Microvascular research最新文献

{"title":"Nrf2 deficiency blunts exercise training-induced adaptations of coronary resistance arteries","authors":"Hyerim Park ,&nbsp;Steven L. Medarev ,&nbsp;Joshua J. Maraj ,&nbsp;Alexis Restrepo ,&nbsp;Steven W. Copp ,&nbsp;Judy M. Muller-Delp","doi":"10.1016/j.mvr.2025.104837","DOIUrl":"10.1016/j.mvr.2025.104837","url":null,"abstract":"<div><div>Exercise training upregulates nuclear factor erythroid 2-related factor 2 (Nrf2) expression and antioxidant production in various tissues; however, little is known about the role of Nrf2 in exercise training-induced adaptations of blood vessels. This study investigated how deletion of Nrf2 affects vasomotor function in coronary resistance arteries in sedentary and exercise-trained rats. Wild-type (WT) and Nrf2 knockout (KO) rats underwent 10 weeks of treadmill exercise or remained sedentary. Coronary resistance arteries were isolated for assessment of vasomotor responses. In resistance arteries from Nrf2 KO rats, endothelin-induced constriction was blunted, but exercise training partially restored responsiveness to endothelin; after exercise training, responses to endothelin were not different between arteries from WT and Nrf2 KO rats. Similarly, KCl-induced constriction was reduced in arteries from Nrf2 KO rats, but exercise training reversed this loss of responsiveness to KCl. Nitric oxide (NO)-mediated vasodilation of coronary resistance arteries was not altered by deletion of Nrf2; however, exercise training enhanced NO-mediated dilation in arteries from WT, but not Nrf2 KO rats. Similarly, exercise training increased vasodilation to low concentrations of potassium (10 and 20 mM KCl) in arteries from WT, but not Nrf2 KO rats. These findings suggest that Nrf2 is critical to maintenance of contractile responses in coronary resistance arteries, but exercise training can restore contractile function through Nrf2-independent mechanisms. In contrast, vasodilatory responses to NO and low-level potassium are maintained in coronary resistance arteries from Nrf2-deficient rats, but exercise training fails to enhance these vasodilatory responses in the absence of Nrf2.</div></div>","PeriodicalId":18534,"journal":{"name":"Microvascular research","volume":"161 ","pages":"Article 104837"},"PeriodicalIF":2.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DDIT4 knockdown suppresses venous malformation progression by inhibiting NF-κB signaling as a potential therapeutic target","authors":"Yang He ,&nbsp;Jian Lin ,&nbsp;Yi Li ,&nbsp;Xiaobo Cheng ,&nbsp;Tong Wang ,&nbsp;Wei Wang ,&nbsp;Weixing Zeng ,&nbsp;Yongsheng Li","doi":"10.1016/j.mvr.2025.104833","DOIUrl":"10.1016/j.mvr.2025.104833","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to investigate the regulatory role and underlying molecular mechanisms of DNA Damage Inducible Transcript 4 (DDIT4) in the pathogenesis of Venous Malformations (VMs), providing foundational experimental evidence for potential targeted therapies.</div></div><div><h3>Methods</h3><div>Bioinformatic analysis identified <em>DDIT4</em> as a key differentially expressed gene in VMs, and the sgGSEA method was employed to predict its potential biological functions. Immunohistochemical staining and immunofluorescence were performed to validate the expression level of DDIT4 and its association with vascular density. A lentiviral VMs cell model was established to assess DDIT4 expression levels. The effects of DDIT4 knockdown on VMs cell function were evaluated, with mechanistic insights gained through transcriptome sequencing and Western blot analysis. Further validation was performed using 3D VMs cell models and nude mouse xenografts with DDIT4 knockdown. Additionally, exogenous functional rescue experiments were conducted by activating the NF-κB pathway with lipopolysaccharide (LPS) in DDIT4 knockdown VMs 3D cell models and nude mouse xenografts to further investigate the role of DDIT4.</div></div><div><h3>Results</h3><div>DDIT4 was upregulated in VMs tissues and correlated with angiogenesis. DDIT4 knockdown increased cell roundness, inhibited proliferation, migration, and NF-κB pathway activation, and blocked angiogenesis in VMs 3D models and lesion formation in nude mouse xenografts, while suppressing the NF-κB pathway in both. NF-κB pathway activation restored angiogenesis in both models.</div></div><div><h3>Conclusions</h3><div>DDIT4 knockdown inhibits VMs progression by suppressing the NF-κB pathway, suggesting that DDIT4 may serve as a potential therapeutic target.</div></div>","PeriodicalId":18534,"journal":{"name":"Microvascular research","volume":"161 ","pages":"Article 104833"},"PeriodicalIF":2.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144506523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional choroidal changes in diabetes and diabetic retinopathy: An ultrawide-field swept-source optical coherence tomography angiography study","authors":"Zhaoxia Zheng ,&nbsp;Lei Hu ,&nbsp;Yue Zhang ,&nbsp;Nianen Liu ,&nbsp;Xiaoya Gu ,&nbsp;Shuang Song ,&nbsp;Xiaobing Yu","doi":"10.1016/j.mvr.2025.104832","DOIUrl":"10.1016/j.mvr.2025.104832","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate choroidal changes in different stages of diabetic retinopathy (DR), and determine the effect of panretinal photocoagulation (PRP) on choroid based on volumetric measurements of ultrawide-field swept-source optical coherence tomography angiography (UWF-SS-OCTA).</div></div><div><h3>Methods</h3><div>This observational study included 56 healthy controls, 192 treatment-naïve DR patients, and 42 PRP-treated DR patients who have undergone UWF-SS-OCTA measurements. Treatment-naïve DR patients were further grouped according to varying severity of DR. Choroidal parameters were analyzed and compared among these groups according to central and peripheral areas. Spearman analysis was performed to determine the association between non-perfusion area (NPA) and choroidal parameters.</div></div><div><h3>Results</h3><div>Compared with healthy controls, choroidal thickness (CT) and volume (CV), including both vascular and stromal volume (CVV/a and CSV/a) were decreased in treatment-naïve DR patients in full range, while choroidal vascularity index (CVI) decreased only in the peripheral area (<em>P</em> = 0.04). In detail, choroid was thinning in no-DR (NDR) and mild NPDR, followed by an increased trend in moderate and late stages of DR. NPA was positively associated with CT, CV, CVV/a, and CSV/a in moderate and late stages of DR. Choroidal parameters decreased in PRP-treated eyes except for an increase of CVI in the central area.</div></div><div><h3>Conclusion</h3><div>Choroid was thinning in treatment-naïve DR eyes. Specifically, choroid decreased in the early stage and further increased with DR progression; increased expression of VEGF may be a key factor in choroidal thickening. PRP treatment could contribute to the redistribution of choroidal blood flow and improve the perfusion of the macula.</div></div>","PeriodicalId":18534,"journal":{"name":"Microvascular research","volume":"161 ","pages":"Article 104832"},"PeriodicalIF":2.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-course and pressure-dependent changes in microvascular responses during ischemic preconditioning","authors":"Sean M. Lubiak ,&nbsp;Mason A. Howard ,&nbsp;Jeffrey T. Schmidt ,&nbsp;Nihar N. Patel ,&nbsp;Anuj J. Prajapati ,&nbsp;Niriham M. Shah ,&nbsp;Emma K. Herring ,&nbsp;David H. Fukuda ,&nbsp;Jeffrey R. Stout ,&nbsp;Joshua L. Keller ,&nbsp;Ethan C. Hill","doi":"10.1016/j.mvr.2025.104831","DOIUrl":"10.1016/j.mvr.2025.104831","url":null,"abstract":"<div><div>This investigation examined a moderate individualized pressure (i.e., percentage of total arterial occlusion pressure [TAOP]) compared to low and high absolute pressures on muscle tissue oxygenation (StO₂) throughout ischemic preconditioning (IPC). Fifteen males randomly completed three cycles of IPC at a low (20 mmHg [IPC_SHAM]), moderate (80% of TAOP [IPC_80%]), and high (220 mmHg [IPC_220mmHg]) pressure. Each cycle lasted 5 min at the assigned pressure, followed by 5 min of zero pressure on the dominant leg. StO₂ was measured continuously and StO₂ indices (i.e., downslope [StO_2down], minimum [StO_2min], upslope [StO_2up], maximum [StO_2max]) were analyzed with Bayesian models. StO_2down and StO_2min were pressure-dependent (IPC_SHAM &lt; IPC_80% &lt; IPC_220mmHg) as indicated by zero absent from all 95% high-density intervals (95% HDI) and 100% probability of an effect (Prob = 100%). During IPC_220mmHg, StO_2up increased from cycle 1 to cycles 2 and 3 but plateaued from cycle 2 to 3 as indicated by zero absent from all 95% HDI's and Prob ≥87.6%. Additionally, StO_2up was greater for IPC_80% and IPC_220mmHg relative to IPC_SHAM for cycles 1 and 2 but was pressure-dependent during cycle 3 as indicated by zero absent from all 95% HDI's and Prob = 98.8%. Lastly, StO_2max was greater for IPC_220mmHg than IPC_SHAM and IPC_80% as indicated by zero absent from all 95% HDI's and Prob = 100%. Collectively, using moderate individualized pressure elicited similar StO_2up as high absolute pressure, but only for cycles 1 and 2. These findings may be attributed to differences in the hypoxic-insult and/or vascular-related mechano-transduction stimuli.</div></div>","PeriodicalId":18534,"journal":{"name":"Microvascular research","volume":"161 ","pages":"Article 104831"},"PeriodicalIF":2.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative image analysis of nailfold capillaries during an in-hospital education program for type 2 diabetes or obesity","authors":"Kengo Miyoshi ,&nbsp;Masatomo Chikamori ,&nbsp;Takashi Ando ,&nbsp;Kengo Nakata ,&nbsp;Tomohisa Aoyama ,&nbsp;Yukiko T. Matsunaga ,&nbsp;Toshimasa Yamauchi","doi":"10.1016/j.mvr.2025.104830","DOIUrl":"10.1016/j.mvr.2025.104830","url":null,"abstract":"<div><div>Nailfold capillaries are small U-shaped vessels located beneath the skin at the proximal part of the fingernail, and their morphology changes owing to various diseases. This study quantitatively analyzed nailfold capillaries using microscopy in patients hospitalized for 2 weeks for education and treatment of type 2 diabetes (T2D) or obesity. Our results suggest that nailfold arterial diameter and smoking history are useful predictors of diabetic neuropathy. An elevated urinary albumin-to-creatinine ratio correlated with decreased venous diameter during hospitalization, reflecting latent intravascular hypoalbuminemia in patients with diabetic nephropathy. Both body mass index and short-term weight reduction during hospitalization correlated with the color contrast between the capillaries and the perivascular zone, defined as delta E. These results suggest that the morphology of nailfold capillaries in T2D and obesity could be useful indicators of diabetic neuropathy and nephropathy, with delta E being a useful indicator of extracellular water volume in these populations. This is the first study to observe short-term changes in nailfold capillary morphology in relation to interventions for lifestyle-related diseases.</div></div>","PeriodicalId":18534,"journal":{"name":"Microvascular research","volume":"161 ","pages":"Article 104830"},"PeriodicalIF":2.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nailfold capillary morphology changes in patients with retinal vein occlusion","authors":"Wenbo Zhang,&nbsp;Hailong Wu,&nbsp;Yadi Zhang,&nbsp;Xiaopeng Gu,&nbsp;Hongping Nie,&nbsp;Yuan Wu","doi":"10.1016/j.mvr.2025.104822","DOIUrl":"10.1016/j.mvr.2025.104822","url":null,"abstract":"<div><h3>Aim</h3><div>To investigate the changes in the morphology of nailfold capillaries in patients with retinal vein occlusion (RVO) and their relationship with retinal vessel density (RVD).</div></div><div><h3>Methods</h3><div>This cross-sectional study, included 30 patients with RVO and 30 normal controls. Nailfold capillaroscopy was used to evaluate the morphology of the nailfold capillaries, and optical coherence tomography angiography was used to evaluate RVD.</div></div><div><h3>Results</h3><div>Abnormal morphological features of nailfold capillaries, including lower capillary density (<em>p</em> &lt; 0.001), more tortuous capillaries (<em>p</em> = 0.003), more capillary dilation &gt;25 μm (<em>p</em> = 0.001), and more avascular areas &gt;200/μm (<em>p</em> &lt; 0.001), were more common in patients with RVO than in normal controls. Compared to the normal eye, the affected eyes of patients with RVO showed lower RVD in the superficial vascular plexus (SCP), intermediate capillary plexus (ICP) and deep capillary plexus (DCP). There following correlations between abnormal nailfold capillaries and RVD in affected eyes of RVO patients were observed: the number of nailfold capillary hemorrhages was negatively associated with RVD in the SCP (ρ = −0.376, <em>p</em> = 0.046) and ICP (ρ = −0.506, <em>p</em> = 0.004); the number of dilated capillaries &gt;25 μm was negatively associated with RVD in the ICP (ρ = −0.389, <em>p</em> = 0.033); and the number of avascular zones &gt;200/μm was negatively associated with RVD in the DCP (ρ = −0.374, <em>p</em> = 0.041).</div></div><div><h3>Conclusions</h3><div>Patients with RVO have abnormal morphology of the nailfold capillaries. In addition, nailfold capillary changes are correlated with RVD, suggesting that systemic microcirculatory abnormalities may be associated with RVO.</div></div>","PeriodicalId":18534,"journal":{"name":"Microvascular research","volume":"160 ","pages":"Article 104822"},"PeriodicalIF":2.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interfering with AQP1 alleviates ferroptosis, improves mitochondrial function and energy metabolic disorder in hypoxia/reoxygenation-induced H9c2 cardiomyocytes via Wnt/β-catenin pathway","authors":"Shali Xiang ,&nbsp;Xuewen Tang","doi":"10.1016/j.mvr.2025.104821","DOIUrl":"10.1016/j.mvr.2025.104821","url":null,"abstract":"<div><div>Myocardial ischemia reperfusion (I/R) injury is the main pathological manifestation of coronary artery disease closely linked with adverse cardiovascular outcomes. Aquaporin 1 (AQP1) is a water molecule that has been reported to be highly expressed during the process of myocardial I/R injury. The aim of this research was to explore the role of AQP1 in myocardial I/R injury and the relevant mechanism of action. RT-qPCR and western blotting were used to detect AQP1 expression. CCK-8 method was used to detect cell viability. JC-1 dye, MitoSox-Red staining and ATP-Red 1 probe were respectively used to detect mitochondrial membrane potential, mitochondrial ROS (mtROS) and ATP synthesis. C11-BODIPY 581/591 probe and FerroOrange probe were respectively used to measure lipid reactive oxygen species (ROS) and Fe(²⁺). Seahorse XFe96 Analyser was used to detect oxygen consumption rate (OCR). Assay kits were used to estimate mitochondrial permeability transition pore (mPTP) opening, total iron and lipid peroxidation levels. Western blotting was used to detect the expression of ferroptosis, energy metabolism and Wnt/β-catenin pathway-related proteins. AQP1 expression was elevated in hypoxia/reoxygenation (H/R)-exposed H9c2 cells. Deficient AQP1 promoted the viability, ameliorated mitochondrial dysfunction, ferroptosis and energy metabolism disorder in H/R-injured H9c2 cells. Further, AQP1 deletion might activate Wnt/β-catenin pathway and XAV939, an inhibitor of Wnt signaling pathway could partially revert the influences of AQP1 knockdown on the viability, mitochondrial function, ferroptosis and energy metabolism in H/R-treated H9c2 cells. To be concluded, AQP1 interference might protect against H/R-induced mitochondrial dysfunction, ferroptosis and energy metabolism disorder in H9c2 cells via modulating Wnt/β-catenin pathway.</div></div>","PeriodicalId":18534,"journal":{"name":"Microvascular research","volume":"160 ","pages":"Article 104821"},"PeriodicalIF":2.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperglycemia-induced blood-brain barrier dysfunction: Mechanisms and therapeutic interventions","authors":"Changsheng Chen ,&nbsp;Xi Xu ,&nbsp;Jiahao Lu ,&nbsp;Yuqing Xiang ,&nbsp;Linsheng Shi ,&nbsp;Dong Liu","doi":"10.1016/j.mvr.2025.104820","DOIUrl":"10.1016/j.mvr.2025.104820","url":null,"abstract":"<div><div>The blood-brain barrier (BBB) serves as a highly selective interface that regulates the transport of molecules between the blood and the brain. Its integrity is essential for maintaining neuronal homeostasis and preventing neuroinflammation. Hyperglycemia, a hallmark of diabetes, is linked to cognitive deficits and central nervous system (CNS) pathologies, including vascular dementia, stroke, and Alzheimer's disease, with BBB damage as a potential contributing factor. As the global prevalence of diabetes rises, understanding the connection between hyperglycemia and BBB dysfunction may facilitate the development of novel treatments that protect or restore BBB integrity, thereby alleviating the neurological complications of diabetes. Furthermore, it may aid in the development of targeted therapies for diabetes-related neurological complications. This literature review examines the emerging insights into the relationship between hyperglycemia and BBB dysfunction. It focuses on the mechanisms underlying BBB dysfunction, the clinical manifestations of this dysfunction in diabetes and cerebrovascular diseases, and potential therapeutic interventions.</div></div>","PeriodicalId":18534,"journal":{"name":"Microvascular research","volume":"160 ","pages":"Article 104820"},"PeriodicalIF":2.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144088816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Day-to-day variability in cutaneous microcirculation measured with multi-exposure laser speckle contrast imaging and multispectral imaging","authors":"Moa Nilsson ,&nbsp;Martin Hultman ,&nbsp;Freya Richter ,&nbsp;Joakim Henricson ,&nbsp;Marcus Larsson ,&nbsp;Tomas Strömberg ,&nbsp;Ingemar Fredriksson ,&nbsp;Fredrik Iredahl","doi":"10.1016/j.mvr.2025.104819","DOIUrl":"10.1016/j.mvr.2025.104819","url":null,"abstract":"<div><h3>Introduction</h3><div>Dysfunctional microcirculation is associated with cardiovascular risk factors, chronic disease such as diabetes and acute conditions like septic shock. The non-invasive optical techniques laser Doppler flowmetry (LDF) and diffuse reflectance spectroscopy (DRS) are often used to measure perfusion and oxygen saturation, but are limited to single-point measurements making them sensitive to spatial variations. The imaging modalities multi-exposure laser speckle contrast imaging (MELSCI) and multi-spectral imaging (MSI) overcome this limitation by capturing the parameters in a larger skin area.</div></div><div><h3>Aim</h3><div>To assess the day-to-day variability of speed-resolved perfusion and oxygen saturation in the forearm and plantar foot at baseline and peak response following arterial occlusion-release, while also evaluating sex and age influences.</div></div><div><h3>Method</h3><div>MELSCI and MSI were used on 48 participants (12 males and 12 females aged 20–30, and 12 males and 12 females aged 50–60) across two measurements within a week. Each measurement lasted 60 min, with perfusion and oxygen saturation being measured at baseline (10 min), during occlusion (5 min), and post-occlusion (5 min) as spatial averages over the entire imaged tissue area.</div></div><div><h3>Results</h3><div>Older age was associated with higher foot perfusion at peak (<em>p</em> = 0.006). Variability (CV) ranged from 1.4 % to 19 %, with foot low-speed perfusion showing a sex- and age-related difference at peak (<em>p</em> = 0.007).</div></div><div><h3>Conclusion</h3><div>Age and sex influenced microcirculatory parameters, aligning with prior research. MELSCI and MSI demonstrated low day-to-day variability, making them promising techniques for clinical disease monitoring. The variability of MELSCI perfusion was lower than previously reported for laser speckle contrast imaging (LSCI) perfusion.</div></div>","PeriodicalId":18534,"journal":{"name":"Microvascular research","volume":"160 ","pages":"Article 104819"},"PeriodicalIF":2.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA regulatory dynamic, emerging diagnostic and therapeutic frontier in atherosclerosis","authors":"Syeda Armana Zaidi,&nbsp;Zhiyu Fan,&nbsp;Talha Chauhdari,&nbsp;Yongsheng Ding","doi":"10.1016/j.mvr.2025.104818","DOIUrl":"10.1016/j.mvr.2025.104818","url":null,"abstract":"<div><div>MicroRNAs (miRNAs), a class of non-coding RNAs, are pivotal post-transcriptional regulators of gene expression with profound implications in the pathogenesis of atherosclerosis (AS). As a progressive arterial disease driven by vascular cells dysfunction, lipid dysregulation and subsequent chronic inflammation, AS remains a leading cause of global morbidity. Recent studies have demonstrated how important miRNAs are in regulating central biological processes in the vascular wall, such as endothelial function, vascular smooth muscle cell (VSMC) phenotypic switching, and macrophage polarization. This review provides comprehensive insight into the role of miRNAs in the development and complexity of atherosclerotic plaques according to their effects on endothelial cells, macrophages, and VSMCs. We also go over the growing prospects of miRNAs as therapeutic targets and diagnostic biomarkers, providing information to be used in the study of vascular diseases. Lastly, we address recent complications and potential applications of miRNA-based approaches in clinical practice.</div></div>","PeriodicalId":18534,"journal":{"name":"Microvascular research","volume":"160 ","pages":"Article 104818"},"PeriodicalIF":2.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}