Medical Oncology最新文献_第2页

A comparative analysis of gallstones from gallbladder cancer patients and cholelithiasis patients unveiling the association between gallstones and gallbladder cancer.

IF 2.8 4区医学

Medical Oncology Pub Date : 2025-02-04 DOI: 10.1007/s12032-025-02614-7

Bhavna Sharma, Ratnakar Shukla, Anand Nagar, Nishith Ekka, Vinay Kumar Kapoor, Anu Behari, Shubha Rani Sharma

{"title":"A comparative analysis of gallstones from gallbladder cancer patients and cholelithiasis patients unveiling the association between gallstones and gallbladder cancer.","authors":"Bhavna Sharma, Ratnakar Shukla, Anand Nagar, Nishith Ekka, Vinay Kumar Kapoor, Anu Behari, Shubha Rani Sharma","doi":"10.1007/s12032-025-02614-7","DOIUrl":"https://doi.org/10.1007/s12032-025-02614-7","url":null,"abstract":"Gallstones (GS) are one of the most common gastrointestinal diseases. Till date medical cure for gallstones is not available. Unlike kidney stones, GS need cholecystectomy, i.e. surgical removal of the gallbladder (GB). GS are asymptomatic in most of the cases. They are the cause of GB inflammation that is chronic cholecystitis. GS have been supposed to be an important risk factor for causing gallbladder cancer (GBC). But the exact relationship between GS and GBC is not clear till date. In this study, we have compared the gallstones from cholelithiasis patients with those from patients with GBC. The size, volume and weight of these GS were comparatively analyzed. We have performed compositional as well as heavy metal analysis of the GS for both groups of patients by FTIR, FESEM and ICP-MS. The size and volume of gallstones from GBC patients was found to be on the higher side. We found that the GS from GBC patients were only of cholesterol type while those from cholelithiasis patients were mixed and pigment type. Heavy metals such as As, Pb, Fe were detected in higher concentration in GS from GBC patients. Thus, heavy metals detected in the gallstones could be regarded as the contributing factors to GBC. Further the mechanism of initiation of cancer by heavy metals in presence of cholesterol GS needs to be studied, so that novel strategies can be developed for the prevention of GBC.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":"42 3","pages":"65"},"PeriodicalIF":2.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon ion irradiation conquers the radioresistance by inducing complex DNA damage and apoptosis in U251 human glioblastomas cells.

IF 2.8 4区医学

Medical Oncology Pub Date : 2025-02-04 DOI: 10.1007/s12032-025-02616-5

Yulu Guo, Pingping Li, Jinhua Zhang, Sijia Hao, Xuan Zhou, Cuixia Di, Feng Long, Hong Zhang, Jing Si

{"title":"Carbon ion irradiation conquers the radioresistance by inducing complex DNA damage and apoptosis in U251 human glioblastomas cells.","authors":"Yulu Guo, Pingping Li, Jinhua Zhang, Sijia Hao, Xuan Zhou, Cuixia Di, Feng Long, Hong Zhang, Jing Si","doi":"10.1007/s12032-025-02616-5","DOIUrl":"https://doi.org/10.1007/s12032-025-02616-5","url":null,"abstract":"Glioblastoma multiforme (GBM) is the most malignant brain tumor, with radiotherapy frequently employed following surgical resection. However, conventional radiation therapies often yield suboptimal results. This study investigated the effects of X-ray and carbon ion irradiation on the glioblastoma cell line U251 to assess the distinctive advantages of carbon ion treatment and explore mechanisms for overcoming radiation resistance. The findings indicated that carbon ion irradiation more effectively inhibited colony formation and induced more severe apoptosis and cell cycle disorder in U251 cells. Immunofluorescence assays revealed larger and more abundant ϒ-H2AX and 53BP1 foci in the carbon ion irradiation group. Western blot analysis demonstrated that carbon ion-induced DNA damage repair involved a complex array of pathways, with the RAD51-mediated homologous recombination (HR) pathway being predominant, while the Rad23B-mediated nucleotide excision repair (NER) pathway and XRCC1-mediated base excision repair (BER) were more relevant in response to X-ray irradiation. These results suggest that carbon ion irradiation may overcome radioresistance by inducing more complex DNA damage and apoptosis, thus providing insights for targeting new strategies in combining gene therapy with radiotherapy.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":"42 3","pages":"64"},"PeriodicalIF":2.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagy induced by metabolic processes leads to solid tumor cell metastatic dormancy and recurrence.

IF 2.8 4区医学

Medical Oncology Pub Date : 2025-02-03 DOI: 10.1007/s12032-025-02607-6

Saeid Ferdousmakan, Dorrin Mansourian, Fatemeh Sadat Seyedi Asl, Zeinab Fathi, Fahimeh Maleki-Sheikhabadi, Mohsen Nabi Afjadi, Hamidreza Zalpoor

{"title":"Autophagy induced by metabolic processes leads to solid tumor cell metastatic dormancy and recurrence.","authors":"Saeid Ferdousmakan, Dorrin Mansourian, Fatemeh Sadat Seyedi Asl, Zeinab Fathi, Fahimeh Maleki-Sheikhabadi, Mohsen Nabi Afjadi, Hamidreza Zalpoor","doi":"10.1007/s12032-025-02607-6","DOIUrl":"10.1007/s12032-025-02607-6","url":null,"abstract":"A crucial cellular mechanism that has a complex impact on the biology of cancer, particularly in solid tumors, is autophagy. This review explores how metabolic processes trigger autophagy, which helps metastatic tumor cells go dormant and recur. During metastasis, tumor cells frequently encounter severe stressors, such as low oxygen levels and nutritional deprivation, which causes them to activate autophagy as a survival tactic. This process allows cancer stem cells (CSCs) to withstand severe conditions while also preserving their features. After years of dormancy, dormant disseminated tumor cells (DTCs) may reappear as aggressive metastatic cancers. The capacity of autophagy to promote resistance to treatments and avoid immune detection is intimately related to this phenomenon. According to recent research, autophagy promotes processes, such as the epithelial-to-mesenchymal transition (EMT) and helps build a pre-metastatic niche, which makes treatment strategies more challenging. Autophagy may be a promising therapeutic target because of its dual function as a tumor suppressor in early-stage cancer and a survival promoter in advanced stages. To effectively treat metastatic diseases, it is crucial to comprehend how metabolic processes interact with autophagy and affect tumor behavior. In order to find novel therapeutic approaches that can interfere with these processes and improve patient outcomes, this study highlights the critical need for additional investigation into the mechanisms by which autophagy controls tumor dormancy and recurrence.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":"42 3","pages":"62"},"PeriodicalIF":2.8,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The anti-cancer activity of Dioscin: an update and future perspective.

IF 2.8 4区医学

Medical Oncology Pub Date : 2025-02-03 DOI: 10.1007/s12032-024-02572-6

MengYue Wang, YaNan Zhang, SongLin Ni, Mo Sun, QiaoLan Wu, XiaoLin Wu, Qian Chen, ShiJun Wang

引用次数: 0

Molecular mechanism of genetic, epigenetic, and metabolic alteration in lung cancer.

IF 2.8 4区医学

Medical Oncology Pub Date : 2025-02-02 DOI: 10.1007/s12032-025-02608-5

Sheeri Fatima, Vineet Kumar, Dhruv Kumar

引用次数: 0

Integrative pan-cancer genomic analysis highlights mitochondrial protein p32 as a potential therapeutic target in Myc-driven tumorigenesis.

IF 2.8 4区医学

Medical Oncology Pub Date : 2025-02-01 DOI: 10.1007/s12032-025-02604-9

Qiufen Bi, Jun Nie, Qiang Wu, Liang Sun, Shuang Zhu, Jin Bai, Yong Liu, Fang Huang, Keli Chai

{"title":"Integrative pan-cancer genomic analysis highlights mitochondrial protein p32 as a potential therapeutic target in Myc-driven tumorigenesis.","authors":"Qiufen Bi, Jun Nie, Qiang Wu, Liang Sun, Shuang Zhu, Jin Bai, Yong Liu, Fang Huang, Keli Chai","doi":"10.1007/s12032-025-02604-9","DOIUrl":"https://doi.org/10.1007/s12032-025-02604-9","url":null,"abstract":"Tumor metabolic reprogramming, particularly involving mitochondrial metabolism, is a hallmark of malignancy. The mitochondrial protein p32 (C1QBP) has emerged as a critical regulator in various cancers, frequently associated with poor patient prognosis. However, the role of p32 across different cancer types remains largely unexplored. Our bioinformatics analysis demonstrates that p32 is significantly overexpressed in several malignancies and is closely involved in multiple oncogenic pathways related to tumor progression and metabolic reprogramming. Moreover, p32 expression positively correlates with genomic heterogeneity and drug sensitivity. We identified a strong association between p32 and c-Myc in both normal and cancerous tissues. We confirmed that p32 is a direct transcriptional target of c-Myc, which upregulates p32 by binding to its promoter. Functional experiments established that p32 is crucial for MYC-driven tumorigenesis, with its knockdown or knockout inhibiting tumor proliferation and extending survival. Targeting p32 may inhibit MYC-driven tumorigenesis, highlighting its potential as a therapeutic target in MYC-driven cancers.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":"42 3","pages":"60"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epstein-Barr virus-infected nasopharyngeal carcinoma therapeutics: oncoprotein targets and clinical implications.

IF 2.8 4区医学

Medical Oncology Pub Date : 2025-01-31 DOI: 10.1007/s12032-025-02610-x

Jacqueline Kar Kei Mark, Aik-Hong Teh, Beow Keat Yap

{"title":"Epstein-Barr virus-infected nasopharyngeal carcinoma therapeutics: oncoprotein targets and clinical implications.","authors":"Jacqueline Kar Kei Mark, Aik-Hong Teh, Beow Keat Yap","doi":"10.1007/s12032-025-02610-x","DOIUrl":"https://doi.org/10.1007/s12032-025-02610-x","url":null,"abstract":"Nasopharyngeal carcinoma (NPC) is a distinctive epithelial cancer closely associated with Epstein-Barr Virus (EBV) infection, posing significant challenges in diagnosis and treatment due to its resistance to conventional therapies and high recurrence rates. Current therapies, including radiotherapy and chemotherapy, exhibit limited efficacy, particularly in recurrent or metastatic cases, highlighting the urgent need for novel therapeutic strategies. Targeting EBV oncoproteins, such as Epstein-Barr Virus encoded Nuclear Antigen 1 (EBNA1), Latent Membrane Protein 1 (LMP1), and Latent Membrane Protein 2 (LMP2), presents a promising therapeutic avenue in NPC treatment. This review discusses the latest advancements in drug discovery targeting EBV oncoproteins, emphasizing the identification of inhibitors for specific functional regions of oncoproteins EBNA1, LMP1, and LMP2. Particular attention is given to the molecular mechanisms of these inhibitors and their preclinical or clinical potential in treating EBV-positive NPC. These developments highlight a promising future for targeted therapies in improving outcomes for NPC patients.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":"42 3","pages":"59"},"PeriodicalIF":2.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive insights of cancer immunotherapy resistance.

IF 2.8 4区医学

Medical Oncology Pub Date : 2025-01-30 DOI: 10.1007/s12032-025-02605-8

Laavanya Das, Subhadip Das

{"title":"A comprehensive insights of cancer immunotherapy resistance.","authors":"Laavanya Das, Subhadip Das","doi":"10.1007/s12032-025-02605-8","DOIUrl":"https://doi.org/10.1007/s12032-025-02605-8","url":null,"abstract":"Cancer is a major global health issue that is usually treated with multiple therapies, such as chemotherapy and targeted therapies like immunotherapy. Immunotherapy is a new and alternative approach to treating various types of cancer that are difficult to treat with other methods. Although immune checkpoint inhibitors have shown promise for long-term efficacy, they have limited effectiveness in common cancer types such as breast, prostate, and lung. Some patients do not respond to immunotherapy, while others develop resistance to the treatment over time, which is classified as primary or acquired resistance. Cancer immunotherapy, specifically immune checkpoint inhibitor-based resistance involves multiple factors such as genes, metabolism, inflammation, and angiogenesis. However, cutting-edge research has identified the mechanisms of immunotherapy resistance and possible solutions. Current research may improve biomarker identification and modify treatment strategies, which will lead to better clinical outcomes. This review provides a comprehensive discussion of the current mechanisms of immunotherapy resistance, related biomarker modulation, and strategies to overcome resistance.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":"42 3","pages":"57"},"PeriodicalIF":2.8,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural compounds as modulators of miRNAs: a new frontier in bladder cancer treatment.

IF 2.8 4区医学

Medical Oncology Pub Date : 2025-01-30 DOI: 10.1007/s12032-025-02613-8

Ahmed I Abulsoud, Shaza H Aly, Sherif S Abdel Mageed, Nourhan M Abdelmaksoud, Walaa A El-Dakroury, Osama A Mohammed, Mustafa Ahmed Abdel-Reheim, Mohamed Bakr Zaki, Nehal I Rizk, Manar Mohammed El Tabaa, Mahmoud Rashed, Riham A El-Shiekh, Ahmed S Doghish

{"title":"Natural compounds as modulators of miRNAs: a new frontier in bladder cancer treatment.","authors":"Ahmed I Abulsoud, Shaza H Aly, Sherif S Abdel Mageed, Nourhan M Abdelmaksoud, Walaa A El-Dakroury, Osama A Mohammed, Mustafa Ahmed Abdel-Reheim, Mohamed Bakr Zaki, Nehal I Rizk, Manar Mohammed El Tabaa, Mahmoud Rashed, Riham A El-Shiekh, Ahmed S Doghish","doi":"10.1007/s12032-025-02613-8","DOIUrl":"https://doi.org/10.1007/s12032-025-02613-8","url":null,"abstract":"Bladder cancer (BC) is a major global health issue with a high recurrence rate and limited effective treatments. Over the past few years, it has become evident that miRNAs play a role in the carcinogenesis process, particularly in regulating genes that promote cancer cell proliferation and invasion. This review focuses on the extent to which natural products can act as potential miRNA modulators for the management of bladder cancer. Polyphenols, flavonoids, and other phytochemicals are natural compounds found to have inherent potential to modulate miRNAs and reform the oncogenic properties of bladder cancer cells regulating cell growth and death. In integration with the current cancer treatment regimes, such natural agents may safely substitute for the traditional chemical chemotherapeutic agents of the conventional approaches. To this end, this review presents the existing knowledge of natural compounds as regulators of miRNA, their mechanisms for the management of BC, the role of their nanoparticles, and future novel therapies. The use of these compounds is not only a therapeutic practice for the conditions of bladder cancer, but it also upholds new avenues for creativity.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":"42 3","pages":"56"},"PeriodicalIF":2.8,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of anoikis in hepatocellular carcinoma: mechanisms and therapeutic potential.

IF 2.8 4区医学

Medical Oncology Pub Date : 2025-01-30 DOI: 10.1007/s12032-025-02612-9

Chen Chen, Mengyao Wang, Daoyuan Tu, Jun Cao, Chi Zhang, Dousheng Bai

{"title":"Roles of anoikis in hepatocellular carcinoma: mechanisms and therapeutic potential.","authors":"Chen Chen, Mengyao Wang, Daoyuan Tu, Jun Cao, Chi Zhang, Dousheng Bai","doi":"10.1007/s12032-025-02612-9","DOIUrl":"https://doi.org/10.1007/s12032-025-02612-9","url":null,"abstract":"Hepatocellular carcinoma (HCC), the most common primary liver cancer, is a highly aggressive malignancy with limited viable therapeutic options. For early HCC, resection surgery is currently the most effective treatment. However, in advanced stages, resection alone does not sufficiently address the disease, so finding a method with a better prognosis is necessary. Anoikis, known as matrix detachment-induced apoptosis or detachment-induced cell death, is crucial for tissue development and homeostasis. Cancer cells develop means to evade anoikis, e.g. anoikis resistance, thereby allowing for cells to survive under anchorage-independent conditions. HCC cells often acquire resistance to anoikis, allowing them to survive after detaching from the extracellular matrix and contributing to tumor spread. This review discusses the mechanisms of anoikis in HCC, exploring the potential of drug-induced anoikis and targeting anoikis resistance as promising therapeutic strategies for treating HCC, analyzing the value of anoikis in the immune of HCC, and propose potential pathways in oncotherapy, which can provide background knowledge for subsequent related research.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":"42 3","pages":"58"},"PeriodicalIF":2.8,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0