Mechanisms of Ageing and Development最新文献_第6页

Potential protein biomarkers in saliva for detection of frailty syndrome by targeted proteomics 通过靶向蛋白质组学检测虚弱综合征的唾液中潜在蛋白质生物标记物

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2024-07-20 DOI: 10.1016/j.mad.2024.111974

Alfonssina Niebla-Cárdenas , Nallely Bueno-Hernández , Angela-Patricia Hernández , Manuel Fuentes , Roberto Méndez-Sánchez , Eva María Arroyo-Anlló , Irene Orera , Giuseppe Lattanzio , Pablo Juanes-Velasco , Carlota Arias-Hidalgo , Ana Silvia Puente-González

{"title":"Potential protein biomarkers in saliva for detection of frailty syndrome by targeted proteomics","authors":"Alfonssina Niebla-Cárdenas , Nallely Bueno-Hernández , Angela-Patricia Hernández , Manuel Fuentes , Roberto Méndez-Sánchez , Eva María Arroyo-Anlló , Irene Orera , Giuseppe Lattanzio , Pablo Juanes-Velasco , Carlota Arias-Hidalgo , Ana Silvia Puente-González","doi":"10.1016/j.mad.2024.111974","DOIUrl":"10.1016/j.mad.2024.111974","url":null,"abstract":"<div><p>Frailty is a physiological geriatric syndrome, caused by immunosenescence, inflammation and alterations at the protein level leading to metabolic and microbiota changes. Currently, this syndrome is evaluated clinically with the Frailty-VIG index. The aim of the study was therefore to investigate the potential suitability of saliva as a non-invasive proximal biological fluid for the characterisation and identification of possible protein-level biomarkers in frailty syndrome. This cross-sectional study was conducted in a rural population of older Spanish adults using the SMR proteomics technique. A differential protein profile of eight potential and surrogate proteins (CYTC, CYTD, CYTS, CYTB, MIF, ALBU, CD44 and B2MG) was detected in saliva, all of which correlated with factors characterising frailty syndrome, such as vascular ageing (arterial stiffness and cardiovascular disease), obesity, mood problems, global cognitive impairment, changes in gait and hand pressure strength. The proteins CYTD (r = 0.415, p = 0.013) and CYTC (r = 0.280, p = 0.026), which were detected differentially in the protein profile, were associated with the Frailty-VIG index. All analysed proteins are associated not only with the clinical symptoms of frailty syndrome, but also with an acute inflammatory response, endothelial cell proliferation and the complement system, among others.</p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"221 ","pages":"Article 111974"},"PeriodicalIF":5.3,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sestrin2 plays a protective role in age-related hearing loss by inhibiting NLRP3-inflammasome activity Sestrin2 通过抑制 NLRP3-炎症小体的活性，在老年性听力损失中发挥保护作用。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2024-07-15 DOI: 10.1016/j.mad.2024.111964

Liting Zheng , Menghua Li , Yalan Li , Liyuan Wu , Konduru Naveena , Mengzhu Zheng , Zhanqun Yang , Yong Pan , Yunshi Zhang , Shujin Chen , Yuehua Qiao , Yice Xu , Long Chen , Xi Shi

引用次数: 0

REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress 通过抑制 TXNIP 介导的氧化应激，敲除 REDD1 可改善内皮细胞衰老。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2024-07-14 DOI: 10.1016/j.mad.2024.111962

Qingqiu Chen , Rong Hu , Hongmei Qiu , Shan Li , Peng Xiang , Yining Lu , Xianmin Wang , Tongchuan Wang , Lan Zhou , Wanping Zhang , E Wen , Limei Ma , Chao Yu

{"title":"REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress","authors":"Qingqiu Chen , Rong Hu , Hongmei Qiu , Shan Li , Peng Xiang , Yining Lu , Xianmin Wang , Tongchuan Wang , Lan Zhou , Wanping Zhang , E Wen , Limei Ma , Chao Yu","doi":"10.1016/j.mad.2024.111962","DOIUrl":"10.1016/j.mad.2024.111962","url":null,"abstract":"<div><p>Endothelial cell senescence characterized by reactive oxygen species (ROS) accumulation and chronic inflammation is widely recognized as a key contributor to atherosclerosis (AS). Regulated in development and DNA damage response 1 (REDD1), a conserved stress-response protein that regulates ROS production, is involved in the pathogenesis of various age-related diseases. However, the role of REDD1 in endothelial cell senescence is still unclear. Here, we screened REDD1 as a differentially expressed senescence-related gene in the AS progression using bioinformatics methods, and validated the upregulation of REDD1 expression in AS plaques, senescent endothelial cells, and aging aorta by constructing AS mice, D-galactose (DG)-induced senescent endothelial cells and DG-induced accelerated aging mice, respectively. siRNA against REDD1 could improve DG-induced premature senescence of endothelial cells and inhibit ROS accumulation, similar to antioxidant N-Acetylcysteine (NAC) treatment. Meanwhile, NAC reduced the upregulation of REDD1 induced by DG, supporting the positive feedback loop between REDD1 and ROS contributes to endothelial cell senescence. Mechanistically, the regulatory effect of REDD1 on ROS might be related to the TXNIP-REDD1 interaction in DG-induced endothelial cell senescence. Collectively, experiments above provide evidence that REDD1 participates in endothelial cell senescence through repressing TXNIP-mediated oxidative stress, which may be involved in the progression of atherosclerosis.</p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"221 ","pages":"Article 111962"},"PeriodicalIF":5.3,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A mechanistic analysis of metformin's biphasic effects on lifespan and healthspan in C. elegans: Elixir in youth, poison in elder 二甲双胍对 elegans 寿命和健康寿命双相影响的机制分析：年轻时的灵丹妙药，年老时的毒药。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2024-07-08 DOI: 10.1016/j.mad.2024.111963

{"title":"A mechanistic analysis of metformin's biphasic effects on lifespan and healthspan in C. elegans: Elixir in youth, poison in elder","authors":"","doi":"10.1016/j.mad.2024.111963","DOIUrl":"10.1016/j.mad.2024.111963","url":null,"abstract":"<div><p>Aging, a complex biological process influenced by genetic, environmental, and pharmacological factors, presents a significant challenge in understanding its underlying mechanisms. In this study, we explored the divergent impacts of metformin treatment on the lifespan and healthspan of young and old <em>C. elegans</em>, demonstrating a intriguing “elixir in youth, poison in elder” phenomenon. By scrutinizing the gene expression changes in response to metformin in young (day 1 of adulthood) and old (days 8) groups, we identified <em>nhr-57</em> and <em>C46G7.1</em> as potential modulators of age-specific responses. Notably, <em>nhr-57</em> and <em>C46G7.1</em> exhibit contrasting regulation patterns, being up-regulated in young worms but down-regulated in old counterparts following metformin treatment. Functional studies employing knockdown approaches targeting <em>nhr-57</em>, a gene under the control of <em>hif-1</em> with a documented protective function against pore-forming toxins in <em>C. elegans</em>, and <em>C46G7.1</em>, unveiled their critical roles in modulating lifespan and healthspan, as well as in mediating the biphasic effects of metformin. Furthermore, deletion of <em>hif-1</em> retarded the influence of metformin, implicating the involvement of <em>hif-1</em>/<em>nhr-57</em> in age-specific drug responses. These findings underscored the necessity of deciphering the mechanisms governing age-related susceptibility to pharmacological agents to tailor interventions for promoting successful aging.</p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"221 ","pages":"Article 111963"},"PeriodicalIF":5.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components 从实验室到临床，健康老龄化和抗衰老医学中的跨代激素作用：食物成分的作用。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2024-07-05 DOI: 10.1016/j.mad.2024.111960

Vittorio Calabrese , Naomi Osakabe , Rosalba Siracusa , Sergio Modafferi , Rosanna Di Paola , Salvatore Cuzzocrea , Ursula M. Jacob , Tilman Fritsch , Ali S. Abdelhameed , Luay Rashan , Uwe Wenzel , Claudio Franceschi , Edward J. Calabrese

{"title":"Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components","authors":"Vittorio Calabrese , Naomi Osakabe , Rosalba Siracusa , Sergio Modafferi , Rosanna Di Paola , Salvatore Cuzzocrea , Ursula M. Jacob , Tilman Fritsch , Ali S. Abdelhameed , Luay Rashan , Uwe Wenzel , Claudio Franceschi , Edward J. Calabrese","doi":"10.1016/j.mad.2024.111960","DOIUrl":"10.1016/j.mad.2024.111960","url":null,"abstract":"<div><p>Neurodegenerative diseases have multifactorial pathogenesis, mainly involving neuroinflammatory processes. Finding drugs able to treat these diseases, expecially because for most of these diseases there are no effective drugs, and the current drugs cause undesired side effects, represent a crucial point. Most <em>in vivo</em> and <em>in vitro</em> studies have been concentrated on various aspects related to neurons (e.g. neuroprotection), however, there has not been focus on the prevention of early stages involving glial cell activation and neuroinflammation. Recently, it has been demonstrated that nutritional phytochemicals including polyphenols, the main active constituents of the Mediterranean diet, maintain redox balance and neuroprotection through the activation of hormetic vitagene pathway. Recent lipidomics data from our laboratory indicate mushrooms as strong nutritional neuronutrients with strongly activity against neuroinflammation in Meniere’ diseaseas, a model of cochleovestibular neural degeneration, as well as in animal model of traumatic brain injury, or rotenone induced parkinson’s disease. Moreover, Hidrox®, an aqueous extract of olive containing hydroxytyrosol, and Boswellia, acting as Nrf2 activators, promote resilience by enhancing the redox potential, and thus, regulate through hormetic mechanisms, cellular stress response mechanisms., Thus, modulation of cellular stress pathways, in particular vitagenes system, may be an innovative approach for therapeutic intervention in neurodegenerative disorders.</p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"220 ","pages":"Article 111960"},"PeriodicalIF":5.3,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New opportunities for antioxidants in amelioration of neurodegenerative diseases 抗氧化剂在改善神经退行性疾病方面的新机遇。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2024-07-02 DOI: 10.1016/j.mad.2024.111961

{"title":"New opportunities for antioxidants in amelioration of neurodegenerative diseases","authors":"","doi":"10.1016/j.mad.2024.111961","DOIUrl":"10.1016/j.mad.2024.111961","url":null,"abstract":"<div><p>This comprehensive review elucidates the critical role of antioxidants to mitigate oxidative stress, a common denominator in an array of neurodegenerative disorders. Oxidative stress-induced damage has been linked to the development of diseases such as Alzheimer's, Parkinson's, Huntington's disease and amyotrophic lateral sclerosis. This article examines a wide range of scientific literature and methodically delineates the several methods by which antioxidants exercise their neuroprotective benefits. It also explores into the complex relationship between oxidative stress and neuroinflammation, focusing on how antioxidants can alter signaling pathways and transcription factors to slow neurodegenerative processes. Key antioxidants, such as vitamins C and E, glutathione, and polyphenolic compounds, are tested for their ability to combat reactive oxygen and nitrogen species. The dual character of antioxidants, which operate as both direct free radical scavengers and regulators of cellular redox homeostasis, is investigated in terms of therapeutic potential. Furthermore, the study focuses on new antioxidant-based therapy techniques and their mechanisms including Nrf-2, PCG1α, Thioredoxin etc., which range from dietary interventions to targeted antioxidant molecules. Insights into ongoing clinical studies evaluating antioxidant therapies in neurodegenerative illnesses offer an insight into the translational potential of antioxidant research. Finally, this review summarizes our present understanding of antioxidant processes in neurodegenerative illnesses, providing important possibilities for future study and treatment development.</p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"221 ","pages":"Article 111961"},"PeriodicalIF":5.3,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating oligodendrocyte precursor cell aging in brain health 导航大脑健康中的少突胶质前体细胞老化。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2024-06-29 DOI: 10.1016/j.mad.2024.111959

Freddy Leenders , Lisa Koole , Helena Slaets , Assia Tiane , Daniel van den Hove , Tim Vanmierlo

{"title":"Navigating oligodendrocyte precursor cell aging in brain health","authors":"Freddy Leenders , Lisa Koole , Helena Slaets , Assia Tiane , Daniel van den Hove , Tim Vanmierlo","doi":"10.1016/j.mad.2024.111959","DOIUrl":"10.1016/j.mad.2024.111959","url":null,"abstract":"<div><p>Oligodendrocyte precursor cells (OPCs) comprise 5–8 % of the adult glial cell population and stand out as the most proliferative cell type in the central nervous system (CNS). OPCs are responsible for generating oligodendrocytes (OLs), the myelinating cells of the CNS. However, OPC functions decline as we age, resulting in impaired differentiation and inadequate remyelination. This review explores the cellular and molecular changes associated with OPC aging, and their impact on OPC differentiation and functionality. Furthermore, it examines the impact of OPC aging within the context of multiple sclerosis and Alzheimer’s disease, both neurodegenerative conditions wherein aged OPCs exacerbate disease progression by impeding remyelination. Moreover, various pharmacological interventions targeting pathways related to senescence and differentiation are discussed as potential strategies to rejuvenate aged OPCs. Enhancing our understanding of OPC aging mechanisms holds promise for developing new therapies to improve remyelination and repair in age-related neurodegenerative disorders.</p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"220 ","pages":"Article 111959"},"PeriodicalIF":5.3,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0047637424000599/pdfft?md5=8f6ec31b977414b6df0f94db28131ae6&pid=1-s2.0-S0047637424000599-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifestyle factors and metabolomic aging biomarkers: Meta-analysis of cross-sectional and longitudinal associations in three prospective cohorts 生活方式因素与代谢组衰老生物标志物：三个前瞻性队列中横截面和纵向关联的元分析。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2024-06-29 DOI: 10.1016/j.mad.2024.111958

L.M. Kuiper , A.P. Smit , D. Bizzarri , E.B. van den Akker , M.J.T. Reinders , M. Ghanbari , J.G.J. van Rooij , T. Voortman , F. Rivadeneira , M.E.T. Dollé , G.C.M. Herber , M.L. Rietman , H.S.J. Picavet , J.B.J. van Meurs , W.M.M. Verschuren

{"title":"Lifestyle factors and metabolomic aging biomarkers: Meta-analysis of cross-sectional and longitudinal associations in three prospective cohorts","authors":"L.M. Kuiper , A.P. Smit , D. Bizzarri , E.B. van den Akker , M.J.T. Reinders , M. Ghanbari , J.G.J. van Rooij , T. Voortman , F. Rivadeneira , M.E.T. Dollé , G.C.M. Herber , M.L. Rietman , H.S.J. Picavet , J.B.J. van Meurs , W.M.M. Verschuren","doi":"10.1016/j.mad.2024.111958","DOIUrl":"10.1016/j.mad.2024.111958","url":null,"abstract":"<div><p>Biological age uses biophysiological information to capture a person’s age-related risk of adverse outcomes. MetaboAge and MetaboHealth are metabolomics-based biomarkers of biological age trained on chronological age and mortality risk, respectively. Lifestyle factors contribute to the extent chronological and biological age differ. The association of lifestyle factors with MetaboAge and MetaboHealth, potential sex differences in these associations, and MetaboAge’s and MetaboHealth’s sensitivity to lifestyle changes have not been studied yet.</p><p>Linear regression analyses and mixed-effect models were used to examine the cross-sectional and longitudinal associations of scaled lifestyle factors with scaled MetaboAge and MetaboHealth in 24,332 middle-aged participants from the Doetinchem Cohort Study, Rotterdam Study, and UK Biobank. Random-effect meta-analyses were performed across cohorts. Repeated metabolomics measurements had a ten-year interval in the Doetinchem Cohort Study and a five-year interval in the UK Biobank.</p><p>In the first study incorporating longitudinal information on MetaboAge and MetaboHealth, we demonstrate associations between current smoking, sleeping ≥8 hours/day, higher BMI, and larger waist circumference were associated with higher MetaboHealth, the latter two also with higher MetaboAge. Furthermore, adhering to the dietary and physical activity guidelines were inversely associated with MetaboHealth. Lastly, we observed sex differences in the associations between alcohol use and MetaboHealth.</p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"220 ","pages":"Article 111958"},"PeriodicalIF":5.3,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quercetin induces senolysis of doxorubicin-induced senescent fibroblasts by reducing autophagy, preventing their pro-tumour effect on osteosarcoma cells 槲皮素通过减少自噬诱导多柔比星诱导的衰老成纤维细胞发生衰老，防止其对骨肉瘤细胞产生促瘤效应

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2024-06-21 DOI: 10.1016/j.mad.2024.111957

Elisa Bientinesi, Sara Ristori, Matteo Lulli, Daniela Monti

{"title":"Quercetin induces senolysis of doxorubicin-induced senescent fibroblasts by reducing autophagy, preventing their pro-tumour effect on osteosarcoma cells","authors":"Elisa Bientinesi, Sara Ristori, Matteo Lulli, Daniela Monti","doi":"10.1016/j.mad.2024.111957","DOIUrl":"10.1016/j.mad.2024.111957","url":null,"abstract":"<div><p>Cellular senescence contributes to ageing and age-related diseases, and multiple therapeutic strategies are being developed to counteract it. Senolytic drugs are being tested in clinical trials to eliminate senescent cells selectively, but their effects and mechanisms are still unclear. Several studies reveal that the upregulation of senescence-associated secretory phenotype (SASP) factors in senescent cells is accompanied by increased autophagic activity to counteract the endoplasmic reticulum (ER) stress. Our study shows that Doxo-induced senescent fibroblasts yield several SASP factors and exhibit increased autophagy. Interestingly, Quercetin, a bioactive flavonoid, reduces autophagy, increases ER stress, and partially triggers senescent fibroblast death. Given the role of senescent cells in cancer progression, we tested the effect of conditioned media from untreated and quercetin-treated senescent fibroblasts on osteosarcoma cells to determine whether senolytic treatment affected tumour cell behaviour. We report that the partial senescent fibroblast clearance, achieved by quercetin, reduced osteosarcoma cell invasiveness, curbing the pro-tumour effects of senescent cells. The reduction of cell autophagic activity and increased ER stress, an undescribed effect of quercetin, emerges as a new vulnerability of Doxo-induced senescent fibroblasts and may provide a potential therapeutic target for cancer treatment, suggesting novel drug combinations as a promising strategy against the tumour.</p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"220 ","pages":"Article 111957"},"PeriodicalIF":5.3,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0047637424000575/pdfft?md5=73580d4a674eba5a0fc777fa2e17c7bb&pid=1-s2.0-S0047637424000575-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the interplay between stress mediators and skin microbiota in shaping age-related hallmarks: A review 探索压力介质和皮肤微位点在形成与年龄有关的特征方面的相互作用：综述。

IF 5.3 3区医学

Mechanisms of Ageing and Development Pub Date : 2024-06-19 DOI: 10.1016/j.mad.2024.111956

Marco Duarte , Sílvia Santos Pedrosa , P. Raaj Khusial , Ana Raquel Madureira

{"title":"Exploring the interplay between stress mediators and skin microbiota in shaping age-related hallmarks: A review","authors":"Marco Duarte , Sílvia Santos Pedrosa , P. Raaj Khusial , Ana Raquel Madureira","doi":"10.1016/j.mad.2024.111956","DOIUrl":"10.1016/j.mad.2024.111956","url":null,"abstract":"<div><p>Psychological stress is a major contributing factor to several health problems (e.g., depression, cardiovascular disease). Around 35 % of the world’s population suffers from it, including younger generations. Physiologically, stress manifests through neuroendocrine pathways (Hypothalamic-Pituitary-Adrenal (HPA) axis and Sympathetic-Adrenal-Medullary (SAM) system) which culminate in the production of stress mediators like cortisol, epinephrine and norepinephrine. Stress and its mediators have been associated to body aging, through molecular mechanisms such as telomere attrition, mitochondrial dysfunction, cellular senescence, chronic inflammation, and dysbiosis, among others. Regarding its impact in the skin, stress impacts its structural integrity and physiological function. Despite this review focusing on several hallmarks of aging, emphasis was placed on skin microbiota dysbiosis. In this line, several studies, comprising different age groups, demographic contexts and body sites, have reported skin microbiota alterations associated with aging, and some effects of stress mediators on skin microbiota have also been reviewed in this paper. From a different perspective, since it is not a “traditional” stress mediator, oxytocin, a cortisol antagonist, has been related to glucorticoids inhibition and to display positive effects on cellular aging. This hormone dysregulation has been associated to psychological issues such as depression, whereas its upregulation has been linked to positive social interaction.</p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"220 ","pages":"Article 111956"},"PeriodicalIF":5.3,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0047637424000563/pdfft?md5=c26c1e1c2a21527b3177f1c4590b6713&pid=1-s2.0-S0047637424000563-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141437060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0