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Burkitt lymphoma in patients with chronic lymphocytic leukemia and other indolent B-cell lymphoid malignancies.
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-03-25 DOI: 10.1080/10428194.2025.2475337
Tadeusz Robak, Agnieszka Pluta, Pawel Robak, Agnieszka Janus, Ewa Wawrzyniak, Marcin Braun
{"title":"Burkitt lymphoma in patients with chronic lymphocytic leukemia and other indolent B-cell lymphoid malignancies.","authors":"Tadeusz Robak, Agnieszka Pluta, Pawel Robak, Agnieszka Janus, Ewa Wawrzyniak, Marcin Braun","doi":"10.1080/10428194.2025.2475337","DOIUrl":"https://doi.org/10.1080/10428194.2025.2475337","url":null,"abstract":"<p><p>The most common form of Richter transformation, observed in 90-95% of patients, is the transformation of chronic lymphocytic leukemia (CLL) into diffuse large B-cell lymphoma (DLBCL). CLL has also been found to transform into Hodgkin lymphoma, prolymphocytic leukemia, and, in extremely rare cases, into other hematological malignancies, including Burkitt lymphoma (BL). This manuscript discusses a case of CLL transforming into BL and reviews a rare collection of cases of Burkitt lymphoma or Burkitt-like lymphoma associated with CLL,B-cell prolymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, lymphoplasmacytic lymphoma and splenic marginal zone lymphoma. It covers the pathogenesis, prognosis, clinical characteristics, and treatment outcomes of Burkitt transformation in CLL and other indolent B-cell lymphoid malignancies patients. A comprehensive search was conducted using PubMed, Web of Science, and Google Scholar for articles published between January 1980 and December 2024 on chronic lymphocytic leukemia, Burkitt lymphoma, indolent lymphoma, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, 8q24/MYC rearrangement, Epstein-Barr virus-positive lymphoma, and translocation t(8;14)(q24;q32). Additional relevant publications were identified by reviewing the references cited in the selected articles.</p>","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1-13"},"PeriodicalIF":2.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Achievement of durable remission of relapsed/refractory acute myeloid leukemia in a child using venetoclax monotherapy.
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-03-25 DOI: 10.1080/10428194.2025.2482135
Juanita E Ferreira, Cassandra P Wang, Paibel Aguayo-Hiraldo, Gordana Raca, Chintan Parekh, David R Freyer, Alexandra E Kovach
{"title":"Achievement of durable remission of relapsed/refractory acute myeloid leukemia in a child using venetoclax monotherapy.","authors":"Juanita E Ferreira, Cassandra P Wang, Paibel Aguayo-Hiraldo, Gordana Raca, Chintan Parekh, David R Freyer, Alexandra E Kovach","doi":"10.1080/10428194.2025.2482135","DOIUrl":"https://doi.org/10.1080/10428194.2025.2482135","url":null,"abstract":"","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1-5"},"PeriodicalIF":2.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A phase-2 study of pembrolizumab in patients with biologically selected subtypes of relapsed/refractory aggressive lymphomas.
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-03-25 DOI: 10.1080/10428194.2025.2478525
Mwanasha H Merrill, Robert A Redd, David C Fisher, Jeremy S Abramson, Jeffrey Barnes, Jaehyuk Choi, Caron A Jacobson, Austin I Kim, Matthew A Lunning, Hallie D Jester, Erin L Jeter, Mikaela M McDonough, Philippe Armand, Eric D Jacobsen
{"title":"A phase-2 study of pembrolizumab in patients with biologically selected subtypes of relapsed/refractory aggressive lymphomas.","authors":"Mwanasha H Merrill, Robert A Redd, David C Fisher, Jeremy S Abramson, Jeffrey Barnes, Jaehyuk Choi, Caron A Jacobson, Austin I Kim, Matthew A Lunning, Hallie D Jester, Erin L Jeter, Mikaela M McDonough, Philippe Armand, Eric D Jacobsen","doi":"10.1080/10428194.2025.2478525","DOIUrl":"https://doi.org/10.1080/10428194.2025.2478525","url":null,"abstract":"","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1-4"},"PeriodicalIF":2.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tyrosine kinase inhibitor discontinuation and reinitiation patterns in CML patients in the US: real-world evidence.
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-03-25 DOI: 10.1080/10428194.2025.2482133
Jyotirmoy Sarker, Ehab L Atallah, Kathryn E Flynn, Aaron N Winn
{"title":"Tyrosine kinase inhibitor discontinuation and reinitiation patterns in CML patients in the US: real-world evidence.","authors":"Jyotirmoy Sarker, Ehab L Atallah, Kathryn E Flynn, Aaron N Winn","doi":"10.1080/10428194.2025.2482133","DOIUrl":"https://doi.org/10.1080/10428194.2025.2482133","url":null,"abstract":"","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1-6"},"PeriodicalIF":2.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovative management of BK virus nephropathy post-HSCT: a case report and therapeutic insights.
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-03-24 DOI: 10.1080/10428194.2025.2480394
Marina Vallvé, Kevin Pasache, Nerea Castillo, Anna Domínguez, Albert Esquirol, Rodrigo Martino, Lluis Guirado, Yolanda Arce, Xoana Barros, Irene García-Cadenas
{"title":"Innovative management of BK virus nephropathy post-HSCT: a case report and therapeutic insights.","authors":"Marina Vallvé, Kevin Pasache, Nerea Castillo, Anna Domínguez, Albert Esquirol, Rodrigo Martino, Lluis Guirado, Yolanda Arce, Xoana Barros, Irene García-Cadenas","doi":"10.1080/10428194.2025.2480394","DOIUrl":"https://doi.org/10.1080/10428194.2025.2480394","url":null,"abstract":"","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1-4"},"PeriodicalIF":2.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-world outcomes after discontinuation of covalent BTK inhibitor-based therapy in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma.
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-03-23 DOI: 10.1080/10428194.2025.2482132
Nitin Jain, Toby A Eyre, Katherine B Winfree, Naleen Raj Bhandari, Manoj Khanal, Tomoko Sugihara, Yongmei Chen, Paolo Abada, Krish Patel
{"title":"Real-world outcomes after discontinuation of covalent BTK inhibitor-based therapy in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma.","authors":"Nitin Jain, Toby A Eyre, Katherine B Winfree, Naleen Raj Bhandari, Manoj Khanal, Tomoko Sugihara, Yongmei Chen, Paolo Abada, Krish Patel","doi":"10.1080/10428194.2025.2482132","DOIUrl":"https://doi.org/10.1080/10428194.2025.2482132","url":null,"abstract":"<p><p>This study described real-world treatment patterns and outcomes among patients with CLL/SLL in the post-cBTKi setting. Included were patients who received at least one cBTKi and subsequent line of therapy (LOT) within the Flatiron Health nationwide electronic health record-derived de-identified database (FHD; <i>N</i> = 1,479) and Optum's de-identified Clinformatics<sup>®</sup> Data Mart Database (CDM; <i>N</i> = 1,020). Frequently observed post-cBTKi treatments in both databases included cBTKi monotherapy (23-30%), anti-CD20 mab monotherapy (∼10%), BCL2i monotherapy (∼9%), BCL2i + anti-CD20 mab (∼9%), cBTKi + BCL2i (∼3%), and cBTKi + anti-CD20 mab (5-7%). From start of immediate LOT following cBTKi discontinuation, median time-to-treatment-discontinuation ranged across databases between 6 and 9 months; median time-to-next-treatment and median overall survival ranged between 18-23 months and 36-57 months, respectively. Observed heterogeneity in treatment patterns and outcomes in two cohorts of patients with CLL/SLL suggests lack of clarity in clinical evidence for treatment choice, and there remains a need for treatment options that deliver improved outcomes in the post-cBTKi setting.</p>","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1-13"},"PeriodicalIF":2.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case report of a pediatric T-cell acute lymphoblastic leukemia with a subclonal GCC2::PDGFRB t(2;5) translocation - implementation for the selection of MRD-targets.
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-03-19 DOI: 10.1080/10428194.2025.2480395
Esther L Monsees, Richard T Hauch, Antonina Wrzeszcz, Michael Spohn, Julia Strauss, Udo Zur Stadt, Martin A Horstmann, Gabriele Escherich, Lena Behrmann
{"title":"A case report of a pediatric T-cell acute lymphoblastic leukemia with a subclonal <i>GCC2::PDGFRB</i> t(2;5) translocation - implementation for the selection of MRD-targets.","authors":"Esther L Monsees, Richard T Hauch, Antonina Wrzeszcz, Michael Spohn, Julia Strauss, Udo Zur Stadt, Martin A Horstmann, Gabriele Escherich, Lena Behrmann","doi":"10.1080/10428194.2025.2480395","DOIUrl":"https://doi.org/10.1080/10428194.2025.2480395","url":null,"abstract":"","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1-5"},"PeriodicalIF":2.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Twice the trouble, half the fun: twin study suggests future direction for young adults with Hodgkin lymphoma.
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-03-14 DOI: 10.1080/10428194.2025.2476650
Michael Daunov, Changchun Deng
{"title":"Twice the trouble, half the fun: twin study suggests future direction for young adults with Hodgkin lymphoma.","authors":"Michael Daunov, Changchun Deng","doi":"10.1080/10428194.2025.2476650","DOIUrl":"https://doi.org/10.1080/10428194.2025.2476650","url":null,"abstract":"","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1-3"},"PeriodicalIF":2.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of treatment-related and de novo CCUS: a retrospective analysis from two centers.
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-03-13 DOI: 10.1080/10428194.2025.2478264
Jennifer Santos, Diana Abbott, Grace Bosma, Andrew Kent, Marc Schwartz, Christine M McMahon, Jonathan Gutman, Daniel A Pollyea, Maria L Amaya
{"title":"Comparison of treatment-related and de novo CCUS: a retrospective analysis from two centers.","authors":"Jennifer Santos, Diana Abbott, Grace Bosma, Andrew Kent, Marc Schwartz, Christine M McMahon, Jonathan Gutman, Daniel A Pollyea, Maria L Amaya","doi":"10.1080/10428194.2025.2478264","DOIUrl":"https://doi.org/10.1080/10428194.2025.2478264","url":null,"abstract":"","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1-3"},"PeriodicalIF":2.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allogeneic stem cell transplantation for MDS-clinical issues, choosing preparative regimens and outcome.
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-03-12 DOI: 10.1080/10428194.2025.2476652
Lara Bischof, Jule Ussmann, Uwe Platzbecker, Madlen Jentzsch, Georg-Nikolaus Franke
{"title":"Allogeneic stem cell transplantation for MDS-clinical issues, choosing preparative regimens and outcome.","authors":"Lara Bischof, Jule Ussmann, Uwe Platzbecker, Madlen Jentzsch, Georg-Nikolaus Franke","doi":"10.1080/10428194.2025.2476652","DOIUrl":"https://doi.org/10.1080/10428194.2025.2476652","url":null,"abstract":"<p><p>Despite the vast heterogeneity of myelodysplastic neoplasm (MDS), treatment options are limited and an allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the only curative approach. While, subsequently, allo-HSCT is the treatment of choice in fit high-risk MDS patients younger than 70 years, it should only be considered in young and fit low-risk MDS patients who suffer from severe and life threatening cytopenias, and fail all available conservative treatment options. With the increasing use of mismatched or haploidentical donors, the majority of MDS patients will have a suitable donor available, however, matched donors should still be preferred if rapidly available. Strategies to prevent relapse after allo-HSCT are scarce, and include the use of donor lymphocytes or the experimental use of hypomethylating agents in patients with impeding relapse detected by MRD or chimerism evaluation. Here, we summarize current treatment options and factors to consider in the context of allo-HSCT in MDS.</p>","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1-14"},"PeriodicalIF":2.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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