Mansoura Journal of Forensic Medicine and Clinical Toxicology最新文献

{"title":"Troponine I versus Creatinine Kinase-MB as Predictor Markers of the Severity and Outcomes in Acute Theophylline Toxicity","authors":"Aliaa Hodeib, Mona M. Ghonem","doi":"10.21608/mjfmct.2019.52476","DOIUrl":"https://doi.org/10.21608/mjfmct.2019.52476","url":null,"abstract":"Theophylline is a bronchodilator drug that is used in the treatment of asthma and chronic obstructive pulmonary diseases. Cardiovascular complications contribute to morbidity and mortality that associate acute theophylline intoxication. The current study aimed to investigate troponin I and creatine kinase-MB as predictors of the severity and outcomes in cases of acute theophylline intoxication. This prospective cohort study included thirty one patients with acute theophylline toxicity admitted to Tanta Poison Control Center during the period from the first of March 2018 to the end of February 2019. Patients were subjected to personal and toxicological history taking, vital signs collection, grading of acute theophylline toxicity and measurement of serum theophylline level. Both troponin I and creatine kinase-MB were measured at admission and 12 hours post admission. Results revealed that, troponin I at time of admission and 12 hours post admission in addition to creatine kinase-MB 12 hours post admission were significantly higher in cases with severe acute theophylline intoxication and patients who required intensive care unit admission. It was concluded that, troponin I could predict the severity and the requirement of intensive care unit admission in acute theophylline toxicity either with early or delayed presentation. On the other hand, creatine kinase-MB could be considered for patients with delayed presentation.","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84061708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual Dimorphism of Anthropometric Measurements of Periorbital Soft Tissues in a Sample of Egyptian Adults","authors":"R. Abdel-Rahman, S. Amr, A. Khalil","doi":"10.21608/mjfmct.2019.46706","DOIUrl":"https://doi.org/10.21608/mjfmct.2019.46706","url":null,"abstract":"The periorbital soft-tissue characteristics provide an immense number of anatomical landmarks which could help in various forensic investigations. This work aimed to assess the forensic value of anthropometric measurements of periorbital soft tissue landmarks in sex discrimination. Two hundred Egyptian healthy young individuals of both sexes were included in the study. Their ages ranged from 18-40 years. The following anthropometric measures were estimated for all participants: inter-inner canthal width (IICD), inter-outer canthal width (IOCD), horizontal palpebral width (HPD), orbital height, upper and lower eyelids heights in addition to some computed orbital indices. A significant difference was found between males and females regarding the IICD, IOCD, HPD, palpebral fissure index and left orbital index. The current observations provide a database for adult periorbital anthropometry in Egyptians. Also, they could aid in personal identification and sex differentiation especially when combined with other facial characteristics. Further anthropometric studies on periorbital soft tissue landmarks are warranted using other modern techniques such as digital photography and software image analysis for documentation of antemortem data which could aid the process of forensic identification in civil and criminal medicolegal investigations.","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78611585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Some Biochemical and Genetic Markers in Predicting The Severity of Brain Injury","authors":"Nagwa M. Ghandour, M. Ragaee, Randa T. Hanna","doi":"10.21608/mjfmct.2019.46712","DOIUrl":"https://doi.org/10.21608/mjfmct.2019.46712","url":null,"abstract":"","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88891323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Animal Model Prepared by Blocking (FOXRED1 gene) for neuro-toxicological studies of Leigh Syndrome","authors":"M. Salama, S. El-Desouky, Aziza Alsayed, Mahmoud El-Hussiny, Abdelrahman M. Moustafa, Emad Fekry, Yasmeen M. Taalab, Wael M. Y. Mohamed","doi":"10.21608/mjfmct.2019.46714","DOIUrl":"https://doi.org/10.21608/mjfmct.2019.46714","url":null,"abstract":"Leigh syndrome (LS) is one of the most puzzling mitochondrial disorders, which is also known as subacute necrotizing encephalopathy. It has an incidence of 1 in 77,000 live births worldwide with poor prognosis. Currently, there is a poor understanding of the underlying pathophysiological mechanisms of the disease without any available effective treatment. Hence, the inevitability for developing suitable animal and cellular models needed for the development of successful new therapeutic modalities. In this short report, we blocked FOXRED1 gene with small interfering RNA (siRNA) using C57bl/6 mice. Results showed neurobehavioral changes in the injected mice along with parallel degeneration in corpus striatum and sparing of the substantianigra similar to what happen in Leigh syndrome cases. FOXRED1 blockage could serve as a new animal model for neuro-toxicological studies of Leigh syndrome due to defective mitochondrial complex I (CI), which echoes damage to corpus striatum and affection of the central dopaminergic system in this disease. Further preclinical studies are required to validate this model.","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74294788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"siRNA Blocking of Mammalian Target of Rapamycin (mTOR) Attenuates Toxicity in Annonacin Induced Tauopathy in Mice","authors":"M. Salama, S. El-Desouky, Aziza Alsayed, Mahmoud El-Hussiny, K. Magdy, Emad Fekry, O. Shabka, S. El-khodery, M. Youssef, M. Sobh, Wael M. Y. Mohamed","doi":"10.21608/mjfmct.2019.46713","DOIUrl":"https://doi.org/10.21608/mjfmct.2019.46713","url":null,"abstract":"","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79098224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Protective Role of Sitagliptin (Januvia) Against Acetaminophen-Induced Hepatotoxicity in Adult Albino Rats","authors":"Mohamed F. Khodeary, S. Morsy","doi":"10.21608/mjfmct.2019.46710","DOIUrl":"https://doi.org/10.21608/mjfmct.2019.46710","url":null,"abstract":"Acetaminophen (APAP) is a commonly used analgesic-antipyretic drug. Overdose of APAP is significant global clinical problem in humans. Sitagliptin (Sitg) an anti-diabetic drug, has shown protective effects against organs toxicities. This work aimed to evaluate the protective effect of Sitg against APAP-induced hepatotoxicity. Forty male rats were divided into four equal groups. Group-I (control; C-GP; distilled water), Group-II (Sitg-GP; 20-mg/kg), Group-III (APAPGP; 500-mg/kg), and Group-IV (Sitg+APAP-GP; 20-mg/kg+500-mg/kg) pretreated with Sitg followed 2-hour later by APAP. The dosages were given once daily by gavage for 15 days and then blood and liver specimens were collected. Liver biomarkers were assayed in sera and included enzymes (aspartate transaminase=AST; alanine transaminase=ALT; alkaline phosphatase=ALP; gamma-glutamyltransferase=GGT; lactate dehydrogenase=LDH), bilirubin (total bilirubin=TB; direct bilirubin=DB; indirect bilirubin=IB), and proteins (total protein=TP; albumin=ALB; globulin=GLB). Oxidative stress biomarkers were estimated in homogenates and included antioxidants (superoxide dismutase=SOD; catalase=CAT; glutathione peroxidase=GPx; glutathione-S-transferase=GST; glutathione=GSH) and oxidative malondialdehyde (MDA) besides tissue total redox status (total oxidative status=TOS; total antioxidant capacity=TAC; oxidative stress index=OSI; OSI=TOS/TAC). The hepatic lesions were semi-quantitatively scored. In APAP-GP, concentrations of all enzymes and bilirubin, MDA, TOS, and OSI were significantly increased, while levels of all proteins, antioxidants, and TAC were significantly decreased. Histopathological changes showed distorted architecture, increased fibrous deposition, and reduced glycogen contents. Pretreatment with Sitg markedly prevented APAP-induced biochemical and histopathological abnormalities. Sitg possess remarkable hepatoprotective effects against APAPinduced hepatotoxicity and may be useful in treatment of APAP-poisoned patients with diabetes mellitus.","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"32 4 Pt 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85766595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Some Scoring Systems in Prediction of Mortality in Acute Carbon Monoxide Poisoned Patients","authors":"Doaa M El-Gharbawy, Heba Khalifa","doi":"10.21608/mjfmct.2019.46717","DOIUrl":"https://doi.org/10.21608/mjfmct.2019.46717","url":null,"abstract":"Carbon monoxide (CO) is known as a silent killer. In Egypt, it is one of the most common causes of death-related poisonings. This study aimed to evaluate some scoring systems; Glasgow coma scale (GCS), acute physiology and chronic health evaluation II (APACHE II), simplified acute physiology score II (SAPS II) and rapid emergency medicine score (REMS) for predicting in-hospital mortality of patients with acute CO poisoning. One hundred and eight acutely CO poisoned patients were included in the study. For each patient, socio-demographic and toxicological data were recorded. Clinical examination and calculation of the four scoring systems were performed. Patients were divided into two groups; survivors and non-survivors. Discrimination was evaluated using ROC curve and calculating the area under the curve (AUC). The current study revealed that median age of the studied patients was 25.5 years, 55.6% were males and 61.1% were from rural areas. All cases were intoxicated accidently. Among the studied 108 patients; 20 patients died in hospital and 88 patients survived. Both APACHE II and SAPS II had the best AUC, followed by REMS then GCS. The AUC of GCS was significantly lower than those of APACHE II, SAPS II and REMS scores; while differences between AUC of APACHE II, SAPS, and REMS were not statistically significant. It could be concluded that REMS is more useful in predicting in-hospital mortality in acute CO poisoning as it is a simple, easy and rapid scoring system rather than more complicated scoring systems such as APACHE II and SAPS II.","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"283 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80215387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Discrimination from Orbital Aperture by Using Computed Tomography: Sample of Egyptian population","authors":"A. Attia, M. Ghoneim, S. Elkhamary","doi":"10.21608/mjfmct.2019.46705","DOIUrl":"https://doi.org/10.21608/mjfmct.2019.46705","url":null,"abstract":"","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85047417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study of Clinical and Laboratory Picture of Acute Tramadol Toxicity in Damietta Governorate","authors":"M. Nasr, S. Mahmoud, Mostafa Mohammad, Hesham S Abd El Samie","doi":"10.21608/mjfmct.2018.47199","DOIUrl":"https://doi.org/10.21608/mjfmct.2018.47199","url":null,"abstract":"Increased rate of seizures and respiratory complications due to tramadol poisoning have been observed, even with first time of tramadol intake. So, the present work was used to investigate the clinical manifestations and laboratory investigations of acute tramadol toxicity and the correlation between toxic tramadol manifestations and blood tramadol level and laboratory parameters. A study was performed on 100 patients (80 males and 20 females) acutely intoxicated with tramadol, admitted to toxicology unit of Al-Azhar University Hospital (New Damietta) in the period from January to December 2017. Informed consent, urine sample was collected and 10 mL of blood was separated and used for extraction of tramadol residues by using a high-performance liquid chromatography (HPLC) and other blood samples were stored at-8°C for routine investigations. Then a detailed clinical examination was done to all patients. Generally, the frequency of seizures was (46 %) with acute tramadol poisoning. There was no correlation between blood tramadol level and toxic manifestations of tramadol poisoning. So, the frequency of seizures and toxic manifestations are not dosed dependent. Cannabis was the most common co-ingested drugs and adult males were more commonly affected by tramadol poisoning. It is recommended that the drug abuse problem must be treated at the level of community problems in order to minimize medical emergencies related to acute tramadol overdose occurring mostly by addiction and further studies should be proposed to extend our knowledge about relationships between sex and seizures among tramadol intoxicated patients","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"132 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85732063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of MicroRNA-24 in Aflatoxin B1 Exposed Patients with Hepatocellular Carcinoma and Cirrhosis","authors":"A. Attia, D. Elhammady, Maha R. Habeeb, N. Abbas, M. Zaki","doi":"10.21608/mjfmct.2018.47006","DOIUrl":"https://doi.org/10.21608/mjfmct.2018.47006","url":null,"abstract":"","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81518291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}