Leukemia research最新文献

{"title":"Corrigendum to \"CircPAN3 contributes to drug resistance in acute myeloid leukemia through regulation of autophagy\" [Leuk. Res., 85 (2019) 106198].","authors":"Jin Shang, Wei-Min Chen, Shan Liu, Zhi-Hong Wang, Tian-Nan Wei, Zhi-Zhong Chen, Wen-Bing Wu","doi":"10.1016/j.leukres.2025.108111","DOIUrl":"https://doi.org/10.1016/j.leukres.2025.108111","url":null,"abstract":"","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":" ","pages":"108111"},"PeriodicalIF":2.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genes with altered expression by 5-Aza treatment in myeloid leukemia cells through methylation in intron 1","authors":"Machiko Fujioka ,&nbsp;Hiroyuki Mishima ,&nbsp;Hidehiro Itonaga ,&nbsp;Yo Hamaguchi ,&nbsp;Uladzislau Korzun ,&nbsp;Koji Ando ,&nbsp;Akira Kinoshita ,&nbsp;Yasushi Miyazaki ,&nbsp;Koh-ichiro Yoshiura","doi":"10.1016/j.leukres.2025.108112","DOIUrl":"10.1016/j.leukres.2025.108112","url":null,"abstract":"<div><div>5-Azacitidine (5-Aza) is a hypomethylating agent with demonstrated therapeutic efficacy for myeloid leukemia. The aim of this study was to identify the genes that mediate the cell killing effect of 5-Aza against leukemia cells through their expression changes and DNA demethylation. RNA sequencing revealed 54 genes with increased transcription levels in both SKM-1 and KG-1a myeloid leukemia cell lines treated with 5-Aza. Long read sequencing revealed 79 genes in which intron 1 exhibited significant DNA demethylation after 5-Aza treatment. Forty-three genes showed both increased gene expression and DNA demethylation in intron 1 in cells treated with 5-Aza. Enrichment signaling pathway analysis demonstrated that genes were associated with “amino acid metabolism,” “neutrophil degranulation,” and “DNA damage response”. We evaluated the prognostic impacts of the 43 genes in acute myeloid leukemia patients using TCGA database. The results revealed that two genes (<em>HDC</em> and <em>MICALL2</em>) with increased expression in leukemia cells after 5-Aza treatment were associated with better overall survival, while six genes (<em>BTG2</em>, <em>CD52</em>, <em>PECAM1</em>, <em>PIK3IP1</em>, <em>PTGS2</em>, and <em>TREML2</em>) correlated with worse overall survival. This study revealed that the epigenetic regulation by DNA demethylation in intron 1 has an important role of 5-Aza treatment in myeloid leukemia cells, and suggests novel targets for the development of combination therapy with 5-Aza.</div></div>","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":"158 ","pages":"Article 108112"},"PeriodicalIF":2.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-dose ropeginterferon alfa-2b and peginterferon alfa-2a have comparable efficacy and tolerability in polycythemia vera","authors":"Neville Lee Jr,&nbsp;Katie Erdos,&nbsp;Aqib Abdul Rahman,&nbsp;Richard T. Silver,&nbsp;Joseph M. Scandura,&nbsp;Ghaith Abu-Zeinah","doi":"10.1016/j.leukres.2025.108110","DOIUrl":"10.1016/j.leukres.2025.108110","url":null,"abstract":"","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":"158 ","pages":"Article 108110"},"PeriodicalIF":2.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health system costs and autologous stem cell transplant receipt for participants with multiple myeloma in the Australian 45 and Up Study","authors":"Sarsha Yap ,&nbsp;Anna Kelly ,&nbsp;David Goldsbury ,&nbsp;Marianne F. Weber ,&nbsp;Xue Qin Yu ,&nbsp;Qingwei Luo ,&nbsp;Karen Canfell ,&nbsp;Eleonora Feletto","doi":"10.1016/j.leukres.2025.108100","DOIUrl":"10.1016/j.leukres.2025.108100","url":null,"abstract":"<div><h3>Background</h3><div>In Australia, the number of people living with multiple myeloma (MM) is projected to increase. We examined the health system costs and autologous stem cell transplant (ASCT) receipt among participants with MM diagnosed between 2006 and 2019 from the Australian 45 and Up Study cohort (267,357 participants).</div></div><div><h3>Materials and methods</h3><div>We identified 520 participants diagnosed with MM using cancer registry records. Direct excess health system costs were calculated by subtracting the mean values observed for 2533 matched participants without cancer from those observed for participants with MM. Costs were calculated from 2 years pre-diagnosis up to 5 years post-diagnosis, for different phases of care and at end of life. Participant characteristics associated with health system costs were analysed using gamma regression. Characteristics associated with ASCT receipt were analysed using competing risks regression.</div></div><div><h3>Results</h3><div>Mean excess health system cost per person was $8846 in the year pre-diagnosis and peaked at $66,249 in the year post-diagnosis. From 2- to 5-years post-diagnosis, mean excess costs per person ranged between $36,453 and $43,059 and remained substantially higher than pre-diagnosis levels. Within the 5-years post-diagnosis, 125 (24.0 %) received ASCT. Older age at diagnosis was strongly associated with lower costs (each one-year increase, relative rate (RR)= 0.97, 95 % CI:0.96–0.98 for initial phase of care costs) and a lower rate of ASCT (each one-year increase, sub-hazard ratio (SHR)= 0.85, 95 % CI:0.83–0.87).</div></div><div><h3>Conclusions</h3><div>Health system costs for individuals with MM were significantly higher post-diagnosis than pre-diagnosis and remained elevated for at least 5-years. This work provides insights for future healthcare requirements for MM.</div></div>","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":"158 ","pages":"Article 108100"},"PeriodicalIF":2.2,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenic mechanisms and targeted therapies for anemia in myelodysplastic syndromes","authors":"Doudou Chang ,&nbsp;Linhua Yang ,&nbsp;Ruijuan Zhang","doi":"10.1016/j.leukres.2025.108099","DOIUrl":"10.1016/j.leukres.2025.108099","url":null,"abstract":"<div><div>Myelodysplastic Syndromes (MDS) are malignant neoplasms of the myeloid lineage originating from hematopoietic stem cells (HSCs), characterized by ineffective hematopoiesis, blood cell dysplasia, and a high risk of transformation to acute leukemia. Anemia affects up to 90 % of MDS patients, significantly increasing symptom burden, impacting quality of life, accelerating disease progression, and is associated with increased morbidity and mortality. The limited therapeutic landscape for addressing anemia in MDS presents a significant challenge in clinical management. This review explores the mechanisms of anemia in MDS（including low-risk MDS and high-risk MDS）, covering disturbances in hematopoiesis, telomere dynamics, inflammation, immune dysregulation, alterations in iron metabolism, and the role of the bone marrow microenvironment. We examine how these factors contribute to the complex pathophysiology of MDS-related anemia and discuss their implications for treatment strategies. Furthermore, we highlight recent advances in understanding the molecular basis of MDS, which have paved the way for novel therapeutic approaches. These include targeted therapies addressing specific genetic mutations, immunomodulatory agents, and innovative approaches to stimulate effective erythropoiesis. We also review emerging treatments such as Luspatercept, along with other novel agents targeting specific pathways, and ongoing clinical trials exploring combination therapies and personalized treatment strategies.</div></div>","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":"158 ","pages":"Article 108099"},"PeriodicalIF":2.2,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment with asciminib after a prior tyrosine kinase inhibitor in patients with chronic-phase chronic myeloid leukemia","authors":"Ehab L. Atallah ,&nbsp;Islam Sadek ,&nbsp;David Wei ,&nbsp;Dominick Latremouille-Viau ,&nbsp;Carmine Rossi ,&nbsp;Andrea Damon ,&nbsp;Daisy Yang ,&nbsp;Remi Bellefleur ,&nbsp;Annie Guérin ,&nbsp;Kejal Jadhav","doi":"10.1016/j.leukres.2025.108089","DOIUrl":"10.1016/j.leukres.2025.108089","url":null,"abstract":"<div><h3>Background</h3><div>In chronic-phase chronic myeloid leukemia (CML-CP), switching tyrosine kinase inhibitor (TKI) therapy due to intolerance or resistance is common. While asciminib, an ABL/BCR::ABL1 TKI targeting the ABL myristoyl pocket, offers improved tolerability and efficacy, there is limited real-world effectiveness data, particularly among patients with treatment with one prior TKI.</div></div><div><h3>Patients and methods</h3><div>A retrospective, US physician panel-based chart review study was conducted on adult patients with CML-CP without T315I treated with asciminib after one prior TKI. Time-on-treatment, and time-to achieving or maintaining MR2 (BCR::ABL1 ≤ 1 %), MMR (BCR::ABL1 ≤ 0.1 %) and DMR (BCR::ABL1 ≤ 0.01 %) were assessed using Kaplan-Meier analyses. Subgroup analyses were performed among patients with first TKI discontinuation due to intolerance or resistance, and by first- or second-generation TKI as first TKI.</div></div><div><h3>Results</h3><div>Overall, 255 patients (median age 62 years, 56.5 % male) were included. Imatinib (49.8 %), dasatinib (34.5 %), nilotinib (10.6 %), and bosutinib (5.1 %) were received as first TKI. Intolerance and resistance to first TKIs were reported for 43.5 % and 23.5 % of patients, respectively. At 48-weeks post-asciminib initiation, 95.0 % of patients (95 % CI: 91.3 %, 97.1 %) remained on asciminib, 84.0 % (95 % CI: 78.6 %, 88.6 %) achieved or maintained MR2, 68.3 % (95 % CI: 61.8 %, 74.5 %) MMR, and 40.6 % (95 % CI: 34.2 %, 47.8 %) DMR.</div></div><div><h3>Conclusions</h3><div>Overall, most patients remained on treatment and achieved or maintained MMR, suggesting that asciminib was well-tolerated and effective. Results were consistent among subgroups, indicating that asciminib is an effective option for patients regardless of prior TKI used, and including those intolerant or resistant to their first TKI.</div></div><div><h3>Micro-abstract</h3><div>There is limited real-world data regarding the effectiveness of asciminib after one prior tyrosine kinase inhibitor (TKI) in chronic-phase chronic myeloid leukemia (CML-CP). In this US physician panel-based chart review, nearly all patients (95 %) remained on asciminib and 68 % achieved or maintained a major molecular response at 48 weeks, suggesting that asciminib is well-tolerated and effective after one prior TKI.</div></div>","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":"157 ","pages":"Article 108089"},"PeriodicalIF":2.2,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145054377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of blinatumomab for CD19 + acute leukemias in patients historically excluded from clinical trials due to comorbidities","authors":"J. Preston Claiborne ,&nbsp;Daniel Li ,&nbsp;Hua-Ling Tsai ,&nbsp;Gabriel Ghiaur ,&nbsp;B. Douglas Smith ,&nbsp;Mark J. Levis ,&nbsp;Amy E. DeZern ,&nbsp;Alex J. Ambinder ,&nbsp;Tania Jain ,&nbsp;Gabrielle T. Prince ,&nbsp;Lukasz P. Gondek ,&nbsp;Theodoros Karantanos ,&nbsp;W. Brian Dalton ,&nbsp;Ivana Gojo ,&nbsp;Jonathan A. Webster","doi":"10.1016/j.leukres.2025.108098","DOIUrl":"10.1016/j.leukres.2025.108098","url":null,"abstract":"<div><h3>Background</h3><div>Blinatumomab has proven efficacy in the frontline, consolidation, and relapsed/refractory settings in B cell acute lymphoblastic leukemia. Its efficacy and safety among patients commonly excluded from clinical trials are unknown.</div></div><div><h3>Patients and Methods</h3><div>This single center, retrospective cohort study included patients treated for acute leukemia with blinatumomab with the following pre-existing conditions: liver dysfunction, renal impairment, central nervous system (CNS) conditions, autoimmune disease, solid organ transplantation, or uncontrolled infection. Rates of blinatumomab completion, efficacy outcomes, cytokine release syndrome (CRS), neurotoxicity (ICANS), and adverse events specific to the impaired organ leading to inclusion were assessed.</div></div><div><h3>Results</h3><div>Thirty-four patients were included, and 88 % completed at least one cycle of blinatumomab. One patient stopped prematurely due to toxicity and three due to lack of response in the relapsed/refractory setting. Response rates and survival were similar by treatment setting to those treated in clinical trials. The 60-day cumulative incidence of grade ≥ 2 CRS and ICANS were 23.5 % and 20.8 %, respectively. No excess liver injury, ICANS, autoimmune flares, organ rejection, or infections were observed in cohorts defined by impairment of each system.</div></div><div><h3>Conclusion</h3><div>Blinatumomab was successfully administered to the vast majority of patients with a baseline condition that would have led to clinical trial exclusion. Adverse events generally occurred at rates similar to prior clinical trials. These data provide the basis to consider removing certain exclusion criteria from future studies involving blinatumomab, allowing more patients to benefit from its efficacy.</div></div>","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":"157 ","pages":"Article 108098"},"PeriodicalIF":2.2,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL CHARACTERISTICS AND TREATMENT EVALUATION OF DIFFUSE LARGE B-CELL LYMPHOMA IN CHINESE CHILDREN AND ADOLESCENTS: A MULTICENTER CLINICAL STUDY OF CHINA-NET CHILDHOOD LYMPHOMA GROUP B-NHL-2017","authors":"Yang Fu,&nbsp;Ling Jin,&nbsp;Yanlong Duan,&nbsp;Jing Yang,&nbsp;Ying Liu,&nbsp;Bo Hu,&nbsp;Mincui Zheng,&nbsp;Yunpeng Dai,&nbsp;Ansheng Liu,&nbsp;Wei Liu,&nbsp;Leping Zhang,&nbsp;Fu Li,&nbsp;Baoxi Zhang,&nbsp;Xiaojun Yuan,&nbsp;Lirong Sun,&nbsp;Rong Liu,&nbsp;Zhuoyu Wen,&nbsp;Runming Jin,&nbsp;Shuquan Zhuang,&nbsp;Lian Jiang,&nbsp;Xiaowen Zhai","doi":"10.1016/j.leukres.2025.107988","DOIUrl":"10.1016/j.leukres.2025.107988","url":null,"abstract":"","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":"156 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROGNOSIS OF CHILDHOOD, ADOLESCENT AND YOUNG ADULT ENKL PATIENTS AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION","authors":"Ayumi Fujimoto,&nbsp;Tatsuhiko Anzai,&nbsp;Koji Kato,&nbsp;Junji Suzumiya,&nbsp;Noboru Asada,&nbsp;Mizuki Watanabe,&nbsp;Hideyuki Nakazawa,&nbsp;Koichi Onodera,&nbsp;Nobuhiro Hiramoto,&nbsp;Junya Kanda,&nbsp;Takahiro Fukuda,&nbsp;Yoshiko Atsuta,&nbsp;Yuhki Koga,&nbsp;Shinichi Kako,&nbsp;Ritsuro Suzuki","doi":"10.1016/j.leukres.2025.107982","DOIUrl":"10.1016/j.leukres.2025.107982","url":null,"abstract":"","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":"156 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INVESTIGATING KINASE DEPENDENCIES IN ALK+ALCL","authors":"Jacques Cornwell,&nbsp;Christopher Steel,&nbsp;Dawid Przystupski,&nbsp;Rogier ten Hoopen,&nbsp;Jamie D. Matthews,&nbsp;Lucy Hare,&nbsp;Nina Prokoph,&nbsp;G. A. Amos Burke,&nbsp;Suzanne D. Turner","doi":"10.1016/j.leukres.2025.107960","DOIUrl":"10.1016/j.leukres.2025.107960","url":null,"abstract":"","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":"156 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}