Magnetochemistry最新文献

Fabrication of Spindle-like ZnO@Fe3O4 Nanocarriers for Targeted Drug Delivery and Controlled Release 纺锤形ZnO@Fe3O4纳米药物靶向递送与控释载体的制备

4区化学

Magnetochemistry Pub Date : 2025-12-23 DOI: 10.3390/magnetochemistry12010002

YongFei GUO, Mao Yang, Yan Wang, Zhigang Tian, Tongguo Si

{"title":"Fabrication of Spindle-like ZnO@Fe3O4 Nanocarriers for Targeted Drug Delivery and Controlled Release","authors":"YongFei GUO, Mao Yang, Yan Wang, Zhigang Tian, Tongguo Si","doi":"10.3390/magnetochemistry12010002","DOIUrl":"https://doi.org/10.3390/magnetochemistry12010002","url":null,"abstract":"Developing precise tumor-targeting delivery systems while minimizing off-target toxicity continues to pose significant challenges in medicine application. The integration of two different functional materials has emerged as a promising strategy in current biomedical research. Herein, a hybrid nanocomposite consisting of Fe3O4 and ZnO was synthesized via a simple approach and employed as a nanoscale drug delivery system to explore the loading capacity and stimuli-responsive release characteristics of the anticancer agent doxorubicin (DOX). Results show that the synthesized nanoparticles (NPs) exhibit a multi-scale nanostructure consisting of the spindle-like ZnO nanorods with a mean length of 280 nm, on which the Fe3O4 NPs with a diameter of around 16 nm are uniformly dispersed. The ZnO@Fe3O4 NPs possess superparamagnetic behavior and a fast response to the external magnet and demonstrate exceptional near-infrared (NIR) photothermal conversion efficiency. In drug release studies, the ZnO@Fe3O4 NPs achieve the controlled DOX release in the simulated acidic tumor microenvironment as well as NIR laser irradiation. Further, the ZnO@Fe3O4-DOX composites significantly suppress the viability of human cervical cancer cells (HeLa) upon laser activation. These findings suggest that ZnO@Fe3O4 NPs are promising candidates for combined photothermal therapy, magnetic-targeted drug delivery, and stimuli-responsive controlled release applications.","PeriodicalId":18194,"journal":{"name":"Magnetochemistry","volume":"12 1","pages":"2-2"},"PeriodicalIF":0.0,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmable Magnetic Navigation of Gelatin Microrobots Enhances AB4 Delivery to Inflamed Lung Epithelium 凝胶微机器人的可编程磁导航增强AB4对炎症肺上皮的递送

4区化学

Magnetochemistry Pub Date : 2025-11-01 DOI: 10.3390/magnetochemistry11110096

Yue Bu, Jianpeng Xu, Chuanhua Li, Zhixi Li, Yongjing Yu, Ziyong Yue

{"title":"Programmable Magnetic Navigation of Gelatin Microrobots Enhances AB4 Delivery to Inflamed Lung Epithelium","authors":"Yue Bu, Jianpeng Xu, Chuanhua Li, Zhixi Li, Yongjing Yu, Ziyong Yue","doi":"10.3390/magnetochemistry11110096","DOIUrl":"https://doi.org/10.3390/magnetochemistry11110096","url":null,"abstract":"Sepsis-induced acute lung injury (SALI) is characterized by dysregulated inflammation with limited therapeutic options. Although Anemoside B4 (AB4) exhibits anti-inflammatory properties, its clinical application is hindered by poor bioavailability. To address this limitation, we developed magnetically guided gelatin microrobots (MG-AB4) for targeted AB4 delivery. The MG-AB4 system consists of a Fe3O4-loaded gelatin shell for enabling precise magnetic navigation (velocity: 110 μm/s), an AB4 core for rapid drug release which is advantageous for acute inflammatory responses, and surface modifications to enhance cellular uptake. Compared with free AB4, MG-AB4 significantly suppressed key inflammatory cytokines (Interleukin-6 (IL-6), Interleukin-1 beta (IL-1β), Tumor necrosis factor-alpha (TNF-α); p < 0.01), inhibited NF-κB activation (p < 0.01), and improved cell viability in an inflammatory model (p < 0.05). This study demonstrates that magnetically guided AB4 delivery using rapidly releasing microrobots is a promising strategy for SALI treatment, wherein the synergy of targeted delivery and potent anti-inflammatory action may effectively mitigate disease progression.","PeriodicalId":18194,"journal":{"name":"Magnetochemistry","volume":"11 11","pages":"96-96"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2312-7481/11/11/96/pdf?version=1761992535","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Dinuclear Dysprosium(III) Single Molecule Magnet of Benzo[h]quinolin-10-ol 苯并[h]喹啉-10-醇双核镝（III）单分子磁体

4区化学

Magnetochemistry Pub Date : 2025-08-24 DOI: 10.3390/magnetochemistry11090073

Limin Zhou, Haibin Lv, Yuning Liang, Dongcheng Liu, Z. P. Yao, Shuchang Luo, Zilu Chen

引用次数: 1

Glutathione and Magnetic Nanoparticle-Modified Nanochannels for the Detection of Cadmium (II) in Cereal Grains 谷胱甘肽和磁性纳米粒子修饰纳米通道检测谷物中镉（II）

4区化学

Magnetochemistry Pub Date : 2025-07-21 DOI: 10.3390/magnetochemistry11070061

Wei Hu, Xinyue Xiang, Donglei Jiang, Na Zhang, Lifeng Wang

{"title":"Glutathione and Magnetic Nanoparticle-Modified Nanochannels for the Detection of Cadmium (II) in Cereal Grains","authors":"Wei Hu, Xinyue Xiang, Donglei Jiang, Na Zhang, Lifeng Wang","doi":"10.3390/magnetochemistry11070061","DOIUrl":"https://doi.org/10.3390/magnetochemistry11070061","url":null,"abstract":"We developed a novel and portable magnetic nanochannel electrochemical sensor for the sensitive detection of cadmium ions (Cd2+), which pose serious risks to food safety and human health. The sensor was fabricated by co-modifying an anodic aluminum oxide (AAO) nanochannel membrane with a composite of glutathione (GSH) and ferric oxide nanoparticles (Fe3O4), denoted as GSH@Fe3O4. This modified membrane was then integrated with a screen-printed carbon electrode (SPCE) to construct the GSH@Fe3O4/GSH@AAO/SPCE sensing platform. The performance of the sensor was evaluated using differential pulse voltammetry (DPV), which demonstrated a strong linear correlation between the peak current response and the concentration of Cd2+ in the range of 5–120 μg/L. The calibration equation was IDPV(μA) = −0.31 + 0.98·CCd2+(μg/L), with an excellent correlation coefficient (R2 = 0.999, n = 3). The calculated limit of detection (LOD) was as low as 0.1 μg/L, indicating the high sensitivity of the system. These results confirm the successful construction of the GSH@Fe3O4/GSH@AAO/SPCE portable nanochannel sensor. This innovative sensing platform provides a rapid, sensitive, and user-friendly approach for the on-site monitoring of heavy metal contamination in agricultural products, especially grains.","PeriodicalId":18194,"journal":{"name":"Magnetochemistry","volume":"11 7","pages":"61-61"},"PeriodicalIF":0.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2312-7481/11/7/61/pdf?version=1753089581","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital Magnetic Sorting for Fractionating Cell Populations with Variable Antigen Expression in Cell Therapy Process Development. 数字磁分选在细胞治疗过程发展中用于分离可变抗原表达的细胞群。

IF 2.5 4区化学

Magnetochemistry Pub Date : 2024-11-01 Epub Date: 2024-10-23 DOI: 10.3390/magnetochemistry10110081

Savannah Bshara-Corson, Andrew Burwell, Timothy Tiemann, Coleman Murray

{"title":"Digital Magnetic Sorting for Fractionating Cell Populations with Variable Antigen Expression in Cell Therapy Process Development.","authors":"Savannah Bshara-Corson, Andrew Burwell, Timothy Tiemann, Coleman Murray","doi":"10.3390/magnetochemistry10110081","DOIUrl":"10.3390/magnetochemistry10110081","url":null,"abstract":"Cellular therapies exhibit immense potential in treating complex diseases with sustained responses. The manufacture of cell therapies involves the purification and engineering of specific cells from a donor or patient to achieve a therapeutic response upon injection. Magnetic cell sorting targeting the presence or absence of surface markers is commonly used for upfront purification. However, emerging research shows that optimal therapeutic phenotypes are characterized not only by the presence or absence of specific antigens but also by antigen density. Unfortunately, current cell purification tools like magnetic or fluorescence-activated cell sorting (FACS) lack the resolution to differentiate populations based on antigen density while maintaining scalability. Utilizing a technique known as digital magnetic sorting (DMS), we demonstrate proof of concept for a scalable, magnetic-based approach to fractionate cell populations based on antigen density level. Targeting CD4 on human leukocytes, DMS demonstrated fractionation into CD4Hi T cells and CD4Low monocytes and neutrophils as quantified by flow cytometry and single-cell RNA seq. DMS also demonstrated high throughput processing at throughputs 3-10× faster than FACS. We believe DMS can be leveraged and scaled to enable antigen density-based sorting in cell therapy manufacturing, leading to the production of more potent and sustainable cellular therapies.","PeriodicalId":18194,"journal":{"name":"Magnetochemistry","volume":"10 11","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and Optimization of the Adsorbent for Phosphorus Removal Using the Response Surface Method 利用响应面法制备和优化除磷吸附剂

IF 2.7 4区化学

Magnetochemistry Pub Date : 2024-01-09 DOI: 10.3390/magnetochemistry10010005

Zhanmei Zhang, Zuqin Zou, Xiaoyu Ren, Yunxuan Huang, Yang Deng, Huaili Zheng

{"title":"Preparation and Optimization of the Adsorbent for Phosphorus Removal Using the Response Surface Method","authors":"Zhanmei Zhang, Zuqin Zou, Xiaoyu Ren, Yunxuan Huang, Yang Deng, Huaili Zheng","doi":"10.3390/magnetochemistry10010005","DOIUrl":"https://doi.org/10.3390/magnetochemistry10010005","url":null,"abstract":"A diatomaceous earth (DE)-based adsorbent DE-Ce was prepared and optimized to remove phosphorus from wastewater. DE was modified through purification–cerium loading, improving its phosphorus adsorption capacity and recycling ability. The preparation conditions were optimized using the Box–Behnken design, and the response surface method was employed to analyze the effects of roasting temperature, cerium concentration, and HCl concentration on the preparation of DE-Ce. Scanning electron microscopy, X-ray fluorescence spectrometry, and X-ray photoelectron spectroscopy were used for characterization, with results indicating that HCl washing can effectively remove impurities. Cerium was mainly loaded onto DE in the form of Ce(OH)3, and pore size and capacity increased following cerium loading, with the formation of a macroporous structure. The obtained DE-Ce adsorbent removed 98.30% phosphorous, with the removal process following the secondary kinetic and Langmuir models. According to material characterization and model analysis results, the phosphorus removal mechanism primarily involves electrostatic adsorption, ligand exchange, and precipitation. Overall, the findings indicate that cerium modification can effectively improve the adsorption capacity of DE.","PeriodicalId":18194,"journal":{"name":"Magnetochemistry","volume":"20 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139443362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Magnetically Induced Local Structure and Volume Fraction on the Electromagnetic Properties of Elastomer Samples with Ferrofluid Droplet Inserts 磁感应局部结构和体积分数对带有铁流体液滴嵌入件的弹性体样品电磁特性的影响

IF 2.7 4区化学

Magnetochemistry Pub Date : 2024-01-02 DOI: 10.3390/magnetochemistry10010004

C. Marin, I. Malaescu

{"title":"The Effect of Magnetically Induced Local Structure and Volume Fraction on the Electromagnetic Properties of Elastomer Samples with Ferrofluid Droplet Inserts","authors":"C. Marin, I. Malaescu","doi":"10.3390/magnetochemistry10010004","DOIUrl":"https://doi.org/10.3390/magnetochemistry10010004","url":null,"abstract":"The magnetic permeability (μ), dielectric permittivity (ε) and electrical conductivity (σ) of six elastomer samples obtained by mixing silicone rubber (RTV-530) with a kerosene-based ferrofluid in different volume fractions (φ), 1.31%, 2.59% and 3.84%, were determined using complex impedance measurements over a frequency range of 500 Hz–2 MHz. Three samples (A0, B0 and C0) were manufactured in the absence of a magnetic field, and the other three samples (Ah, Bh and Ch) were manufactured in the presence of a magnetic field, H = 43 kA/m. The component μ″ of the complex effective magnetic permeability of all samples presents a maximum at a frequency, fmax, that moves to higher values by increasing φ, with this maximum being attributed to Brownian relaxation processes. The conductivity spectrum, σ (f), of all samples follows the Jonscher universal law, which allows for both the determination of the static conductivity, σDC, and the barrier energy of the electrical conduction process, Wm. For the same φ, Wm is lower, and σDC is higher in the samples Ah, Bh and Ch than in the samples A0, B0 and C0. The performed study is useful in manufacturing elastomers with predetermined properties and for possible applications such as magneto-dielectric flexible electronic devices, which can be controlled by the volume fraction of particles or by an external magnetic field.","PeriodicalId":18194,"journal":{"name":"Magnetochemistry","volume":"122 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139391467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Li et al. Dry Friction Performances of MoNx Coatings Deposited by High–Power Pulsed Magnetron Sputtering. Magnetochemistry 2023, 9, 60 更正：高功率脉冲磁控溅射沉积的 MoNx 涂层的干摩擦性能。磁化学，2023，9，60

IF 2.7 4区化学

Magnetochemistry Pub Date : 2023-12-29 DOI: 10.3390/magnetochemistry10010003

Fuqiang Li, Wei Dai, Qimin Wang, Haiqing Li, Zhengtao Wu

引用次数: 0

The Influence of Viscosity on Heat Dissipation under Conditions of the High-Frequency Oscillating Magnetic Field 高频振荡磁场条件下粘度对散热的影响

IF 2.7 4区化学

Magnetochemistry Pub Date : 2023-12-24 DOI: 10.3390/magnetochemistry10010002

M. Molčan, A. Skumiel, Jana Tóthová, K. Paulovičová, P. Kopčanský, M. Timko

{"title":"The Influence of Viscosity on Heat Dissipation under Conditions of the High-Frequency Oscillating Magnetic Field","authors":"M. Molčan, A. Skumiel, Jana Tóthová, K. Paulovičová, P. Kopčanský, M. Timko","doi":"10.3390/magnetochemistry10010002","DOIUrl":"https://doi.org/10.3390/magnetochemistry10010002","url":null,"abstract":"High-frequency components such as microprocessors, transistors, antennas, voltage-controlled oscillators, and many others generate a large amount of heat. In the absence of satisfactory cooling, these components may suffer damage or even destruction. Therefore, it is important to find effective ways to cool these components. A possible solution is to use oil-based magnetic fluids. Magnetic fluids contain magnetic particles dispersed in oil, and their properties, including viscosity, affect their cooling capabilities. Viscosity can be changed by adding various additives or by adjusting the concentration of magnetic particles. The advantage of using oil-based magnetic fluids for cooling is that they allow for precise dosing and control of the amount of fluid applied to the component, reducing thermal losses and increasing cooling efficiency. In addition, oil-based magnetic fluids can also act as a dielectric, reducing electrical noise and increasing electromagnetic compatibility with the components. Analyzing the heating rate of magnetic fluids consisting of mineral oils in an alternating magnetic field with a frequency of 500 kHz, we have shown the capability of controlling thermal losses by adjusting the viscosity of the carrier liquid.","PeriodicalId":18194,"journal":{"name":"Magnetochemistry","volume":"90 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139159916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Molecular Materials Insights 功能分子材料透视

IF 2.7 4区化学

Magnetochemistry Pub Date : 2023-12-20 DOI: 10.3390/magnetochemistry10010001

Laura C. J. Pereira, D. Belo

引用次数: 0