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Routine magnetic resonance central nervous system imaging may be avoided in high-risk systemic diffuse large B-cell lymphoma with negative cerebrospinal fluid analyses. 脑脊液分析阴性的高危系统性弥漫性大b细胞淋巴瘤可避免常规中枢神经系统磁共振成像。
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-06-01 Epub Date: 2025-01-14 DOI: 10.1080/10428194.2025.2451725
Rory Bennett, Manu Juneja, Mary Ann Anderson, Adrian Minson, Kirsten Herbert, Graham J Lieschke, Andrew W Roberts, Kylie D Mason, John F Seymour, Michael Dickinson
{"title":"Routine magnetic resonance central nervous system imaging may be avoided in high-risk systemic diffuse large B-cell lymphoma with negative cerebrospinal fluid analyses.","authors":"Rory Bennett, Manu Juneja, Mary Ann Anderson, Adrian Minson, Kirsten Herbert, Graham J Lieschke, Andrew W Roberts, Kylie D Mason, John F Seymour, Michael Dickinson","doi":"10.1080/10428194.2025.2451725","DOIUrl":"10.1080/10428194.2025.2451725","url":null,"abstract":"","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1138-1141"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unmet needs and lived experience of patients receiving CAR T-cell therapy. 接受CAR - t细胞治疗的患者未满足的需求和生活经历。
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-06-01 Epub Date: 2025-01-21 DOI: 10.1080/10428194.2025.2455488
Patrick J O'Shea, Patrick Connor Johnson, Areej El-Jawahri, Thomas W Leblanc
{"title":"Unmet needs and lived experience of patients receiving CAR T-cell therapy.","authors":"Patrick J O'Shea, Patrick Connor Johnson, Areej El-Jawahri, Thomas W Leblanc","doi":"10.1080/10428194.2025.2455488","DOIUrl":"10.1080/10428194.2025.2455488","url":null,"abstract":"<p><p>Chimeric Antigen Receptor T-Cell (CAR-T) therapy is an effective therapy and promising frontier in the treatment of hematologic malignancies. However, this revolutionary treatment has led to new challenges for patients, caregivers, and the healthcare system. In this review article, we discuss the various difficulties patients face both in the acute and long-term period following CAR-T infusion. We highlight the various ways these difficulties are addressed, as well as further areas of research and support needed to improve patient experience. Additionally, we consider the difficulties and burdens placed on caregivers and healthcare systems, as well as barriers to accessing CAR-T therapy. Finally, we address future directions of research and intervention development to meet patient and caregiver needs and improve equitable access. We pose early integration of specialty palliative care for individuals and their caregivers undergoing CAR-T therapy as one promising strategy to help improve patient experience and meet their needs.</p>","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1010-1020"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High burden and poor outcomes of myelodysplastic neoplasms (MDS) in the real-world: a 10-year audit of three Australian hospitals. 现实世界中骨髓增生异常肿瘤（MDS）的高负担和不良预后：对三家澳大利亚医院的10年审计
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-06-01 Epub Date: 2025-02-18 DOI: 10.1080/10428194.2025.2467783
Zoe Loh, Michael Ashby, Marzia Rahman, Evangeline Y Wong, Doen Ming Ong, Susan Morgan, Chong Chyn Chua
{"title":"High burden and poor outcomes of myelodysplastic neoplasms (MDS) in the real-world: a 10-year audit of three Australian hospitals.","authors":"Zoe Loh, Michael Ashby, Marzia Rahman, Evangeline Y Wong, Doen Ming Ong, Susan Morgan, Chong Chyn Chua","doi":"10.1080/10428194.2025.2467783","DOIUrl":"10.1080/10428194.2025.2467783","url":null,"abstract":"","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1162-1165"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of RAS-associated leukoproliferative disease (RALD) and Rosai-Dorfman disease in a patient with KRAS mutation. KRAS突变患者ras相关白质增生性疾病（RALD）和Rosai-Dorfman病的治疗
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-05-29 DOI: 10.1080/10428194.2025.2512025
Roberta S Azevedo, Luis Fayad, Rashmi Kanagal-Shamanna, Sanam Loghavi, Shimin Hu, Carlos E Bueso-Ramos, Koji Sasaki, Tareq Abuasab, Fareed Khawaja, Hannah Goulart, Iman Abou Dalle, Gautam Borthakur, Naveen Pemmaraju
{"title":"Treatment of RAS-associated leukoproliferative disease (RALD) and Rosai-Dorfman disease in a patient with <i>KRAS</i> mutation.","authors":"Roberta S Azevedo, Luis Fayad, Rashmi Kanagal-Shamanna, Sanam Loghavi, Shimin Hu, Carlos E Bueso-Ramos, Koji Sasaki, Tareq Abuasab, Fareed Khawaja, Hannah Goulart, Iman Abou Dalle, Gautam Borthakur, Naveen Pemmaraju","doi":"10.1080/10428194.2025.2512025","DOIUrl":"https://doi.org/10.1080/10428194.2025.2512025","url":null,"abstract":"","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1-5"},"PeriodicalIF":2.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of respiratory syncytial virus infection among hospitalized adults with hematological malignancies. 血液系统恶性肿瘤住院成人呼吸道合胞病毒感染的结局。
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-05-29 DOI: 10.1080/10428194.2025.2512030
Nikhil Vojjala, Lakshmi Kattamuri, Ritwik Dey, Rishab Prabhu, Aditi Sharma, Kunal Sharma, Geetha Krishnamoorthy, Vijendra Singh
{"title":"Outcomes of respiratory syncytial virus infection among hospitalized adults with hematological malignancies.","authors":"Nikhil Vojjala, Lakshmi Kattamuri, Ritwik Dey, Rishab Prabhu, Aditi Sharma, Kunal Sharma, Geetha Krishnamoorthy, Vijendra Singh","doi":"10.1080/10428194.2025.2512030","DOIUrl":"https://doi.org/10.1080/10428194.2025.2512030","url":null,"abstract":"","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1-4"},"PeriodicalIF":2.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphoma: factors associated with unplanned diagnostic pathways and survival -a nationwide Danish register-based cohort study. 淋巴瘤：与非计划诊断途径和生存相关的因素——丹麦全国基于登记的队列研究。
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-05-27 DOI: 10.1080/10428194.2025.2508299
Linda Aagaard Rasmussen, Peter Vedsted, Henry Jensen, Henrik Frederiksen, Tarec Christoffer El-Galaly, Peter de Nully Brown, Line Flytkjær Virgilsen
{"title":"Lymphoma: factors associated with unplanned diagnostic pathways and survival -a nationwide Danish register-based cohort study.","authors":"Linda Aagaard Rasmussen, Peter Vedsted, Henry Jensen, Henrik Frederiksen, Tarec Christoffer El-Galaly, Peter de Nully Brown, Line Flytkjær Virgilsen","doi":"10.1080/10428194.2025.2508299","DOIUrl":"https://doi.org/10.1080/10428194.2025.2508299","url":null,"abstract":"<p><p>The objective was to investigate how patient characteristics, clinical characteristics and prognosis were associated with lymphoma diagnoses in unplanned pathways. We included 7,157 consecutive patients diagnosed with lymphoma in a nationwide register-based study in Denmark. An unplanned pathway was defined as an acute admission within 30 days before diagnosis and compared to all other pathways combined. A total of 21% of patients were diagnosed in unplanned pathways, varying from 13% in indolent non-Hodgkin lymphoma to 32% in aggressive non-Hodgkin lymphoma. The probability of being diagnosed in an unplanned pathway was higher for patients with comorbidity, B-symptoms, abnormal blood test results, advanced disease stage and poor performance score (PS) at diagnosis. Diagnosis in an unplanned pathway was associated with higher mortality, for example, HR 2.03 (95% CI:1.74-2.38 for PS 0). Increased disease severity at diagnosis was associated with unplanned diagnostic pathways. Diagnosis in an unplanned pathway was associated with higher mortality.</p>","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1-12"},"PeriodicalIF":2.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Co-occurrence of aplastic anemia and NLPHL with full recovery after local resection and radiation. 再生障碍性贫血和NLPHL共存，局部切除和放疗后完全恢复。
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-05-27 DOI: 10.1080/10428194.2025.2507194
Tzvika Porges, Kayed Al-Athamen, Yehonatan Sherf
{"title":"Co-occurrence of aplastic anemia and NLPHL with full recovery after local resection and radiation.","authors":"Tzvika Porges, Kayed Al-Athamen, Yehonatan Sherf","doi":"10.1080/10428194.2025.2507194","DOIUrl":"https://doi.org/10.1080/10428194.2025.2507194","url":null,"abstract":"","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1-4"},"PeriodicalIF":2.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Childhood body mass index at diagnosis and its association with non-Hodgkin lymphoma in the United States: a children's oncology group data analysis project. 美国儿童诊断时的体重指数及其与非霍奇金淋巴瘤的关系：一个儿童肿瘤组数据分析项目。
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-05-26 DOI: 10.1080/10428194.2025.2506502
Shelby Mestnik, Andrew R Marley, Zhanni Lu, Lucie M Turcotte, Erin Marcotte, Logan G Spector
{"title":"Childhood body mass index at diagnosis and its association with non-Hodgkin lymphoma in the United States: a children's oncology group data analysis project.","authors":"Shelby Mestnik, Andrew R Marley, Zhanni Lu, Lucie M Turcotte, Erin Marcotte, Logan G Spector","doi":"10.1080/10428194.2025.2506502","DOIUrl":"https://doi.org/10.1080/10428194.2025.2506502","url":null,"abstract":"<p><p>Childhood obesity has historically increased with time. Associations are noted between obesity and cancer in adults; but little investigation has been done in children. We conducted a matched case control study to assess the association between body mass index (BMI) and Non-Hodgkin Lymphoma (NHL) in children. Case information is from Children's Oncology Group and controls from National Health and Nutrition Examination Survey. There was no association between obesity and NHL overall, but patients less than 10 years, showed a positive association if outside of the normal BMI range, both obesity and underweight. Additionally, there was an association between NHL and underweight overall, in males, and in non-Hispanic/Latino children. Obesity showed an inverse association with NHL in females and children older than 10. We were not able to assess causality. Disease causing weight loss prior to diagnosis likely skewed baseline weights lower. Additional studies with BMI prior to diagnosis are needed.</p>","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1-6"},"PeriodicalIF":2.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toxicity, progression-free survival, and quality of life of patients treated with zanubrutinib versus ibrutinib: a Q-TWiST analysis from the ALPINE study in relapsed or refractory chronic lymphocytic leukemia. 扎鲁替尼与依鲁替尼治疗的患者的毒性、无进展生存期和生活质量：来自ALPINE研究的复发或难治性慢性淋巴细胞白血病的Q-TWiST分析。
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-05-23 DOI: 10.1080/10428194.2025.2506501
Vincent Lévy, Tushar Srivastava, Raju Gautam, Shilpi Swami, Kaijun Wang, Keri Yang, Leyla Mohseninejad
{"title":"Toxicity, progression-free survival, and quality of life of patients treated with zanubrutinib versus ibrutinib: a Q-TWiST analysis from the ALPINE study in relapsed or refractory chronic lymphocytic leukemia.","authors":"Vincent Lévy, Tushar Srivastava, Raju Gautam, Shilpi Swami, Kaijun Wang, Keri Yang, Leyla Mohseninejad","doi":"10.1080/10428194.2025.2506501","DOIUrl":"https://doi.org/10.1080/10428194.2025.2506501","url":null,"abstract":"<p><p>Zanubrutinib demonstrated significantly longer progression-free survival versus ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia (R/R CLL) in the ALPINE trial. This post-hoc analysis using ALPINE data aimed to understand the benefit-risk associated with zanubrutinib versus ibrutinib employing quality-adjusted time without symptoms/toxicity (Q-TWiST) methodology. Survival data were partitioned into 3 health-states: TOX (time with toxicity); TWiST (time without symptoms/toxicity); and REL (time after relapse). Q-TWiST was estimated as mean time in each health-state weighted by respective utility score. In the base case, comprising high-risk patients, mean durations (in months) for zanubrutinib versus ibrutinib were 11.54 versus 11.38 (TOX), 14.45 versus 11.09 (TWiST), and 1.70 versus 3.78 (REL). Mean duration of Q-TWiST was 21.07 (zanubrutinib) versus 18.67 months (ibrutinib; difference: 2.40 months; 95%CI: 1.9-2.9; <i>p</i><.001). This analysis demonstrated a significant Q-TWiST gain for zanubrutinib versus ibrutinib in high-risk R/R CLL patients, providing valuable insights that may inform clinical decision-making.</p>","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1-9"},"PeriodicalIF":2.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic utility of plasma circulating tumor DNA (ctDNA) in primary large B-cell lymphoma of the central nervous system (PCNS-LBCL): A paradigm shift? 血浆循环肿瘤DNA （ctDNA）在原发性中枢神经系统大b细胞淋巴瘤（PCNS-LBCL）中的诊断价值：范式转变？
IF 2.2 4区 医学
Leukemia & Lymphoma Pub Date : 2025-05-23 DOI: 10.1080/10428194.2025.2508298
Andrei Bucaloiu, Pouya Jamshidi, Karan Dixit, Madina Sukhanova, Hamza Tariq
{"title":"Diagnostic utility of plasma circulating tumor DNA (ctDNA) in primary large B-cell lymphoma of the central nervous system (PCNS-LBCL): A paradigm shift?","authors":"Andrei Bucaloiu, Pouya Jamshidi, Karan Dixit, Madina Sukhanova, Hamza Tariq","doi":"10.1080/10428194.2025.2508298","DOIUrl":"https://doi.org/10.1080/10428194.2025.2508298","url":null,"abstract":"","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":" ","pages":"1-4"},"PeriodicalIF":2.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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