Marmara Pharmaceutical Journal最新文献_第2页

Social isolation and predator scent tests alter brain BDNF levels differentially according to gender, in rats and effects of fluoxetine 社会隔离和捕食者气味测试会根据性别、老鼠和氟西汀的影响改变大脑BDNF水平

Marmara Pharmaceutical Journal Pub Date : 2018-04-06 DOI: 10.12991/MPJ.2018.56

A. Aykaç, Şule Öncül, R. Onur

{"title":"Social isolation and predator scent tests alter brain BDNF levels differentially according to gender, in rats and effects of fluoxetine","authors":"A. Aykaç, Şule Öncül, R. Onur","doi":"10.12991/MPJ.2018.56","DOIUrl":"https://doi.org/10.12991/MPJ.2018.56","url":null,"abstract":"We compared different stress conditions on brain BDNF levels, in rats exposed to social isolation test (SIT) and predator scent tests (PST). BDNF expression in the frontal cortex, hippocampus, and amygdala was compared, and effects of chronic fluoxetine (FLU) treatment were evaluated. Rats were exposed to SIT and PST for one month. FLU was given (5 mg/kg/day, ip) throughout stress procedures. Controls, stress, and treatment groups were evaluated in elevated plus maze, anxiety scores were calculated. BDNF expression was determined by Western blot. SIT and PST induced anxiety in both sexes, females had greater anxiety scores than males (p<0.05). FLU restored anxiety scores in both sexes (p<0.01) in both tests. Male and female rats exhibited reduced cortical BDNF levels in SIT (p<0.001). PST reduced cortical BDNF in females, but increased in males. Hippocampal BDNF expression was lowered in SIT (p<0.01) and PST (p<0.001) in both sexes. Female rats had 40% lower BDNF expression than males in the amygdala in SIT. FLU did not restore cortical BDNF in females in both tests, but reduced increased BDNF levels in males in PST (p<0.001). FLU did not restore reduced brain BDNF in males in the hippocampus and amygdala, but restored in hippocampus, in females. Our findings indicate that sex differences must be considered in studies related to mood disorders of animal models, and suggest that BDNF expression in different brain regions are altered differentially in a gender-dependent manner in rats. Antianxiety effect of FLU is not mediated through increasing BDNF activity in cortex in both genders. Increased BDNF in hippocampus and amygdala may reflect antidepressant effect of FLU in female rats, but not in males.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"188 1","pages":"190-198"},"PeriodicalIF":0.0,"publicationDate":"2018-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79741493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Plants used in traditional treatment against hemorrhoids in Turkey 土耳其用于痔疮传统治疗的植物

Marmara Pharmaceutical Journal Pub Date : 2018-04-06 DOI: 10.12991/MPJ.2018.49

Meryem Seyda Erbay, A. Sarı

{"title":"Plants used in traditional treatment against hemorrhoids in Turkey","authors":"Meryem Seyda Erbay, A. Sarı","doi":"10.12991/MPJ.2018.49","DOIUrl":"https://doi.org/10.12991/MPJ.2018.49","url":null,"abstract":"Due to its geographic location, variable climate and traditional culture, Turkey has a rich flora and the use of plants in folk medicine is very favorable. That practice and knowledge have been passed down from generation to generation. Ethnobotanical surveys are carried out to record traditional treatment methods of plants. In this study, which was prepared by screening of ethnobotanical researches made in Turkey, 241 taxa were recorded in the traditional treatment of hemorrhoids. Information about scientific and local names, families, used parts and usage patterns of these plants are given. According to the research results, the most commonly used plants in hemorrhoid treatment are plants belonging to Asteraceae, Lamiaceae, Rosaceae, Scrophulariaceae, Araceae, Polygonaceae and Cupressaceae families. The species commonly used in different regions of Turkey are Achillea sp., Arum sp., Cichorium intybus L., Dracunculus vulgaris Schott, Ecballium elaterium (L.) A. Rich., Ficus carica L., Hypericum perforatum L., H. scabrum L., Juglans regia L., Peganum harmala L., Rosa canina L., Rubus sp., Sambucus ebulus L., S. nigra L., Teucrium polium L., Urtica dioica L., Verbascum sp..","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"1 1","pages":"110-132"},"PeriodicalIF":0.0,"publicationDate":"2018-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78369648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety 含咪唑[2,1-b]噻唑基团的新型4-噻唑烷酮的合成及抗病毒活性评价

Marmara Pharmaceutical Journal Pub Date : 2018-04-06 DOI: 10.12991/MPJ.2018.61

N. Güzeldemirci, E. Pehlivan, L. Naesens

引用次数: 11

In vitro genotoxic and antigenotoxic effects of delphinidin chloride on human peripheral blood lymphocytes 氯化飞燕草苷对人外周血淋巴细胞的体外基因毒性和抗基因毒性作用

Marmara Pharmaceutical Journal Pub Date : 2018-04-06 DOI: 10.12991/MPJ.2018.58

Mehmet Tahir Husunet, H. B. Ila

引用次数: 0

Comparative phytochemical evaluation of natural and micropropagated plants of Bacopa monnieri (L.) 假马齿苋(Bacopa monnieri)天然植株与微繁植株的植物化学评价比较

Marmara Pharmaceutical Journal Pub Date : 2018-01-12 DOI: 10.12991/MPJ.2018.42

V. Rangari, S. Killedar, S. Jadhav, Trupti Ghatage, F. Tamboli

{"title":"Comparative phytochemical evaluation of natural and micropropagated plants of Bacopa monnieri (L.)","authors":"V. Rangari, S. Killedar, S. Jadhav, Trupti Ghatage, F. Tamboli","doi":"10.12991/MPJ.2018.42","DOIUrl":"https://doi.org/10.12991/MPJ.2018.42","url":null,"abstract":"http://doi.org/10.12991/mpj.2018.42 Marmara Pharm J 2018;22(1): 66-73 Received: 17.06.2017 / Accepted: 08.11.2017 Corresponding Author: Firoj A. Tamboli E-mail: firojtamboli143@gmail.com Phone: +91 9503709095 ORCID No: https://orcid.org/0000-0002-5809-6303 How to cite this article: Tamboli FA, Rangari VD, Killedar SG, Jadhav SU, Ghatage TS, Kore VP. Comparative phytochemical evaluation of natural and micropropagated plants of Bacopa monnieri (L.). Marmara Pharm J. 2018; 22 (1): 66-73. ABSTRACT: Bacopa monnieri Linn. an important medicinal plant of Scrophulariaceae family and is distributed in the wet and marshy lands throughout India, Nepal, Sri Lanka, China, Taiwan, and Hawaii. It is endangered species so it is necessary to preserve germplasm. The objective of this research work is the comparative phytochemical evaluation of natural and micro-propagated plants of Bacopa monnieri (BM). It shows the presence of various phytoconstituents namely, alkaloids, saponins, phenolics, and flavonoids. These phytoconstituents are responsible for anti-oxidant and various other activity of the plant. The protocols for tissue culture has been developed for regeneration of the BM plant from small part (nodal segment). The regenerated plant having the similar potential in terms of phytoconstituents. The protocols of Murashige and Skoog medium can be used for the clonal regeneration of plant on the large scale through which it can be protected and preserved for the long duration in small space. From the comparative phytochemical investigation by HPTLC, the phytoconstituents which occur in the micro propagated plant are similar to that of the natural plant of B. monnieri.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"17 1","pages":"66-73"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81713601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Comparatively Investigation of Grape Molasses Produced by Conventional and Industrial Techniques 葡萄糖蜜的常规工艺与工业工艺比较研究

Marmara Pharmaceutical Journal Pub Date : 2018-01-12 DOI: 10.12991/MPJ.2018.39

M. Charehsaz, Etil Guzelmeric, E. Acar, E. Yeşilada, S. Helvacıoğlu

引用次数: 12

In Vitro Antioxidant And Cytotoxic Activity of Muscari neglectum Growing in Turkey 土耳其木鼠的体外抗氧化和细胞毒活性研究

Marmara Pharmaceutical Journal Pub Date : 2018-01-12 DOI: 10.12991/mpj.2018.43

S. Kayıran, T. Taşkın, Mahmoud Abudayyak, E. Ozkan

引用次数: 4

Comparative assessment of phytochemical composition, antioxidant and anticholinesterase activities of two Basidiomycota Truffle Fungi from Turkey 两种土耳其松露担子菌的植物化学成分、抗氧化和抗胆碱酯酶活性比较研究

Marmara Pharmaceutical Journal Pub Date : 2018-01-12 DOI: 10.12991/MPJ.2018.41

Ebru Deveci, Fatih Çayan, M. Duru, Gülsen Tel‐Çayan

{"title":"Comparative assessment of phytochemical composition, antioxidant and anticholinesterase activities of two Basidiomycota Truffle Fungi from Turkey","authors":"Ebru Deveci, Fatih Çayan, M. Duru, Gülsen Tel‐Çayan","doi":"10.12991/MPJ.2018.41","DOIUrl":"https://doi.org/10.12991/MPJ.2018.41","url":null,"abstract":"© 2017 Marmara University Press, All Rights Reserved http://doi.org/10.12991/mpj.2018.41 Marmara Pharm J 2018;22(1): 59-65 Received: 14.06.2017 / Accepted: 16.08.2017 Corresponding Author: Gülsen Tel-Çayan E-mail: gulsentel@mu.edu.tr; gulsentelcayan@gmail.com Phone: +90 252 2111494 ORCID No: https://orcid.org/0000-0002-1916-7391 How to cite this article: Tel-Çayan G, Deveci E, Çayan F, Duru ME. Comparative assessment of phytochemical composition, antioxidant and anticholinesterase activities of two Basidiomycota Truffle Fungi from Turkey. Marmara Pharm J. 2018; 22 (1): 59-65. ABSTRACT: The aim of the present study was to compare phytochemical composition and biological activities of various extracts of two Basidiomycota truffle collected from Turkey. Analysis of phytochemical compositions in terms of phenolic and fatty acid compositions was determined using HPLC-DAD, GC and GC/MS. Fumaric (10.62, 4.12 μg/g) and protocatechuic acids (2.71, 20.50 μg/g) were identified as the major organic and phenolic acids in Chondrogaster pachysporus and Setchelliogaster tenuipes truffles. Linoleic acid (53.03 %) for C. pachysporus and palmitic acid (38.60 %) for S. tenuipes were found to be the most dominant fatty acids. The extracts were also tested for their antioxidant and anticholinesterase activities. As for antioxidant and anticholinesterase activity results, C. pachysporus truffle showed better activity than S. tenuipes. This work presents the first phytochemical study on C. pachysporus and S. tenuipes truffles and sheds light on their potential usage as the natural source in the food, pharmaceutical, and cosmetic industries.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"38 1","pages":"59-65"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84709320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Methanol extract of Solanum violaceum root possesess antiobesity, hypolipidemic, thrombolytic and membrane stabilizing activity 堇菜根甲醇提取物具有抗肥胖、降血脂、溶栓、稳膜等作用

Marmara Pharmaceutical Journal Pub Date : 2018-01-12 DOI: 10.12991/mpj.2018.47

M. I. H. Khan, M. Billah, M. S. Hossain, S. K. Ahamed

{"title":"Methanol extract of Solanum violaceum root possesess antiobesity, hypolipidemic, thrombolytic and membrane stabilizing activity","authors":"M. I. H. Khan, M. Billah, M. S. Hossain, S. K. Ahamed","doi":"10.12991/mpj.2018.47","DOIUrl":"https://doi.org/10.12991/mpj.2018.47","url":null,"abstract":"http://doi.org/10.12991/mpj.2018.47 Marmara Pharm J 2018;22(1): 96-102 Corresponding Author: Mohammad Salim Hossain E-mail: Email: pharmasalim@yahoo.com Phone: +8801711200410 ORCID No: 0000-0002-5710-1115 Received: 14.05.2017 / Accepted: 03.10.2017 ABSTRACT: Roots of Solanum violaceum (S. violaceum) is used traditionally in different therapeutic applications in Bangladesh. Root extract of S. violaceum was investigated for total phenolic content (TPC), antiobesity, anti-hyperlipidemic, membrane stability and thrombolytic activity. Total phenolic content (TPC) was determined using folin-ciocalteu method. High fat diet induced obese mice were used for anti obesity and antihyperlipidemic test. Body weight gain, blood total cholesterol, triglyceride level were analyzed. Thrombolytic and membrane stability activity were evaluated by using human erythrocytes. Total phenolic content in root extract of S. violaceum was calculated as 51.26 mg gallic acid equivalent GAE/g of dry weight. The extractive supplementation with dose of 200mg/ kg and 400mg/kg were capable of lowering the level of triglyceride and total cholesterol significantly (p<0.05) in high fat diet (HFD) induced obese mice in a dose dependent manner. As a membrane stabilizing agent, crude extract was able to inhibit the erythrocyte heamolysis significantly (p< 0.05) with a value of 28.02±5.09% and 32.97± 4.12% respectively for heat and hypotonic solution induced condition. Moreover, 21.56 ±2.62 % of clot lysis was exhibited by the extract for its thrombolytic activity. The root of S. violaceum justifies its potential as anti obese agent. Further research is recommended to find out the active metabolites from this source.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"10 1","pages":"96-102"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78490657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Evaluation of anti-lipase activity of leaf and bark extracts from Aquilaria subintegra and A. malaccensis 亚整沉香和马勒木香叶、皮提取物抗脂肪酶活性评价

Marmara Pharmaceutical Journal Pub Date : 2018-01-12 DOI: 10.12991/MPJ.2018.46

Mastura Ibrahim, S. Azziz, Chee Fah Wong, Wan Mustaffa Wan Din, W. Mahamod, Yuhanis Mhd Bakri, M. S. Ahmad, Rozita Yahaya, N. Ismail, Wan Mohd Nuzul Hakimi Wan Salleh

{"title":"Evaluation of anti-lipase activity of leaf and bark extracts from Aquilaria subintegra and A. malaccensis","authors":"Mastura Ibrahim, S. Azziz, Chee Fah Wong, Wan Mustaffa Wan Din, W. Mahamod, Yuhanis Mhd Bakri, M. S. Ahmad, Rozita Yahaya, N. Ismail, Wan Mohd Nuzul Hakimi Wan Salleh","doi":"10.12991/MPJ.2018.46","DOIUrl":"https://doi.org/10.12991/MPJ.2018.46","url":null,"abstract":"© 2017 Marmara University Press, All Rights Reserved http://doi.org/10.12991/mpj.2018.46 Marmara Pharm J 2018;22(1): 91-95 How to cite this article: Ibrahim M, Syed Abdul Azziz SS, Wong CF, Wan Mohamad Din WNI, Wan Mahamod WR, Bakri YM, Ahmad MS, Yahaya R, Ismail NH, Salleh WMNHW. Evaluation of anti-lipase activity of leaf and bark extracts from Aquilaria subintegra and A. malaccensis. Marmara Pharm J. 2018; 22 (1): 91-95 Received: 30.05.2017 / Accepted: 15.09.2017 Corresponding Author: Saripah Salbiah Syed Abdul Azziz, Chee Fah Wong E-mail: saripah@fsmt.upsi.edu.my, cheefah@fsmt.upsi.edu.my Phone: +6015 48797313, +6015 48797326 ORCID No: 0000-0002-8499-3745, 0000-0003-1114-7000 ABSTRACT: Obesity is one of the serious health condition in the world and contributes to many chronic illnesses augmenting to high risk of death rate. With the purpose of obesity treatment, natural sources come to be significant to replace commercial drugs due to their harmful effect to the body. Therefore, a lot of studies were conducted on natural sources due to their potential as medicinal herbs. Aquilaria sp. plants are well known in traditional medicine as a sedative, analgesic and digestive. Even though there were no reports on applications of Aquilaria sp. towards obesity treatment, this plant has traditionally been used as laxative for weight reducing. In this study, the anti-lipase activity of an extract of barks and leaves from A. subintegra and A. malaccensis were investigated. The anti-lipase activity was measured by colorimetric assay on pancreatic lipase activity using porcine pancreatic lipase (PPL; triacylglycerol lipase, EC 3.1.1.3). The result indicated that among these two species of Aquilaria, A. malaccensis bark in dichloromethane crude showed high anti-lipase activity. Thus, these results suggest that Aquilaria sp. plant extracts might be of therapeutic interest with respect to the treatment.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"6 1","pages":"91-95"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84352888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2