通过微阵列数据分析探讨结外自然杀伤/T细胞淋巴瘤合并EBV的发病机制

IF 2.1 4区医学 Q3 HEMATOLOGY

Leukemia research Pub Date : 2025-06-27 DOI:10.1016/j.leukres.2025.107909

Yin-yin Peng, Xiao-qiong Tang, Xin Wang

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引用次数: 0

摘要

目的鉴定结外自然杀伤/ t细胞淋巴瘤（ENKL）和eb病毒（EBV）发生发展的共同基因，并分析其富集、蛋白-蛋白相互作用（PPI）网络及其枢纽基因。方法利用GEO数据库中的GEO2R工具对数据集GSE85599和GSE169644的差异表达基因（deg）进行分析，利用STRING数据库对差异表达基因的PPI网络进行分析，利用Cytoscape软件对枢纽基因进行分析，并利用DAVID数据库对差异表达基因的富集进行分析。结果共鉴定出152个基因，其中包括TOP2A、AURKB、CDC20、MCM4、CCNB1、TYMS、FEN1、RRM2、CCNA2、MCM3、KIF11、BUB1、MCM6和CDC6等14个枢纽基因。PPI网络和富集分析表明，deg与核相关过程高度相关。结论本研究鉴定了ENKL和EBV感染的共同基因，发现了14个可能在两者之间起中介作用的枢纽基因。希望本研究能为进一步研究EBV感染与ENKL的分子机制提供新的见解。

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Exploring the pathogenesis of extranodal natural killer/T cell lymphoma complicated With EBV via microarray data analysis

Objectives

To identify the common genes playing roles in the development of both the Extranodal Natural Killer/T-cell lymphoma (ENKL) and Epstein-Barr virus (EBV), and to analyze their enrichment, protein-protein interaction (PPI) nework, and their hub genes.

Methods

We analyzed the differential expressed genes (DEGs) of data sets GSE85599 and GSE169644 from the Gene Expression Omnibus (GEO) database using its GEO2R tool, analyzed the PPI network of DEGs using STRING database, analyzed the hub genes using Cytoscape software, and analyzed the enrichment of DEGs using DAVID database.

Results

We identified 152 DEGs, and 14 hub genes among them, including TOP2A, AURKB, CDC20, MCM4, CCNB1, TYMS, FEN1, RRM2, CCNA2, MCM3, KIF11, BUB1, MCM6 and CDC6. PPI network and enrichment analysis show that DEGs are highly relavant with the process related with nucleus.

Conclusions

In this study we identified the common DEGs of ENKL and EBV infections, found 14 hub DEGs that may mediate between them. Hope this study could provide new insights for further study of the molecular mechanism between EBV infection and ENKL.

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来源期刊

Leukemia research 医学-血液学

CiteScore

4.00

自引率

3.70%

发文量

259

审稿时长

1 months

期刊介绍： Leukemia Research an international journal which brings comprehensive and current information to all health care professionals involved in basic and applied clinical research in hematological malignancies. The editors encourage the submission of articles relevant to hematological malignancies. The Journal scope includes reporting studies of cellular and molecular biology, genetics, immunology, epidemiology, clinical evaluation, and therapy of these diseases.