Light, science & applications最新文献_第8页

Wireless sequential dual light delivery for programmed PDT in vivo. 无线顺序双光传输用于体内程序化光导治疗。

IF 19.4 1区物理与天体物理

Light, science & applications Pub Date : 2024-05-15 DOI: 10.1038/s41377-024-01437-x

Jiayi Liu, Bowen Sun, Wenkai Li, Han-Joon Kim, Shu Uin Gan, John S Ho, Juwita Norasmara Bte Rahmat, Yong Zhang

{"title":"Wireless sequential dual light delivery for programmed PDT in vivo.","authors":"Jiayi Liu, Bowen Sun, Wenkai Li, Han-Joon Kim, Shu Uin Gan, John S Ho, Juwita Norasmara Bte Rahmat, Yong Zhang","doi":"10.1038/s41377-024-01437-x","DOIUrl":"10.1038/s41377-024-01437-x","url":null,"abstract":"Using photodynamic therapy (PDT) to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of light. Polymeric nanocarriers are widely used for photosensitizer delivery, while the self-quenching of the encapsulated photosensitizers would impair the PDT efficacy. Furthermore, the generated short-lived reactive oxygen spieces (ROS) can hardly diffuse out of nanocarriers, resulting in low PDT efficacy. Therefore, a smart nanocarrier system which can be degraded by light, followed by photosensitizer activation can potentially overcome these limitations and enhance the PDT efficacy. A light-sensitive polymer nanocarrier encapsulating photosensitizer (RB-M) was synthesized. An implantable wireless dual wavelength microLED device which delivers the two light wavelengths sequentially was developed to programmatically control the release and activation of the loaded photosensitizer. Two transmitter coils with matching resonant frequencies allow activation of the connected LEDs to emit different wavelengths independently. Optimal irradiation time, dose, and RB-M concentration were determined using an agent-based digital simulation method. In vitro and in vivo validation experiments in an orthotopic rat liver hepatocellular carcinoma disease model confirmed that the nanocarrier rupture and sequential low dose light irradiation strategy resulted in successful PDT at reduced photosensitizer and irradiation dose, which is a clinically significant event that enhances treatment safety.","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"113"},"PeriodicalIF":19.4,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140922613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetically controllable multimode interference in topological photonic crystals. 拓扑光子晶体中的磁可控多模干涉。

IF 19.4 1区物理与天体物理

Light, science & applications Pub Date : 2024-05-14 DOI: 10.1038/s41377-024-01433-1

Weiyuan Tang, Mudi Wang, Shaojie Ma, Che Ting Chan, Shuang Zhang

{"title":"Magnetically controllable multimode interference in topological photonic crystals.","authors":"Weiyuan Tang, Mudi Wang, Shaojie Ma, Che Ting Chan, Shuang Zhang","doi":"10.1038/s41377-024-01433-1","DOIUrl":"10.1038/s41377-024-01433-1","url":null,"abstract":"Topological photonic insulators show promise for applications in compact integrated photonic circuits due to their ability to transport light robustly through sharp bendings. The number of topological edge states relies on the difference between the bulk Chern numbers across the boundary, as dictated by the bulk edge correspondence. The interference among multiple topological edge modes in topological photonics systems may allow for controllable functionalities that are particularly desirable for constructing reconfigurable photonic devices. In this work, we demonstrate magnetically controllable multimode interference based on gyromagnetic topological photonic insulators that support two unidirectional edge modes with different dispersions. We successfully achieve controllable power splitting in experiments by engineering multimode interference with the magnetic field intensity or the frequency of wave. Our work demonstrates that manipulating the interference among multiple chiral edge modes can facilitate the advancement of highly efficient and adaptable microwave devices.","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"112"},"PeriodicalIF":19.4,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11091070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140916739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strong-field photoelectron holography in the subcycle limit. 亚周期极限下的强场光电子全息技术。

IF 19.4 1区物理与天体物理

Light, science & applications Pub Date : 2024-05-08 DOI: 10.1038/s41377-024-01457-7

Tsendsuren Khurelbaatar, Jaewuk Heo, ShaoGang Yu, XuanYang Lai, XiaoJun Liu, Dong Eon Kim

引用次数: 0

Quartz-enhanced multiheterodyne resonant photoacoustic spectroscopy. 石英增强多外差共振光声光谱仪。

IF 19.4 1区物理与天体物理

Light, science & applications Pub Date : 2024-03-22 DOI: 10.1038/s41377-024-01425-1

Jiapeng Wang, Hongpeng Wu, Angelo Sampaolo, Pietro Patimisco, Vincenzo Spagnolo, Suotang Jia, Lei Dong

{"title":"Quartz-enhanced multiheterodyne resonant photoacoustic spectroscopy.","authors":"Jiapeng Wang, Hongpeng Wu, Angelo Sampaolo, Pietro Patimisco, Vincenzo Spagnolo, Suotang Jia, Lei Dong","doi":"10.1038/s41377-024-01425-1","DOIUrl":"10.1038/s41377-024-01425-1","url":null,"abstract":"The extension of dual-comb spectroscopy (DCS) to all wavelengths of light along with its ability to provide ultra-large dynamic range and ultra-high spectral resolution, renders it extremely useful for a diverse array of applications in physics, chemistry, atmospheric science, space science, as well as medical applications. In this work, we report on an innovative technique of quartz-enhanced multiheterodyne resonant photoacoustic spectroscopy (QEMR-PAS), in which the beat frequency response from a dual comb is frequency down-converted into the audio frequency domain. In this way, gas molecules act as an optical-acoustic converter through the photoacoustic effect, generating heterodyne sound waves. Unlike conventional DCS, where the light wave is detected by a wavelength-dependent photoreceiver, QEMR-PAS employs a quartz tuning fork (QTF) as a high-Q sound transducer and works in conjunction with a phase-sensitive detector to extract the resonant sound component from the multiple heterodyne acoustic tones, resulting in a straightforward and low-cost hardware configuration. This novel QEMR-PAS technique enables wavelength-independent DCS detection for gas sensing, providing an unprecedented dynamic range of 63 dB, a remarkable spectral resolution of 43 MHz (or ~0.3 pm), and a prominent noise equivalent absorption of 5.99 × 10-6 cm-1·Hz-1/2.","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"77"},"PeriodicalIF":19.4,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10957990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phase-driven progress in nanophotonic biosensing. 纳米光子生物传感技术的阶段性进展。

IF 19.4 1区物理与天体物理

Light, science & applications Pub Date : 2024-03-18 DOI: 10.1038/s41377-024-01415-3

Isabel Barth, Hakho Lee

引用次数: 0

A von-Neumann-like photonic processor and its application in studying quantum signature of chaos. 类冯-牛曼光子处理器及其在研究混沌量子特征中的应用。

IF 19.4 1区物理与天体物理

Light, science & applications Pub Date : 2024-03-14 DOI: 10.1038/s41377-024-01413-5

Shang Yu, Wei Liu, Si-Jing Tao, Zhi-Peng Li, Yi-Tao Wang, Zhi-Peng Zhong, Raj B Patel, Yu Meng, Yuan-Ze Yang, Zhao-An Wang, Nai-Jie Guo, Xiao-Dong Zeng, Zhe Chen, Liang Xu, Ning Zhang, Xiao Liu, Mu Yang, Wen-Hao Zhang, Zong-Quan Zhou, Jin-Shi Xu, Jian-Shun Tang, Yong-Jian Han, Chuan-Feng Li, Guang-Can Guo

{"title":"A von-Neumann-like photonic processor and its application in studying quantum signature of chaos.","authors":"Shang Yu, Wei Liu, Si-Jing Tao, Zhi-Peng Li, Yi-Tao Wang, Zhi-Peng Zhong, Raj B Patel, Yu Meng, Yuan-Ze Yang, Zhao-An Wang, Nai-Jie Guo, Xiao-Dong Zeng, Zhe Chen, Liang Xu, Ning Zhang, Xiao Liu, Mu Yang, Wen-Hao Zhang, Zong-Quan Zhou, Jin-Shi Xu, Jian-Shun Tang, Yong-Jian Han, Chuan-Feng Li, Guang-Can Guo","doi":"10.1038/s41377-024-01413-5","DOIUrl":"10.1038/s41377-024-01413-5","url":null,"abstract":"Photonic quantum computation plays an important role and offers unique advantages. Two decades after the milestone work of Knill-Laflamme-Milburn, various architectures of photonic processors have been proposed, and quantum advantage over classical computers has also been demonstrated. It is now the opportune time to apply this technology to real-world applications. However, at current technology level, this aim is restricted by either programmability in bulk optics or loss in integrated optics for the existing architectures of processors, for which the resource cost is also a problem. Here we present a von-Neumann-like architecture based on temporal-mode encoding and looped structure on table, which is capable of multimode-universal programmability, resource-efficiency, phase-stability and software-scalability. In order to illustrate these merits, we execute two different programs with varying resource requirements on the same processor, to investigate quantum signature of chaos from two aspects: the signature behaviors exhibited in phase space (13 modes), and the Fermi golden rule which has not been experimentally studied in quantitative way before (26 modes). The maximal program contains an optical interferometer network with 1694 freely-adjustable phases. Considering current state-of-the-art, our architecture stands as the most promising candidate for real-world applications.","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"74"},"PeriodicalIF":19.4,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrabright near-infrared light. 超亮近红外线光。

IF 19.4 1区物理与天体物理

Light, science & applications Pub Date : 2024-03-13 DOI: 10.1038/s41377-024-01416-2

Andries Meijerink

引用次数: 0

Light People: Prof. Kei May Lau, newly elected US NAE member in Hong Kong, talks about future of photonics and women in science. 光人：新当选的美国 NAE 香港会员刘基美（Kei May Lau）教授畅谈光子学的未来和科学界的女性。

IF 19.4 1区物理与天体物理

Light, science & applications Pub Date : 2024-03-11 DOI: 10.1038/s41377-024-01401-9

Yating Wan, Chenzi Guo

{"title":"Light People: Prof. Kei May Lau, newly elected US NAE member in Hong Kong, talks about future of photonics and women in science.","authors":"Yating Wan, Chenzi Guo","doi":"10.1038/s41377-024-01401-9","DOIUrl":"10.1038/s41377-024-01401-9","url":null,"abstract":"Editorial: Photonics technology remains a driving force in today's scientific landscape, marked by continuous innovation and cross-disciplinary relevance. In an enlighting conversation with Light: Science & Applications, Prof. Kei May Lau, a pioneer in photonics research, shares her deep insights on the evolution of technologies of LEDs, lasers, challenges of hetero-epitaxy, and the future of micro-LEDs and quantum dot lasers. Recently honored as a member of the US National Academy of Engineering (NAE) for her significant contributions to photonics and electronics using III-V semiconductors on silicon, Prof. Lau stands out as the sole Hong Kong scholar inducted into the NAE this year, joining 114 new and 21 international members. In this exclusive Light People interview, Prof. Lau shares her journey as a pioneering woman in engineering, her commitment to mentorship and academia, and her perspective on advancing female representation in science. The summary provided is distilled from Prof. Lau's thoughtful responses during the interview. For a deeper exploration of Prof. Lau's experiences and advice, the full interview is available in the Supplementary material.","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"72"},"PeriodicalIF":19.4,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10980171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-power, electrically-driven continuous-wave 1.55-μm Si-based multi-quantum well lasers with a wide operating temperature range grown on wafer-scale InP-on-Si (100) heterogeneous substrate. 在晶圆级硅基 InP-on-Si (100) 异质衬底上生长的大功率、电驱动连续波 1.55μm 硅基多量子阱激光器，具有宽工作温度范围。

IF 19.4 1区物理与天体物理

Light, science & applications Pub Date : 2024-03-11 DOI: 10.1038/s41377-024-01389-2

Jialiang Sun, Jiajie Lin, Min Zhou, Jianjun Zhang, Huiyun Liu, Tiangui You, Xin Ou

{"title":"High-power, electrically-driven continuous-wave 1.55-μm Si-based multi-quantum well lasers with a wide operating temperature range grown on wafer-scale InP-on-Si (100) heterogeneous substrate.","authors":"Jialiang Sun, Jiajie Lin, Min Zhou, Jianjun Zhang, Huiyun Liu, Tiangui You, Xin Ou","doi":"10.1038/s41377-024-01389-2","DOIUrl":"10.1038/s41377-024-01389-2","url":null,"abstract":"A reliable, efficient and electrically-pumped Si-based laser is considered as the main challenge to achieve the integration of all key building blocks with silicon photonics. Despite the impressive advances that have been made in developing 1.3-μm Si-based quantum dot (QD) lasers, extending the wavelength window to the widely used 1.55-μm telecommunication region remains difficult. In this study, we develop a novel photonic integration method of epitaxial growth of III-V on a wafer-scale InP-on-Si (100) (InPOS) heterogeneous substrate fabricated by the ion-cutting technique to realize integrated lasers on Si substrate. This ion-cutting plus epitaxial growth approach decouples the correlated root causes of many detrimental dislocations during heteroepitaxial growth, namely lattice and domain mismatches. Using this approach, we achieved state-of-the-art performance of the electrically-pumped, continuous-wave (CW) 1.55-µm Si-based laser with a room-temperature threshold current density of 0.65 kA/cm-2, and output power exceeding 155 mW per facet without facet coating in CW mode. CW lasing at 120 °C and pulsed lasing at over 130 °C were achieved. This generic approach is also applied to other material systems to provide better performance and more functionalities for photonics and microelectronics.","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"71"},"PeriodicalIF":19.4,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10925601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring van der Waals materials with high anisotropy: geometrical and optical approaches. 探索具有高各向异性的范德华材料：几何和光学方法。

IF 19.4 1区物理与天体物理

Light, science & applications Pub Date : 2024-03-08 DOI: 10.1038/s41377-024-01407-3

Aleksandr S Slavich, Georgy A Ermolaev, Mikhail K Tatmyshevskiy, Adilet N Toksumakov, Olga G Matveeva, Dmitriy V Grudinin, Kirill V Voronin, Arslan Mazitov, Konstantin V Kravtsov, Alexander V Syuy, Dmitry M Tsymbarenko, Mikhail S Mironov, Sergey M Novikov, Ivan Kruglov, Davit A Ghazaryan, Andrey A Vyshnevyy, Aleksey V Arsenin, Valentyn S Volkov, Kostya S Novoselov

{"title":"Exploring van der Waals materials with high anisotropy: geometrical and optical approaches.","authors":"Aleksandr S Slavich, Georgy A Ermolaev, Mikhail K Tatmyshevskiy, Adilet N Toksumakov, Olga G Matveeva, Dmitriy V Grudinin, Kirill V Voronin, Arslan Mazitov, Konstantin V Kravtsov, Alexander V Syuy, Dmitry M Tsymbarenko, Mikhail S Mironov, Sergey M Novikov, Ivan Kruglov, Davit A Ghazaryan, Andrey A Vyshnevyy, Aleksey V Arsenin, Valentyn S Volkov, Kostya S Novoselov","doi":"10.1038/s41377-024-01407-3","DOIUrl":"10.1038/s41377-024-01407-3","url":null,"abstract":"The emergence of van der Waals (vdW) materials resulted in the discovery of their high optical, mechanical, and electronic anisotropic properties, immediately enabling countless novel phenomena and applications. Such success inspired an intensive search for the highest possible anisotropic properties among vdW materials. Furthermore, the identification of the most promising among the huge family of vdW materials is a challenging quest requiring innovative approaches. Here, we suggest an easy-to-use method for such a survey based on the crystallographic geometrical perspective of vdW materials followed by their optical characterization. Using our approach, we found As2S3 as a highly anisotropic vdW material. It demonstrates high in-plane optical anisotropy that is ~20% larger than for rutile and over two times as large as calcite, high refractive index, and transparency in the visible range, overcoming the century-long record set by rutile. Given these benefits, As2S3 opens a pathway towards next-generation nanophotonics as demonstrated by an ultrathin true zero-order quarter-wave plate that combines classical and the Fabry-Pérot optical phase accumulations. Hence, our approach provides an effective and easy-to-use method to find vdW materials with the utmost anisotropic properties.","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"68"},"PeriodicalIF":19.4,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10920635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0