The journal of medical investigation : JMI最新文献_第3页

Development of p53-targeting drugs that increase radioresistance in normal tissues. p53靶向药物的发展，增加正常组织的辐射耐药性。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.66.219

Shintaro Ochi, Y. Nishiyama, A. Morita

{"title":"Development of p53-targeting drugs that increase radioresistance in normal tissues.","authors":"Shintaro Ochi, Y. Nishiyama, A. Morita","doi":"10.2152/jmi.66.219","DOIUrl":"https://doi.org/10.2152/jmi.66.219","url":null,"abstract":"Radiation damage to normal tissues is a serious concern in radiation therapy. Advances in radiotherapeutic technology have improved the dose distribution of the target volumes and risk organs, but damage to risk organs that are located within the irradiation field still limits the allowable prescription dose. To overcome this dose-limiting toxicity, and to further improve the efficacy of radiotherapy, the development of drugs that protect normal tissues but not cancer tissues from the effects of radiation are expected to be developed based on molecular target-based drugs. p53 is a well-known transcription factor that is closely associated with radiation-induced cell death. In radiation-injured tissues, p53 induces apoptosis in hematopoietic lineages, whereas it plays a radioprotective role in the gastrointestinal epithelium. These facts suggest that p53 inhibitor would be effective for radioprotection of the hematopoietic system, and that a drug that upregulates the radioprotective functions of p53 would enhance the radioresistance of gastrointestinal tissues. In this review, we summarize recent progress regarding the prevention of radiation injury by regulating p53 and provide new strategic insights into the development of radioprotectors in radiotherapy. J. Med. Invest. 66 : 219-223, August, 2019.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114447499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Follicular fluid 8-Hydroxy-2-Deoxyguanosine (8-OHdG) as biomarker for oxidative stress in intracytoplasmic sperm injection. 卵泡液8-羟基-2-脱氧鸟苷(8-OHdG)作为胞浆内精子注射中氧化应激的生物标志物。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.69.112

Maher Abbood Mukheef, R. Ali, Hanaa Hameed Abbas Alheidery

{"title":"Follicular fluid 8-Hydroxy-2-Deoxyguanosine (8-OHdG) as biomarker for oxidative stress in intracytoplasmic sperm injection.","authors":"Maher Abbood Mukheef, R. Ali, Hanaa Hameed Abbas Alheidery","doi":"10.2152/jmi.69.112","DOIUrl":"https://doi.org/10.2152/jmi.69.112","url":null,"abstract":"Oxidative stress (OS) is a situation that occurs as a result of un-equilibrium between reactive oxygen species (ROS) formation and the antioxidant defence system. 8-hydroxy-2-deoxyguanosine (8-OHdG), an oxidized form of deoxyguanosine, is found in higher levels in aging oocytes. In this cross-sectional study, we aimed to evaluate the effect of 8-OHdG on the intracytoplasmic sperm injection (ICSI). Follicular fluid (FF) samples were taken after removing the oocyte for later analysis of 8-OHdG. The couples participants were categorized according to the cause of subfertility into three groups (female factor, malefactor, and unexplained infertility). Further division according to pregnancy state was done to evaluate the precise role of 8-OHdG on pregnancy state and ICSI outcome. Result : This study showed that the 8-OHdG levels significantly higher in non-pregnant women (p<0.05). Correlation study showed that 8-OHdG level in follicular fluid is negatively correlating with the number of retrieved oocytes, metaphase two oocytes (MII), fertilized oocytes (2PN = two pronuclei), cleaved zygotes, good quality embryos, and the difference was statistically significant (p<0.05). Conclusion: The study revealed that the 8-OHdG level in follicular fluid negatively influences ICSI outcome and it is higher in non-pregnant women. J. Med. Invest. 69 : 112-116, February, 2022.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114598230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Serum YKL-40 Level is Associated with Geriatric Nutritional Risk Index (GNRI) and γ-GTP in Hemodialysis Patients. 血液透析患者血清YKL-40水平与老年营养风险指数(GNRI)和γ-GTP相关

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.69.101

Kohsuke Yamada, T. Hyodo, Syunichiro Urabe, S. Haga, Toshio Hosaka

引用次数: 1

Surgical training in video-assisted neck surgery-based thyroidectomy using fresh frozen human cadavers. 以新鲜冷冻尸体为基础的视频辅助颈部甲状腺切除术的外科训练。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.66.293

M. Aoyama, H. Takizawa, Mitsuhiro Tsuboi, S. Yamasaki, Yoshihiro Tsuruo, A. Tangoku

{"title":"Surgical training in video-assisted neck surgery-based thyroidectomy using fresh frozen human cadavers.","authors":"M. Aoyama, H. Takizawa, Mitsuhiro Tsuboi, S. Yamasaki, Yoshihiro Tsuruo, A. Tangoku","doi":"10.2152/jmi.66.293","DOIUrl":"https://doi.org/10.2152/jmi.66.293","url":null,"abstract":"Endoscopic surgery has been introduced in various surgical fields. Endoscopic surgery requires different skills from open surgery due to the restricted surgical field and difficulty in identifying anatomical structures from certain viewpoints. Therefore, surgeons need to undergo sufficient surgical training before performing such surgery in the clinical setting. We examined the utility of fresh frozen human cadavers for surgical training aimed at introducing video-assisted neck surgery (VANS) at our department. First, we performed surgical training using fresh human cadavers four times. Next, we performed hemi-thyroidectomy with VANS in 5 clinical patients. After the cadaver training and the actual surgery, the surgeons evaluated each step of the surgical procedure using a 3-point scale. In the cadaver training, the scores for steps : creation of a subcutaneous tunnel and lifting up the skin flap and pre-thyroid muscles were higher than other steps. And a tracheal injury occurred as a complication. However, we were able to recognize anatomical structures under the endoscopic view. And it was also useful for confirming the role of surgical staff and simulating the placement of surgical equipment. Surgical training using fresh frozen human cadavers was effective at introducing a new surgical method. J. Med. Invest. 66 : 293-296, August, 2019.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"199 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129524604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Complication of portal vein thrombosis after right hemihepatectomy in a patient lacking the portal vein bifurcation. 缺乏门静脉分叉的右半肝切除术后门静脉血栓形成的并发症。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.315

H. Teraoku, Y. Arakawa, M. Yoshikawa, S. Yamada, Yu Saito, S. Iwahashi, T. Ikemoto, Y. Morine, S. Imura, M. Shimada

引用次数: 4

False-negatives due to poor specimens can be prevented based on the macroscopic findings for breast Vacuum-Assisted Biopsy specimens. 根据乳腺真空辅助活检标本的宏观表现，可以预防因标本质量差而导致的假阴性。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.69.51

Ayumi Izumori, Masako Takahashi, S. Sasa, Hiroaki Inoue, A. Tangoku, M. Kanematsu, M. Sasa

{"title":"False-negatives due to poor specimens can be prevented based on the macroscopic findings for breast Vacuum-Assisted Biopsy specimens.","authors":"Ayumi Izumori, Masako Takahashi, S. Sasa, Hiroaki Inoue, A. Tangoku, M. Kanematsu, M. Sasa","doi":"10.2152/jmi.69.51","DOIUrl":"https://doi.org/10.2152/jmi.69.51","url":null,"abstract":"PURPOSE\u0000Ultrasound-guided breast tissue biopsy is an essential technique for diagnosing breast disease, but sample errors reduce its accuracy. This study investigated whether the histopathological results can be inferred from the macroscopic findings for Ultrasound-guided breast Vacuum Assisted Biopsy (VAB) specimens.\u0000\u0000\u0000METHODS\u0000Biopsy specimens from 101 patients who underwent mammary gland VAB were photographed with a smartphone, and the relationships between the macroscopic findings and the pathological results were examined.\u0000\u0000\u0000RESULTS\u0000A significant difference was observed with regard to the presence/absence of turbidity: malignancy was detected in 33/37 (89%) specimens with turbidity and in 2/47 (4%) cases without turbidity (p<0.001). A significant difference was also observed regarding the surface properties:malignancy was detected in 14/70 (19%) smooth specimens and in 24/29 (83%) rough specimens (p<0.001). Also, malignancy was detected in 11/13 (85%) specimens with white spots, and the difference was significant (p<0.001). In addition, the characteristics of intraductal papilloma, fibroadenoma, and mastopathy could be confirmed by macroscopic findings.\u0000\u0000\u0000CONCLUSIONS\u0000When needle-biopsy of a lesion that is targeted for resection yields macroscopic findings that match the predicted histopathological findings, it can be thought that the biopsy had been properly performed. This means that false-negatives due to poor specimens can be prevented. J. Med. Invest. 69 : 51-56, February, 2022.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129561401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of olive oil consumption on aging in a senescence-accelerated mice-prone 8 (SAMP8) model. 食用橄榄油对衰老加速小鼠8 (SAMP8)模型衰老的影响。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.66.241

M. Bando, Saeko Masumoto, Masashi Kuroda, R. Tsutsumi, H. Sakaue

{"title":"Effect of olive oil consumption on aging in a senescence-accelerated mice-prone 8 (SAMP8) model.","authors":"M. Bando, Saeko Masumoto, Masashi Kuroda, R. Tsutsumi, H. Sakaue","doi":"10.2152/jmi.66.241","DOIUrl":"https://doi.org/10.2152/jmi.66.241","url":null,"abstract":"Background : Mediterranean diets have been linked to a reduced risk of cancer, vascular illnesses, Parkinson's and Alzheimer's disease. Olive oil is the primary fat source in the Mediterranean diet ; however, only a few studies have investigated the effect of olive oil on aging. In the present study, we aimed to determine whether consumption of olive oil significantly influences aging and memory in senescence-accelerated mouse-prone 8 (SAMP8). Methods : SAMP8 and senescence-accelerated mouse resistant 1 (SAMR1) mice were fed either 7% soy oil or 1% olive oil and 6% soy oil during a six-month study period. Reduction in memory in passive avoidance learning was examined after two months from the initiation of the experiment. Results : The weight of organs including the liver, kidney, spleen, and fat tissue changed significantly and memory performance was reduced in SAMP8 than in SAMR1 mice. There were no significant differences in SAMP8 and SAMR1 mice; however, blood triglyceride level decreased significantly in SAMP8 mice fed on olive oil. Conclusions : These results suggest that consuming olive oil may not have a protective role in aging and memory recall, but beneficial effects may be related to improvement in lipid metabolism. J. Med. Invest. 66 : 241-247, August, 2019.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129725071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Efficacy of proton pump inhibitor in combination with rikkunshito in patients complaining of globus pharyngeus. 质子泵抑制剂联合立健脾治疗咽球性麻痹的疗效观察。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.227

Seiichi Nakano, Hidetaka Iwasaki, Eiji Kondo, Katsushi Miyazaki, Haruhiko Shizuku, Seiichiro Kamimura, Junya Fukuda, Ryo Kanamura, N. Takeda

{"title":"Efficacy of proton pump inhibitor in combination with rikkunshito in patients complaining of globus pharyngeus.","authors":"Seiichi Nakano, Hidetaka Iwasaki, Eiji Kondo, Katsushi Miyazaki, Haruhiko Shizuku, Seiichiro Kamimura, Junya Fukuda, Ryo Kanamura, N. Takeda","doi":"10.2152/jmi.63.227","DOIUrl":"https://doi.org/10.2152/jmi.63.227","url":null,"abstract":"OBJECTIVE\u0000Globus pharyngeus (GP) is a common symptom of laryngopharyngeal reflux disease (LPRD), and proton pump inhibitor (PPI) and rikkunshito, a traditional Japanese medicine having prokinetic effect improve LPRD symptoms. In the present study, we examined the efficacy of high-dose PPI in combination with rikkunshito in patients complaining of GP.\u0000\u0000\u0000METHODS\u0000106 patients complaining of GP without any organic endoscopic findings were enrolled.\u0000\u0000\u0000RESULTS\u0000Patients were first administrated with high-dose PPI alone for 4 to 8 weeks and the symptom was improved in 65 patients. Among 41 patients with PPI-refractory GP, 22 patients were administrated with high-dose PPI in combination with rikkunshito, and the symptom was improved in 14 of 22 patients 4 weeks later. The average value of a modified reflux symptom index of the responders was similar to that of non-responders. Only a few patients had positive values in reflux finding scores in both groups.\u0000\u0000\u0000CONCLUSION\u0000The present findings suggest the existence of a high prevalence of LPRD in patients complaining of GP. The data also suggest that gastroesophageal dysmotility is involved in GP, in addition to excessive acid reflux. The pre-therapeutic laryngopharyngeal symptoms and endoscopic findings could not predict the efficacy of the treatment for GP. J. Med. Invest. 63: 227-229, August, 2016.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126693873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Successful Emergency Carotid Endarterectomy after Thrombolysis with Intravenous Recombinant Tissue-Type Plasminogen Activator. 静脉重组组织型纤溶酶原激活剂溶栓后颈动脉内膜切除术成功。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.300

Yoko Yamamoto, Toshiyuki Okazaki, K. Yoda, Y. Tada, S. Nagahiro

引用次数: 4

Delayed Diagnosis of Primary Bone and Soft Tissue Tumors Initially Treated as Degenerative Spinal Disorders. 原发性骨和软组织肿瘤最初治疗为退行性脊柱疾病的延迟诊断。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.274

Toshihiko Nishisho, T. Sakai, Fumitake Tezuka, Kosaku Higashino, S. Takao, Y. Takata, Ryo Miyagi, S. Toki, Mitsunobu Abe, Kazuta Yamashita, A. Nagamachi, K. Sairyo

{"title":"Delayed Diagnosis of Primary Bone and Soft Tissue Tumors Initially Treated as Degenerative Spinal Disorders.","authors":"Toshihiko Nishisho, T. Sakai, Fumitake Tezuka, Kosaku Higashino, S. Takao, Y. Takata, Ryo Miyagi, S. Toki, Mitsunobu Abe, Kazuta Yamashita, A. Nagamachi, K. Sairyo","doi":"10.2152/jmi.63.274","DOIUrl":"https://doi.org/10.2152/jmi.63.274","url":null,"abstract":"Background Symptoms of primary bone and soft tissue tumors located in the trunk mimic those of degenerative spinal disorders such as low back pain or pain or numbness of the legs. Due to their rarity, especially in sarcoma located in the trunk, diagnosis is sometimes delayed. Methods A retrospective review was performed of the records of 383 patients with primary bone and soft tissue tumors who visit our out patient clinic from 2011 to 2013 at a single institution. Patients with delayed diagnosis of primary bone and soft tissue tumors initially treated as degenerative spinal disorders for more than 2 months were identified. Results Of the 383 patients, 5 (1.3%) were initially diagnosed as having degenerative spinal disorders. All 5 patients had bone or soft tissue tumors in the lumbar spine or pelvis. Three patients had a malignant tumor (osteosarcoma, chondrosarcoma, or small round cell sarcoma) at the progressive stage, and 1 died of lung metastasis. Two patients had a benign tumor (aneurysmal bone cyst or simple bone cyst). Conclusions Our findings suggest that when low back pain and leg pain are refractory to conservative treatment, further radiological examination should be conducted. J. Med. Invest. 63: 274-277, August, 2016.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"25 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120901817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6