A. Mahfoud, A. Kerbal, A. Nakkabi, M. E. Yazidi, M. Akhazzane, M. Bakhouch, Y. Kanzouai, Rachid Bouzammit, G. A. Houari
{"title":"由2-芳基-3-苯基-1-吲哚酮经区域非对映特异性1,3-偶极环加成合成新的螺杂环-融合异恶唑啉","authors":"A. Mahfoud, A. Kerbal, A. Nakkabi, M. E. Yazidi, M. Akhazzane, M. Bakhouch, Y. Kanzouai, Rachid Bouzammit, G. A. Houari","doi":"10.13171/MJC02105141076GH","DOIUrl":null,"url":null,"abstract":"New spiroisoxazolines 3 have been synthesized by 1,3-dipolar cycloaddition of arylnitrile oxides with 2-arylidenes-3-phenyl-1-indanones. The reaction occurs in a regiospecific and diastereospecific manner and leads to one cycloadduct in all the cases. The proposed structure of the obtained cycloadducts was established based on spectroscopic data and confirmed by radiocrystallographic study. The spectral data were in favor of the observed regiochemistry and diastereoselectivity of this reaction.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"2 1","pages":"194-200"},"PeriodicalIF":0.0000,"publicationDate":"2021-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis of new spiroheterocycles-fused isoxazoline from 2-arylidenes-3-phenyl-1-indanones through a regio-and diastereospecific 1,3-dipolar cycloaddition\",\"authors\":\"A. Mahfoud, A. Kerbal, A. Nakkabi, M. E. Yazidi, M. Akhazzane, M. Bakhouch, Y. Kanzouai, Rachid Bouzammit, G. A. Houari\",\"doi\":\"10.13171/MJC02105141076GH\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"New spiroisoxazolines 3 have been synthesized by 1,3-dipolar cycloaddition of arylnitrile oxides with 2-arylidenes-3-phenyl-1-indanones. The reaction occurs in a regiospecific and diastereospecific manner and leads to one cycloadduct in all the cases. The proposed structure of the obtained cycloadducts was established based on spectroscopic data and confirmed by radiocrystallographic study. The spectral data were in favor of the observed regiochemistry and diastereoselectivity of this reaction.\",\"PeriodicalId\":18513,\"journal\":{\"name\":\"Mediterranean Journal of Chemistry\",\"volume\":\"2 1\",\"pages\":\"194-200\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-05-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mediterranean Journal of Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.13171/MJC02105141076GH\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mediterranean Journal of Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.13171/MJC02105141076GH","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis of new spiroheterocycles-fused isoxazoline from 2-arylidenes-3-phenyl-1-indanones through a regio-and diastereospecific 1,3-dipolar cycloaddition
New spiroisoxazolines 3 have been synthesized by 1,3-dipolar cycloaddition of arylnitrile oxides with 2-arylidenes-3-phenyl-1-indanones. The reaction occurs in a regiospecific and diastereospecific manner and leads to one cycloadduct in all the cases. The proposed structure of the obtained cycloadducts was established based on spectroscopic data and confirmed by radiocrystallographic study. The spectral data were in favor of the observed regiochemistry and diastereoselectivity of this reaction.
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