Middle East Journal of Digestive Diseases最新文献_第6页

Liver Enzymes Changes and their Association with Outcome in Hospital Inpatients with COVID-19 in Jordan. 约旦住院COVID-19患者肝酶变化及其与预后的关系

Middle East Journal of Digestive Diseases Pub Date : 2025-04-01 Epub Date: 2025-04-30 DOI: 10.34172/mejdd.2025.414

Tarek Mazzawi, Hadeel Alshahwan, Ban Aladamat, Sara Al Nsour, Leen Asfour, Dana Abu Hanak, Seema Al-Shehab

{"title":"Liver Enzymes Changes and their Association with Outcome in Hospital Inpatients with COVID-19 in Jordan.","authors":"Tarek Mazzawi, Hadeel Alshahwan, Ban Aladamat, Sara Al Nsour, Leen Asfour, Dana Abu Hanak, Seema Al-Shehab","doi":"10.34172/mejdd.2025.414","DOIUrl":"10.34172/mejdd.2025.414","url":null,"abstract":"Background: Abnormal levels of liver enzymes have been reported in patients with COVID-19 and severe clinical presentation. However, limited studies exist in our region regarding the impact of COVID-19 on the liver's function. Thus, we aimed to investigate liver enzyme changes and their association with prognosis and outcome in hospitalized patients with COVID-19 in Jordan.Methods: This retrospective cohort study included 359 patients with COVID-19 who were admitted to Ministry of Health hospitals all around Jordan during the second pandemic wave of COVID-19. Data such as liver enzymes, patients demographics, and outcomes were collected and statistically analysed.Results: Approximately 39.6% of infected patients had elevated liver enzymes, and 5.9% had elevated enzymes more than twice the upper limit of normal (ULN). Among these patients, 40.8% had both aspartate aminotransferases (AST) and alanine aminotransferases (ALT) elevation, 52.1% had AST elevation alone, and 7.0% had ALT elevation alone. Factors associated with worse prognosis and outcome were older age, male sex, and comorbid autoimmune conditions. The peak and at-discharge values of AST and ALT showed significant differences.Conclusion: Liver enzyme abnormality is common among patients with COVID-19 and AST is the most common abnormality. AST and ALT elevation can be associated with longer hospital stays, older age, and male sex.","PeriodicalId":18517,"journal":{"name":"Middle East Journal of Digestive Diseases","volume":"17 2","pages":"105-111"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Balancing Relief and Risk: The Dual Impact of Cannabis on Gastrointestinal Health. 平衡救济和风险：大麻对胃肠道健康的双重影响。

Middle East Journal of Digestive Diseases Pub Date : 2025-04-01 Epub Date: 2025-04-30 DOI: 10.34172/mejdd.2025.421

Amir Mohammad Salehi, Maryam Hasanzarrini, Mohanna Yarahmadi, Fatemeh Shahbazi

引用次数: 0

Chromogranin A as a Novel Biomarker of Irritable Bowel Syndrome in Adults: A Systematic Review and Meta-Analysis. 铬粒蛋白A作为成人肠易激综合征的一种新的生物标志物：一项系统综述和荟萃分析。

Middle East Journal of Digestive Diseases Pub Date : 2025-04-01 Epub Date: 2025-04-30 DOI: 10.34172/mejdd.2025.418

Virly Nanda Muzellina, Nicolas Daniel Widjanarko, Jonathan Christianto Subagya, Steven Alvianto

{"title":"Chromogranin A as a Novel Biomarker of Irritable Bowel Syndrome in Adults: A Systematic Review and Meta-Analysis.","authors":"Virly Nanda Muzellina, Nicolas Daniel Widjanarko, Jonathan Christianto Subagya, Steven Alvianto","doi":"10.34172/mejdd.2025.418","DOIUrl":"10.34172/mejdd.2025.418","url":null,"abstract":"Background: Irritable bowel syndrome (IBS) is a chronic condition characterized by recurring abdominal discomfort and irregular bowel movements. Currently, IBS diagnosis lacks specific radiological, biochemical, or endoscopic markers. Chromogranin A (CgA), a gastrointestinal protein, shows variation between patients with IBS and healthy controls. This study aimed to evaluate differences in CgA concentrations between these groups.Methods: This review was conducted in 2023 using the PRISMA 2020 guidelines. All observational research was retrieved from MEDLINE, EBSCO-Host, ScienceDirect, and ProQuest electronic databases using a predefined search strategy. Study quality was assessed using the Newcastle-Ottawa Scale (NOS), and meta-analysis was conducted using Review Manager (RevMan) 5.4.Results: Nine out of 14 studies eligible for meta-analysis revealed significantly higher CgA cell density (P=0.0001) in all patients with IBS compared with controls. This difference persisted across colon regions (left: P=0.04, right: P=0.0009) and duodenum (P<0.00001). Subgroup analysis found no significant disparity in CgA cell density between diarrhea and constipation-predominant IBS within the duodenum or colon.Conclusion: CgA cell density showed trends toward IBS compared with control groups, with significant concentration differences found in the duodenum, left, and right colon. Therefore, current findings might offer a histopathological approach to confirm the IBS diagnosis.","PeriodicalId":18517,"journal":{"name":"Middle East Journal of Digestive Diseases","volume":"17 2","pages":"128-138"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Approaches of Antibiotic Therapy and Surgical Intervention in Managing Recurrent Perirectal Abscess in Children Under Two Years Old. 2岁以下儿童复发性直肠周围脓肿的抗生素治疗与手术治疗的比较。

Middle East Journal of Digestive Diseases Pub Date : 2025-04-01 Epub Date: 2025-04-30 DOI: 10.34172/mejdd.2025.417

Amrollah Salimi, Mohadeseh Najafi, Ahmad Kachoie, Mostafa Vahedian, Enayatollah Noori

{"title":"Comparative Approaches of Antibiotic Therapy and Surgical Intervention in Managing Recurrent Perirectal Abscess in Children Under Two Years Old.","authors":"Amrollah Salimi, Mohadeseh Najafi, Ahmad Kachoie, Mostafa Vahedian, Enayatollah Noori","doi":"10.34172/mejdd.2025.417","DOIUrl":"10.34172/mejdd.2025.417","url":null,"abstract":"Background: Recurrent perirectal abscesses in children under 2 years pose management challenges due to high relapse risks, with limited evidence comparing long-term outcomes of antibiotic therapy versus surgical drainage. This study aimed to compare antibiotic treatment approaches and surgical interventions in managing this condition.Methods: This retrospective cohort study analyzed 336 medical records of children under two years old with perianal abscesses treated at Hazrat Masoumeh Children's Hospital from 2012-2019. Patients were divided into three groups: antibiotic treatment only, spontaneous drainage, and incision and drainage. Data, including demographics, abscess characteristics, and treatment outcomes (recurrence, fistula formation), were analyzed using SPSS software version 26.Results: A retrospective cohort study of 336 children with perianal abscesses found no significant differences in age, weight, sex, or nutritional status among the three treatment groups (P>0.05). However, statistically significant differences were observed in abscess location (distance from the anus) and size, with the incision and drainage group having larger and more distally located abscesses (P<0.05). Colic was less prevalent in the antibiotic-only group. The spontaneous drainage group had a significantly higher recurrence rate (37%). Antibiotic type distribution was similar across groups. The antibiotic-only group showed symptom resolution within 3-10 days, averaging 6 days.Conclusion: In general, according to the lowest rate of recurrence in the group receiving antibiotics and the average duration of short treatment of 6 days, the antibiotic approach is the preferred and primary method for the treatment and prevention of abscess recurrence.","PeriodicalId":18517,"journal":{"name":"Middle East Journal of Digestive Diseases","volume":"17 2","pages":"123-127"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetically Regulating Non-coding RNAs in Colorectal Cancer: Promises and Potentials. 非编码rna在结直肠癌中的表观遗传学调控：前景和潜力。

Middle East Journal of Digestive Diseases Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.34172/mejdd.2025.404

Zahra Taheri, Majid Zaki-Dizaji

引用次数: 0

COVID-19 and Upper Gastrointestinal Bleeding; Etiology, Risk Factors, and Outcomes: A Case-Control Study. COVID-19与上消化道出血；病因、危险因素和结果：一项病例对照研究。

Middle East Journal of Digestive Diseases Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.34172/mejdd.2025.406

Sara Shafieipour, Mohammad Rezaei Zadeh Rukerd, Niloofar Farsiu, Mohsen Nakhaie, Samaneh Jahangiri, Maysam Yousefi, Hanieh Mirkamali, Aryan Mohamadinezhad

{"title":"COVID-19 and Upper Gastrointestinal Bleeding; Etiology, Risk Factors, and Outcomes: A Case-Control Study.","authors":"Sara Shafieipour, Mohammad Rezaei Zadeh Rukerd, Niloofar Farsiu, Mohsen Nakhaie, Samaneh Jahangiri, Maysam Yousefi, Hanieh Mirkamali, Aryan Mohamadinezhad","doi":"10.34172/mejdd.2025.406","DOIUrl":"https://doi.org/10.34172/mejdd.2025.406","url":null,"abstract":"Background: COVID-19-associated gastrointestinal (GI) symptoms are often self-limiting; however, gastrointestinal bleeding (GIB) is a critical complication in patients with COVID-19. The present study investigates the etiology, risk factors, esophagogastroduodenoscopy (EGD) findings, and outcomes associated with upper gastrointestinal bleeding (UGIB) in hospital inpatients with COVID-19.Methods: In this retrospective case-control study, 127 patients with COVID-19 in Kerman, Iran, were diagnosed using reverse transcription polymerase chain reaction (RT-PCR) and subsequently divided into case and control groups from January 2022 to July 2022.Results: This study evaluated 64 patients with COVID-19 with UGIB and 63 patients without. The case group reported previous history of GIB and cirrhosis at 17.2% and 12.5%, respectively (P=0.001 and P=0.01). Melena (37.5%) and peptic ulcer (21.87%) were the most common UGIB symptom and EGD findings, respectively. In the comparison of the case group with the control group, the duration of the patient's stay in the intensive care unit (ICU) (11.58±1.13 vs. 8.29±1.06 days), the need for invasive mechanical ventilation (IMV) (17.2% vs. 8.1%), and the mortality rate (26.6% vs. 18.9%) were recorded (P=0.03, 0.124, and 0.07, respectively).Conclusion: Patients with COVID-19 and UGIB have a more prevalent ICU stay compared with those without. Melena and peptic ulcer were the most common presentations and EGD findings in these patients. Additionally, liver cirrhosis and a history of previous GIB increased the risk of GIB in patients with COVID-19.","PeriodicalId":18517,"journal":{"name":"Middle East Journal of Digestive Diseases","volume":"17 1","pages":"25-30"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatocellular Carcinoma: The Search for an Optimal Screening Test. 肝细胞癌：寻找最佳筛选试验。

Middle East Journal of Digestive Diseases Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.34172/mejdd.2025.407

Sara Haj Ali, Shahd I Alqato, Amjad M Almansi, Noor S Haj Ali, Mohammad A Amaireh

{"title":"Hepatocellular Carcinoma: The Search for an Optimal Screening Test.","authors":"Sara Haj Ali, Shahd I Alqato, Amjad M Almansi, Noor S Haj Ali, Mohammad A Amaireh","doi":"10.34172/mejdd.2025.407","DOIUrl":"https://doi.org/10.34172/mejdd.2025.407","url":null,"abstract":"Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third leading cause of cancer-related death, with a 5-year survival rate of 10%-12%. It usually develops in the setting of chronic liver disease (CLD), with chronic viral hepatitis, alcohol, and non-alcoholic fatty liver disease (NAFLD) being the most common risk factors. Some patients are at higher risk of developing hepatocellular cancer, so it is important to screen them regularly to diagnose the disease at an early stage and improve their chances for curative treatment. Six-monthly ultrasound with or without alpha-fetoprotein (AFP) is the currently recommended surveillance method. AFP has been used as a biomarker for liver cancer; however, it has low sensitivity and specificity, which necessitates the search for other, more accurate biomarkers. Promising biomarkers include lens culinaris agglutinin-reactive AFP, des-gamma-carboxy prothrombin, methylated DNA markers, plasma microRNA expression, circulating tumor DNA, and circulating tumor cells. In addition, combinations of biomarkers, like the GALAD score and the Doylestown algorithm, may help in the early detection of HCC. In this review, we summarize the screening tests for early detection of HCC that have been studied over the last decade.","PeriodicalId":18517,"journal":{"name":"Middle East Journal of Digestive Diseases","volume":"17 1","pages":"31-39"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Interplay of Coping Strategies and Quality of Life in Inflammatory Bowel Disease: A Systematic Review. 炎症性肠病应对策略与生活质量的相互作用：系统综述。

Middle East Journal of Digestive Diseases Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.34172/mejdd.2025.409

Lining Wang, Norafisyah Makhdzir, Zarina Haron

{"title":"The Interplay of Coping Strategies and Quality of Life in Inflammatory Bowel Disease: A Systematic Review.","authors":"Lining Wang, Norafisyah Makhdzir, Zarina Haron","doi":"10.34172/mejdd.2025.409","DOIUrl":"https://doi.org/10.34172/mejdd.2025.409","url":null,"abstract":"Background: This systematic review, grounded in coping theory, examines the relationship between coping strategies and quality of life (QoL) in patients with inflammatory bowel disease. It synthesizes current findings and guides future research to address existing knowledge gaps.Methods: A comprehensive search of Scopus, PubMed, Google Scholar, and Web of Science (from April 2000 to April 2024) identified 17 peer-reviewed studies.Results: Coping strategies directly and indirectly influence the QoL of patients with inflammatory bowel disease (IBD). Adaptive strategies, such as problem-solving and seeking social support, consistently improve QoL even in patients with active disease by promoting better disease management and emotional well-being. Maladaptive strategies, such as avoidance and emotional detachment, lead to decreased QoL and increased psychological distress. In addition, self-efficacy and psychological resilience play a key role in mediating the relationship between coping and QoL. However, coping strategies differ by disease stage and between demographic groups.Conclusion: This study identifies significant gaps in research, such as limited multi-center and longitudinal studies, cross-cultural inconsistencies, and insufficient focus on specific populations. These gaps restrict understanding of the long-term effects of coping strategies. Future research should combine quantitative and qualitative methods to better capture patients' experiences, aiding the development of personalized interventions.","PeriodicalId":18517,"journal":{"name":"Middle East Journal of Digestive Diseases","volume":"17 1","pages":"60-67"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Performance between White Light Imaging and Narrow Band Imaging in Distinguishing Neoplastic and Non-neoplastic Colorectal Polyps. 白光成像与窄带成像鉴别结直肠肿瘤与非肿瘤息肉的比较研究。

Middle East Journal of Digestive Diseases Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.34172/mejdd.2025.405

Kaka Renaldi, Lily Verawati, Hasan Maulahela, Nur Rahadiani, Aulia Rizka, Ari Fahrial Syam, Dyah Purnamasari, Chyntia Olivia Maurine Jasirwan, Dicky Levenus Tahapary

{"title":"Comparison of Performance between White Light Imaging and Narrow Band Imaging in Distinguishing Neoplastic and Non-neoplastic Colorectal Polyps.","authors":"Kaka Renaldi, Lily Verawati, Hasan Maulahela, Nur Rahadiani, Aulia Rizka, Ari Fahrial Syam, Dyah Purnamasari, Chyntia Olivia Maurine Jasirwan, Dicky Levenus Tahapary","doi":"10.34172/mejdd.2025.405","DOIUrl":"https://doi.org/10.34172/mejdd.2025.405","url":null,"abstract":"Background: White light imaging (WLI) is the current standard colonoscopy technique for diagnosing colorectal polyps in Indonesia. Various endoscopic imaging techniques have been developed to improve the accuracy of diagnosing colorectal polyps, one of which is narrow band imaging (NBI). We conducted a diagnostic study comparing the performance of NBI against WLI in distinguishing neoplastic from non-neoplastic colorectal polyps.Methods: This was a diagnostic study that analyzes endoscopic pictures of colorectal polyps in patients who underwent colonoscopy using the WLI and NBI techniques. Previously collected biopsy tissue specimens were re-examined by a single pathologist.Results: There were 117 subjects analyzed, and the proportion of subjects with neoplastic polyps was 65.8%. Common indications for colonoscopy were hematochezia (24.8%) and abdominal pain (23.9%). WLI showed moderate inter-observer reliability (kappa value=0.591), while NBI showed significant reliability (kappa value=0.674). NBI demonstrated better sensitivity (84.4%; 95% CI 74.4%-91.7%) and accuracy (78.6%; 95% CI 70.1%-85.7%) compared with WLI (sensitivity 74%; 95% CI 62.8%-83.4% and accuracy 71.8%; 95% CI 62.7%-79.7%). However, the specificity was the same (67.5%; 95% CI 50.9%-81.4%).Conclusion: NBI has better performance than WLI in distinguishing neoplastic and non-neoplastic colorectal polyps.","PeriodicalId":18517,"journal":{"name":"Middle East Journal of Digestive Diseases","volume":"17 1","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

L-Shaped Configuration of Multiple Magnet Ingestion: A Case Report. 多磁体摄入的l形结构：1例报告。

Middle East Journal of Digestive Diseases Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.34172/mejdd.2025.410

Mehran Hakimzadeh, Mitra Ahmadi, Hazhir Javaherizadeh

引用次数: 0