Singh, Sunita Chauhan, Rohit Dutt, Rajesh Goyal, Deependra Singh","doi":"10.2174/0118764029280588231215044630","DOIUrl":"https://doi.org/10.2174/0118764029280588231215044630","url":null,"abstract":"\u0000\u0000Topical delivery of NSAIDs through organogels might transport lornoxicam\u0000to the site of action, minimizing gastrointestinal problems and adverse effects.\u0000\u0000\u0000\u0000In the current investigation, a lecithin organogel containing lornoxicam was made by\u0000microemulsion method. For this purpose, a certain amount of pure soya lecithin was dispersed in\u0000suitable isopropyl myristate as a dispersant and emulsifier at room temperature to form the oily\u0000phase. The lecithin was completely dissolved in the combination by the next morning. Sorbic acid\u0000was then added to the mixture as a preservative, Pluronic F-127 and potassium sorbate were\u0000weighed out, and then they were mixed with cold water to create an aqueous phase, and menthol\u0000was added. On the next morning, lornoxicam, the active component, became soluble in polyethylene\u0000glycol-400 and combined with the lecithin isopropyl palmitate mixture. The oily portion\u0000was agitated using a mechanical stirrer at 400 rpm while the aqueous phase was introduced\u0000gradually.\u0000\u0000\u0000\u0000The lornoxicam organogel preparation was it was assessed for its physical appearance,\u0000organoleptic characteristics, consistency, gelation temperature, drug content, and in vitro release\u0000studies. The active ingredient content of formulation F5 was the highest at 93.33. Formulations\u0000F4 and F5 were selected for kinetic studies because they had all physical characteristics under\u0000reasonable limits, the active ingredient level was the greatest, and the active ingredient release\u0000was the fastest in eight hours.\u0000\u0000\u0000\u0000The transdermal organogel formulation of lornoxicam was found to be effective for\u0000topical distribution of the drug and when administered topically, it has strong anti-inflammatory\u0000and anti-rheumatic action.\u0000","PeriodicalId":18543,"journal":{"name":"Micro and Nanosystems","volume":"27 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140494348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advances in Neutrophil Cell Membrane-coated Nano Drug Delivery Systems: A Comprehensive Review","authors":"Neha Bajwa","doi":"10.2174/0118764029272246231120045443","DOIUrl":"https://doi.org/10.2174/0118764029272246231120045443","url":null,"abstract":"\u0000\u0000Cell-mediated drug delivery systems have gained significant attention in medical research\u0000due to their potential for enhanced therapeutic specificity and efficacy in various diseases. Among\u0000immune cells, neutrophils (NEs) have emerged as a promising candidate for drug delivery due to their\u0000prevalence and rapid response in inflammatory sites. However, the short lifespan and challenges associated\u0000with the in vitro cultivation of NEs have hindered their direct use for drug administration. This\u0000review aims to highlight the importance of NEs as effective drug-delivery vehicles and elucidate the\u0000underlying mechanisms contributing to their pharmacological efficacy. By analyzing recent studies\u0000and advancements in the field, we will discuss the strategies employed to harness NEs as drug carriers,\u0000including coating nanostructures with NE cell membranes.\u0000Additionally, we will explore the unique properties of NEs that enable targeted drug delivery, such as\u0000their ability to navigate through complex biological environments and actively migrate toward inflamed\u0000tissues. Furthermore, we will delve into the mechanisms of NE-mediated drug release and the\u0000potential applications of NE-based drug delivery systems in various therapeutic areas. Overall, this\u0000review provides valuable insights into the use of NEs as drug delivery mechanisms and offers perspectives\u0000on the future directions of this exciting field.\u0000","PeriodicalId":18543,"journal":{"name":"Micro and Nanosystems","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140494849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suryakanta Swain, H. B. Samal, Santosh Satpathy, B. R. Jena, G. Pattnaik, Sheerin Bashas, Sonu Barad
{"title":"The Prospective Applications of arising Nanostructured Dielectric\u0000Materials in Storage of Energy: A Comprehensive Review","authors":"Suryakanta Swain, H. B. Samal, Santosh Satpathy, B. R. Jena, G. Pattnaik, Sheerin Bashas, Sonu Barad","doi":"10.2174/0118764029277532231231100117","DOIUrl":"https://doi.org/10.2174/0118764029277532231231100117","url":null,"abstract":"\u0000\u0000The manufacture and study of innovative materials that enable the availability of relevant technologies are vital in light of the energy demands of various human activities\u0000and the need for a substantial shift in the energy matrix.\u0000\u0000\u0000\u0000A strategy based on the creation of enhanced applications for batteries has been devised\u0000to reduce the conversion, storage, and feeding of renewable energy like fuel cells and electrochemical capacitors.\u0000\u0000\u0000\u0000Conductive polymers (CP) can be utilised instead of traditional inorganic chemicals.\u0000Electrochemical energy storage devices with similar capabilities can be built using approaches\u0000based on the production of composite materials and nanostructures.\u0000\u0000\u0000\u0000CP's nanostructuring is notable for its concentration on synergistic coupling with other materials, which sets it apart from other nanostructures that have been developed in the preceding two\u0000decades. This is due to the fact that, when paired with other materials, their distinctive morphology\u0000and adaptability significantly enhance performance in areas like the suppression of ionic diffusion\u0000trajectories, electronic transport and the improvement of ion penetrability and intercalation spaces.\u0000\u0000\u0000\u0000The present study forecasts the wide-ranging modern applications of diverse\u0000nanostructured dielectric materials along with its future prospectives. The potential contributions of\u0000nanostructured carbon nanotubes to the development of innovative materials for energy storage devices are also critically discussed in this context, which delivers a summary of the present state of\u0000information on this emerging topic.\u0000","PeriodicalId":18543,"journal":{"name":"Micro and Nanosystems","volume":"55 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139598994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}