Medical physics最新文献

{"title":"Longitudinal in silico imaging study comparing digital mammography and digital breast tomosynthesis systems","authors":"Miguel A. Lago,&nbsp;Aldo Badano","doi":"10.1002/mp.17571","DOIUrl":"10.1002/mp.17571","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>In silico clinical trials are becoming more sophisticated and allow for realistic assessment and comparisons of medical image system models. These fully computational models enable fast and affordable trial designs that can closely capture trends seen on real clinical trials.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To evaluate three breast imaging system models for digital mammography (DM) and digital breast tomosynthesis (DBT) in a fully-in-silico longitudinal study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We developed in silico models for three different breast imaging systems by modeling relevant characteristics such as detector technology, pixel size, number of projections, and angular span. We use a computational image reader to detect masses at different growing stages to compute the relative system performance. Similarly, we compare calcification cluster detectability across systems. The Detectability area under the ROC curve (AUC) was calculated for each combination of breast density, device model, lesion size and type, and search area. We compared the absolute and relative AUC values for DM and DBT. The trial consisted of 45 000 simulated images corresponding to 750 virtual digital patient models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We observed proportional AUC values with increasing mass size. On the other hand, higher breast densities showed lower AUC values. For masses, we found significant performance differences between device models. The highest average AUC difference between DBT and DM was 0.109, benefiting DBT. For calcifications, DM showed higher performance than DBT, especially in highly dense breasts. The highest AUC difference on a model was –0.055, benefiting DM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In this fully-in-silico imaging trial, we compared three imaging systems with different detector technologies on the same cohort of virtual digital patient models. We found that breast device systems can lead to visibility differences in masses and calcifications. Our longitudinal, multi-device in silico study was possible because of the versatility and flexibility of in silico methods. This study shows the advantages of this in silico methodology in lowering the resources needed for device development, optimization, and regulatory evaluation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18384,"journal":{"name":"Medical physics","volume":"52 3","pages":"1960-1968"},"PeriodicalIF":3.2,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and 3D printing of pelvis phantoms for cementoplasty","authors":"Cléa Sieffert,&nbsp;Laurence Meylheuc,&nbsp;Bernard Bayle,&nbsp;Julien Garnon","doi":"10.1002/mp.17560","DOIUrl":"10.1002/mp.17560","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Percutaneous image-guided cementoplasty is a medical procedure for strengthening bones structurally altered by disease, such as osteolytic metastasis. This procedure involves injecting biocompatible liquid bone cement, through one or more trocars into the damaged bone. Within a few minutes the bone cement hardens and restores the rigidity of the bony structure. The introduction of this technique in the case of large cancellous bones, such as the pelvis, raises some practical issues such as: how to manage the flow of cement with variable viscosity over time and how to inject a large amount of cement under fluoroscopy to effectively restore the patient's ability to bear weight?&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Purpose&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;As a means of training for young practitioners to ensure maximal filling of a metastatic bone area, we have designed and manufactured a pelvic phantom capable of replicating cement diffusion in healthy and metastatic bone under fluoroscopic and computed tomography guidance.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The preliminary stage of the study consisted of an analysis of various lattice structures, with the objective of reproducing the haptic feedback experienced during the needle insertion and diffusion of cement within the trabecular bone. Cementoplasty tests were conducted by an experienced radiologist under fluoroscopy and CT guidance to evaluate the performance of the lattice structure. The initial analysis provided the groundwork for the design of the phantom pelvis, which was then evaluated against a patient case. The phantom was divided into two distinct components: a disposable section with lattice structure, intended for the injection of cement, and a reusable part representing the pelvic bones. Two additive manufacturing methods were selected for the production of the phantom: Stereolithography (SLA) for the lattice structure and Fused Deposition Modeling (FDM) for the pelvic bones. The disposable component was composed of different lattice structures, selected to best match the anatomic conditions of both healthy and diseased areas visible on the patient images. Subsequently, the performance of the phantom was validated against patient images through a cementoplasty test.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 12 distinct lattice structures were subjected to three tests of cementoplasty. Stochastic lattices with 500 microns beam thickness and densities varying from 15% to 5% demonstrated the most effective replication of the needle haptic feedback, as w","PeriodicalId":18384,"journal":{"name":"Medical physics","volume":"52 3","pages":"1454-1467"},"PeriodicalIF":3.2,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mp.17560","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encoding matching criteria for cross-domain deformable image registration","authors":"Zhuoyuan Wang,&nbsp;Haiqiao Wang,&nbsp;Dong Ni,&nbsp;Ming Xu,&nbsp;Yi Wang","doi":"10.1002/mp.17565","DOIUrl":"10.1002/mp.17565","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Most existing deep learning-based registration methods are trained on single-type images to address same-domain tasks, resulting in performance degradation when applied to new scenarios. Retraining a model for new scenarios requires extra time and data. Therefore, efficient and accurate solutions for cross-domain deformable registration are in demand.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Purpose&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We argue that the tailor-made matching criteria in traditional registration methods is one of the main reason they are applicable in different domains. Motivated by this, we devise a registration-oriented encoder to model the matching criteria of image features and structural features, which is beneficial to boost registration accuracy and adaptability.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Specifically, a general feature encoder (Encoder-G) is proposed to capture comprehensive medical image features, while a structural feature encoder (Encoder-S) is designed to encode the structural self-similarity into the global representation. Moreover, by updating Encoder-S using one-shot learning, our method can effectively adapt to different domains. The efficacy of our method is evaluated using MRI images from three different domains, including brain images (training/testing: 870/90 pairs), abdomen images (training/testing: 1406/90 pairs), and cardiac images (training/testing: 64770/870 pairs). The comparison methods include traditional method (SyN) and cutting-edge deep networks. The evaluation metrics contain dice similarity coefficient (DSC) and average symmetric surface distance (ASSD).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In the single-domain task, our method attains an average DSC of 68.9%/65.2%/72.8%, and ASSD of 9.75/3.82/1.30 mm on abdomen/cardiac/brain images, outperforming the second-best comparison methods by large margins. In the cross-domain task, without one-shot optimization, our method outperforms other deep networks in five out of six cross-domain scenarios and even surpasses symmetric image normalization method (SyN) in two scenarios. By conducting the one-shot optimization, our method successfully surpasses SyN in all six cross-domain scenarios.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Our method yields favorable results in the single-domain task while ensuring improved generalization and adaptation performance in the cross-domain task, showing its feasibility for the challenging cross-domain registration applications. The code is publicly available at https://github.com/JuliusWang-7","PeriodicalId":18384,"journal":{"name":"Medical physics","volume":"52 4","pages":"2305-2315"},"PeriodicalIF":3.2,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 2D detector array for relative dosimetry and beam steering for FLASH radiotherapy with electrons","authors":"Andreas A. Schönfeld,&nbsp;Jeff Hildreth,&nbsp;Alexandra Bourgouin,&nbsp;Veronika Flatten,&nbsp;Jakub Kozelka,&nbsp;William Simon,&nbsp;Andreas Schüller","doi":"10.1002/mp.17573","DOIUrl":"10.1002/mp.17573","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;FLASH radiotherapy is an emerging treatment modality using ultra-high dose rate beams. Much effort has been made to develop suitable dosimeters for reference dosimetry, yet the spatial beam characteristics must also be characterized to enable computerized treatment planning, as well as quality control and service of a treatment delivery device. In conventional radiation therapy, this is commonly achieved by beam profile scans in a water phantom using a point detector. In ultra-high dose rate beams, the delivered dose needed for a set of beam profile scans may exceed the regulatory dose limit specified for a typical treatment room, or degrade components of the scanning system and scanning detector. Point detector scans also cannot quantify the pulse-to-pulse stability of a beam profile. Detector arrays can overcome these challenges, but to date, no detector arrays suitable for ultra-high dose rate beams are commercially available.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Purpose&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The study presents the development and characterization of a two-dimensional detector array for measuring pulse-resolved spatial fluence distributions in real-time and temporal structure of intra-pulse dose rate of ultra-high pulsed dose rate (UHPDR) electron beams used in FLASH radiotherapy.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The performance of the SunPoint 1 diode was evaluated by measuring the response of the EDGE Detector in a 20 MeV UHPDR electron beam with a dose per pulse of 0.04 Gy – 6 Gy at a pulse duration of 1 µs or 1.9 µs, and instantaneous dose rates of 0.040 – 3.2 MGy·s&lt;sup&gt;−1&lt;/sup&gt;. Based on the findings regarding a suitable signal acquisition technique, a PROFILER 2 detector array made of SunPoint 1 diodes was then modified by minimizing trace resistance, applying a reverse bias, and implementing an RC component to each diode to optimize the transfer of the collected charge during a pulse. The resultant “FLASH Profiler” was then tested in the same UHPDR electron beam.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The FLASH Profiler exhibited a linear response within ± 3% deviation over the investigated dose per pulse range. The FLASH Profiler array showed good agreement with the absolute dose measured using a flashDiamond point detector and an integrating current transformer for dose-per-pulse values of up to 6 Gy. The FLASH Profiler was able to measure lateral beam profiles in real-time and on a single-pulse basis. The ability to capture and display the profiles during steering of UHPDR beams was demonstrated. ","PeriodicalId":18384,"journal":{"name":"Medical physics","volume":"52 3","pages":"1845-1857"},"PeriodicalIF":3.2,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mp.17573","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosimetric study of synchrotron rapid beam off control and skip spot function for high beam intensity proton therapy","authors":"Masashi Yagi,&nbsp;Keith M. Furutani,&nbsp;Toshiyuki Ogata,&nbsp;Takuya Nomura,&nbsp;Masumi Umezawa,&nbsp;Xiaoying Liang,&nbsp;Kei Yamada,&nbsp;Hideya Yamazaki,&nbsp;Shinichi Shimizu,&nbsp;Chris J. Beltran","doi":"10.1002/mp.17589","DOIUrl":"10.1002/mp.17589","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;All Hitachi proton pencil beam scanning facilities currently use discrete spot scanning (DSS). Mayo Clinic Florida (MCF) is installing a Hitachi particle therapy system with advanced technologies, including fast scan speeds, high beam intensity, rapid beam off control (RBOC), a skip spot function, and proton pencil beam scanning using dose driven continuous scanning (DDCS). A potential concern of RBOC is the generation of a shoulder at the end of the normal spot delivery due to a flap spot (FS) with a flap dose (FD), which has been investigated for carbon synchrotron but not for proton delivery. While investigated, for instance, for Hitachi's installation at MCF, this methodology could be applicable for all future high intensity proton deliveries.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Purpose&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;No Hitachi proton facility currently uses the proposed RBOC. This study aimed to understand the dosimetric impact of proton FD at MCF by simulating the FS with a Hitachi proton machine in research mode, reflecting the higher proton intensities expected with RBOC at MCF.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Method&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Experiments were conducted to simulate MCF RBOC at Kyoto Prefecture University of Medicine (KPUM) in research mode, reducing delay time (Td) from 1.5 ms to 0.1 ms. 5,000 contiguous spots were delivered on the central axis for proton energies of 70.2, 142.5, and 220.0 MeV; at normal, high dose rate (HDR), and ultra-high dose rate (uHDR) intensities; and at vertical and horizontal gantry angles for different Td. Measurements were taken using a fast oscilloscope and the nozzle's spot position monitor (SPM) and dose monitor (DM). A model was developed to predict FD dependence on beam intensity and assess the dosimetric impact for prostate and brain treatment plans. Two simulation types were planned: a flap DSS plan with FS at every spot and a flap DDCS plan with FS only at the end of each layer.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Result&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;FD was observed for RBOC with Td = 0.1 ms, showing no gantry angle dependence. FD increased with higher delayed dose rate (DDR), that is, beam intensity. The planning study showed dose volume histogram deterioration with increased FD compared to the clinical plan, but it was only significant for uHDR intensities. Deterioration was marginal in flap DSS plans for the HDR intensities planned at MCF, and flap DDCS plans were even less sensitive than flap DSS plans.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;MCF is installing proton DDCS with higher beam intensities, a skip spot fu","PeriodicalId":18384,"journal":{"name":"Medical physics","volume":"52 3","pages":"1867-1877"},"PeriodicalIF":3.2,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional dosimetry using multiple-energy delivery and a single-layer detector for quality assurance in proton pencil beam scanning","authors":"Roberto Righetto,&nbsp;Elena Fogazzi,&nbsp;Francesco Tommasino,&nbsp;Paolo Farace","doi":"10.1002/mp.17584","DOIUrl":"10.1002/mp.17584","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In Proton Therapy, the presence of implants along the beam path is known to potentially affect the dose distribution. The way such implants are managed in the planning process can vary in the different treatment planning systems (TPSs) and different centers. A specific validation procedure should be accomplished to verify the accuracy of TPS computation in these conditions and accept the applied process before treating patients.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Purpose&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The aim of this study is to present a quality assurance (QA) tool in pencil beam scanning proton therapy by a method based on multiple-energy delivery and a single-layer two-dimensional detector and to apply it for verifying three-dimensional dose computation and correcting CT calibration in the presence of implants.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Multiple-energy delivery with a single-layer detector (MESL) acquisitions were performed for 80 energy layers (70-150MeV), composed of equally weighted pencil beam spots. MESL measures were acquired using a two-dimensional MatriXX-IBA detector. A transformation of the energy modulation to spatial modulation was obtained by using the power-law relationship of initial energy and range. The setup design involved a reference configuration, allowing to compensate for potential offsets, and the same configuration with an additional phantom to be measured. Both setups were imaged by a CT scanner, and the dose was computed by the TPS. The comparison of TPS-computed and MESL-measured data of the phantom was performed by producing a 2D map of range-error. For testing the procedure, plastic slabs and rods made of tissue equivalent materials (TEMs), with known water equivalent path length (WEPL), were used. Range error mapping was then applied to verify dose computation with a titanium cylinder and a titanium implant. Numerical procedures were obtained by modifying at the TPS the segmented volume, or the value in the CT calibration curve for the titanium objects. The optimal values were then determined by identifying the one that minimizes residual range error.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The results of the consistency test on the plastic slabs and the TEM rods showed differences between measured and expected WEPL below 1%, confirming the reliability of the method and the energy-spatial transformation. In the titanium cylinder, the optimal volume and the point in the calibration curve (relative to the titanium saturated value), to be used for TPS simulation is about the real size of the cylinder and the tabulated stopping power value. However, the optimal va","PeriodicalId":18384,"journal":{"name":"Medical physics","volume":"52 3","pages":"1769-1778"},"PeriodicalIF":3.2,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graph theory analysis of a human body metabolic network: A systematic and organ-specific study","authors":"Jingxuan Ruan,&nbsp;Yaping Wu,&nbsp;Haiyan Wang,&nbsp;Zhenxing Huang,&nbsp;Ziwei Liu,&nbsp;Xinlang Yang,&nbsp;Yongfeng Yang,&nbsp;Hairong Zheng,&nbsp;Dong Liang,&nbsp;Meiyun Wang,&nbsp;Zhanli Hu","doi":"10.1002/mp.17568","DOIUrl":"10.1002/mp.17568","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Purposes&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Positron emission tomography (PET) imaging is widely used to detect focal lesions or diseases and to study metabolic abnormalities between organs. However, analyzing organ correlations alone does not fully capture the characteristics of the metabolic network. Our work proposes a graph-based analysis method for quantifying the topological properties of the network, both globally and at the nodal level, to detect systemic or single-organ metabolic abnormalities caused by diseases such as lung cancer.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We used whole-body &lt;sup&gt;18&lt;/sup&gt;F-fluorodeoxyglucose (&lt;sup&gt;18&lt;/sup&gt;F-FDG) standardized uptake value (SUV) images from 32 lung cancer patients and 20 healthy controls to construct two-organ glucose metabolism correlation networks at the population level. We calculated five global measures and three nodal centralities for these networks to explore the small-world, rich-club and modular organization in the metabolic network. Additionally, we analyzed the preference for connections significantly affected by lung cancer by dividing organs according to system level and spatial location.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In lung cancer patients, functional segregation in metabolic networks increased (increased &lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;msub&gt;\u0000 &lt;mi&gt;C&lt;/mi&gt;\u0000 &lt;mi&gt;p&lt;/mi&gt;\u0000 &lt;/msub&gt;\u0000 &lt;annotation&gt;${{C}_p}$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt;, &lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;msub&gt;\u0000 &lt;mi&gt;E&lt;/mi&gt;\u0000 &lt;mi&gt;loc&lt;/mi&gt;\u0000 &lt;/msub&gt;\u0000 &lt;annotation&gt;${{E}_{{mathrm{loc}}}}$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt;, and &lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mi&gt;Q&lt;/mi&gt;\u0000 &lt;annotation&gt;$Q$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt;, &lt;i&gt;t&lt;/i&gt; &lt; 0), whereas functional integration decreased (increased &lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;msub&gt;\u0000 &lt;mi&gt;L&lt;/mi&gt;\u0000 &lt;mi&gt;p&lt;/mi&gt;\u0000 &lt;/msub&gt;\u0000 &lt;annotation&gt;${{L}_p}$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt;, &lt;i&gt;t&lt;/i&gt; &lt; 0, and decreased &lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;msub&gt;\u0000 &lt;mi&gt;E&lt;/mi&gt;\u0000 &lt;mi&gt;glob&lt;/mi&gt;\u0000 &lt;/msub&gt;\u0000 &lt;annotation&gt;${{E}_{{mathrm{glob}}}}$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt;, &lt;i&gt;t&lt;/i&gt; &gt; 0), indicating more localized and ","PeriodicalId":18384,"journal":{"name":"Medical physics","volume":"52 4","pages":"2340-2355"},"PeriodicalIF":3.2,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy verification of protoacoustic measurements in a heterogeneous phantom by an optical hydrophone","authors":"Ye Chen,&nbsp;Koki Kasamatsu,&nbsp;Yasutoshi Kuriyama,&nbsp;Tomonori Uesugi,&nbsp;Yoshihiro Ishi,&nbsp;Taichi Murakami,&nbsp;Sena Hidani,&nbsp;Michael Caulfield,&nbsp;Mehmet Burcin Unlu,&nbsp;Wolfgang Rohringer,&nbsp;Taeko Matsuura","doi":"10.1002/mp.17575","DOIUrl":"10.1002/mp.17575","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Protoacoustics has emerged as a promising real-time range measurement method for proton therapy. Optical hydrophones (OHs) are considered suitable to detect protoacoustic waves owing to their ultracompact size and high sensitivity. In our previous research, we demonstrated that the time-of-arrival (TOA) measured by an OH showed good agreement with the simulated ground truth in a homogeneous medium.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The purpose of the study was to experimentally evaluate the accuracy of the TOA and compression peak pressures detected by the OH. Protoacoustic waves that undergo the typical distortions occurring in the human body were investigated. In such cases, the use of small detectors such as OHs is desirable to minimize the effects of detector size and directivity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A 100-MeV proton pencil beam emitted from a fixed-field alternating gradient accelerator was irradiated onto a homogeneous water phantom and a water phantom with a half- or full-sized silicone plate downstream of the Bragg peak (BP) or a bone plate that covered half of the beam cross-section in the beam path. The OH was shifted 70 mm laterally across the beam axis downstream of the BP to measure the protoacoustic waves. The k-WAVE acoustic wave transport simulation was employed as the ground truth. The TOA and the first compression peak pressures were compared between the simulation and experiment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The TOA deviation against the ground truth was primarily attributed to alignment errors of the measurement devices and phantoms, with deviations of &lt; 1 mm. The peak pressure distribution closely resembled the ground truth, with FWHM differences of 0.0%–3.0% for the tested geometries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The OH was able to determine the TOA and peak pressures with sufficient accuracy in heterogeneous phantoms, even without considering the effect of the size of the detector or directivity on the measurements.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18384,"journal":{"name":"Medical physics","volume":"52 3","pages":"1893-1902"},"PeriodicalIF":3.2,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbubble enhanced ultrasound with low mechanical index promotes therapeutic angiogenesis in hind limb ischemia mouse model","authors":"Qiong Zhu,&nbsp;Ying He,&nbsp;Xiao Xiao Dong,&nbsp;Yali Xu,&nbsp;Yi Zhang,&nbsp;Zheng Liu","doi":"10.1002/mp.17539","DOIUrl":"10.1002/mp.17539","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Microbubble enhanced ultrasound (MEUS) can augment tissue perfusion by angiogenesis yet the best treatment ultrasound power in the initial ischemia period is uncertain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Considering the mechanical index (MI) is the most commonly used parameter for regulating diagnostic ultrasound power, here, we explored the effects of MEUS mediated by different MI on perfusion and sought to characterize the angiogenesis in the early stage of ischemia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Experiments were conducted on hind limb ischemia mouse model (HLI) and MEUS was administrated in the first week every other day following induction of HLI for four times. MEUS was conducted with a modified diagnostic ultrasound in combination with a lipid microbubble at 3 MHz and 21 cycles employing MI 0.3 (0.8 MPa), 0.7 (1.32 MPa) and 1.3 (2.78 MPa), respectively. Semi-quantitative visual score and blood perfusion quantitation by contrast-enhanced ultrasound were performed before each treatment. Hematoxylin-eosin staining and immunohistochemistry with CD31 were performed after four times treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed HLI mice in MI 0.3 mediated MEUS group longitudinally exhibited more blood perfusion in calf muscle and less visible necrosis compared to other experimental groups in the early stage. Additionally, diffused inflammatory cells with greater number of vessels in calf muscle were observed in MI 0.3 group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Low MI mediated MEUS had significantly greater effects on augmenting muscle blood perfusion and reducing necrosis in the initial period after HLI surgery. These effects are most likely mediated by angiogenesis stimulated by low MI mediated MEUS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18384,"journal":{"name":"Medical physics","volume":"52 3","pages":"1706-1716"},"PeriodicalIF":3.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-specific mapping of fundus photographs to three-dimensional ocular imaging","authors":"Corné Haasjes,&nbsp;T. H. Khanh Vu,&nbsp;Jan-Willem M. Beenakker","doi":"10.1002/mp.17576","DOIUrl":"10.1002/mp.17576","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Ocular proton beam therapy (OPT) planning would benefit from an accurate incorporation of fundus photographs, as various intra-ocular structures, such as the fovea, are not visible on conventional modalities such as Magnetic Resonance Imaging (MRI). However, the use of fundus photographs in OPT is limited, as the eye's optics induce a nonuniform patient-specific deformation to the images.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To develop a method to accurately map fundus photographs to three-dimensional images.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Personalized optical raytracing simulations were performed for 27 subjects, using subject-specific eye models based on corneal topography, biometry, and MRI. Light rays were traced through the eye for angles of 0°–85° with respect to the optical axis, in steps of 5°. These simulations provided a reference mapping between camera angles and retinal locations and were used to develop a mapping method without raytracing. The accuracy of this and earlier proposed methods was evaluated. Finally, the most accurate method was implemented in RayOcular, an image-based OPT planning system, and the fundus photography-based tumor contour was compared with MRI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>When a patient-specific second nodal point is taken as a reference to describe the retinal location, the camera, and retinal angles show a strong linear relation with a small variation between subjects. At a camera angle of 60°, for example, a corresponding retinal angle of 59.9° ± 0.4° (mean ± SD) was found. When this linear relation is used to predict the corresponding retinal location (without raytracing) of a camera angle of 40°, the mean (Euclidian distance) error in the retinal location was 0.02 mm (SD = 0.06 mm), which was significantly (<i>p</i> &lt; 0.001) lower than earlier proposed methods including EYEPLAN 4.16 mm (SD = 0.25 mm), the Lamberth projection −0.12 mm (SD = 0.46 mm) or polar projection 0.26 mm (SD = 0.57 mm). When implemented in the fundus view of RayOcular, the median distance between contours based on MRI and fundus photography was 0.2 mm (IQR = 0.1–0.3 mm).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The second nodal point provides a patient-specific reference for an accurate mapping of fundus photographs to three-dimensional images with sub-millimeter errors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18384,"journal":{"name":"Medical physics","volume":"52 4","pages":"2330-2339"},"PeriodicalIF":3.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mp.17576","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}