Malaysian Journal of Medical and Biological Research最新文献_第6页

METHYLENE BLUE INHIBITS THE INTERACTION BETWEEN HEPARAN SULFATE AND SARS-COV-2 SPIKE PROTEIN; A REVIEW OF EVIDENCE FOR A HYPOTHESIS. 亚甲基蓝抑制硫酸肝素与sars-cov-2刺突蛋白的相互作用;对一个假设的证据的回顾

Malaysian Journal of Medical and Biological Research Pub Date : 2021-10-01 DOI: 10.31674/mjmr.2021.v05i04.002

N. Indika, Nirmalie Gayathrie Fonseka

{"title":"METHYLENE BLUE INHIBITS THE INTERACTION BETWEEN HEPARAN SULFATE AND SARS-COV-2 SPIKE PROTEIN; A REVIEW OF EVIDENCE FOR A HYPOTHESIS.","authors":"N. Indika, Nirmalie Gayathrie Fonseka","doi":"10.31674/mjmr.2021.v05i04.002","DOIUrl":"https://doi.org/10.31674/mjmr.2021.v05i04.002","url":null,"abstract":"The addition of methylene blue to the standard treatment protocol has been shown to improve respiratory rate and oxygen saturation in COVID-19 patients, reducing morbidity and mortality. Evidence to date suggests that methylene blue inhibits protein-protein interactions between SARS-CoV-2 Spike protein and angiotensin-converting enzyme 2, which in turn inhibits the cell entry of SARS-CoV-2. However, the methylene blue dye-binding characteristics of sulfated glycosaminoglycans suggest additional inhibitory effects of the spike protein-heparan sulfate interaction. We hypothesize that the binding of cationic methylene blue neutralizes polyanionic heparan sulfate molecules on the host cell surface. As a consequence, electrostatic interactions between negatively charged heparan sulfate and the positively charged receptor binding domain of SARS-CoV-2 spike protein will be inhibited. Thus, methylene blue will exhibit a \"shielding effect\" on the heparan sulfate proteoglycans, inhibiting viral attachment to the cell surface. The proposed mechanism corroborates the possible broad-spectrum antiviral activity of methylene blue against multiple human coronaviruses that exploit the electrostatic interactions with sulfated glycosaminoglycans for virus entry. Methylene blue would exhibit the same anti-adhesive activity at the blood-brain-barrier and olfactory neuroepithelium, corroborating potential benefits in ameliorating post-COVID-19 neurological impairment. However, as cationic dyes can bind to both free glycosaminoglycans in circulation as well as proteoglycans attached to the cell surface, co-administration of intravenous heparin could possibly antagonize the proposed antiviral activity. This critical review focuses on empirical evidence to support the hypothesized heparan sulfate-dependent antiviral activity of MB.","PeriodicalId":18105,"journal":{"name":"Malaysian Journal of Medical and Biological Research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90426037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HYDRONEPHROSIS: A CASE OF URETERAL METASTASISOF PROSTATE CANCER 肾积水:前列腺癌输尿管转移1例

Malaysian Journal of Medical and Biological Research Pub Date : 2021-10-01 DOI: 10.31674/mjmr.2021.v05i04.006

Mohd Aznan Md Aris, Mazilah Mazlan, N. S. K. Roslee

引用次数: 1

A CASE REPORT: POSTPRANDIAL HYPOGLYCAEMIA IN INTERMITTENT FASTING DIET FOR TYPE 2 DIABETES MELLITUS PATIENT 2型糖尿病患者间歇性禁食后餐后低血糖1例报告

Malaysian Journal of Medical and Biological Research Pub Date : 2021-10-01 DOI: 10.31674/mjmr.2021.v05i04.003

Syazana Aqilah Zulkifli, M. Aris

引用次数: 0

Biomarkers and Bioactivity in Drug Discovery using a Joint Modelling Approach 使用联合建模方法的药物发现中的生物标志物和生物活性

Malaysian Journal of Medical and Biological Research Pub Date : 2021-09-21 DOI: 10.18034/mjmbr.v8i2.585

Kawsher Rahman

{"title":"Biomarkers and Bioactivity in Drug Discovery using a Joint Modelling Approach","authors":"Kawsher Rahman","doi":"10.18034/mjmbr.v8i2.585","DOIUrl":"https://doi.org/10.18034/mjmbr.v8i2.585","url":null,"abstract":"Biomarkers that are validated and robust are required for the enhancement of diagnosis, the observation of drug-related activity, therapeutic reactions, and as the blueprint for developing safer and more direct therapeutic efforts for a variety of chronic ailments. Various kinds of biomarkers have proven impactful when it comes to the discovery and development of drugs, but the procedure that involves identifying and verifying ailment-specific biomarkers has proven to be hassling. In recent times, there have been some advancements in multiple omics (also known as multi-omics) methods like transcriptomic, cytometry, genomics, proteomics, metabolomics and imaging. These advancements have made it possible for the discovery and development of distinct biomarkers for complicated chronic ailments to be accelerated expeditiously. In spite of the fact that numerous drawbacks still need to be looked into, ongoing efforts for the discovery and improvement of illness-associated biomarkers will go a long way in optimizing decision-making across the entire process of drug development and expand our comprehension of the infection processes. In addition, when the preclinical biomarkers are effectively translated into the clinic, the way will pave well to an equally effective implementation of personalized therapies throughout complicated illness environments to become beneficial to patients, healthcare service providers and the industry of bio-pharma. \u0000 ","PeriodicalId":18105,"journal":{"name":"Malaysian Journal of Medical and Biological Research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74774660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Generators and Optimizers Failure Modes 分子发生器和优化器失效模式

Malaysian Journal of Medical and Biological Research Pub Date : 2021-09-07 DOI: 10.18034/mjmbr.v8i2.583

Mani Manavalan

{"title":"Molecular Generators and Optimizers Failure Modes","authors":"Mani Manavalan","doi":"10.18034/mjmbr.v8i2.583","DOIUrl":"https://doi.org/10.18034/mjmbr.v8i2.583","url":null,"abstract":"In recent years, there has been an uptick in interest in generative models for molecules in drug development. In the field of de novo molecular design, these models are used to make molecules with desired properties from scratch. This is occasionally used instead of virtual screening, which is limited by the size of the libraries that can be searched in practice. Rather than screening existing libraries, generative models can be used to build custom libraries from scratch. Using generative models, which may optimize molecules straight towards the desired profile, this time-consuming approach can be sped up. The purpose of this work is to show how current shortcomings in evaluating generative models for molecules can be avoided. We cover both distribution-learning and goal-directed generation with a focus on the latter. Three well-known targets were downloaded from ChEMBL: Janus kinase 2 (JAK2), epidermal growth factor receptor (EGFR), and dopamine receptor D2 (DRD2) (Bento et al. 2014). We preprocessed the data to get binary classification jobs. Before calculating a scoring function, the data is split into two halves, which we shall refer to as split 1/2. The ratio of active to inactive users. Our goal is to train three bioactivity models with equal prediction performance, one to be used as a scoring function for chemical optimization and the other two to be used as performance evaluation models. Our findings suggest that distribution-learning can attain near-perfect scores on many existing criteria even with the most basic and completely useless models. According to benchmark studies, likelihood-based models account for many of the best technologies, and we propose that test set likelihoods be included in future comparisons.","PeriodicalId":18105,"journal":{"name":"Malaysian Journal of Medical and Biological Research","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84675440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Risk of Neurodegeneration in Patients with Morgellons Disease: A Focus on the Potential Risk of Developing Alzheimer’s 莫吉隆斯病患者神经退行性变的风险:发展为阿尔茨海默氏症的潜在风险

Malaysian Journal of Medical and Biological Research Pub Date : 2021-09-03 DOI: 10.18034/mjmbr.v8i2.579

J. Grimm

引用次数: 0

EFFECT OF HERBAL THERAPY STEEPING SALAM LEAF TO DECREASE IN BLOOD GLUCOSE LEVELS IN ELDERLY PATIENTS WITH DIABETES MELLITUS IN THE VILLAGE OF SUKODONO SUBDISTRICT OF SIDOARJO CITY 中草药浸泡萨拉姆叶对西多阿霍市苏可多诺街道村老年糖尿病患者血糖水平的影响

Malaysian Journal of Medical and Biological Research Pub Date : 2021-07-01 DOI: 10.31674/mjmr.2021.v05i03.006

N. Anggraini

{"title":"EFFECT OF HERBAL THERAPY STEEPING SALAM LEAF TO DECREASE IN BLOOD GLUCOSE LEVELS IN ELDERLY PATIENTS WITH DIABETES MELLITUS IN THE VILLAGE OF SUKODONO SUBDISTRICT OF SIDOARJO CITY","authors":"N. Anggraini","doi":"10.31674/mjmr.2021.v05i03.006","DOIUrl":"https://doi.org/10.31674/mjmr.2021.v05i03.006","url":null,"abstract":"Introduction: Diabetes mellitus is a metabolic disease most often occurs in the elderly due to decreased function of the pancreas which produce insulin function. The number of elderly patients with DM in the village of Tell subdistrict of Sidoarjo regency Sukodono ignorance alternative ways to control blood sugar levels. The purpose of this study was to analyze the influence of herbal therapy steeping Salam leaves against a decrease in blood glucose levels in the elderly. Methods:This study design pre Experiment (One-group pre-post test design). Samples were taken using purposive sampling and obtained as many as 28 elderly Tell Rural District of Sukodono Sidoarjo. The independent variable is the herbal therapy steeping Salam leaves and the dependent variable is blood glucose levels in the elderly. Test Gluchose research instruments used for the measurement of blood sugar levels. Test data analysis using Paired T-test ? ? 0.05. Results:The results showed that the steeping Salam leaves for lowering blood glucose levels in elderly people with diabetes mellitus is evidenced by the results of Test Paired t-test showed ? = 0.000 before and after the treatment groups. Conclution:Seeing the results of this study can be concluded that the steeping Salam leaves containing astringent compounds can affect insulin sensitivity thereby stimulating the parasympathetic autonomic nerve stimulation and stimulate the release of insulin from the pancreas gland. Furthermore, the public are advised to be used as an alternative way to control blood sugar levels.","PeriodicalId":18105,"journal":{"name":"Malaysian Journal of Medical and Biological Research","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87482267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

PRESCRIBING PATTERN OF INTRAVENOUS ANTIBIOTICS FOR HOSPITALIZED PATIENT IN HOSPITAL JERANTUT 医院住院患者静脉注射抗生素处方模式分析

Malaysian Journal of Medical and Biological Research Pub Date : 2021-07-01 DOI: 10.31674/mjmr.2021.v05i03.005

Sumaiyah Abdul Aziz

引用次数: 0

REDUCING ANXIETY LEVELS THROUGH INTEGRATIVE INTERVENTION OF FIVE-FINGER HYPNOSIS AND AROMATHERAPY 通过五指催眠和芳香疗法的综合干预降低焦虑水平

Malaysian Journal of Medical and Biological Research Pub Date : 2021-07-01 DOI: 10.31674/mjmr.2021.v05i03.002

D. Hartono, U. A. Hidayat, Y. Cahyati, Sandeep Poddar

{"title":"REDUCING ANXIETY LEVELS THROUGH INTEGRATIVE INTERVENTION OF FIVE-FINGER HYPNOSIS AND AROMATHERAPY","authors":"D. Hartono, U. A. Hidayat, Y. Cahyati, Sandeep Poddar","doi":"10.31674/mjmr.2021.v05i03.002","DOIUrl":"https://doi.org/10.31674/mjmr.2021.v05i03.002","url":null,"abstract":"Anxiety is the most common mental disorder, around 3.6% of the population. Effective care and treatment for anxiety disorders are needed. This is done so that individuals who experience these disorders can return to being productive in meeting their life needs and do not depend on other people. Currently, client management is not only given psychopharmaceutical treatment but also with a psychotherapy approach. \u0000\u0000This study aims to determine the integrative effect of five-finger hypnosis and aromatherapy on the level of anxiety of patients at the Mental Polyclinic of dr. Soekardjo City of Tasikmalaya. The method used is research quantitative with research quasi-experimental design pre-test and post-test with control design. Bivariate analysis on the variables before and after the intervention using paired t-test, and independent t-test to see the comparison of anxiety scores after intervention in the control group and the intervention group.\u0000\u0000The results showed 60 respondents, 30 control group respondents received Five Finger Hypnosis treatment for 4 times a week for 3 weeks, while 30 people in the intervention group received a combination of Five Finger Hypnosis and Aromatherapy for 4 times a week for 3 weeks. Before and after the intervention was carried out, the level of anxiety was measured using the Hamilton Anxiety Rating Scale (HARS). The analysis showed that there was a difference in the average score of anxiety before and after the intervention in the intervention group. Further analysis found that there was a significant difference in the average score of anxiety after the intervention between the control group and the intervention group. therapy Five finger hypnosis and aromatherapy should be used as an independent nursing intervention in dealing with anxiety problems.","PeriodicalId":18105,"journal":{"name":"Malaysian Journal of Medical and Biological Research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91124113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

IMPACT OF COVID-19 PANDEMIC ON MENTAL AND EMOTIONAL WELLBEING AMONG CHILDREN: A SYSTEMATIC REVIEW COVID-19大流行对儿童心理和情绪健康的影响:一项系统综述

Malaysian Journal of Medical and Biological Research Pub Date : 2021-07-01 DOI: 10.31674/mjmr.2021.v05i03.003

Dior Manta Tambunan, N. Nurjanah, S. Rahmayanti, Rahmi Imelisa, F. M. Said, Bibi Florina Abdullah

{"title":"IMPACT OF COVID-19 PANDEMIC ON MENTAL AND EMOTIONAL WELLBEING AMONG CHILDREN: A SYSTEMATIC REVIEW","authors":"Dior Manta Tambunan, N. Nurjanah, S. Rahmayanti, Rahmi Imelisa, F. M. Said, Bibi Florina Abdullah","doi":"10.31674/mjmr.2021.v05i03.003","DOIUrl":"https://doi.org/10.31674/mjmr.2021.v05i03.003","url":null,"abstract":"Background: Coronavirus pandemic represents a huge threat and phenomenal risks on mental and emotional wellness among children. This systematic review expects to integrate academic research literature that provides details regarding the impact of COVID-19 on emotional wellbeing and mental status among children.\u0000\u0000Methods: A systematic research engine was escorted on PubMed, Proquest, ScienceDirect, and Google Scholar with keywords: Children, COVID-19, Mental Status, Psychological Status from December 2019 to 18 November 2020 following the PRISMA guidelines. Articles were chosen dependent on the predetermined eligibility criteria. The included articles to review used the Quality Assessment Tool Adapted from the National Institutes of Health (NIH).\u0000\u0000Results: A total of 17,059 records were identified using the keywords. After removal of duplicates and initial screening, seven articles met the inclusion criteria of COVID-19 influence on mental and emotional wellbeing among children. The research design was a longitudinal and cross-sectional online survey with the children age range was 3 – 18 years old.\u0000\u0000Conclusions: COVID-19 Pandemic has a significant influence on mental and emotional wellbeing among children. Some children experienced depressive indication, difficulty concentrating, anxiety, touchy and easy to get irritated.\u0000\u0000Limitations: Online survey generalized the results, younger children might need assistance from parents during filling up the questionnaire, small sampling size.","PeriodicalId":18105,"journal":{"name":"Malaysian Journal of Medical and Biological Research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76926695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1