Deciphering Osteosarcopenia through the hallmarks of aging

IF 5.3 3区医学 Q2 CELL BIOLOGY

Mechanisms of Ageing and Development Pub Date : 2024-10-11 DOI:10.1016/j.mad.2024.111997

Francisca Franulic , Felipe Salech , Daniel Rivas , Gustavo Duque

引用次数: 0

Abstract

Osteosarcopenia is a major driver of functional loss and a risk factor for falls, fractures, disability and mortality in older adults, urgently requiring the development of effective interventions to address it. The hallmarks of aging provide a theoretical and practical framework that allows for the structured organization of current knowledge and the planning of new development lines. This article comprehensively reviews the currently available literature on the role of the hallmarks of aging in the development of osteosarcopenia, thereby offering a panoramic view of the state of the art and knowledge gaps in this field.

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从衰老的标志解密骨肉疏松症

骨质疏松症是导致老年人功能丧失的一个主要因素，也是导致老年人跌倒、骨折、残疾和死亡的一个风险因素，迫切需要开发有效的干预措施来解决这一问题。老龄化的特征提供了一个理论和实践框架，可以有条理地组织现有知识并规划新的发展路线。本文全面回顾了有关老龄化特征在骨肉疏松症发展过程中的作用的现有文献，从而对这一领域的技术水平和知识差距提供了一个全景式的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mechanisms of Ageing and Development 医学-老年医学

CiteScore

11.10

自引率

1.90%

发文量

审稿时长

32 days

期刊介绍： Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.