Magnetochemistry最新文献

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Microstructural Engineering of Magnetic Wood for Enhanced Magnetothermal Conversion 磁性木材增强磁热转换的微结构工程
4区 化学
Magnetochemistry Pub Date : 2026-01-13 DOI: 10.3390/magnetochemistry12010011
Yuxi Lin, Chen Chen, Wei Xu
{"title":"Microstructural Engineering of Magnetic Wood for Enhanced Magnetothermal Conversion","authors":"Yuxi Lin, Chen Chen, Wei Xu","doi":"10.3390/magnetochemistry12010011","DOIUrl":"https://doi.org/10.3390/magnetochemistry12010011","url":null,"abstract":"The increasing energy crisis demands sustainable functional materials. Wood, with its natural three-dimensional porous structure, offers an ideal renewable template. This study demonstrates that microstructural engineering of wood is a decisive strategy for enhancing magnetothermal conversion. Using eucalyptus wood, we precisely tailored its pore architecture via delignification and synthesized Fe3O4 nanoparticles in situ through coprecipitation. We systematically investigated the effects of delignification and precursor immersion time (24, 48, 72 h) on the loading, distribution, and magnetothermal performance of the composites. Delignification drastically increased wood porosity, raising the Fe3O4 loading capacity from ~5–6% (in non-delignified wood) to over 14%. Immersion time critically influenced nanoparticle distribution: 48 h achieved optimal deep penetration and uniformity, whereas extended time (72 h) induced minor local agglomeration. The optimized composite (MDW-48) achieved an equilibrium temperature of 51.2 °C under a low alternating magnetic field (0.06 mT, 35 kHz), corresponding to a temperature rise (ΔT) > 24 °C and a Specific Loss Power (SLP) of 1.31W·g−1. This performance surpasses that of the 24 h sample (47 °C, SLP = 1.16 W·g−1) and rivals other bio-based magnetic systems. This work establishes a clear microstructure–property relationship: delignification enables high loading, while controlled impregnation tunes distribution uniformity, both directly governing magnetothermal efficiency. Our findings highlight delignified magnetic wood as a robust, sustainable platform for efficient low-field magnetothermal conversion, with promising potential in low-carbon thermal management.","PeriodicalId":18194,"journal":{"name":"Magnetochemistry","volume":"12 1","pages":"11-11"},"PeriodicalIF":0.0,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2312-7481/12/1/11/pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147909044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabrication of Spindle-like ZnO@Fe3O4 Nanocarriers for Targeted Drug Delivery and Controlled Release 纺锤形ZnO@Fe3O4纳米药物靶向递送与控释载体的制备
4区 化学
Magnetochemistry Pub Date : 2025-12-23 DOI: 10.3390/magnetochemistry12010002
YongFei GUO, Mao Yang, Yan Wang, Zhigang Tian, Tongguo Si
{"title":"Fabrication of Spindle-like ZnO@Fe3O4 Nanocarriers for Targeted Drug Delivery and Controlled Release","authors":"YongFei GUO, Mao Yang, Yan Wang, Zhigang Tian, Tongguo Si","doi":"10.3390/magnetochemistry12010002","DOIUrl":"https://doi.org/10.3390/magnetochemistry12010002","url":null,"abstract":"Developing precise tumor-targeting delivery systems while minimizing off-target toxicity continues to pose significant challenges in medicine application. The integration of two different functional materials has emerged as a promising strategy in current biomedical research. Herein, a hybrid nanocomposite consisting of Fe3O4 and ZnO was synthesized via a simple approach and employed as a nanoscale drug delivery system to explore the loading capacity and stimuli-responsive release characteristics of the anticancer agent doxorubicin (DOX). Results show that the synthesized nanoparticles (NPs) exhibit a multi-scale nanostructure consisting of the spindle-like ZnO nanorods with a mean length of 280 nm, on which the Fe3O4 NPs with a diameter of around 16 nm are uniformly dispersed. The ZnO@Fe3O4 NPs possess superparamagnetic behavior and a fast response to the external magnet and demonstrate exceptional near-infrared (NIR) photothermal conversion efficiency. In drug release studies, the ZnO@Fe3O4 NPs achieve the controlled DOX release in the simulated acidic tumor microenvironment as well as NIR laser irradiation. Further, the ZnO@Fe3O4-DOX composites significantly suppress the viability of human cervical cancer cells (HeLa) upon laser activation. These findings suggest that ZnO@Fe3O4 NPs are promising candidates for combined photothermal therapy, magnetic-targeted drug delivery, and stimuli-responsive controlled release applications.","PeriodicalId":18194,"journal":{"name":"Magnetochemistry","volume":"12 1","pages":"2-2"},"PeriodicalIF":0.0,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Programmable Magnetic Navigation of Gelatin Microrobots Enhances AB4 Delivery to Inflamed Lung Epithelium 凝胶微机器人的可编程磁导航增强AB4对炎症肺上皮的递送
4区 化学
Magnetochemistry Pub Date : 2025-11-01 DOI: 10.3390/magnetochemistry11110096
Yue Bu, Jianpeng Xu, Chuanhua Li, Zhixi Li, Yongjing Yu, Ziyong Yue
{"title":"Programmable Magnetic Navigation of Gelatin Microrobots Enhances AB4 Delivery to Inflamed Lung Epithelium","authors":"Yue Bu, Jianpeng Xu, Chuanhua Li, Zhixi Li, Yongjing Yu, Ziyong Yue","doi":"10.3390/magnetochemistry11110096","DOIUrl":"https://doi.org/10.3390/magnetochemistry11110096","url":null,"abstract":"Sepsis-induced acute lung injury (SALI) is characterized by dysregulated inflammation with limited therapeutic options. Although Anemoside B4 (AB4) exhibits anti-inflammatory properties, its clinical application is hindered by poor bioavailability. To address this limitation, we developed magnetically guided gelatin microrobots (MG-AB4) for targeted AB4 delivery. The MG-AB4 system consists of a Fe3O4-loaded gelatin shell for enabling precise magnetic navigation (velocity: 110 μm/s), an AB4 core for rapid drug release which is advantageous for acute inflammatory responses, and surface modifications to enhance cellular uptake. Compared with free AB4, MG-AB4 significantly suppressed key inflammatory cytokines (Interleukin-6 (IL-6), Interleukin-1 beta (IL-1β), Tumor necrosis factor-alpha (TNF-α); p < 0.01), inhibited NF-κB activation (p < 0.01), and improved cell viability in an inflammatory model (p < 0.05). This study demonstrates that magnetically guided AB4 delivery using rapidly releasing microrobots is a promising strategy for SALI treatment, wherein the synergy of targeted delivery and potent anti-inflammatory action may effectively mitigate disease progression.","PeriodicalId":18194,"journal":{"name":"Magnetochemistry","volume":"11 11","pages":"96-96"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2312-7481/11/11/96/pdf?version=1761992535","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
pH and Magnetic-Responsive Carboxymethyl Chitosan/Sodium Alginate Composites for Gallic Acid Delivery pH和磁响应的羧甲基壳聚糖/海藻酸钠复合材料递送没食子酸
4区 化学
Magnetochemistry Pub Date : 2025-09-28 DOI: 10.3390/magnetochemistry11100085
Kun Fang, Pei Li, Hanbing Wang, Xiangrui Huang, Y F Li
{"title":"pH and Magnetic-Responsive Carboxymethyl Chitosan/Sodium Alginate Composites for Gallic Acid Delivery","authors":"Kun Fang, Pei Li, Hanbing Wang, Xiangrui Huang, Y F Li","doi":"10.3390/magnetochemistry11100085","DOIUrl":"https://doi.org/10.3390/magnetochemistry11100085","url":null,"abstract":"Gallic acid (GA) exhibits a broad range of biological activities; however, its clinical application is significantly limited by poor stability, rapid degradation, and low bioavailability. Consequently, developing responsive delivery platforms to enhance GA stability and targeted release has become an important research focus. Herein, GA was encapsulated within novel composite hydrogel beads (CMC-SA-Fe3O4@GA) prepared via crosslinking carboxymethyl chitosan (CMC) and sodium alginate (SA) with Fe3O4 nanoparticles (NPs) to facilitate efficient drug delivery. The formulation was characterized and evaluated in terms of drug-loading capacity, controlled-release properties, antioxidant activity, antibacterial performance, and biocompatibility. The results indicated that the GA loading efficiency reached 31.07 ± 1.23%. Application of an external magnetic field accelerated GA release, with the observed release kinetics fitting the Ritger–Peppas model. Furthermore, antioxidant capacity, evaluated by DPPH assays, demonstrated excellent antioxidant activity of the CMC-SA-Fe3O4@GA composite beads. Antibacterial tests confirmed sustained inhibitory effects against Escherichia coli and Staphylococcus aureus. In vitro, cellular assays indicated favorable biocompatibility with normal hepatic cells (HL-7702) and effective inhibition of hepatocellular carcinoma cells (HepG2). Overall, the novel pH- and magnetic field-responsive CMC-SA-Fe3O4@GA hydrogel system developed in this work offers considerable potential for controlled delivery of phenolic compounds, demonstrating promising applicability in biomedical and food-related fields.","PeriodicalId":18194,"journal":{"name":"Magnetochemistry","volume":"11 10","pages":"85-85"},"PeriodicalIF":0.0,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2312-7481/11/10/85/pdf?version=1759059942","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147878393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A Dinuclear Dysprosium(III) Single Molecule Magnet of Benzo[h]quinolin-10-ol 苯并[h]喹啉-10-醇双核镝(III)单分子磁体
4区 化学
Magnetochemistry Pub Date : 2025-08-24 DOI: 10.3390/magnetochemistry11090073
Limin Zhou, Haibin Lv, Yuning Liang, Dongcheng Liu, Z. P. Yao, Shuchang Luo, Zilu Chen
{"title":"A Dinuclear Dysprosium(III) Single Molecule Magnet of Benzo[h]quinolin-10-ol","authors":"Limin Zhou, Haibin Lv, Yuning Liang, Dongcheng Liu, Z. P. Yao, Shuchang Luo, Zilu Chen","doi":"10.3390/magnetochemistry11090073","DOIUrl":"https://doi.org/10.3390/magnetochemistry11090073","url":null,"abstract":"To develop single molecule magnets, a dinuclear complex [Dy2(HOBQ)4Cl6] (1) was prepared from the reaction of DyCl3 with benzo[h]quinolin-10-ol (HOBQ). Each Dy(III) ion shows a compressed octahedral geometry and the two Dy(III) ions in 1 are bridged by two Cl− ligands to construct a dinuclear structure with the four HOBQ ligands on the axial positions and six Cl− ligands in the equatorial plane. Magnetic measurements showed that complex 1 is a field-induced single molecule magnet having an obvious magnetic hysteresis loop with an energy barrier of 71(2) K. These experimental results are corroborated by the ab initio complete active space self-consistent field (CASSCF) calculations which also interpret the magneto-structural correlation. It is a typical example to achieve Dy(III) SMM through regulating coordination geometry, i.e., lengthening equatorial coordination bonds and shortening axial ones to form a compressed octahedral geometry.","PeriodicalId":18194,"journal":{"name":"Magnetochemistry","volume":"11 9","pages":"73-73"},"PeriodicalIF":0.0,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2312-7481/11/9/73/pdf?version=1756019566","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Enhanced Magnetocaloric Effect and Single-Molecule Magnet Behavior in a Series of Sulfur-Containing Ligand-Based Ln9 Clusters (Ln = Gd, Tb, and Dy) 一系列含硫配体Ln9簇(Ln = Gd, Tb,和Dy)中增强的磁热效应和单分子磁体行为
4区 化学
Magnetochemistry Pub Date : 2025-08-22 DOI: 10.3390/magnetochemistry11090070
Ya-Wei Geng, Tong Guo, Xiaoqin Wang, Tian Han
{"title":"Enhanced Magnetocaloric Effect and Single-Molecule Magnet Behavior in a Series of Sulfur-Containing Ligand-Based Ln9 Clusters (Ln = Gd, Tb, and Dy)","authors":"Ya-Wei Geng, Tong Guo, Xiaoqin Wang, Tian Han","doi":"10.3390/magnetochemistry11090070","DOIUrl":"https://doi.org/10.3390/magnetochemistry11090070","url":null,"abstract":"As an important branch of lanthanide-based complexes, clusters show unique properties in magnetocaloric effect (MCE) and single-molecule magnets (SMMs) using O/N ligands, while research on heavy p-block elements (e.g., S atom) with larger atomic radii and more diffuse p valence orbitals as coordinating atoms remains relatively scarce. Herein, using the sulfur-containing ligand of 2-pyridinethiol 1-oxide (HL), we successfully synthesized a series of hourglass-like Ln9 clusters [Ln9(L)17(μ3-OH)9(μ4-OH)]·nH2O (1: Ln = Gd, n = 3; 2: Ln = Tb, n = 3; 3: Ln = Dy, n = 1). Magnetic data analysis reveals that cluster 1 shows a significant MCE, with the entropy change (−ΔSm) reaching a maximum of 34.41 J kg−1 K−1 at 2 K under ΔH = 7 T. Cluster 3, meanwhile, exhibits distinct frequency- and temperature-dependent behavior, indicating its SMM characteristics. Interestingly, despite possessing the highest molar mass among reported Gd9 clusters with MCE, 1 exhibits a competitive −ΔSm value, highlighting the critical role of sulfur-containing ligand on the structure and even exchange interactions. This work offers new insights into synthesizing high-performance MCE materials and understanding magneto-structural relationships.","PeriodicalId":18194,"journal":{"name":"Magnetochemistry","volume":"11 9","pages":"70-70"},"PeriodicalIF":0.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2312-7481/11/9/70/pdf?version=1755868245","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Glutathione and Magnetic Nanoparticle-Modified Nanochannels for the Detection of Cadmium (II) in Cereal Grains 谷胱甘肽和磁性纳米粒子修饰纳米通道检测谷物中镉(II)
4区 化学
Magnetochemistry Pub Date : 2025-07-21 DOI: 10.3390/magnetochemistry11070061
Wei Hu, Xinyue Xiang, Donglei Jiang, Na Zhang, Lifeng Wang
{"title":"Glutathione and Magnetic Nanoparticle-Modified Nanochannels for the Detection of Cadmium (II) in Cereal Grains","authors":"Wei Hu, Xinyue Xiang, Donglei Jiang, Na Zhang, Lifeng Wang","doi":"10.3390/magnetochemistry11070061","DOIUrl":"https://doi.org/10.3390/magnetochemistry11070061","url":null,"abstract":"We developed a novel and portable magnetic nanochannel electrochemical sensor for the sensitive detection of cadmium ions (Cd2+), which pose serious risks to food safety and human health. The sensor was fabricated by co-modifying an anodic aluminum oxide (AAO) nanochannel membrane with a composite of glutathione (GSH) and ferric oxide nanoparticles (Fe3O4), denoted as GSH@Fe3O4. This modified membrane was then integrated with a screen-printed carbon electrode (SPCE) to construct the GSH@Fe3O4/GSH@AAO/SPCE sensing platform. The performance of the sensor was evaluated using differential pulse voltammetry (DPV), which demonstrated a strong linear correlation between the peak current response and the concentration of Cd2+ in the range of 5–120 μg/L. The calibration equation was IDPV(μA) = −0.31 + 0.98·CCd2+(μg/L), with an excellent correlation coefficient (R2 = 0.999, n = 3). The calculated limit of detection (LOD) was as low as 0.1 μg/L, indicating the high sensitivity of the system. These results confirm the successful construction of the GSH@Fe3O4/GSH@AAO/SPCE portable nanochannel sensor. This innovative sensing platform provides a rapid, sensitive, and user-friendly approach for the on-site monitoring of heavy metal contamination in agricultural products, especially grains.","PeriodicalId":18194,"journal":{"name":"Magnetochemistry","volume":"11 7","pages":"61-61"},"PeriodicalIF":0.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2312-7481/11/7/61/pdf?version=1753089581","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Efficient Degradation of Oxytetracycline in Wastewater Using Fe/Mn-Modified Magnetic Oak Biochar: Pathways and Mechanistic Investigation 铁锰改性磁性橡木生物炭对废水中土霉素的高效降解:途径及机理研究
4区 化学
Magnetochemistry Pub Date : 2025-06-06 DOI: 10.3390/magnetochemistry11060049
Yujie Zhou, Y. B. Fu, Xiaoxue Niu, Bohan Wu, Xinghan Liu, Hao Fu, Zichuan Ma, Hao Cai, Yuheng Liu
{"title":"The Efficient Degradation of Oxytetracycline in Wastewater Using Fe/Mn-Modified Magnetic Oak Biochar: Pathways and Mechanistic Investigation","authors":"Yujie Zhou, Y. B. Fu, Xiaoxue Niu, Bohan Wu, Xinghan Liu, Hao Fu, Zichuan Ma, Hao Cai, Yuheng Liu","doi":"10.3390/magnetochemistry11060049","DOIUrl":"https://doi.org/10.3390/magnetochemistry11060049","url":null,"abstract":"Antibiotic resistance has been recognized as a global threat to human health. Therefore, it is urgent to develop effective strategies to address the contamination of water environments caused by antibiotics. In this study, Fe/Mn bimetallic-modified biochar (FMBC) was synthesized through a one-pot oxidation/reduction-hydrothermal co-precipitation method, demonstrating an exceptional photocatalytic-Fenton degradation performance for oxytetracycline (OTC). Characterization techniques including FTIR, SEM, XRD, VSM, and N2 adsorption–desorption analysis confirmed that the Fe/Mn bimetals were successfully loaded onto the surface of biochar in the form of Fe3O4 and MnFe2O4 mixed crystals and exhibited favorable paramagnetic properties that facilitate magnetic recovery. A key innovation is the utilization of biochar’s inherent phenol/quinone structures as reactive sites and electron transfer mediators, which synergistically interact with the loaded bimetallic oxides to significantly enhance the generation of highly reactive ·OH radicals, thereby boosting catalytic activity. Even after five recycling cycles, the material exhibited minimal changes in degradation efficiency and bimetallic crystal structure, indicating its notable stability and reusability. The photocatalytic degradation experiment conducted in a Fenton-like reaction system demonstrates that, under the conditions of pH 4.0, a H2O2 concentration of 5.16 mmol/L, a catalyst dosage of 0.20 g/L, and an OTC concentration of 100 mg/L, the optimal degradation efficiency of 98.3% can be achieved. Additionally, the pseudo-first-order kinetic rate constant was determined to be 4.88 min−1. Furthermore, this study elucidated the detailed degradation mechanisms, pathways, and the influence of various ions, providing valuable theoretical insights and technical support for the degradation of antibiotics in real wastewater.","PeriodicalId":18194,"journal":{"name":"Magnetochemistry","volume":"11 6","pages":"49-49"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2312-7481/11/6/49/pdf?version=1749220926","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147903661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Decaying Oscillating Pulsed Magnetic Field Induces Lysosome-Dependent Cell Death in A375 Melanoma via Magneto-Mechanical Force 衰减振荡脉冲磁场通过磁机械力诱导A375黑色素瘤中溶酶体依赖性细胞死亡
4区 化学
Magnetochemistry Pub Date : 2025-04-14 DOI: 10.3390/magnetochemistry11040033
Yan Mi, Jianli Wang, Sifan Tang, Chi Ma, Wei Zheng, Jiayu Chen
{"title":"Decaying Oscillating Pulsed Magnetic Field Induces Lysosome-Dependent Cell Death in A375 Melanoma via Magneto-Mechanical Force","authors":"Yan Mi, Jianli Wang, Sifan Tang, Chi Ma, Wei Zheng, Jiayu Chen","doi":"10.3390/magnetochemistry11040033","DOIUrl":"https://doi.org/10.3390/magnetochemistry11040033","url":null,"abstract":"The synergistic application of magnetic fields and iron oxide nanorod particles (IONPs) presents a novel therapeutic approach for inducing lysosome-dependent cell death (LDCL) via magneto-mechanical force (MMF). This study demonstrates the efficacy of decaying oscillating pulsed magnetic fields (DOPMFs) to propel IONPs to induce rapid tumor regression via lysosomal membrane permeabilization (LMP). The systematic evaluation of dose-dependent parameters revealed that DOPMF intensity and pulse number critically determine A375 melanoma cell viability reduction. Mechanistic investigations identified two hallmark biomarkers of LMP: increased cytosolic cathepsin B activity and downregulated LAMP-2 expression. Crucially, in vivo experiments using A375 melanoma-bearing mouse models corroborated the therapeutic potential of this approach, showing significant tumor growth inhibition without systemic toxicity or invasive procedures. Collectively, our findings demonstrate that MMF by IONPs under DOPMF stimulation exhibits significant efficacy in suppressing melanoma proliferation, offering a non-invasive, targeted approach for oncological intervention.","PeriodicalId":18194,"journal":{"name":"Magnetochemistry","volume":"11 4","pages":"33-33"},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2312-7481/11/4/33/pdf?version=1744624107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147898482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Experimental Study on Thermal Conductivity of Hybrid Magnetic Fluids Under External Magnetic Field 外加磁场作用下混合磁流体导热系数的实验研究
4区 化学
Magnetochemistry Pub Date : 2025-04-03 DOI: 10.3390/magnetochemistry11040030
Licong Jin, Jixian Yang, Qian Li, Xin Tian, Decai Li
{"title":"Experimental Study on Thermal Conductivity of Hybrid Magnetic Fluids Under External Magnetic Field","authors":"Licong Jin, Jixian Yang, Qian Li, Xin Tian, Decai Li","doi":"10.3390/magnetochemistry11040030","DOIUrl":"https://doi.org/10.3390/magnetochemistry11040030","url":null,"abstract":"In the paper, a hybrid magnetic fluid is prepared by adding carbon nanotubes to pure ferrofluid to improve its thermal conductivity. Furthermore, an electromagnet is used as magnetic source equipment, and the magnetic field strength in the air gap of the electromagnet is analyzed in theory, simulations, and experiments. A thermal conductivity measurement apparatus for magnetic fluid is established according to the transient hot-wire method. The effects of weight fraction and the length of carbon nanotubes, the external magnetic field strength, and the magnetic field duration time on the thermal conductivity of hybrid magnetic fluid are experimentally investigated. The results show that the thermal conductivity of the hybrid magnetic fluid is significantly improved by adding long carbon nanotubes (10–30 μm), and the thermal conductivity could be enhanced by 23.39% when its weight fraction is 1%. The magnetic field strength (41, 81, 122, 162 mT) and magnetic field duration time have little influence on the thermal conductivity of the hybrid magnetic fluid. The thermal conductivity of the hybrid magnetic fluid has good stability.","PeriodicalId":18194,"journal":{"name":"Magnetochemistry","volume":"11 4","pages":"30-30"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2312-7481/11/4/30/pdf?version=1743693603","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147912208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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