Light, science & applications最新文献

{"title":"Quantum dot-enabled infrared hyperspectral imaging with single-pixel detection.","authors":"Heyan Meng, Yuan Gao, Xuhong Wang, Xianye Li, Lili Wang, Xian Zhao, Baoqing Sun","doi":"10.1038/s41377-024-01476-4","DOIUrl":"10.1038/s41377-024-01476-4","url":null,"abstract":"<p><p>Near-infrared (NIR) hyperspectral imaging is a powerful technique that enables the capture of three-dimensional (3D) spectra-spatial information within the NIR spectral range, offering a wide array of applications. However, the high cost associated with InGaAs focal plane array (FPA) has impeded the widespread adoption of NIR hyperspectral imaging. Addressing this challenge, in this study, we adopt an alternative approach-single-pixel detection for NIR hyperspectral imaging. Our investigation reveals that single-pixel detection outperforms conventional FPA, delivering a superior signal-to-noise ratio (SNR) for both spectral and imaging reconstruction. To implement this strategy, we leverage self-assembled colloidal quantum dots (CQDs) and a digital micromirror device (DMD) for NIR spectral and spatial information multiplexing, complemented by single-pixel detection for simultaneous spectral and image reconstruction. Our experimental results demonstrate successful NIR hyperspectral imaging with a detection window about 600 nm and an average spectral resolution of 8.6 nm with a pixel resolution of 128 × 128. The resulting spectral and spatial data align well with reference instruments, which validates the effectiveness of our approach. By circumventing the need for expensive and bulky FPA and wavelength selection components, our solution shows promise in advancing affordable and accessible NIR hyperspectral imaging technologies, thereby expanding the range of potential applications.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"121"},"PeriodicalIF":19.4,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11130170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly-efficient VCSEL breaking the limit.","authors":"Dieter Bimberg, Fumio Koyama, Kenichi Iga","doi":"10.1038/s41377-024-01455-9","DOIUrl":"10.1038/s41377-024-01455-9","url":null,"abstract":"","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"123"},"PeriodicalIF":19.4,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11133414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mid-infrared computational temporal ghost imaging.","authors":"Han Wu, Bo Hu, Lu Chen, Fei Peng, Zinan Wang, Goëry Genty, Houkun Liang","doi":"10.1038/s41377-024-01426-0","DOIUrl":"10.1038/s41377-024-01426-0","url":null,"abstract":"<p><p>Ghost imaging in the time domain allows for reconstructing fast temporal objects using a slow photodetector. The technique involves correlating random or pre-programmed probing temporal intensity patterns with the integrated signal measured after modulation by the temporal object. However, the implementation of temporal ghost imaging necessitates ultrafast detectors or modulators for measuring or pre-programming the probing intensity patterns, which are not available in all spectral regions especially in the mid-infrared range. Here, we demonstrate a frequency downconversion temporal ghost imaging scheme that enables to extend the operation regime to arbitrary wavelengths regions where fast modulators and detectors are not available. The approach modulates a signal with temporal intensity patterns in the near-infrared and transfers the patterns to an idler via difference-frequency generation in a nonlinear crystal at a wavelength where the temporal object can be retrieved. As a proof-of-concept, we demonstrate computational temporal ghost imaging in the mid-infrared with operating wavelength that can be tuned from 3.2 to 4.3 μm. The scheme is flexible and can be extended to other regimes. Our results introduce new possibilities for scan-free pump-probe imaging and the study of ultrafast dynamics in spectral regions where ultrafast modulation or detection is challenging such as the mid-infrared and THz regions.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"124"},"PeriodicalIF":19.4,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11133385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualization of cristae and mtDNA interactions via STED nanoscopy using a low saturation power probe.","authors":"Wei Ren, Xichuan Ge, Meiqi Li, Jing Sun, Shiyi Li, Shu Gao, Chunyan Shan, Baoxiang Gao, Peng Xi","doi":"10.1038/s41377-024-01463-9","DOIUrl":"10.1038/s41377-024-01463-9","url":null,"abstract":"<p><p>Mitochondria are crucial organelles closely associated with cellular metabolism and function. Mitochondrial DNA (mtDNA) encodes a variety of transcripts and proteins essential for cellular function. However, the interaction between the inner membrane (IM) and mtDNA remains elusive due to the limitations in spatiotemporal resolution offered by conventional microscopy and the absence of suitable in vivo probes specifically targeting the IM. Here, we have developed a novel fluorescence probe called HBmito Crimson, characterized by exceptional photostability, fluorogenicity within lipid membranes, and low saturation power. We successfully achieved over 500 frames of low-power stimulated emission depletion microscopy (STED) imaging to visualize the IM dynamics, with a spatial resolution of 40 nm. By utilizing dual-color imaging of the IM and mtDNA, it has been uncovered that mtDNA tends to habitat at mitochondrial tips or branch points, exhibiting an overall spatially uniform distribution. Notably, the dynamics of mitochondria are intricately associated with the positioning of mtDNA, and fusion consistently occurs in close proximity to mtDNA to minimize pressure during cristae remodeling. In healthy cells, >66% of the mitochondria are Class III (i.e., mitochondria >5 μm or with >12 cristae), while it dropped to <18% in ferroptosis. Mitochondrial dynamics, orchestrated by cristae remodeling, foster the even distribution of mtDNA. Conversely, in conditions of apoptosis and ferroptosis where the cristae structure is compromised, mtDNA distribution becomes irregular. These findings, achieved with unprecedented spatiotemporal resolution, reveal the intricate interplay between cristae and mtDNA and provide insights into the driving forces behind mtDNA distribution.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"116"},"PeriodicalIF":19.4,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11116397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141087109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etching-free pixel definition in InGaN green micro-LEDs.","authors":"Zhiyuan Liu, Yi Lu, Haicheng Cao, Glen Isaac Maciel Garcia, Tingang Liu, Xiao Tang, Na Xiao, Raul Aguileta Vazquez, Mingtao Nong, Xiaohang Li","doi":"10.1038/s41377-024-01465-7","DOIUrl":"10.1038/s41377-024-01465-7","url":null,"abstract":"<p><p>The traditional plasma etching process for defining micro-LED pixels could lead to significant sidewall damage. Defects near sidewall regions act as non-radiative recombination centers and paths for current leakage, significantly deteriorating device performance. In this study, we demonstrated a novel selective thermal oxidation (STO) method that allowed pixel definition without undergoing plasma damage and subsequent dielectric passivation. Thermal annealing in ambient air oxidized and reshaped the LED structure, such as p-layers and InGaN/GaN multiple quantum wells. Simultaneously, the pixel areas beneath the pre-deposited SiO₂ layer were selectively and effectively protected. It was demonstrated that prolonged thermal annealing time enhanced the insulating properties of the oxide, significantly reducing LED leakage current. Furthermore, applying a thicker SiO₂ protective layer minimized device resistance and boosted device efficiency effectively. Utilizing the STO method, InGaN green micro-LED arrays with 50-, 30-, and 10-µm pixel sizes were manufactured and characterized. The results indicated that after 4 h of air annealing and with a 3.5-μm SiO₂ protective layer, the 10-µm pixel array exhibited leakage currents density 1.2 × 10^-6 A/cm² at -10 V voltage and a peak on-wafer external quantum efficiency of ~6.48%. This work suggests that the STO method could become an effective approach for future micro-LED manufacturing to mitigate adverse LED efficiency size effects due to the plasma etching and improve device efficiency. Micro-LEDs fabricated through the STO method can be applied to micro-displays, visible light communication, and optical interconnect-based memories. Almost planar pixel geometry will provide more possibilities for the monolithic integration of driving circuits with micro-LEDs. Moreover, the STO method is not limited to micro-LED fabrication and can be extended to design other III-nitride devices, such as photodetectors, laser diodes, high-electron-mobility transistors, and Schottky barrier diodes.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"117"},"PeriodicalIF":19.4,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11116531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141087062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omnidirectional color wavelength tuning of stretchable chiral liquid crystal elastomers.","authors":"Seungmin Nam, Wontae Jung, Jun Hyuk Shin, Su Seok Choi","doi":"10.1038/s41377-024-01470-w","DOIUrl":"10.1038/s41377-024-01470-w","url":null,"abstract":"<p><p>Wavelength-tunable structural colors using stimuli-responsive materials, such as chiral liquid crystals (CLCs), have attracted increasing attention owing to their high functionality in various tunable photonic applications. Ideally, on-demand omnidirectional wavelength control is highly desirable from the perspective of wavelength-tuning freedom. However, despite numerous previous research efforts on tunable CLC structural colors, only mono-directional wavelength tuning toward shorter wavelengths has been employed in most studies to date. In this study, we report the ideally desired omnidirectional wavelength control toward longer and shorter wavelengths with significantly improved tunability over a broadband wavelength range. By using areal expanding and contractive strain control of dielectric elastomer actuators (DEAs) with chiral liquid crystal elastomers (CLCEs), simultaneous and omnidirectional structural color-tuning control was achieved. This breakthrough in omnidirectional wavelength control enhances the achievable tuning freedom and versatility, making it applicable to a broad range of high-functional photonic applications.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"114"},"PeriodicalIF":19.4,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11109264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141074665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wireless sequential dual light delivery for programmed PDT in vivo.","authors":"Jiayi Liu, Bowen Sun, Wenkai Li, Han-Joon Kim, Shu Uin Gan, John S Ho, Juwita Norasmara Bte Rahmat, Yong Zhang","doi":"10.1038/s41377-024-01437-x","DOIUrl":"10.1038/s41377-024-01437-x","url":null,"abstract":"<p><p>Using photodynamic therapy (PDT) to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of light. Polymeric nanocarriers are widely used for photosensitizer delivery, while the self-quenching of the encapsulated photosensitizers would impair the PDT efficacy. Furthermore, the generated short-lived reactive oxygen spieces (ROS) can hardly diffuse out of nanocarriers, resulting in low PDT efficacy. Therefore, a smart nanocarrier system which can be degraded by light, followed by photosensitizer activation can potentially overcome these limitations and enhance the PDT efficacy. A light-sensitive polymer nanocarrier encapsulating photosensitizer (RB-M) was synthesized. An implantable wireless dual wavelength microLED device which delivers the two light wavelengths sequentially was developed to programmatically control the release and activation of the loaded photosensitizer. Two transmitter coils with matching resonant frequencies allow activation of the connected LEDs to emit different wavelengths independently. Optimal irradiation time, dose, and RB-M concentration were determined using an agent-based digital simulation method. In vitro and in vivo validation experiments in an orthotopic rat liver hepatocellular carcinoma disease model confirmed that the nanocarrier rupture and sequential low dose light irradiation strategy resulted in successful PDT at reduced photosensitizer and irradiation dose, which is a clinically significant event that enhances treatment safety.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"113"},"PeriodicalIF":19.4,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140922613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetically controllable multimode interference in topological photonic crystals.","authors":"Weiyuan Tang, Mudi Wang, Shaojie Ma, Che Ting Chan, Shuang Zhang","doi":"10.1038/s41377-024-01433-1","DOIUrl":"10.1038/s41377-024-01433-1","url":null,"abstract":"<p><p>Topological photonic insulators show promise for applications in compact integrated photonic circuits due to their ability to transport light robustly through sharp bendings. The number of topological edge states relies on the difference between the bulk Chern numbers across the boundary, as dictated by the bulk edge correspondence. The interference among multiple topological edge modes in topological photonics systems may allow for controllable functionalities that are particularly desirable for constructing reconfigurable photonic devices. In this work, we demonstrate magnetically controllable multimode interference based on gyromagnetic topological photonic insulators that support two unidirectional edge modes with different dispersions. We successfully achieve controllable power splitting in experiments by engineering multimode interference with the magnetic field intensity or the frequency of wave. Our work demonstrates that manipulating the interference among multiple chiral edge modes can facilitate the advancement of highly efficient and adaptable microwave devices.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"112"},"PeriodicalIF":19.4,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11091070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140916739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strong-field photoelectron holography in the subcycle limit.","authors":"Tsendsuren Khurelbaatar, Jaewuk Heo, ShaoGang Yu, XuanYang Lai, XiaoJun Liu, Dong Eon Kim","doi":"10.1038/s41377-024-01457-7","DOIUrl":"10.1038/s41377-024-01457-7","url":null,"abstract":"<p><p>Strong-field photoelectron holography is promising for the study of electron dynamics and structure in atoms and molecules, with superior spatiotemporal resolution compared to conventional electron and X-ray diffractometry. However, the application of strong-field photoelectron holography has been hindered by inter-cycle interference from multicycle fields. Here, we address this challenge by employing a near-single-cycle field to suppress the inter-cycle interference. We observed and separated two distinct holographic patterns for the first time. Our measurements allow us not only to identify the Gouy phase effect on electron wavepackets and holographic patterns but also to correctly extract the internuclear separation of the target molecule from the holographic pattern. Our work leads to a leap jump from theory to application in the field of strong-field photoelectron holography-based ultrafast imaging of molecular structures.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"108"},"PeriodicalIF":19.4,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11076600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140876805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quartz-enhanced multiheterodyne resonant photoacoustic spectroscopy.","authors":"Jiapeng Wang, Hongpeng Wu, Angelo Sampaolo, Pietro Patimisco, Vincenzo Spagnolo, Suotang Jia, Lei Dong","doi":"10.1038/s41377-024-01425-1","DOIUrl":"10.1038/s41377-024-01425-1","url":null,"abstract":"<p><p>The extension of dual-comb spectroscopy (DCS) to all wavelengths of light along with its ability to provide ultra-large dynamic range and ultra-high spectral resolution, renders it extremely useful for a diverse array of applications in physics, chemistry, atmospheric science, space science, as well as medical applications. In this work, we report on an innovative technique of quartz-enhanced multiheterodyne resonant photoacoustic spectroscopy (QEMR-PAS), in which the beat frequency response from a dual comb is frequency down-converted into the audio frequency domain. In this way, gas molecules act as an optical-acoustic converter through the photoacoustic effect, generating heterodyne sound waves. Unlike conventional DCS, where the light wave is detected by a wavelength-dependent photoreceiver, QEMR-PAS employs a quartz tuning fork (QTF) as a high-Q sound transducer and works in conjunction with a phase-sensitive detector to extract the resonant sound component from the multiple heterodyne acoustic tones, resulting in a straightforward and low-cost hardware configuration. This novel QEMR-PAS technique enables wavelength-independent DCS detection for gas sensing, providing an unprecedented dynamic range of 63 dB, a remarkable spectral resolution of 43 MHz (or ~0.3 pm), and a prominent noise equivalent absorption of 5.99 × 10^-6cm^-1·Hz^-1/2.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"77"},"PeriodicalIF":19.4,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10957990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}