Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics最新文献

{"title":"Reduction of measurement errors in OCT scanning","authors":"E. Morel, P. M. Tabla, M. Sallese, J. Torga","doi":"10.1117/12.2282108","DOIUrl":"https://doi.org/10.1117/12.2282108","url":null,"abstract":"Optical coherence tomography (OCT) is a non-destructive optical technique, which uses a light source with a wide band width that focuses on a point in the sample to determine the distance (strictly, the optical path difference, OPD) between this point and a reference surface. The point can be superficial or at an interior interface of the sample (transparent or semitransparent), allowing topographies and / or tomographies in different materials. The Michelson interferometer is the traditional experimental scheme for this technique, in which a beam of light is divided into two arms, one the reference and the other the sample. The overlap of reflected light in the sample and in the reference generates an interference signal that gives us information about the OPD between arms. In this work, we work on the experimental configuration in which the reference signal and the reflected signal in the sample travel on the same arm, improving the quality of the interference signal. Among the most important aspects of this improvement we can mention that the noise and errors produced by the relative reference–sample movement and by the dispersion of the refractive index are considerably reduced. It is thus possible to obtain 3D images of surfaces with a spatial resolution in the order of microns. Results obtained on the topography of metallic surfaces, glass and inks printed on paper are presented.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127475895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of absorption in the top layer of a two layer sample on spectroscopic spectral domain interferometry of the bottom layer","authors":"F. Fleischhauer, T. Feuchter, L. Leick, R. Rajendram, A. Podoleanu","doi":"10.1117/12.2281928","DOIUrl":"https://doi.org/10.1117/12.2281928","url":null,"abstract":"Spectroscopic spectral domain interferometry and spectroscopic optical coherence tomography combine depth information with spectrally-resolved localised absorption data. These additional data can improve diagnostics by giving access to functional information of the investigated sample. One possible application is measuring oxygenation levels at the retina for earlier detection of several eye diseases. Here measurements with different hollow glass tube phantoms are shown to measure the impact of a superficial absorbing layer on the precision of reconstructed attenuation spectra of a deeper layer. Measurements show that a superficial absorber has no impact on the reconstructed absorption spectrum of the deeper absorber. Even when diluting the concentration of the deeper absorber so far that an incorrect absorption maximum is obtained, still no influence of the superficially placed absorber is identified.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129051017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing signal-to-noise ratio of swept-source optical coherence tomography by oversampling in k-space","authors":"Karim Nagib, Biniyam Mezgebo, Rahul Thakur, Namal Fernando, B. Kordi, S. Sherif","doi":"10.1117/12.2283015","DOIUrl":"https://doi.org/10.1117/12.2283015","url":null,"abstract":"Optical coherence tomography systems suffer from noise that could reduce ability to interpret reconstructed images correctly. We describe a method to increase the signal-to-noise ratio of swept-source optical coherence tomography (SSOCT) using oversampling in k-space. Due to this oversampling, information redundancy would be introduced in the measured interferogram that could be used to reduce white noise in the reconstructed A-scan. We applied our novel scaled nonuniform discrete Fourier transform to oversampled SS-OCT interferograms to reconstruct images of a salamander egg. The peak-signal-to-noise (PSNR) between the reconstructed images using interferograms sampled at 250MS/s andz50MS/s demonstrate that this oversampling increased the signal-to-noise ratio by 25.22 dB.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"90 9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114389076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subretinal hyper-reflective material seen on optical coherence tomography as a biomarker for disease monitoring in age-related macular degeneration","authors":"H. B. Lee, B. Ong, M. Katta, C. Yvon, L. Lu, R. Zakri, N. Patel","doi":"10.1117/12.2287271","DOIUrl":"https://doi.org/10.1117/12.2287271","url":null,"abstract":"Subretinal hyper-reflective material (SHRM) seen on optical coherence tomography (OCT) is thought to be a collection of fibrous tissues and vascular networks that are identified in age-related macular degeneration (ARMD). We have carried out a retrospective analysis of 91 OCT scans of neovascular ARMD subtypes including classic and occult choroidal neovascularization (CNV) and retinal angiomatous proliferation (RAP). All three subtypes received ranibizumab, an anti-vascular endothelial growth factor (Anti-VEGF) intravitreal injections on an as-needed basis following the loading doses. Volumes of SHRM were calculated using caliper measurements of maximal height and length of SHRM seen on OCT. The ellipsoid formula derived from tumour models was used to calculate the volume. It was found that occult CNV and RAP have larger SHRM volumes than those of classic CNV. SHRM volumes reduced overall following loading doses of Anti-VEGF injections at 4 months in all three subtypes. However, a rebound increase in volume was noticed in both occult CNV and RAP cohort at 12 months despite the initial, steeper reductions in the subtypes. These findings were consistent with the data seen in volume measurement using Topcon’s automated segmentation algorithm in a smaller cohort of patients. We propose that SHRM should be used as a potential biomarker to quantify both disease progression and prognosis of neovascular ARMD alongside other conventional methods.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121999207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolution dependence on phase extraction by the Hilbert transform in phase calibrated and dispersion compensated ultrahigh resolution spectrometer-based OCT","authors":"N. Israelsen, M. Maria, T. Feuchter, A. Bradu, A. Podoleanu, O. Bang","doi":"10.1117/12.2282295","DOIUrl":"https://doi.org/10.1117/12.2282295","url":null,"abstract":"Ultrahigh resolution optical coherence tomography (UHR-OCT) is enabled by using a broad band source. Simultaneously, this makes the OCT image more sensitive to dispersion mismatch in the interferometer. In spectral domain OCT, dispersion left uncompensated in the interferometer and detector non-linearities lead together to an unknown chirp of the detected interferogram. One method to compensate for the chirp is to perform a pixel-wavenumber calibration versus phase that requires numerical extraction of the phase. Typically a Hilbert transform algorithm is employed to extract the optical phase versus wavenumber for calibration and dispersion compensation. In this work we demonstrate UHR-OCT at 1300 nm using a Super continuum source and highlight the resolution constraints in using the Hilbert transform algorithm when extracting the optical phase for calibration and dispersion compensation. We demonstrate that the constraints cannot be explained purely by the numerical errors in the data processing module utilizing the Hilbert transform but must be dictated by broadening mechanisms originating from the experimentally obtained interferograms.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"232 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123193703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental impression technique using optoelectronic devices","authors":"C. Sinescu, Souman Barua, F. Topala, M. Negruțiu, Virgil-Florin Duma, A. Gabor, C. Zaharia, A. Bradu, A. Podoleanu","doi":"10.1117/12.2281775","DOIUrl":"https://doi.org/10.1117/12.2281775","url":null,"abstract":"INTRODUCTION: The use of Optical Coherence Tomography (OCT) as a non-invasive and high precision quantitative information providing tool has been well established by researches within the last decade. The marginal discrepancy values can be scrutinized in optical biopsy made in three dimensional (3D) micro millimetre scale and reveal detailed qualitative and quantitative information of soft and hard tissues. OCT-based high resolution 3D images can provide a significant impact on finding recurrent caries, restorative failure, analysing the precision of crown preparation, and prosthetic elements marginal adaptation error with the gingiva and dental hard tissues. During the CAD/CAM process of prosthodontic restorations, the circumvent of any error is important for the practitioner and the technician to reduce waste of time and material. Additionally, OCT images help to achieve a new or semi-skilled practitioner to analyse their crown preparation works and help to develop their skills faster than in a conventional way. The aim of this study is to highlight the advantages of OCT in high precision prosthodontic restorations. MATERIALS AND METHODS: 25 preparations of frontal and lateral teeth were performed for 7 different patients. The impressions of the prosthetic fields were obtained both using a conventional optoelectronic system (Apolo Di, Syrona) and a Spectral Domain using OCT (Dental prototype, working at 860 nm). For the conventional impression technique the preparation margins were been prelevated by gingival impregnated cords. No specific treatments were performed by the OCT impression technique. RESULTS: The scanning performed by conventional optoelectronic system proved to be quick and accurate in terms of impression technology. The results were represented by 3D virtual models obtained after the scanning procedure was completed. In order to obtain a good optical impression a gingival retraction cord was inserted between the prepared tooth and the gingival tissue for a better elevation of the tooth cervical margin preparation. Spectral OCT was enforced in order to observe the quality but also the advantages coming from this technology. No special preparation was performed for this operation. CONCLUSION: Considering these aspects, OCT could be used as a valuable tool for dental impression technology, being non-invasive but also non-destructive on the marginal gingival tissue, in comparison with conventional optoelectronic technology where the gingival retraction cord is still mandatory.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115037758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fast detection of vascular plaque in optical coherence tomography images using a reduced feature set","authors":"A. Prakash, Mariano Ocana Macias, M. Hewko, M. Sowa, S. Sherif","doi":"10.1117/12.2283017","DOIUrl":"https://doi.org/10.1117/12.2283017","url":null,"abstract":"Optical coherence tomography (OCT) images are capable of detecting vascular plaque by using the full set of 26 Haralick textural features and a standard K-means clustering algorithm. However, the use of the full set of 26 textural features is computationally expensive and may not be feasible for real time implementation. In this work, we identified a reduced set of 3 textural feature which characterizes vascular plaque and used a generalized Fuzzy C-means clustering algorithm. Our work involves three steps: 1) the reduction of a full set 26 textural feature to a reduced set of 3 textural features by using genetic algorithm (GA) optimization method 2) the implementation of an unsupervised generalized clustering algorithm (Fuzzy C-means) on the reduced feature space, and 3) the validation of our results using histology and actual photographic images of vascular plaque. Our results show an excellent match with histology and actual photographic images of vascular tissue. Therefore, our results could provide an efficient pre-clinical tool for the detection of vascular plaque in real time OCT imaging.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120952127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OCT-based angiography in real time with hand-held probe","authors":"G. Gelikonov, A. Moiseev, S. Ksenofontov, D. A. Terpelov, V. Gelikonov","doi":"10.1117/12.2281597","DOIUrl":"https://doi.org/10.1117/12.2281597","url":null,"abstract":"This work is dedicated to development of the OCT system capable to visualize blood vessel network for everyday clinical use. Following problems were solved during the development: compensation of specific natural tissue displacements, induced by contact scanning mode and physiological motion of patients (e.g. respiratory and cardiac motions) and on-line visualization of vessel net to provide the feedback for system operator.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127227797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noise study of all-normal dispersion supercontinuum sources for potential application in optical coherence tomography","authors":"I. B. Gonzalo, R. D. Engelsholm, O. Bang","doi":"10.1117/12.2283060","DOIUrl":"https://doi.org/10.1117/12.2283060","url":null,"abstract":"Commercially available silica-fiber-based and ultra-broadband supercontinuum (SC) sources are typically generated by pumping close to the zero-dispersion wavelength (ZDW) of a photonic crystal fiber (PCF), using high-power picosecond or nanosecond laser pulses. Despite the extremely broad bandwidths, such sources are characterized by large intensity fluctuations, limiting their performance for applications in imaging such as optical coherence tomography (OCT). An approach to eliminate the influence of noise sensitive effects is to use a so-called all-normal dispersion (ANDi) fiber, in which the dispersion is normal for all the wavelengths of interest. Pumping these types of fibers with short enough femtosecond pulses allows to suppress stimulated Raman scattering (SRS), which is known to be as noisy process as modulation instability (MI), and coherent SC is generated through self-phase modulation (SPM) and optical wave breaking (OWB). In this study, we show the importance of the pump laser and fiber parameters in the design of low-noise ANDi based SC sources, for application in OCT. We numerically investigate the pulse-to-pulse fluctuations of the SC, calculating the relative intensity noise (RIN) as a function of the pump pulse duration and fiber length. Furthermore, we experimentally demonstrate the role of the fiber length on the RIN of the ANDi SC, validating the results calculated numerically. In the end, we compare the RIN of a commercial SC source based on MI and the ANDi SC source developed here, which shows better noise performance when it is carefully designed.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115159104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-noise supercontinuum sources based on all-normal dispersion fibers: exploring their prospects and limitations","authors":"A. Heidt, T. Feurer","doi":"10.1117/12.2293132","DOIUrl":"https://doi.org/10.1117/12.2293132","url":null,"abstract":"Supercontinuum (SC) sources based on optical fibers exhibiting flat and normal group velocity dispersion (GVD) in the entire wavelength region of interest, so-called all-normal dispersion (ANDi) fibers, have become a well-accepted alternative to the more conventional approach of pumping fibers in the anomalous GVD region. The conservation of a single ultrashort pulse and the suppression of noise-amplifying nonlinear effects during SC generation make ANDi fibers particularly attractive for ultrafast and noise-sensitive applications. Here we discuss current possibilities and future prospects, but also the limitations of ANDi fiber SC sources, focusing particularly on coherence and noise performance for various pump pulse regimes.","PeriodicalId":184459,"journal":{"name":"Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133883183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}