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[Effect of minoxidil on DNA synthesis in cultured fibroblasts from healthy skin or keloids]. 米诺地尔对健康皮肤或瘢痕疙瘩培养成纤维细胞DNA合成的影响。
Medicina cutanea ibero-latino-americana Pub Date : 1990-01-01
G Piñol, F Rueda, F Martí, L Puig, J M De Moragas
{"title":"[Effect of minoxidil on DNA synthesis in cultured fibroblasts from healthy skin or keloids].","authors":"G Piñol,&nbsp;F Rueda,&nbsp;F Martí,&nbsp;L Puig,&nbsp;J M De Moragas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A potential therapeutic role of minoxidil in fibrotic or sclerotic conditions, such as keloids, has been suggested on the basis of its reported ability to inhibit the proliferation of human dermal fibroblasts. We have studied the effect of minoxidil on 3H-deoxythymidine uptake in cultures of human dermal fibroblasts derived from lesional and non-lesional skin from patients with keloids. The effect of the addition of fetal bovine serum, plasma and growth factors (insulin, EGF, PDGF, FGF and beta-TGF) to the medium has also been studied. Minoxidil, at concentrations ranging from 500 to 1,000 microM., caused an increase in DNA synthesis, which was proportional to the initial degree of fibroblast activation. Concentrations higher than 1,000 microM. caused a cytotoxic effect. Some reservations arise on the potential therapeutic use of minoxidil in conditions characterized by increased fibroblast proliferation, given the narrow margin between activation of DNA synthesis and cytotoxicity we have found in our experimental model.</p>","PeriodicalId":18373,"journal":{"name":"Medicina cutanea ibero-latino-americana","volume":"18 1","pages":"13-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13366270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Wells syndrome (3 cases)]. [威尔斯综合征(3例)]。
Medicina cutanea ibero-latino-americana Pub Date : 1990-01-01
A Ojeda, J Mazuecos, I Sotillo, F Camacho
{"title":"[Wells syndrome (3 cases)].","authors":"A Ojeda,&nbsp;J Mazuecos,&nbsp;I Sotillo,&nbsp;F Camacho","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This report describes three cases of eosinophilic cellulitis (Wells' syndrome) observed during six years. In the author's opinion this condition is not frequent, but neither exceptional. A revision of clinico-pathological, etiopathogenic and therapeutics aspects is carried out.</p>","PeriodicalId":18373,"journal":{"name":"Medicina cutanea ibero-latino-americana","volume":"18 2","pages":"124-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13367590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Tubular apocrine adenoma. Description of 4 cases]. 管状大汗腺瘤。[4例描述]。
Medicina cutanea ibero-latino-americana Pub Date : 1990-01-01
M A Barnadas, A Moreno, R Pujol, R G Freeman, J M De Moragas
{"title":"[Tubular apocrine adenoma. Description of 4 cases].","authors":"M A Barnadas,&nbsp;A Moreno,&nbsp;R Pujol,&nbsp;R G Freeman,&nbsp;J M De Moragas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We present four new cases of tubular apocrine adenoma. Clinical histopathological and ultrastructural findings are discussed. The presence of carcinoembryonic antigen (CEA) has been studied in three cases of tubular apocrine adenoma. This antigen was found predominantly in the lumen of the ducts and in the apical portion of the luminal cells. This pattern is similar to the distribution described in normal sweat glands and in other adnexal tumors.</p>","PeriodicalId":18373,"journal":{"name":"Medicina cutanea ibero-latino-americana","volume":"18 1","pages":"35-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13367686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Eosinophilic cellulitis (Wells syndrome)]. [嗜酸性蜂窝织炎(威尔斯综合征)]。
Medicina cutanea ibero-latino-americana Pub Date : 1990-01-01
N E Oriban
{"title":"[Eosinophilic cellulitis (Wells syndrome)].","authors":"N E Oriban","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There is a 37 years old patient with a erythemato-nodular pathology on her lower limbs, which has relapsed during three years. The characteristics of the eosinophilic cellulitis are observed in the microscopic study. The clinical and laboratory attributes of this entity are discussed, according to the world medical literature.</p>","PeriodicalId":18373,"journal":{"name":"Medicina cutanea ibero-latino-americana","volume":"18 2","pages":"128-31"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13367591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Subungual keratoacanthoma]. [蹄下角化棘皮瘤]。
Medicina cutanea ibero-latino-americana Pub Date : 1990-01-01
M Evole Buselli, R Botella Estrada, M Hernández Martí, J M Fortea Baixauli, A Aliaga Boniche
{"title":"[Subungual keratoacanthoma].","authors":"M Evole Buselli,&nbsp;R Botella Estrada,&nbsp;M Hernández Martí,&nbsp;J M Fortea Baixauli,&nbsp;A Aliaga Boniche","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We present a case of subungueal keratoacanthoma. The tumor recurred three months after extirpation and didn't resolve spontaneously. The patient need a new surgery a year later. We revised the literature and comment the clinical and histological features that define this distinct entity and differentiate it from common keratoacanthoma and subungueal squamous cell carcinoma.</p>","PeriodicalId":18373,"journal":{"name":"Medicina cutanea ibero-latino-americana","volume":"18 2","pages":"145-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13367595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Perforating annular granuloma in an atypical location]. [非典型部位的穿孔环形肉芽肿]。
Medicina cutanea ibero-latino-americana Pub Date : 1990-01-01
M C Gutiérrez, A Hasson, D Arias, E Zamora, L Martín, A Barat, A De Castro
{"title":"[Perforating annular granuloma in an atypical location].","authors":"M C Gutiérrez,&nbsp;A Hasson,&nbsp;D Arias,&nbsp;E Zamora,&nbsp;L Martín,&nbsp;A Barat,&nbsp;A De Castro","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report a case of perforating granuloma annulare characterized by a scare number of lesions, that were located around breast areola. The patient was a young female without personal or family remarkable history.</p>","PeriodicalId":18373,"journal":{"name":"Medicina cutanea ibero-latino-americana","volume":"18 1","pages":"5-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13367689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Zosteriform eruption in a girl during resolution of varicella]. [女孩水痘消退期间带状疱疹状爆发]。
Medicina cutanea ibero-latino-americana Pub Date : 1990-01-01
L J del Pozo, J Vilella
{"title":"[Zosteriform eruption in a girl during resolution of varicella].","authors":"L J del Pozo,&nbsp;J Vilella","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We show the case of a six-years-old little girl with a herpes zoster which appeared while a varicella was resolving. We are discussing the diagnosis difficulties of this process.</p>","PeriodicalId":18373,"journal":{"name":"Medicina cutanea ibero-latino-americana","volume":"18 3","pages":"151-3"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13414235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Fibrous hamartoma in childhood]. [儿童纤维错构瘤]。
Medicina cutanea ibero-latino-americana Pub Date : 1990-01-01
G de Anda, A Viñas, M Pous, L Pazos de di Matteo, R Vignale
{"title":"[Fibrous hamartoma in childhood].","authors":"G de Anda,&nbsp;A Viñas,&nbsp;M Pous,&nbsp;L Pazos de di Matteo,&nbsp;R Vignale","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A new case of fibrous hamartoma of infancy is described as a benign but persistent soft-tissue tumor that appears during the first 2 years of life, as a rare condition. The histopathological study shows the three characteristic elements: fibrous, uni-locular adipose tissue and mixoid mesenchymal tissue. The histogenesis of this peculiar tumor is discussed.</p>","PeriodicalId":18373,"journal":{"name":"Medicina cutanea ibero-latino-americana","volume":"18 3","pages":"175-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13414239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Vasculitic urticaria: study of 12 cases]. 血管性荨麻疹:附12例分析
Medicina cutanea ibero-latino-americana Pub Date : 1990-01-01
M L Hassan, J A Perez Cejudo, E Yachi del Pino, R G Schroh
{"title":"[Vasculitic urticaria: study of 12 cases].","authors":"M L Hassan,&nbsp;J A Perez Cejudo,&nbsp;E Yachi del Pino,&nbsp;R G Schroh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Twelve cases of chronic urticaria with histopathologic features of lecocitoclastic allergic angitis are studied. The type of cutaneous lesion, personal and familiar atopic history and the presence of autoimmune disease are described. Light microscopy, direct immunofluorescence, anti DNA, antinuclear, antithyroid, Ro, La, Rnp and Sm antibodies, total complement levels, C3 and C4, rheumatoid factor, latex, ASTO, cryoglobulines and complete workup were investigated, taking into account natural progression and response to therapy. Two different groups are defined: 1) normocomplementemic (5 patients) and 2) hypocomplementemic (7 patients). They were all women except one. The cutaneous lesions were indistinguishable in the two groups. Only in the second group there was an associated disease (systemic lupus erythematosus, Sjogren syndrome disease, lupus-Sjogren overlap, autoimmune thyroid disease). Urticaria had been present from the onset of the disease in 4 patients, and occurred later during its course in 8 others. Five patients had thyroid disease (Hashimoto thyroiditis or Graves disease), two of them being mother and daughter. Another patient had a family history of Grave's disease and urticaria. Anti DNA antibodies were found in 7 cases, and anti Ro + La + in 3 cases. Response to treatment was variable with spontaneous cycles of worsening and remissions. One of the patients found a relationship with certain foods. Histopathologic results are related in both clinical normocomplementemic and hypocomplementemic groups. No significant differences were found between the two groups, but Ro+ and La+ patients exhibit more intense cariorexis and neutrophilic infiltrates.</p>","PeriodicalId":18373,"journal":{"name":"Medicina cutanea ibero-latino-americana","volume":"18 3","pages":"179-84"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13414240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Epithelioid sarcoma. Immunohistochemical study. Therapy with recombinant alfa interferon]. (上皮样肉瘤。免疫组织化学研究。重组α干扰素治疗]。
Medicina cutanea ibero-latino-americana Pub Date : 1990-01-01
J Porta, R Azcune, A E Ardura, A Arra, C F Gatti
{"title":"[Epithelioid sarcoma. Immunohistochemical study. Therapy with recombinant alfa interferon].","authors":"J Porta,&nbsp;R Azcune,&nbsp;A E Ardura,&nbsp;A Arra,&nbsp;C F Gatti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case of Epithelioid Sarcoma in a 26 years old woman is reported. Clinical aspects of this entity are commented. Immunomarcation with monoclonal and policlonal antibodies was made, the findings were compared to those of the literature. Supervivence of the patient for 6 years without agressive surgery is remarked. Treatment was ruled out with recombinant alfa interferon for the last 3 years.</p>","PeriodicalId":18373,"journal":{"name":"Medicina cutanea ibero-latino-americana","volume":"18 3","pages":"191-6"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13414243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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