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Author Correction: Planarized THz quantum cascade lasers for broadband coherent photonics. 作者更正:用于宽带相干光子学的平面化太赫兹量子级联激光器。
IF 19.4 1区 物理与天体物理
Light, science & applications Pub Date : 2024-07-04 DOI: 10.1038/s41377-024-01467-5
Urban Senica, Andres Forrer, Tudor Olariu, Paolo Micheletti, Sara Cibella, Guido Torrioli, Mattias Beck, Jérôme Faist, Giacomo Scalari
{"title":"Author Correction: Planarized THz quantum cascade lasers for broadband coherent photonics.","authors":"Urban Senica, Andres Forrer, Tudor Olariu, Paolo Micheletti, Sara Cibella, Guido Torrioli, Mattias Beck, Jérôme Faist, Giacomo Scalari","doi":"10.1038/s41377-024-01467-5","DOIUrl":"10.1038/s41377-024-01467-5","url":null,"abstract":"","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"152"},"PeriodicalIF":19.4,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time-of-flight resolved stimulated Raman scattering microscopy using counter-propagating ultraslow Bessel light bullets generation. 利用反向传播超低贝塞尔光子弹生成的飞行时间分辨受激拉曼散射显微镜。
IF 19.4 1区 物理与天体物理
Light, science & applications Pub Date : 2024-07-01 DOI: 10.1038/s41377-024-01498-y
Shulang Lin, Li Gong, Zhiwei Huang
{"title":"Time-of-flight resolved stimulated Raman scattering microscopy using counter-propagating ultraslow Bessel light bullets generation.","authors":"Shulang Lin, Li Gong, Zhiwei Huang","doi":"10.1038/s41377-024-01498-y","DOIUrl":"10.1038/s41377-024-01498-y","url":null,"abstract":"<p><p>We present a novel time-of-flight resolved Bessel light bullet-enabled stimulated Raman scattering (B<sup>2</sup>-SRS) microscopy for deeper tissue 3D chemical imaging with high resolution without a need for mechanical z-scanning. To accomplish the tasks, we conceive a unique method to enable optical sectioning by generating the counter-propagating pump and Stokes Bessel light bullets in the sample, in which the group velocities of the Bessel light bullets are made ultraslow (e.g., v<sub>g</sub> ≈ 0.1c) and tunable by introducing programmable angular dispersions with a spatial light modulator. We theoretically analyze the working principle of the collinear multicolor Bessel light bullet generations and velocity controls with the relative time-of-flight resolved detection for SRS 3D deep tissue imaging. We have also built the B<sup>2</sup>-SRS imaging system and present the first demonstration of B<sup>2</sup>-SRS microscopy with Bessel light bullets for 3D chemical imaging in a variety of samples (e.g., polymer bead phantoms, biological samples such as spring onion tissue and porcine brain) with high resolution. The B<sup>2</sup>-SRS technique provides a > 2-fold improvement in imaging depth in porcine brain tissue compared to conventional SRS microscopy. The method of optical sectioning in tissue using counter-propagating ultraslow Bessel light bullets developed in B<sup>2</sup>-SRS is generic and easy to perform and can be readily extended to other nonlinear optical imaging modalities to advance 3D microscopic imaging in biological and biomedical systems and beyond.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"148"},"PeriodicalIF":19.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anisotropy-free arrayed waveguide gratings on X-cut thin film lithium niobate platform of in-plane anisotropy. 面内各向异性的 X 切面铌酸锂薄膜平台上的无各向异性阵列波导光栅。
IF 19.4 1区 物理与天体物理
Light, science & applications Pub Date : 2024-06-29 DOI: 10.1038/s41377-024-01506-1
Junjie Yi, Changjian Guo, Ziliang Ruan, Gengxin Chen, Haiqiang Wei, Liwang Lu, Shengqi Gong, Xiaofu Pan, Xiaowan Shen, Xiaowei Guan, Daoxin Dai, Kangping Zhong, Liu Liu
{"title":"Anisotropy-free arrayed waveguide gratings on X-cut thin film lithium niobate platform of in-plane anisotropy.","authors":"Junjie Yi, Changjian Guo, Ziliang Ruan, Gengxin Chen, Haiqiang Wei, Liwang Lu, Shengqi Gong, Xiaofu Pan, Xiaowan Shen, Xiaowei Guan, Daoxin Dai, Kangping Zhong, Liu Liu","doi":"10.1038/s41377-024-01506-1","DOIUrl":"10.1038/s41377-024-01506-1","url":null,"abstract":"<p><p>Arrayed waveguide grating is a versatile and scalable integrated light dispersion device, which has been widely adopted in various applications, including, optical communications and optical sensing. Recently, thin-film lithium niobate emerges as a promising photonic integration platform, due to its ability of shrinking largely the size of typical lithium niobate based optical devices. This would also enable multifunctional photonic integrated chips on a single lithium niobate substrate. However, due to the intrinsic anisotropy of the material, to build an arrayed waveguide grating on X-cut thin-film lithium niobate has never been successful. Here, a universal strategy to design anisotropy-free dispersive components on a uniaxial in-plane anisotropic photonic integration platform is introduced for the first time. This leads to the first implementation of arrayed waveguide gratings on X-cut thin-film lithium niobate with various configurations and high-performances. The best insertion loss of 2.4 dB and crosstalk of -24.1 dB is obtained for the fabricated arrayed waveguide grating devices. Applications of such arrayed waveguide gratings as a wavelength router and in a wavelength-division multiplexed optical transmission system are also demonstrated.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"147"},"PeriodicalIF":19.4,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging probing perspective of two-dimensional materials physics: terahertz emission spectroscopy. 二维材料物理学的新兴探测视角:太赫兹发射光谱学。
IF 19.4 1区 物理与天体物理
Light, science & applications Pub Date : 2024-06-29 DOI: 10.1038/s41377-024-01486-2
Yifei Wu, Yuqi Wang, Di Bao, Xiaonan Deng, Simian Zhang, Lin Yu-Chun, Shengxian Ke, Jianing Liu, Yingjie Liu, Zeli Wang, Pingren Ham, Andrew Hanna, Jiaming Pan, Xinyue Hu, Zhengcao Li, Ji Zhou, Chen Wang
{"title":"Emerging probing perspective of two-dimensional materials physics: terahertz emission spectroscopy.","authors":"Yifei Wu, Yuqi Wang, Di Bao, Xiaonan Deng, Simian Zhang, Lin Yu-Chun, Shengxian Ke, Jianing Liu, Yingjie Liu, Zeli Wang, Pingren Ham, Andrew Hanna, Jiaming Pan, Xinyue Hu, Zhengcao Li, Ji Zhou, Chen Wang","doi":"10.1038/s41377-024-01486-2","DOIUrl":"10.1038/s41377-024-01486-2","url":null,"abstract":"<p><p>Terahertz (THz) emission spectroscopy (TES) has emerged as a highly effective and versatile technique for investigating the photoelectric properties of diverse materials and nonlinear physical processes in the past few decades. Concurrently, research on two-dimensional (2D) materials has experienced substantial growth due to their atomically thin structures, exceptional mechanical and optoelectronic properties, and the potential for applications in flexible electronics, sensing, and nanoelectronics. Specifically, these materials offer advantages such as tunable bandgap, high carrier mobility, wideband optical absorption, and relatively short carrier lifetime. By applying TES to investigate the 2D materials, their interfaces and heterostructures, rich information about the interplay among photons, charges, phonons and spins can be unfolded, which provides fundamental understanding for future applications. Thus it is timely to review the nonlinear processes underlying THz emission in 2D materials including optical rectification, photon-drag, high-order harmonic generation and spin-to-charge conversion, showcasing the rich diversity of the TES employed to unravel the complex nature of these materials. Typical applications based on THz emissions, such as THz lasers, ultrafast imaging and biosensors, are also discussed. Step further, we analyzed the unique advantages of spintronic terahertz emitters and the future technological advancements in the development of new THz generation mechanisms leading to advanced THz sources characterized by wide bandwidth, high power and integration, suitable for industrial and commercial applications. The continuous advancement and integration of TES with the study of 2D materials and heterostructures promise to revolutionize research in different areas, including basic materials physics, novel optoelectronic devices, and chips for post-Moore's era.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"146"},"PeriodicalIF":19.4,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chiral quantum heating and cooling with an optically controlled ion. 利用光学控制离子进行手性量子加热和冷却。
IF 19.4 1区 物理与天体物理
Light, science & applications Pub Date : 2024-06-26 DOI: 10.1038/s41377-024-01483-5
Jin-Tao Bu, Jian-Qi Zhang, Ge-Yi Ding, Jia-Chong Li, Jia-Wei Zhang, Bin Wang, Wen-Qiang Ding, Wen-Fei Yuan, Liang Chen, Qi Zhong, Ali Keçebaş, Şahin K Özdemir, Fei Zhou, Hui Jing, Mang Feng
{"title":"Chiral quantum heating and cooling with an optically controlled ion.","authors":"Jin-Tao Bu, Jian-Qi Zhang, Ge-Yi Ding, Jia-Chong Li, Jia-Wei Zhang, Bin Wang, Wen-Qiang Ding, Wen-Fei Yuan, Liang Chen, Qi Zhong, Ali Keçebaş, Şahin K Özdemir, Fei Zhou, Hui Jing, Mang Feng","doi":"10.1038/s41377-024-01483-5","DOIUrl":"10.1038/s41377-024-01483-5","url":null,"abstract":"<p><p>Quantum heat engines and refrigerators are open quantum systems, whose dynamics can be well understood using a non-Hermitian formalism. A prominent feature of non-Hermiticity is the existence of exceptional points (EPs), which has no counterpart in closed quantum systems. It has been shown in classical systems that dynamical encirclement in the vicinity of an EP, whether the loop includes the EP or not, could lead to chiral mode conversion. Here, we show that this is valid also for quantum systems when dynamical encircling is performed in the vicinity of their Liouvillian EPs (LEPs), which include the effects of quantum jumps and associated noise-an important quantum feature not present in previous works. We demonstrate, using a Paul-trapped ultracold ion, the first chiral quantum heating and refrigeration by dynamically encircling a closed loop in the vicinity of an LEP. We witness the cycling direction to be associated with the chirality and heat release (absorption) of the quantum heat engine (quantum refrigerator). Our experiments have revealed that not only the adiabaticity breakdown but also the Landau-Zener-Stückelberg process play an essential role during dynamic encircling, resulting in chiral thermodynamic cycles. Our observations contribute to further understanding of chiral and topological features in non-Hermitian systems and pave a way to exploring the relation between chirality and quantum thermodynamics.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"143"},"PeriodicalIF":19.4,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EventLFM: event camera integrated Fourier light field microscopy for ultrafast 3D imaging. EventLFM:用于超快三维成像的事件相机集成傅立叶光场显微镜。
IF 19.4 1区 物理与天体物理
Light, science & applications Pub Date : 2024-06-26 DOI: 10.1038/s41377-024-01502-5
Ruipeng Guo, Qianwan Yang, Andrew S Chang, Guorong Hu, Joseph Greene, Christopher V Gabel, Sixian You, Lei Tian
{"title":"EventLFM: event camera integrated Fourier light field microscopy for ultrafast 3D imaging.","authors":"Ruipeng Guo, Qianwan Yang, Andrew S Chang, Guorong Hu, Joseph Greene, Christopher V Gabel, Sixian You, Lei Tian","doi":"10.1038/s41377-024-01502-5","DOIUrl":"10.1038/s41377-024-01502-5","url":null,"abstract":"<p><p>Ultrafast 3D imaging is indispensable for visualizing complex and dynamic biological processes. Conventional scanning-based techniques necessitate an inherent trade-off between acquisition speed and space-bandwidth product (SBP). Emerging single-shot 3D wide-field techniques offer a promising alternative but are bottlenecked by the synchronous readout constraints of conventional CMOS systems, thus restricting data throughput to maintain high SBP at limited frame rates. To address this, we introduce EventLFM, a straightforward and cost-effective system that overcomes these challenges by integrating an event camera with Fourier light field microscopy (LFM), a state-of-the-art single-shot 3D wide-field imaging technique. The event camera operates on a novel asynchronous readout architecture, thereby bypassing the frame rate limitations inherent to conventional CMOS systems. We further develop a simple and robust event-driven LFM reconstruction algorithm that can reliably reconstruct 3D dynamics from the unique spatiotemporal measurements captured by EventLFM. Experimental results demonstrate that EventLFM can robustly reconstruct fast-moving and rapidly blinking 3D fluorescent samples at kHz frame rates. Furthermore, we highlight EventLFM's capability for imaging of blinking neuronal signals in scattering mouse brain tissues and 3D tracking of GFP-labeled neurons in freely moving C. elegans. We believe that the combined ultrafast speed and large 3D SBP offered by EventLFM may open up new possibilities across many biomedical applications.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"144"},"PeriodicalIF":19.4,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Color coded metadevices toward programmed terahertz switching. 实现编程太赫兹开关的彩色编码元器件。
IF 19.4 1区 物理与天体物理
Light, science & applications Pub Date : 2024-06-25 DOI: 10.1038/s41377-024-01495-1
Weibao He, Xiang'ai Cheng, Siyang Hu, Ziheng Ren, Zhongyi Yu, Shun Wan, Yuze Hu, Tian Jiang
{"title":"Color coded metadevices toward programmed terahertz switching.","authors":"Weibao He, Xiang'ai Cheng, Siyang Hu, Ziheng Ren, Zhongyi Yu, Shun Wan, Yuze Hu, Tian Jiang","doi":"10.1038/s41377-024-01495-1","DOIUrl":"10.1038/s41377-024-01495-1","url":null,"abstract":"<p><p>Terahertz modulators play a critical role in high-speed wireless communication, non-destructive imaging, and so on, which have attracted a large amount of research interest. Nevertheless, all-optical terahertz modulation, an ultrafast dynamical control approach, remains to be limited in terms of encoding and multifunction. Here we experimentally demonstrated an optical-programmed terahertz switching realized by combining optical metasurfaces with the terahertz metasurface, resulting in 2-bit dual-channel terahertz encoding. The terahertz metasurface, made up of semiconductor islands and artificial microstructures, enables effective all-optical programming by providing multiple frequency channels with ultrafast modulation at the nanosecond level. Meanwhile, optical metasurfaces covered in terahertz metasurface alter the spatial light field distribution to obtain color code. According to the time-domain coupled mode theory analysis, the energy dissipation modes in terahertz metasurface can be independently controlled by color excitation, which explains the principle of 2-bit encoding well. This work establishes a platform for all-optical programmed terahertz metadevices and may further advance the application of composite metasurface in terahertz manipulation.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"142"},"PeriodicalIF":19.4,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Light People: Professor Che Ting Chan, curiosity drives to create the impossibilities. 光的人陈哲庭教授,好奇心驱使他创造不可能。
IF 19.4 1区 物理与天体物理
Light, science & applications Pub Date : 2024-06-21 DOI: 10.1038/s41377-024-01497-z
Tingting Sun, Ying Xiong
{"title":"Light People: Professor Che Ting Chan, curiosity drives to create the impossibilities.","authors":"Tingting Sun, Ying Xiong","doi":"10.1038/s41377-024-01497-z","DOIUrl":"10.1038/s41377-024-01497-z","url":null,"abstract":"<p><p>EDITORIAL: \"When something is said to be impossible, there are two points for researchers to initially clarify: whether it really is forbidden by the laws of nature; or whether it is simply that no material that currently exists in nature can do that.\" Metamaterials are such magical beings, which have physical properties like invisibility, negative refraction, super-resolution, and perfect absorption that are absent from natural materials. It has been rated by Science as one of the top ten scientific and technological breakthroughs affecting human beings in the 21st century.In this issue of Light People, we spoke with a \"magic\" creator, Professor Che Ting Chan, the Associate Vice-President (Research & Development) of the Hong Kong University of Science and Technology (HKUST), Member of the Hong Kong Academy of Sciences and Fellow of the American Physical Society. He has researched a number of theoretical problems in material physics, investigated the theory behind what they seek to achieve, and modulated light (electromagnetism) and acoustic waves through metamaterials. In the following, let's take a closer look at Professor Che Ting Chan's research life, and appreciate his style and the background of his accomplishment.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"141"},"PeriodicalIF":19.4,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11190227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Silicon-photonics-enabled chip-based 3D printer. 基于芯片的硅光子三维打印机。
IF 19.4 1区 物理与天体物理
Light, science & applications Pub Date : 2024-06-06 DOI: 10.1038/s41377-024-01478-2
Sabrina Corsetti, Milica Notaros, Tal Sneh, Alex Stafford, Zachariah A Page, Jelena Notaros
{"title":"Silicon-photonics-enabled chip-based 3D printer.","authors":"Sabrina Corsetti, Milica Notaros, Tal Sneh, Alex Stafford, Zachariah A Page, Jelena Notaros","doi":"10.1038/s41377-024-01478-2","DOIUrl":"10.1038/s41377-024-01478-2","url":null,"abstract":"<p><p>Imagine if it were possible to create 3D objects in the palm of your hand within seconds using only a single photonic chip. Although 3D printing has revolutionized the way we create in nearly every aspect of modern society, current 3D printers rely on large and complex mechanical systems to enable layer-by-layer addition of material. This limits print speed, resolution, portability, form factor, and material complexity. Although there have been recent efforts in developing novel photocuring-based 3D printers that utilize light to transform matter from liquid resins to solid objects using advanced methods, they remain reliant on bulky and complex mechanical systems. To address these limitations, we combine the fields of silicon photonics and photochemistry to propose the first chip-based 3D printer. The proposed system consists of only a single millimeter-scale photonic chip without any moving parts that emits reconfigurable visible-light holograms up into a simple stationary resin well to enable non-mechanical 3D printing. Furthermore, we experimentally demonstrate a stereolithography-inspired proof-of-concept version of the chip-based 3D printer using a visible-light beam-steering integrated optical phased array and visible-light-curable resin, showing 3D printing using a chip-based system for the first time. This work demonstrates the first steps towards a highly-compact, portable, and low-cost solution for the next generation of 3D printers.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"132"},"PeriodicalIF":19.4,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11153580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deformable microlaser force sensing. 可变形微激光力传感。
IF 19.4 1区 物理与天体物理
Light, science & applications Pub Date : 2024-06-05 DOI: 10.1038/s41377-024-01471-9
Eleni Dalaka, Joseph S Hill, Jonathan H H Booth, Anna Popczyk, Stefan R Pulver, Malte C Gather, Marcel Schubert
{"title":"Deformable microlaser force sensing.","authors":"Eleni Dalaka, Joseph S Hill, Jonathan H H Booth, Anna Popczyk, Stefan R Pulver, Malte C Gather, Marcel Schubert","doi":"10.1038/s41377-024-01471-9","DOIUrl":"10.1038/s41377-024-01471-9","url":null,"abstract":"<p><p>Mechanical forces are key regulators of cellular behavior and function, affecting many fundamental biological processes such as cell migration, embryogenesis, immunological responses, and pathological states. Specialized force sensors and imaging techniques have been developed to quantify these otherwise invisible forces in single cells and in vivo. However, current techniques rely heavily on high-resolution microscopy and do not allow interrogation of optically dense tissue, reducing their application to 2D cell cultures and highly transparent biological tissue. Here, we introduce DEFORM, deformable microlaser force sensing, a spectroscopic technique that detects sub-nanonewton forces with unprecedented spatio-temporal resolution. DEFORM is based on the spectral analysis of laser emission from dye-doped oil microdroplets and uses the force-induced lifting of laser mode degeneracy in these droplets to detect nanometer deformations. Following validation by atomic force microscopy and development of a model that links changes in laser spectrum to applied force, DEFORM is used to measure forces in 3D and at depths of hundreds of microns within tumor spheroids and late-stage Drosophila larva. We furthermore show continuous force sensing with single-cell spatial and millisecond temporal resolution, thus paving the way for non-invasive studies of biomechanical forces in advanced stages of embryogenesis, tissue remodeling, and tumor invasion.</p>","PeriodicalId":18093,"journal":{"name":"Light, science & applications","volume":"13 1","pages":"129"},"PeriodicalIF":19.4,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11150448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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