Ayat Abbasi-Shahkouh, Kimiya Rashidan, Abbas Azadmehr, Amir Atashi
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引用次数: 0
Abstract
Neutrophil extracellular traps (NETs) are networks of decondensed chromatin and neutrophil granule proteins that trap invading microorganisms. However, since their discovery, especially in recent years, NETs have attracted increasing attention as key elements involved in the pathogenesis of a wide range of pathologic conditions including cardiovascular diseases, autoimmune and inflammatory diseases, and cancer. Many studies outlined that NETs contribute to regulating the biological behavior of many solid tumors and contribute to their initiation, progression, and metastasis. However, little is known regarding their implication in hematological malignancies and liquid tumors. In this comprehensive study, we review the studies focusing on the role of NETs in the pathophysiology of leukemia.
期刊介绍：
Leukemia & Lymphoma in its fourth decade continues to provide an international forum for publication of high quality clinical, translational, and basic science research, and original observations relating to all aspects of hematological malignancies. The scope ranges from clinical and clinico-pathological investigations to fundamental research in disease biology, mechanisms of action of novel agents, development of combination chemotherapy, pharmacology and pharmacogenomics as well as ethics and epidemiology. Submissions of unique clinical observations or confirmatory studies are considered and published as Letters to the Editor
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