Hyperglycemia-induced blood-brain barrier dysfunction: Mechanisms and therapeutic interventions

IF 2.7 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Microvascular research Pub Date : 2025-05-18 DOI:10.1016/j.mvr.2025.104820

Changsheng Chen , Xi Xu , Jiahao Lu , Yuqing Xiang , Linsheng Shi , Dong Liu

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引用次数: 0

Abstract

The blood-brain barrier (BBB) serves as a highly selective interface that regulates the transport of molecules between the blood and the brain. Its integrity is essential for maintaining neuronal homeostasis and preventing neuroinflammation. Hyperglycemia, a hallmark of diabetes, is linked to cognitive deficits and central nervous system (CNS) pathologies, including vascular dementia, stroke, and Alzheimer's disease, with BBB damage as a potential contributing factor. As the global prevalence of diabetes rises, understanding the connection between hyperglycemia and BBB dysfunction may facilitate the development of novel treatments that protect or restore BBB integrity, thereby alleviating the neurological complications of diabetes. Furthermore, it may aid in the development of targeted therapies for diabetes-related neurological complications. This literature review examines the emerging insights into the relationship between hyperglycemia and BBB dysfunction. It focuses on the mechanisms underlying BBB dysfunction, the clinical manifestations of this dysfunction in diabetes and cerebrovascular diseases, and potential therapeutic interventions.

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高血糖诱导的血脑屏障功能障碍：机制和治疗干预

血脑屏障（BBB）作为一个高度选择性的界面，调节血液和大脑之间的分子运输。其完整性对于维持神经元稳态和预防神经炎症至关重要。高血糖症是糖尿病的一个标志，它与认知缺陷和中枢神经系统（CNS）病理（包括血管性痴呆、中风和阿尔茨海默病）有关，血脑屏障损伤是一个潜在的促成因素。随着全球糖尿病患病率的上升，了解高血糖和血脑屏障功能障碍之间的联系可能有助于开发保护或恢复血脑屏障完整性的新疗法，从而减轻糖尿病的神经系统并发症。此外，它可能有助于开发针对糖尿病相关神经系统并发症的靶向治疗方法。这篇文献综述探讨了高血糖和血脑屏障功能障碍之间关系的新见解。它侧重于血脑屏障功能障碍的机制，这种功能障碍在糖尿病和脑血管疾病中的临床表现，以及潜在的治疗干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microvascular research 医学-外周血管病

CiteScore

6.00

自引率

3.20%

发文量

158

审稿时长

43 days

期刊介绍： Microvascular Research is dedicated to the dissemination of fundamental information related to the microvascular field. Full-length articles presenting the results of original research and brief communications are featured. Research Areas include: • Angiogenesis • Biochemistry • Bioengineering • Biomathematics • Biophysics • Cancer • Circulatory homeostasis • Comparative physiology • Drug delivery • Neuropharmacology • Microvascular pathology • Rheology • Tissue Engineering.