Mediterranean Journal of Chemistry最新文献

{"title":"Regioselective reduction of benzylidene acetals from a bis-heterocyclic pyrimidino-pyranoside platform","authors":"Issa Samb, M. Gaye","doi":"10.13171/MJC02109271584SAMB","DOIUrl":"https://doi.org/10.13171/MJC02109271584SAMB","url":null,"abstract":"After the preparation with few steps of the original bicyclic osidic scaffold of pyrimidino-pyranoside type, the exploration of the reactivity of the pyranose part allowed us to carry out different procedures for opening 4,6-O-benzylidene.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87735791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquid-liquid separation of Cd (II) from Cu-sulfide cake prepared from sulfate solution of Abu-Thor ore material, Southwestern, Sinai, Egypt","authors":"Elham G. Awny","doi":"10.13171/MJC02108231573AWNY","DOIUrl":"https://doi.org/10.13171/MJC02108231573AWNY","url":null,"abstract":"The present work is concerned with the subsequent liquid-liquid separation of Cu, Zn, and Cd compounds from Cu- sulfide cake prepared from the sulfate solution of Abu-Thor Gibbsite-bearing shale ore material. This ore was found assaying 0.014% of Cd, 0.5% of Cu, and 0.55% of Zn as the elements of interest, by using 25% of H2SO4 solution at a solid/liquid ratio of 1/3 reaction time of 90 min at a temperature of 80 ◦C. About 96.5% of Cu (II), 99.3% of Cd (II), and 95.6% of Zn (II), respectively, were dissolved. After filtration, the prepared sulfate solution was treated with a suitable weight of Na2S to prepare the working Cu-sulfide cake, which was then wholly re-dissolved in 10% of H2SO4 solution to prepare the working sulfate solution, which contained the elements of interest. This solution was gone out to the organic solvent process for complete separating between the Cu (II), Zn (II) ions in the organic phase, and Cd (II) ions in the aqueous phase. The effective extraction parameters such as pH value, LIX concentration, contact time, and organic/aqueous ratio were studied. The obtained data cleared that the pH value of 2.5 was found effective for separating Cd (II) in the aqueous phase and both Zn (II) and Cu (II) in the organic phase. Where Cd (II) ions were precipitated as CdS using Na2S solution at pH 0.89, on the other side, both Zn (II) and Cu (II) were completely separated in the stripping process using Na2CO3 solution.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74666495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of new bimetallic phosphate (Al/Ag3PO4) and study for its Catalytic performance in the synthesis of 1,2-dihydro-l-phenyl-3H-naphth [1,2-e]-[1,3] oxazin-3-one derivatives","authors":"Achraf El Hallaoui, Tourya Ghailane, S. Chehab, Y. Merroun, R. Ghailane, S. Boukhris, T. Guedira, A. Souizi","doi":"10.13171/MJC02108091579ELHALLAOUI","DOIUrl":"https://doi.org/10.13171/MJC02108091579ELHALLAOUI","url":null,"abstract":"This work aims to prepare a new bimetallic phosphate catalyst using a new simple and effective method. This new catalyst was ready for the first time by a modification of Triple Super Phosphate (TSP) fertilizer with silver sulfate (AgSO4), followed by the impregnation of the aluminum atoms using aluminum nitrate (Al(NO3)3). The use of Al/Ag3PO4, for the first time as a heterogeneous catalyst in organic chemistry, offers a new, efficient, and green pathway for synthesizing 1,2-dihydro-l-phenyl-3H-naphth[1,2-e]-[1,3]oxazin-3-one derivatives by one-pot three-component cyclocondensation of b-naphthol, aryl aldehyde, and urea. The structure and the morphology of the prepared catalyst were characterized by spectroscopic methods such as X-Ray Diffraction (XRD), Fourier Transform Infrared spectroscopy (FT-IR), and dispersive X-ray spectrometry coupled with a scanning electron microscope (EDX-SEM). In addition, the optimization of the reaction parameters was carried out considering the effect of catalyst amount, the temperature, and the solvent. The procedure described herein allowed a comfortable preparation of oxazine derivatives with excellent yields, short reaction times, and in the absence of organic solvent.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80361212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of HPLC Method for the Quantification of Atorvastatin in Pharmaceutical Dosage Forms and Biological Fluid","authors":"S. Haque","doi":"10.13171/MJC02106301581HAQUE","DOIUrl":"https://doi.org/10.13171/MJC02106301581HAQUE","url":null,"abstract":"A reverse phase HPLC method was developed for the determination of atorvastatin. The mobile phase involved for the separation was phosphate buffer and acetonitrile with a ratio of 10:1. The HPLC column C18 ODS hypersil column (250 mm×4.6 mm, 5 μm) was used and detected at 215 nm.   The run time of the current method was 5 minutes with excellent specificity; no interferences were observed in the pharmaceutical dosage form. The process was validated according to ICH guidelines. The linearity of the proposed method was within the range of 0.25–3.8 µg/ml. The LOD and LOQ values were found to be 0.21 and 0.64 µg/ml. The % recovery and %RSD were within the range of 98–100 %, and ±2% for accuracy, precision, robustness, ruggedness results. All the values are acceptable as per ICH guidelines. As well, this enhanced technique was applied to calculate the amount of atorvastatin in human urine samples. Therefore, the present method is reliable for quantifying atorvastatin in quality control samples in academic and pharmaceutical industries and can easily be used in research development and hospitals. ","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"152 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76782721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of microbial and level of Cadmium, Chromium and Lead contamination on drinking water refilling station in Bungus Teluk Kabung, West Sumatera, Indonesia","authors":"Azimatur Rahmi, Rahma Yulia, Asmaul Husna, Amelia Amir","doi":"10.13171/MJC02106041571AA","DOIUrl":"https://doi.org/10.13171/MJC02106041571AA","url":null,"abstract":"Refill drinking water is a choice of drinking water, especially for the middle-income community due to the convenience and affordable price. Many studies in Indonesia reported that drinking water from drinking water refilling stations is less safe or contaminated by coliform. This study assessed the microbial and level of several heavy metals (Cadmium, chromium, and Lead) contamination on refill drinking water from drinking water refilling station in Bungus Teluk Kabung West Sumatera, Indonesia. It found that Cadmium, Chromium, and Lead were detected in all samples. Still, none of their levels exceed the maximum permissible limits based on the guideline value on Ministry of Health Republic of Indonesia number 492/MENKES/PER/IV/2010. Lead was found as the highest amount in sample B and then Chromium in sample A with values of 0.367 ppb and 0.143 ppb. The microbial contamination presence in all three refill drinking water samples with the total coliform was 28, 15, and 240 MPN per 100 ml for samples A, B, and C. Sample C has the highest microbial risk compare to A and B. The presence of E. Coli was also confirmed for all samples, and the metallic sheen identified it in all culture samples. Because the standard of the microbial parameter must be zero for coliform and E. Coli, these results revealed that all three refill drinking water samples from drinking water refilling stations Bungus Teluk Kabung are not eligible for direct consumption and could harm human health. The proper water treatment process or change in raw water sources need to be considered in the future. Inspection and monitoring from the health authority should be scheduled regularly to protect the consumers.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"29 1","pages":"201-206"},"PeriodicalIF":0.0,"publicationDate":"2021-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81670892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of new spiroheterocycles-fused isoxazoline from 2-arylidenes-3-phenyl-1-indanones through a regio-and diastereospecific 1,3-dipolar cycloaddition","authors":"A. Mahfoud, A. Kerbal, A. Nakkabi, M. E. Yazidi, M. Akhazzane, M. Bakhouch, Y. Kanzouai, Rachid Bouzammit, G. A. Houari","doi":"10.13171/MJC02105141076GH","DOIUrl":"https://doi.org/10.13171/MJC02105141076GH","url":null,"abstract":"New spiroisoxazolines 3 have been synthesized by 1,3-dipolar cycloaddition of arylnitrile oxides with 2-arylidenes-3-phenyl-1-indanones. The reaction occurs in a regiospecific and diastereospecific manner and leads to one cycloadduct in all the cases. The proposed structure of the obtained cycloadducts was established based on spectroscopic data and confirmed by radiocrystallographic study. The spectral data were in favor of the observed regiochemistry and diastereoselectivity of this reaction.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"2 1","pages":"194-200"},"PeriodicalIF":0.0,"publicationDate":"2021-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85688947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theoretical Characterization of the Hydrogen Bonding Interaction Sites of Mycolactone C Using the ONIOM Method","authors":"François Kassi Kadjo, S. T. Affi, Yao Silvère Diki N’guessan, M. Koné, Georges Stéphane Dembélé, N. Ziao","doi":"10.13171/MJC02104261574MGRK","DOIUrl":"https://doi.org/10.13171/MJC02104261574MGRK","url":null,"abstract":"In this work, the ONIOM method, recognized for its effectiveness on large molecules, was used to determine the geometric, energetic, and spectroscopic parameters of hydrogen bond interactions of mycolactone C. Mycolactone C; one of the most virulent forms of toxin, found in Africa and Australia. It has eight (08) oxygen heteroatoms which are all hybridized sp2 and sp3. Using quantum chemistry methods, at the ONIOM level (B3LYP/6-311+G (d, p): AM1), we have determined the preferential binding sites of the hydrogen bonds in the eight mycolactone C oxygen heteroatoms studied. Analysis of the results revealed that the heteroatom O5sp2 is the most suitable site for creating a strong hydrogen bond based on the geometric, energetic (free enthalpy of complexation), and spectroscopic (vibration frequency shifts) parameters. Identifying this O5sp2 heteroatom is a significant step forward in developing a methodology for eradicating the infection and the destructive effects of this toxin.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87125347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrooxidation of simulated wastewater containing pharmaceutical amoxicillin on thermally prepared IrO2/Ti","authors":"Thiery Auguste Foffié Appia, L. Ouattara","doi":"10.13171/MJC02104071566FTAA","DOIUrl":"https://doi.org/10.13171/MJC02104071566FTAA","url":null,"abstract":"<p>The electrooxidation of amoxicillin (AMX) on the iridium oxide electrode thermally prepared (400°C) has been investigated by cyclic voltammetry and preparative electrolysis. Physical characterization by Scanning Electron Microscopy (SEM) showed that the IrO₂ electrode has a rough surface with pores' presence. In cyclic voltammetry, the oxidation of AMX occurs directly at the anode's surface or via the higher degree oxide of iridium oxide (IrO₃).  It is noted that the oxidation process of AMX can be controlled by diffusion combined with the phenomenon of adsorption. In preparative electrolysis, the effect of several parameters has been investigated. These are the current density, the support medium, the initial pH. The findings obtained show a weak degradation of amoxicillin. The Chemical Oxygen Demand (COD) reduction rate is less than 11% under our experimental conditions, indicating that the IrO2 electrode leads to the parent compound's conversion. Also, the degradation of the organic compound is favored in a very acidic medium.<strong></strong></p><p>Furthermore, the effect of inorganic ions such as SO₄^2-, PO₄^3-, NO₃^-, Cl^- was evaluated. Investigations show that these ions' effects are diverse, with COD reduction rates ranging from 2.47%; 2.68%; 7.7%; 16.41%, and 71.65%, respectively, in the absence and the presence of SO₄^2-, PO₄^3-, NO₃^-, Cl^-ions. SO₄^2- have virtually no effect on enhancing the degradation of amoxicillin. PO₄^3- ions provide a slight improvement in amoxicillin degradation. As for nitrate ions, their influence is 2.31 times that of phosphate ions. Chloride ions improve the performance of the electrooxidation of amoxicillin on IrO2 very significantly. The presence of chloride ions makes it possible to go from 2928.35 (absence of inorganic ions) to 33.19 kWh per Kg of COD. This represents an energy gain of over 98%.</p>","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72909506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Structure-Activity Study against Plasmodium falciparum of a Series of Derivatives of Azetidine-2-Carbonitriles by the Method of Density Functional Theory","authors":"Jean Stéphane N’dri, B. Ouattara, M. Koné, Ahmont Landry Claude Kablan, Georges Stéphane Dembélé, C. Kodjo, N. Ziao","doi":"10.13171/MJC02103241572MGRK","DOIUrl":"https://doi.org/10.13171/MJC02103241572MGRK","url":null,"abstract":"This work deals with a Quantitative Structure-Activity study against Plasmodium falciparum of a series of Azetidine-2-carbonitrile derivatives. Using the MLR and MNLR methods from excel and xlstat software, we have been able to develop two QSAR models based on molecular descriptors and plasmodial activity. Calculation level B3LYP/6-311 G (d, p) was used to determine molecular descriptors. The statistical indicators of the first model obtained by the MLR method are: the regression coefficient found was R = 0.939 with a standard deviation S =0.266, Fischer's coefficient F =82.064, and a cross-validation correlation coefficient QCV 2 =0.935. The parameters of the second model developed by the MNLR method are: the regression coefficient R: de 0.953, a standard deviation S of 0.258, the Fischer's test F of 108.957, and the correlation coefficient of the cross-validation QCV 2 =0.951. Moreover, these models have shown some interesting statistical performance. The energy of the highest occupied molecular orbital (EHOMO), the dipole moment (μD), and the partition coefficient (log P) are the molecular descriptors responsible for the Plasmodium falciparum activity of Azetidine-derivatives 2-carbonitriles. Furthermore, the partition coefficient is the primary descriptor for predicting the biological activity of the studied compounds. From the findings, Eriksson et al. and the external validation criteria of Tropsha used to implement the test are verified and accurate.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"3 1","pages":"162"},"PeriodicalIF":0.0,"publicationDate":"2021-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87428932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review: Synthesis of Urea in Several Methods","authors":"Asep Rizki Pradana, Asep Royani, Kiki Zulfikri, N. Tuffahati, R. Azzahra, Tasya Qori Amini, A. Nandiyanto","doi":"10.13171/MJC02103121554ARP","DOIUrl":"https://doi.org/10.13171/MJC02103121554ARP","url":null,"abstract":"Urea (CO (NH) 2 ) is one of the compositions in making fertilizer. Fertilizer is crucial, especially for plant growth (affecting plant fertility). If a plant had urea fertilizer on the soil, nitrogen in the fertilizer releases quickly, and it will cause environmental pollution. Therefore, many studies want to develop urea fertilizer to be more efficient to use. The purpose of this review is to find the most appropriate method for the efficient use of urea as seen from the material used, the technique used, and the results obtained. This review shows that the most appropriate method is the slow release method with NaOH and fly ash ingredients. Because this method can increase the effective utilization of urea, reduce environmental pollution, and be relatively more straightforward, the raw material is more affordable and spread widely in the market.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"7 1","pages":"146-161"},"PeriodicalIF":0.0,"publicationDate":"2021-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78434030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}