Magnetic resonance imaging最新文献

{"title":"Correction of orientation dependence in magnetization transfer measures in the context of tractometry: Challenges, pitfalls and solutions","authors":"Philippe Karan ,&nbsp;Manon Edde ,&nbsp;Guillaume Gilbert ,&nbsp;Muhamed Barakovic ,&nbsp;Stefano Magon ,&nbsp;Maxime Descoteaux","doi":"10.1016/j.mri.2025.110522","DOIUrl":"10.1016/j.mri.2025.110522","url":null,"abstract":"<div><div>In this work we investigate the feasibility of a correction method for removing the orientation dependence of magnetization transfer (MT) measures in the context of tractometry. Following previous work on the track-based characterization of such orientation dependence using diffusion MRI, a correction method was developed. It uses polynomial fits to extrapolate the single-fiber characterizations and allows the MT measures across all white matter tracks to be shifted towards a chosen reference value, effectively removing the bias of fiber orientation with respect to the main magnetic field. Three different references were tested on a dataset of one hundred acquisitions and the performance was accessed by evaluating the removal of the orientation dependence and the reduction of variance between acquisitions, while also exploring the effects on tractometry results. Throughout these experiments, various challenges and pitfalls of an empirical correction method were laid out, like the absence of ground truth or the lack of knowledge about the complex behavior of the phenomenon in crossing-fiber voxels. Nonetheless, a solution was presented, paving the way towards a fully validated correction method for MT measures.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"124 ","pages":"Article 110522"},"PeriodicalIF":2.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Unveiling cartilage nanostructures via anisotropic relaxometry of water protons: feasibility or fallacy?”","authors":"Theodore Aptekarev ,&nbsp;Gregory Furman ,&nbsp;Vladimir Sokolovsky ,&nbsp;Yang Xia","doi":"10.1016/j.mri.2025.110523","DOIUrl":"10.1016/j.mri.2025.110523","url":null,"abstract":"<div><div>This Reply addresses the issues raised in the Letter, entitled “Unveiling Cartilage Nanostructures via Anisotropic Relaxometry of Water Protons: Feasibility or Fallacy?” by Y. Pang, K. Momot, and V. Mlynárik (<em>Magnetic Resonance Imaging,</em> 123, 2025, 110508). The authors of the previous letter claimed that our model and theoretical results presented in our paper “Depth-dependent characterization of cartilage nanostructures using MRI signal decays” (<em>Magnetic Resonance Imaging</em>, 120, 2025, 110395) are incorrect. Here, we demonstrate that our model is based on theoretical and experimental data obtained using various methods, and that our results are consistent with previously published findings. Our developed approach allows analyzing the tissue structure: estimating the volumes of ellipsoidal water-filled nanocavities, their angular distributions, and the variations of these characteristics with depth. The principal difference of the new method from the early published studies is that these characteristics were obtained using a single NMR/MRI signal (echo decay) without a sample rotation.</div><div>We believe our results contribute to a better understanding of the complex issues related to MRI signal and tissue nanostructures.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"124 ","pages":"Article 110523"},"PeriodicalIF":2.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pure steady-state CEST","authors":"Johannes Hammacher,&nbsp;Christoph Kolbitsch,&nbsp;Patrick Schuenke","doi":"10.1016/j.mri.2025.110506","DOIUrl":"10.1016/j.mri.2025.110506","url":null,"abstract":"<div><h3>Summary:</h3><div>A novel steady-state CEST sequence design, based on the underlying physical model of longitudinal magnetization development during CEST saturation and data acquisition is presented and validated <em>in-silico</em>, <em>in vitro</em> and <em>in vivo</em>. This design ensures consistent data acquisition in the pure CEST steady-state, leading to high MTR_asym scores and image quality, both <em>in vitro</em> and <em>in vivo</em>, when compared to contemporary sequential and steady-state CEST sequences.</div></div><div><h3>Purpose:</h3><div>The aim of this study was to enhance CEST sequences by utilizing the pure CEST steady-state in order to deliver higher CEST effects and better sensitivity.</div></div><div><h3>Methods:</h3><div>A novel CEST saturation/readout scheme was designed, tested in numerical simulations and subsequently validated <em>in vitro</em> and <em>in vivo</em>.</div></div><div><h3>Results:</h3><div>The novel Multi-2D Spiral pure steady-state CEST sequence showed to deliver advantageous sensitivity and efficacy.</div></div><div><h3>Conclusion:</h3><div>Constraining image acquisition to the pure CEST steady-state showed promising results in first <em>in vitro</em> and <em>in vivo</em> experiments.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"124 ","pages":"Article 110506"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the transverse relaxation enhancement effect in 1H-MRI of the lung","authors":"Flavio Carinci ,&nbsp;Felix A. Breuer ,&nbsp;Peter M. Jakob","doi":"10.1016/j.mri.2025.110514","DOIUrl":"10.1016/j.mri.2025.110514","url":null,"abstract":"<div><h3>Purpose</h3><div>Presenting a technique to quantify the transverse relaxation time <em>T</em>_2,diff, which is associated with the diffusion of water molecules through the internal magnetic field gradients of the lung <em>in-vivo</em>.</div></div><div><h3>Methods</h3><div>A Half-Fourier-Acquired Single-shot Turbo spin-Echo (HASTE) pulse sequence with Hahn-echo preparation was implemented and used for image acquisition. Quantification of <em>T</em>_2,diff was performed by acquiring multiple images with identical TE, but with a different number of refocusing pulses between excitation and signal acquisition. <em>T</em>_2,diff was quantified on a voxel-by-voxel basis from the signal attenuation in the different acquisitions.</div><div>Phantom experiments were performed to evaluate the ability of the proposed technique to discriminate signals with different <em>T</em>_2,diff. Six samples containing a mixture of water and glass microspheres of different nominal diameters were used. The dependence of <em>T</em>_2,diff on the sphere diameter was compared with that obtained from the conventional Hahn-echo experiment. <em>In-vivo</em> experiments were performed to investigate the dependence of <em>T</em>_2,diff on both lung inflation and perfusion. For this, data were acquired in eleven healthy volunteers in different breathing states and different cardiac phases.</div></div><div><h3>Results</h3><div>Phantom experiments showed a monotonic increase of <em>T</em>_2,diff with the sphere diameter in agreement with the results of the Hahn-echo experiment, demonstrating an excellent discrimination between signals with different <em>T</em>_2,diff. <em>In-vivo</em> experiments showed a rather homogeneous distribution of <em>T</em>_2,diff throughout the lung with a slight dependence on inflation. Mean values obtained in the diastolic cardiac phase resulted in 29 ms at Functional Residual Capacity (FRC) and in 24 ms at Total Lung Capacity (TLC). In the systolic phase the mean value at FRC was 14 ms, indicating a strong dependence of <em>T</em>_2,diff on perfusion.</div></div><div><h3>Conclusion</h3><div>The proposed technique allows to quantify <em>T</em>_2,diff of the lung in a single breath-hold of approximately 10s duration and could help in detecting functional and microstructural injuries of the lung.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"124 ","pages":"Article 110514"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating breast lesions with ultrafast DCE-MRI: The impact of temporal resolution on pharmacokinetics","authors":"Tianwen Xie ,&nbsp;Yan Huang ,&nbsp;Caixia Fu ,&nbsp;Robert Grimm ,&nbsp;Marcel Dominik Nickel ,&nbsp;Qin Xiao ,&nbsp;Weijun Peng ,&nbsp;Ruimin Li ,&nbsp;Yajia Gu","doi":"10.1016/j.mri.2025.110512","DOIUrl":"10.1016/j.mri.2025.110512","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the impact of temporal resolution on pharmacokinetic parameters and the performance in diagnosing breast cancer.</div></div><div><h3>Methods</h3><div>This prospective study included 89 consecutive patients with 97 lesions (76 malignant and 21 benign). Ultrafast dynamic contrast-enhanced (UF-DCE) imaging was performed on a 3-T MRI scanner using CAIPIRINHA-Dixon-TWIST-VIBE (CDTV) with a native temporal resolution of 4.5 s per phase. The CDTV data were downsampled at various temporal resolutions ranging from 9.0 to 58.5 s, creating eight additional datasets. Pharmacokinetic parameters, including <em>K</em>^trans, <em>k</em>_ep, and <em>v</em>_e, were calculated using Tofts model and population-based arterial input function (AIF). Paired-sample <em>t-</em>test with Bonferroni correction and ROC curves were used for statistical analysis.</div></div><div><h3>Results</h3><div>As temporal resolution decreased from 4.5 s, <em>K</em>^trans and <em>k</em>_ep values increased, while <em>v</em>_e values decreased. The AUCs of <em>K</em>^trans, <em>k</em>_ep, and <em>v</em>_e at 4.5-s temporal resolution were 0.648, 0.778, and 0.685, respectively. Temporal resolutions shorter than 18 s showed less than a 10 % deviation in <em>K</em>^trans and <em>k</em>_ep of quantitative parameters compared to the 4.5-s reference. No significant difference was noted among AUC pairs for any of the parameters (corrected <em>p</em> &gt; 0.00625).</div></div><div><h3>Conclusions</h3><div>Our results revealed that the temporal resolution significantly impacted pharmacokinetic parameters based on the population-based AIF from UF-DCE MRI. However, the diagnostic ability to characterize breast cancer might not be substantially affected. A temporal resolution shorter than 18 s is recommended for accurate calculation of pharmacokinetic parameters.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"124 ","pages":"Article 110512"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI-based radiomics predicts complete responses to initial transcatheter arterial chemoembolization in virus-associated early and intermediate stage HCC","authors":"Xinran Wen ,&nbsp;Zhaoyang Xu ,&nbsp;Hongbo Wang ,&nbsp;Yan Wang ,&nbsp;Qiaoyu Gu ,&nbsp;Xiran Jiang ,&nbsp;Cong Chen ,&nbsp;Yalian Yu","doi":"10.1016/j.mri.2025.110513","DOIUrl":"10.1016/j.mri.2025.110513","url":null,"abstract":"<div><h3>Background</h3><div>To evaluate the value of a multiparametric MRI-based nomogram on predicting response to transcatheter arterial chemoembolization (TACE) in virus-associated hepatocellular carcinoma (HCC) patients;</div></div><div><h3>Methods</h3><div>This study enrolled 235 and 51 patients from Center 1 and 2, respectively. All patients underwent baseline MRI scans before treatment. The least absolute shrinkage and selection operator (LASSO) regression method was used to screen radiomics features from intra- and peri-tumor areas to establish the radiomics signatures (RS). The nomogram model was built by integrating the RS and clinical predictors. Receiver operating characteristics (ROC), calibration and decision curve analyses (DCA) curves were used to assess predictive performances of radiomics models;</div></div><div><h3>Results</h3><div>In the training, internal validation and external validation cohort, the AUCs based on developed RS were 0.848, 0.759 and 0.762, respectively. The clinical model consisted of 4 significant distinct clinical predictors, including HBsAg, AFP, BCLC staging and size. To enhance diagnostic efficiency, we integrated 11 radiomics features and 4 clinical predictors to develop a nomogram model, which showed increased AUCs to 0.892, 0.851 and 0.787 in the training, internal validation and external validation cohort, respectively;</div></div><div><h3>Conclusions</h3><div>This study demonstrates that multiparametric MRI-based radiomics nomogram can preoperatively predict responses to TACE in virus-associated HCC.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"124 ","pages":"Article 110513"},"PeriodicalIF":2.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASD-HybridNet: A hybrid deep learning framework for detection of autism spectrum disorder","authors":"Nirmal Rai ,&nbsp;P.C. Pradhan ,&nbsp;Hemanta Saikia ,&nbsp;Rinkila Bhutia ,&nbsp;O.P. Singh","doi":"10.1016/j.mri.2025.110492","DOIUrl":"10.1016/j.mri.2025.110492","url":null,"abstract":"<div><div>Current diagnostic methods for autism spectrum disorder (ASD) are based on subjective behavioral assessments, which present challenges to an accurate and early diagnosis. This paper proposes a hybrid deep learning framework, ASD-HybridNet, which integrates both region of interest (ROI) time series data and functional connectivity (FC) maps derived from functional magnetic resonance imaging (fMRI) data to improve ASD detection. Experiments on the ABIDE dataset demonstrate the effectiveness of the proposed method compared to existing approaches.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"124 ","pages":"Article 110492"},"PeriodicalIF":2.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD-GANs : Conditional dynamic training with GANs for enhanced post-gadolinium glioblastoma MRIs","authors":"Aymen Ahriz ,&nbsp;Rachida Saouli ,&nbsp;Lara Raad ,&nbsp;Jean Cousty","doi":"10.1016/j.mri.2025.110509","DOIUrl":"10.1016/j.mri.2025.110509","url":null,"abstract":"<div><div>Gliomas are brain tumors originating from glial cells, graded I to IV by the WHO, with Grade IV glioblastoma (GBM) being the most aggressive. Magnetic resonance imaging (MRI) is crucial for monitoring disease progression and guiding therapy in glioma patients. However, gadolinium, a contrast agent used for visualization, poses risks of accumulation, particularly in patients with nephrogenic systemic fibrosis, renal disease, diabetic nephropathy, or low glomerular filtration rate. This underscores the need for innovative imaging solutions. This paper proposes a method for generating synthetic T1-weighted Contrast-Enhanced (T1CE) images, enabling tumor visualization without gadolinium injection. This approach aims to improve patient outcomes by accurately delineating tumor characteristics while avoiding gadolinium-related risks. We introduce a Generative Adversarial Network (GAN) for T1CE MRI synthesis, utilizing a dynamic training mechanism with condition-based discriminators adjusted based on tumor presence in each batch. This ensures precise T1CE image synthesis. Furthermore, this work introduces progressive intensity training, which prioritizes learning from dark intensity regions before gradually incorporating medium and light intensities, enhancing fine detail capture. This strategy is applied to Pix2pix and our two frameworks, Conditional-Patch Discriminator (CPD-GAN) and Double Conditional Discriminators (DCD-GAN), resulting in their progressive intensity versions: PiPix2pix, PiCPD-GAN, and PiDCD-GAN. Validated on the Brats2020 dataset, the proposed methodology demonstrates superior performance in multi-modality imaging compared to state-of-the-art methods. Experimental results, particularly for DCD-GAN and its Pi variant, highlight their effectiveness in T1CE image synthesis, offering a safer and more reliable alternative for glioma diagnosis and monitoring.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"124 ","pages":"Article 110509"},"PeriodicalIF":2.0,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A concentric-loops coil enhancing RF coil B1 efficiency and reducing imaging noise compared to traditional single-loop coil","authors":"Xin Li,&nbsp;Xiao-Hong Zhu,&nbsp;Wei Chen","doi":"10.1016/j.mri.2025.110499","DOIUrl":"10.1016/j.mri.2025.110499","url":null,"abstract":"<div><div>We proposed a simple approach to optimize a concentric-loops RF coil, consisting of an inner primary coil as the driving coil and an outer secondary coil as a passive resonator. By adjusting the tuning capacitor in the secondary loop to raise its self-resonance frequency to be slightly above the operating Larmor frequency, we enabled the preferred operation condition (additive mode), where both secondary and primary loops contributed to the largely enhanced RF coil transmit and receive magnetic fields (<em>B</em>_<em>1</em>) within the area enclosed by the primary loop as compared to a single-loop secondary coil. Compared to a single secondary loop coil as control, electromagnetic (EM) simulations and phantom MRS/MRI at 10.5 Tesla (T) ¹⁷O (60.6 MHz), 7 T ³¹P (120.7 MHz), and 1.5 T ¹H (63.8 MHz) operating frequencies show that the concentric-loops coil (8 cm diameter for the secondary loop coil) provides 1.2 to 1.4-fold higher <em>B</em>_<em>1</em> and coil detection sensitivity in the near-coil region (0–3 cm). In the far region, it offers slightly enhanced <em>B</em>_<em>1</em> and coil sensitivity, which becomes similar to the control coil at 9 cm away from the coil plane. Additionally, the concentric-loops coil reduces imaging noise by 15–30 %, collectively, resulting in an ∼1.7-fold signal-to-noise ratio (SNR) gain at the near-coil region. The concentric-loops coil with the presented optimization strategy provides an effective and simple coil design with largely improved imaging SNR compared to a conventional single-loop coil for a broad range of MRS/MRI applications across different field strengths.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"124 ","pages":"Article 110499"},"PeriodicalIF":2.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of vascular calcification and Vessel Wall in patients with lower extremity artery disease using CT-like imaging","authors":"Hidehisa Hatakeyama ,&nbsp;Takayuki Sakai ,&nbsp;Sakuramaru Suzuki ,&nbsp;Daichi Murayama ,&nbsp;Hajime Itou ,&nbsp;Shigehiro Ochi","doi":"10.1016/j.mri.2025.110511","DOIUrl":"10.1016/j.mri.2025.110511","url":null,"abstract":"<div><h3>Purpose</h3><div>Lower extremity artery disease (LEAD), a major manifestation of peripheral arterial disease (PAD), is significantly influenced by vascular calcification, which impacts treatment outcomes. This study evaluates the feasibility of CT-like imaging using 3D multi-echo T2*-weighted image (T2*WI) for assessing vascular calcifications and vessel wall area in patients with LEAD.</div></div><div><h3>Materials and methods</h3><div>A 3.0 T MRI system was used to acquire CT-like images from 20 patients with LEAD (median age: 75.0 years). Vascular calcifications were assessed in 10 patients who had previously undergone non-contrast CT, while vessel wall area was evaluated in another 10 patients using three-dimensional (3D) fat-suppressed T1-weighted turbo spin-echo (FS-T1 TSE).</div></div><div><h3>Results</h3><div>CT-like imaging demonstrated moderate agreement with non-contrast CT for the visual assessment of vascular calcifications (κ = 0.75) and a strong correlation for the quantitative evaluation of calcification (<em>r</em> = 0.91–0.96). Bland–Altman analysis showed minimal bias in vessel wall area measurements between CT-like imaging and FS-T1 TSE.</div></div><div><h3>Conclusion</h3><div>CT-like imaging is a feasible technique for assessing vascular calcifications and vessel wall area in patients with LEAD. The absence of radiation exposure makes it a promising alternative to CT for vascular evaluation.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"123 ","pages":"Article 110511"},"PeriodicalIF":2.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}