Malaria Research and Treatment最新文献

{"title":"Expression of Concern on “Protective Effect of Quercetin on Chloroquine-Induced Oxidative Stress and Hepatotoxicity in Mice”","authors":"and Treatment","doi":"10.1155/2020/8153970","DOIUrl":"https://doi.org/10.1155/2020/8153970","url":null,"abstract":"","PeriodicalId":18089,"journal":{"name":"Malaria Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82225701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Plasmodium falciparum</i> and <i>Plasmodium vivax</i> Prevalence in Ethiopia: A Systematic Review and Meta-Analysis.","authors":"Teshiwal Deress, Mekonnen Girma","doi":"10.1155/2019/7065064","DOIUrl":"10.1155/2019/7065064","url":null,"abstract":"<p><strong>Background: </strong>Malaria is a protozoan disease caused by the <i>Plasmodium</i> species. Among the five <i>Plasmodium</i> species. Among the five <i>Plasmodium falciparum</i> and <i>Plasmodium vivax</i> malaria are by far the most predominant and widely <i>distributed in Ethiopia.</i> Malaria is one of the leading causes of morbidity and mortality globally, particularly in the sub-Saharan countries including Ethiopia. It is also a major obstacle to socio-economic development in the country.</p><p><strong>Methods: </strong>Articles were searched from PubMed, Google Scholar, and Science Direct databases. The pooled prevalence estimates were analyzed using the DerSimonian-Laird random-effects model and the possible sources of heterogeneity were evaluated through subgroup analysis, metaregression, and sensitivity analysis. Publication bias was analyzed using funnel plots and Egger's test statistics. The data management and analysis were done using STATA 15.1 version software.</p><p><strong>Results: </strong>Among 922 studies initially identified, thirty-five full-text articles fulfilled the inclusion criteria and included in the study. The combined, <i>Plasmodium falciparum</i> and <i>Plasmodium vivax</i> malaria are by far the most predominant and widely.</p><p><strong>Conclusions: </strong>This systematic review and meta-analysis showed a high malaria prevalence in Ethiopia. Therefore, previous prevention and control measures should be revised and/or strengthened as appropriate and new strategies should be implemented. In addition, technical, financial and material support, and coordination of the regional capacity building and logistics should be adequately implemented.</p>","PeriodicalId":18089,"journal":{"name":"Malaria Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37669098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Incidence of Malaria Parasites in Screened Donor Blood for Transfusion.","authors":"Samuel Antwi-Baffour,&nbsp;Ransford Kyeremeh,&nbsp;Atta Poku Amoako,&nbsp;Lawrence Annison,&nbsp;John Ocquaye-Mensah Tetteh,&nbsp;Mahmood Abdulai Seidu","doi":"10.1155/2019/1457406","DOIUrl":"https://doi.org/10.1155/2019/1457406","url":null,"abstract":"<p><p>Malaria is a protozoan parasitic infection of humans resulting from one or more of the five species of the genus <i>Plasmodium</i> and its burden across the world particularly in the tropics is well known. Blood transfusion on the other hand is a necessary intervention in saving lives. However, it can lead to transfusion transmitted infections including malaria if the blood was donated by an infected person. It is therefore important that the blood from donors in malaria prone environment be examined thoroughly for malaria parasites. The objective of this study was to investigate the incidence of malaria parasites in donor blood. A total of 1,500 samples from donors were examined using microscopy, rapid diagnostic test (RDT), and molecular method for malaria parasites. Malaria parasites were detected in forty-eight (48), 49 and 47 of the blood samples using microscopy, RDT, and molecular method respectively. This gave an average prevalence of 3.2%. All the blood groups examined had some malaria positivity except blood group O and A negative. In all the positive samples, the trophozoites of <i>Plasmodium falciparum</i> were detected. There was no association between blood group type and prevalence of the malaria parasites. There was also no association between age and prevalence of malaria parasite. The results attest to the potential risk of blood transfusion transmitted malaria and thus pose a great risk to blood recipients, especially the malaria vulnerable groups of children and pregnant women. Even though the prevalence in this study was not high enough, together with other results from elsewhere, it can be said that the screening of donated blood or donors for malaria parasites is necessary so that measures will be put in place not to transfuse patients at risk.</p>","PeriodicalId":18089,"journal":{"name":"Malaria Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/1457406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37498675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oviposition and Development of Anopheles coluzzii coetzee and Wilkerson in Salt Water","authors":"E. Nwaefuna, Ibalafake Ibisobia Bagshaw, F. Gbogbo, M. Osae","doi":"10.1155/2019/9523962","DOIUrl":"https://doi.org/10.1155/2019/9523962","url":null,"abstract":"Anopheles coluzzii is an important vector of malaria in sub-Saharan Africa particularly of the most dangerous malaria parasite. It completes its life cycle in water and a change in physicochemical properties particularly that of salinity of water may affect egg laying and perhaps the development of eggs to maturity. Studies have shown that climate change may alter the transmission of many vector-borne diseases in different parts of the world and global warming will also raise sea levels which will lead to an increase in saline and brackish water body in coastal areas. This study investigated the salinity tolerance level of An. coluzzii. It involved creation of artificial environments of different salinity gradients using rainwater and sea water and the subsequent exposure of the media to An. coluzzii for laying of eggs and development of larvae to adult. Anopheles coluzzii showed ovipositional preference for less saline media as there was significant negative correlation between number of eggs laid and salinity of oviposition media. Effect of salinity was evident in egg development and larval survival, as no egg hatched in >30% sea water, all L3 larvae died in >40% seawater, and the maximum seawater concentration for L4 survival was 30%. An LC50 of 17.51% (95% CI: 9.31–24.56)% and 23.4% (95% CI: 16.76–22.30)% were calculated for L3 and L4 larvae respectively. Adults emerging from fresh and low saline water of 10% seawater had greater energy reserve than those emerging from 20% and 30% seawater. Increasing salinity did not affect wing length of the emerging adult. Despite the increased stress on larval development, some individuals survived and went on to emerge as adults in conditions that seem to be representative of brackish water. This may imply that an increase in brackish water sites caused by rising sea levels might create more suitable breeding sites for this species.","PeriodicalId":18089,"journal":{"name":"Malaria Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74165199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Factors Associated with Acute Kidney Injury among Malaria Patients in Dar es Salaam: A Cross-Sectional Study","authors":"M. S. Muhamedhussein, S. Ghosh, K. Khanbhai, E. Maganga, Z. Nagri, M. Manji","doi":"10.1155/2019/4396108","DOIUrl":"https://doi.org/10.1155/2019/4396108","url":null,"abstract":"Introduction Falciparum malaria still remains as a major cause of morbidity and mortality worldwide. Acute kidney injury is a known complication of malaria, and it is reported to occur in up to 40% of adult patients with severe falciparum malaria in endemic regions like sub-Saharan Africa. Objectives To determine the prevalence and factors associated with acute kidney injury among falciparum malaria patients in a tertiary level private hospital in Dar es Salaam. Methodology In a cross-sectional study design, 104 adults with falciparum malaria were enrolled consecutively over 6 months from April to September 2015. The diagnosis of acute kidney injury (AKI) in these patients was established using the KDIGO classification criteria. The prevalence of AKI was obtained at 48 hours from admission and at day 7. Different sociodemographic and clinical parameters which were associated with acute kidney injury at 48 hours and at day 7 were identified by hypothesis testing using chi squared tests followed by multivariate logistic regression analysis. Factors with a p value less than 0.05 were considered significant. Results The participants were predominantly males 65.4% (68/104) and a third (36.5% (38/104)) were between 46 and 65 years. The prevalence of AKI among malaria patients at 48 hours was 26% (27/104). The prevalence of AKI among malaria patients at day 7 was 18.3% (19/104). On multivariate logistic regression, we found that factors that were significantly associated with AKI at 48 hours were male sex (OR 127, CI 3.4–4700, P = 0.008) and hemoglobin <7.5g/dl (OR 36.5, CI 1.7–797.7, P = 0.022), and factor associated with AKI at day 7 was baseline platelet count <25×103 per mm3 (OR 77.8 CI 1.045–5798.6, P = 0.048). Only two patients needed hemodialysis (1.9%) and there were no deaths. Conclusion Acute kidney injury is a common complication in patient with falciparum malaria. When managed well it has an excellent prognosis and necessitates dialysis in only a minority of patients. Male sex and hemoglobin is associated with AKI at 48 hours and baseline platelet count is associated with AKI at 7 days.","PeriodicalId":18089,"journal":{"name":"Malaria Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78716294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: Amodiaquine-Artesunate versus Artemether-Lumefantrine against Uncomplicated Malaria in Children Less Than 14 Years in Ngaoundere, North Cameroon: Efficacy, Safety, and Baseline Drug Resistant Mutations in pfcrt, pfmdr1, and pfdhfr Genes","authors":"I. Ali, P. Netongo, Barbara Atogho-Tiedeu, Eric-Olivier Ngongang, A. Ajua, E. Achidi, andWilfred F. Mbacham","doi":"10.1155/2019/4274315","DOIUrl":"https://doi.org/10.1155/2019/4274315","url":null,"abstract":"[This retracts the article DOI: 10.1155/2013/234683.].","PeriodicalId":18089,"journal":{"name":"Malaria Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74747746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Imported Malaria in Netrokona District of Bangladesh 2013-2018: Analysis of Surveillance Data","authors":"Md Abdul Karim, M. Kabir, Md Ashraf Siddiqui, Md Shahidul Islam Laskar, Anjan Saha, S. Naher","doi":"10.1155/2019/6780258","DOIUrl":"https://doi.org/10.1155/2019/6780258","url":null,"abstract":"Introduction Netrokona is one of the first phase malaria elimination targeted 8 districts of Bangladesh by 2021. The district constitutes only 7% of the population but contributes half of the malaria cases in that area. Most of the cases of that district are imported from Meghalaya State of India. The study was conducted to understand the epidemiology of these imported malaria cases for further strategy development to prevent both imported and introduced cases. Methodology The study was retrospectively conducted on the malaria cases confirmed by microscopy and/or RDT by the government and/or NGO service providers between 2013 and 2018. The information of the cases was collected from the verbal “investigation” report of individual malaria confirmed cases. The respondents of the “investigation” were either the patients or their family members. Out of the 713 cases during the study period, descriptive analysis of 626 cases (based on the completeness of “investigation form”) of the district was done using MS Excel version 2016. Results Proportion of imported malaria in Netrokona district increased from 60% in 2013 to 95% in 2018 which persists throughout the year with a little seasonal fluctuation. The overall contribution of these imported cases is 93% by cross-border workers by population type and 84%, 66%, and 95% by male, labour, and tribal population considering the factors of sex, occupation, and ethnicity, respectively. Population aged between 15 and 49 years contributed 82% of these imported cases. All of these cases occurred in the internationally bordering belt with Meghalaya State of India. Species-wise distribution revealed lower P. falciparum (63%) and higher mixed (28%) infection in imported cases compared to the 71% Pf and 20% mixed infection among the indigenous infections whereas P. vivax is similar in both cases. Conclusion Imported malaria is an emerging issue that has a potential risk of increased local transmission which might be a challenge to malaria elimination in that area. Appropriate interventions targeting the cross-border workers are essential to prevent the introduced cases and subsequently avoid reestablishment when elimination of the disease is achieved.","PeriodicalId":18089,"journal":{"name":"Malaria Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90804937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Haematological Parameters as Predictors of Malaria Infection Using a Logistic Regression Model: A Case Study of a Hospital in the Ashanti Region of Ghana.","authors":"Ellis Kobina Paintsil, Akoto Yaw Omari-Sasu, Matthew Glover Addo, Maxwell Akwasi Boateng","doi":"10.1155/2019/1486370","DOIUrl":"10.1155/2019/1486370","url":null,"abstract":"<p><p>Malaria is the leading cause of morbidity in Ghana representing 40-60% of outpatient hospital attendance with about 10% ending up on admission. Microscopic examination of peripheral blood film remains the most preferred and reliable method for malaria diagnosis worldwide. But the level of skills required for microscopic examination of peripheral blood film is often lacking in Ghana. This study looked at determining the extent to which haematological parameters and demographic characteristics of patients could be used to predict malaria infection using logistic regression. The overall prevalence of malaria in the study area was determined to be 25.96%; nonetheless, 45.30% of children between the ages of 5 and 14 tested positive. The binary logistic model developed for this study identified age, haemoglobin, platelet, and lymphocyte as the most significant predictors. The sensitivity and specificity of the model were 77.4% and 75.7%, respectively, with a PPV and NPV of 52.72% and 90.51%, respectively. Similar to RDT this logistic model when used will reduce the waiting time and improve the diagnosis of malaria.</p>","PeriodicalId":18089,"journal":{"name":"Malaria Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37385879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Frequency of <i>Pfdhps</i> A581G Mutation in <i>Plasmodium falciparum</i> Isolates from Gabonese HIV-Infected Individuals.","authors":"Jeanne Vanessa Koumba Lengongo, Yaye Dié Ndiaye, Marie Louise Tshibola Mbuyi, Jacques Mari Ndong Ngomo, Daouda Ndiaye, Marielle Karine Bouyou Akotet, Denise Patricia Mawili-Mboumba","doi":"10.1155/2019/9523259","DOIUrl":"10.1155/2019/9523259","url":null,"abstract":"<p><strong>Background: </strong>Studying malaria parasites cross resistance to sulfadoxine-pyrimethamine (SP) and trimethoprim-sulfamethoxazole (cotrimoxazole, CTX) is necessary in areas coendemic for malaria and HIV. Polymorphism and frequency of drug resistance molecular markers, <i>Pfdhfr</i> and <i>Pfdhps</i> genes have been assessed in <i>Plasmodium falciparum</i> isolates from HIV-infected adults, in Gabon.</p><p><strong>Materiel and methods: </strong>A cross-sectional study was conducted in three HIV care and treatment centers, at Libreville, the capital city of Gabon and at Oyem and Koulamoutou, two rural cities between March 2015 and June 2016. <i>P. falciparum</i>-infected HIV adults were selected. Analysis of <i>Pfdhfr</i> and <i>Pfdhps</i> genes was performed using high resolution melting (HRM) technique.</p><p><strong>Results: </strong><i>Pfdhps</i> A581G mutation was found in 23.5% (8/34) of the isolates. Triple <i>Pfdhfr</i> mutation (51I-59R-108N) was predominant (29.4%; n=10) while 17.6% (n=6) of the isolates carried a quadruple mutation <i>(Pfdhfr</i> 51I-59R-108N + <i>Pfdhps</i> 437G; <i>Pfdhfr</i> 51I-108N + <i>Pfdhps</i> 437G-<i>Pfdhps</i>581G; <i>Pfdhfr</i> 51I-59R-108N + <i>Pfdhps</i> 581G). Highly resistant genotype was detected in around 10% (n=3) of the isolates. The quintuple mutation (triple <i>Pfdhfr</i> 51I-59R-108N and double <i>Pfdhps</i>437-581) was only found in isolates from two patients who did not use CTX. The most frequent haplotypes were those with a single mutation (<b>N</b>CNIAKA) (36%) and a quadruple mutation (<b>N</b>C<b>I</b>I<b>G</b>K<b>G</b>, <b>NRI</b>I<b>G</b>KA, and <b>NRI</b>IAK<b>G</b>). Mixed unknown genotypes were found at codon 164 in three isolates. Mixed genotypes were more frequent at codons 51 (23.5%; n=8) and 59 (20.5%; n=7) (<i>p</i><0.01).</p><p><strong>Conclusion: </strong><i>Pfdhps</i> A581G mutation as well as new combination of quintuple mutations is found for the first time in isolates from HIV-infected patients in Gabon in comparison to a previous study. The detection of these genotypes at a nonnegligible frequency underlines the need of a regular surveillance of antifolates drug resistance.</p>","PeriodicalId":18089,"journal":{"name":"Malaria Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37341443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Activation of Fetal Hofbauer Cells in Primigravidas Is Associated with Decreased Birth Weight in Symptomatic Placental Malaria.","authors":"Stephanie L Gaw,&nbsp;Bethann S Hromatka,&nbsp;Sadiki Ngeleza,&nbsp;Sirirak Buarpung,&nbsp;Nida Ozarslan,&nbsp;Antoinette Tshefu,&nbsp;Susan J Fisher","doi":"10.1155/2019/1378174","DOIUrl":"https://doi.org/10.1155/2019/1378174","url":null,"abstract":"<p><strong>Background: </strong>Placental malaria is a leading global cause of low birth weight neonates, especially in first-time mothers. To better understand the role of innate immunity in placental malaria, we investigated the relationships between histopathological markers of placental malaria, fetal and maternal macrophage responses, and perinatal outcomes in a cross-sectional case control study of pregnant women presenting with symptomatic malaria at the time of delivery.</p><p><strong>Results: </strong>Primigravidas showed increased hemozoin deposition in placental villi (<i>p</i>=0.02), syncytiotrophoblasts (<i>p</i>=0.01), and fetal Hofbauer cells (<i>p=</i>0.01). The percentage of hemozoin-positive villi negatively correlated with infant birth weight (regression coefficient [b] = -0.03 kg decrease in birth weight per % increase in hemozoin-positive villi, <i>p</i>=0.035). Malaria-infected placentas showed a twofold increase in Hofbauer cells (<i>p</i><0.001) and maternal macrophages (<i>p</i><0.001). Placental malaria was associated with a threefold increase in the percentage of M2 maternal macrophages (19.2% vs 6.4%, <i>p</i>=0.01). Primigravidas showed a significant decrease in the Hofbauer cell M2-percentage in placental malaria (92.7% vs. 97.0%, <i>p</i>=0.04), which was predictive of infant birth weight (b=0.08 kg increase in birth weight per % increase in M2 Hofbauer cells, <i>p</i>=0.001). There was no association between maternal macrophage response and infant birth weights.</p><p><strong>Conclusions: </strong>Placentas with malarial infection had increased numbers of fetal Hofbauer cells in the villous stroma and maternal macrophages in the intervillous space. In primigravidas, decreased anti-inflammatory M2-type Hofbauer cells were predictive of lower birth weight. M2-type maternal macrophages were increased in placental malaria, but there was no association with gravidity or birth weight. These results suggested a protective role of M2 Hofbauer cells in fetal growth restriction.</p>","PeriodicalId":18089,"journal":{"name":"Malaria Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/1378174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37323262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}