Lupus最新文献

{"title":"Current smoking is related to severe damage in systemic lupus erythematosus patients.","authors":"M A Cosatti, S A Muñoz, M T Tamborenea, M García, A Curti, A Cappuccio, O Rillo, P M Imamura, E Schneeberger, F Dal Pra, M Ballent, M L Cousseau, J Velasco Zamora, V Saurit, S Toloza, M C Danielsen, V I Bellomio, C Graf, S Paira, J Cavallasca, B Pons Estel, J L Cristian Moreno, M Díaz, P Alba, M Verando, G Tate, E Mysler, J Sarano, E E Civit, F Risueño, P Álvarez Sepúlveda, M S Larroude, M F Méndez, A Conforti, D Sohn, C A Helling, S Roverano, S Malm-Green, D Medina Bornachera, A Alvarez, A Eimon, G Pendón, M Mayer, J Marin, C N Pisoni","doi":"10.1177/09612033241301182","DOIUrl":"10.1177/09612033241301182","url":null,"abstract":"<p><strong>Objective: </strong>To assess the relationship between smoking exposure and organ damage accrual measured by Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index for Systemic Lupus Erythematosus score (SLICC-SDI) in consecutive patients with systemic lupus erythematosus (SLE) from Argentina.</p><p><strong>Methods: </strong>623 consecutive SLE patients (fulfilling ≥4, 1997 ACR criteria) were included in this cross-sectional study. Sociodemographic and disease related variables including SLICC-SDI score and smoking status were collected. Patients currently smoking were considered \"smokers\", and \"non-smokers\" those who never smoked and former smokers. SLICC-SDI was divided into two categories: <3 and ≥3 was defined as severe damage.</p><p><strong>Results: </strong>Six hundred and 23 patients were included in the analysis, 89% women. Eighty-four per cent were non-smokers and 16 % were current smokers 83 percent of patients had SLICC-SDI <3 and 17 % had SLICC-SDI ≥3. Twenty one percent of patients with SLICC-SDI ≥3 and 15% with <3 SLICC-SDI were current smokers (<i>p</i> 0.081). In the multiple regression analysis, current smoking (OR 1.82, CI 95% 1.01-3.31, <i>p</i> 0.046), older age (OR 1.04, CI 95% 1.00-1.05, <i>p</i> 0.034), disease duration (OR 1.03, CI 95% 1.00-1.07, <i>p</i> 0.021) and cyclophosphamide exposure (OR 2.97, CI 95% 1.49-5.88, <i>p</i> 0.002) were related to SLICC-SDI ≥3.</p><p><strong>Conclusion: </strong>In our sample of patients, current smoking, older age, disease duration and cyclophosphamide were related to severe damage (SLICC-SDI ≥3).</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"28-33"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early subclinical macular disease in asymptomatic patients with primary antiphospholipid syndrome: A quantitative multimodal retinal evaluation.","authors":"Leandro Cabral Zacharias, Taurino Dos Santos Rodrigues Neto, Epitácio Dias da Silva Neto, Mário Luiz Ribeiro Monteiro, Gustavo Guimarães Moreira Balbi, Flávio Signorelli, Alex Haruo Higashi, Eloisa Bonfá, Danieli Castro Oliveira de Andrade","doi":"10.1177/09612033241307895","DOIUrl":"10.1177/09612033241307895","url":null,"abstract":"<p><strong>Purpose: </strong>To perform a quantitative multimodal evaluation in 25 patients with primary antiphospholipid syndrome (PAPS) without ocular complaints and to compare them with 25 healthy individuals.</p><p><strong>Methods: </strong>A structural and functional ophthalmological evaluation using optical coherence tomography angiography (OCTA) and microperimetry (MP) exam in 25 patients with PAPS, followed at a tertiary rheumatology outpatient clinic, was performed. All ophthalmologic manifestations were documented and subsequent statistical analysis was performed for comparative purposes, with significance set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>We included 100 eyes of 50 subjects (25 patients with PAPS without ocular complaints and 25 healthy individuals). Quantitative OCTA assessment revealed significant differences between PAPS patients and controls in both the superficial vascular complex (SVC) and deep vascular complex (DVC) using high-speed protocol, as well as in the SVC in the high-resolution protocol. Analysis of the foveal avascular zone (FAZ) parameters showed a larger area of FAZ in the DVC in PAPS patients using the high-speed method compared to the control group (<i>p</i> = 0.047). In MP quantitative analysis, the PAPS group exhibited lower central (<i>p</i> = 0.041) and global (<i>p</i> < 0.001) retinal sensitivity compared to the control group, along with sectoral differences, except in the inferior sector.</p><p><strong>Conclusions: </strong>PAPS patients present lower vascular density and retinal sensitivity compared to the control group, even in patients without paracentral acute middle maculopathy (PAMM). Our findings underscore the significance of ocular evaluation beyond symptomatic assessment in these patients.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"79-87"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diving deep into lupus: Gastrointestinal involvement insights from the Oman lupus study.","authors":"Nasra K Al-Adhoubi, Issa Al Salmi, Juma Al Kaabi, Farida Al-Balushi, Maha Ali, Talal Al Lawati, Bsh Al Lawati, Reem Abdwani, Ali Al Shamsi, Musallam Al Mashaani, Divij Krishna Jha, Sherin Sayed, Tariq Al-Araimi, Prabha Liyanage, Hilal Al Kalbani, Humaid A Al Wahshi","doi":"10.1177/09612033241292704","DOIUrl":"10.1177/09612033241292704","url":null,"abstract":"<p><strong>Objectives: </strong>This multicenter longitudinal study investigated the prevalence of gastrointestinal (GI) manifestations in lupus patients and determined the risk factors associated with mortality.</p><p><strong>Methods: </strong>This study is part of the Oman Lupus Study, which included 1160 patients who met the classification criteria for systemic lupus erythematosus (SLE) from January 2006 to February 2020. All patients were screened for GI symptoms and involvement.</p><p><strong>Results: </strong>We identified 91 patients with GI manifestations, with a prevalence rate of 8.53% in the pediatric group and 7.75% in the adult group, and this difference was not statistically significant (<i>p</i> = .755). Ischemic colitis was significantly associated with longer disease duration (<i>p</i> < .001) and positivity for B2-glycoprotein I (B2GPI) autoantibodies (<i>p</i> < .0001). Moreover, a significant correlation was found between ischemic colitis and hematologic manifestations (<i>p</i> = .001), lupus nephritis (<i>p</i> = .007), pulmonary complications (<i>p</i> = .000-.039), and some cardiac complications (<i>p</i> = .012-.269). Mortality rates were greater in patients with GI involvement (24.37%), including those with ischemic colitis (<i>p</i> = .005), chronic peritonitis (<i>p</i> < .001), and spleen/liver infarction (<i>p</i> = .001). Sepsis, thrombocytopenia, and different internal organ involvement rates were significantly associated with increased mortality.</p><p><strong>Conclusion: </strong>This research provides significant insights into GI manifestations in lupus patients. A higher mortality rate was found to be associated with organ involvement, disease duration, autoantibody profile, and specific complications. Considering this fact, it is vital to prioritize management strategies to improve clinical outcomes in this group of patients.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1637-1644"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the Editor.","authors":"Graham Rv Hughes","doi":"10.1177/09612033241302577","DOIUrl":"https://doi.org/10.1177/09612033241302577","url":null,"abstract":"","PeriodicalId":18044,"journal":{"name":"Lupus","volume":"33 14","pages":"1525"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral mononuclear cells and systemic lupus erythematosus association: Integrated study of single-cell sequencing and mendelian randomization analysis.","authors":"Shi Jian, Han Li","doi":"10.1177/09612033241292705","DOIUrl":"10.1177/09612033241292705","url":null,"abstract":"<p><strong>Objective: </strong>Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease predominantly affecting women. Despite advances in treatment, recent developments in single-cell RNA sequencing (scRNA-seq) and Mendelian randomization (MR) continue to facilitate the need for precision medicine.</p><p><strong>Methods: </strong>Data obtained from the GSE135779 dataset underwent quality control, normalization, and dimensionality reduction using Seurat and MonacoImmuneData. Marker genes identified subgroups for analysis with CellChat and ClusterProfilerR. MR analysis of these genes' eQTLs was performed to establish causal relationships with SLE using IEU Open GWAS project data.</p><p><strong>Results: </strong>Single-cell analysis revealed distinct cellular subtypes and highlighted increased monocyte levels in patients with SLE. MR analysis revealed 12 genes, particularly interferon induced protein with tetratricopeptide repeats 3 (IFIT3), causally related to SLE. Gene ontology and the Kyoto encyclopedia of genes and genomes analyses identified pathways significant to SLE pathogenesis. Visualization of these genes at the single-cell level revealed their role in disease progression. Cell communication differences between IFIT3-positive and -negative groups were also observed.</p><p><strong>Conclusion: </strong>This study demonstrates the potential of scRNA-seq and MR in identifying critical factors in SLE pathogenesis, thereby supporting the need for targeted therapies. Identifying IFIT3, among other genes, as central to SLE progression opens new avenues for precision medicine approaches in SLE management.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1526-1537"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do novel inflammation biomarkers arising from routine complete blood count play a role in patients with systemic lupus erythematosus?","authors":"Thilo Gambichler, Zenaida Numanovic, Imke Apel, Schapoor Hessam, Laura Susok, Xenofon Baraliakos, Philipp Sewerin","doi":"10.1177/09612033241295865","DOIUrl":"10.1177/09612033241295865","url":null,"abstract":"<p><strong>Background: </strong>Laboratory-based biomarkers accurately presenting systemic lupus erythematosus (SLE) disease activity may have a practical value in clinical routine. As shown in many other conditions, complete blood count (CBC)-derived biomarkers may also play a role in SLE.</p><p><strong>Objectives: </strong>We aimed to study for the first time the pan-immune-inflammation value (PIV, monocytes x platelets x neutrophils/lymphocytes) and the more established systemic immune-inflammation index (SII, neutrophils x platelets /lymphocytes) in SLE patients and correlate it with serological and clinical findings including disease outcomes.</p><p><strong>Methods: </strong>In this retrospective multicentric investigation, we reviewed the clinical records of 148 SLE who had an available CBC at baseline. The latter served for the determination of the neutrophil-to-lymphocyte ratio (NLR), SII, and the PIV. Control groups were studied as well. Univariable as well as multivariable statistics were employed.</p><p><strong>Results: </strong>The values for baseline systemic immune-inflammation biomarkers (SIIB) studied were significantly (<i>p</i> < 0.0001) higher than those observed in healthy controls but comparable to those obtained from patients with other inflammatory conditions. Multivariable analysis revealed that ANA titer > 1:640 remained the only significant (<i>p</i> < 0.0001) baseline predictor of SLE flare (odds ratio: 7.6, 95% CI 3.1 to 18.8). Improvement of SLE following treatment was associated with the absence of lymphopenia as well as ANA > 1:640 (<i>p</i> = 0.041). The SLEDAI-2K significantly correlated with NLR, SII, CRP, lymphocytes, and monocytes only on univariable testing.</p><p><strong>Conclusions: </strong>Compared to healthy controls the CBC-based SIIB investigated are significantly increased in SLE patients. However, SIIB do not appear to be useful in managing SLE clinically. Nevertheless, we confirm that higher ANA titers can predict flares of SLE.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1556-1561"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health seeking behaviour and diagnostic delays in SLE: A multi-ethnic Malaysian cohort study.","authors":"Fatimah Zanirah Nordin, Syahrul Sazliyana Shaharir, Mohd Shahrir Mohamed Said, Rozita Mohd, Rajalingham Sakthiswary, Tengku Amatullah Madeehah Tengku Mohd, Mohd Hafiz Jaafar, Wong Chin Yew","doi":"10.1177/09612033241297548","DOIUrl":"10.1177/09612033241297548","url":null,"abstract":"<p><strong>Introduction: </strong>Heterogeneity of the clinical manifestations of systemic lupus erythematosus (SLE) may lead to diagnostic delays. This study is aimed at determining the health-seeking behaviour patterns and factors associated with diagnostic delays in a multi-ethnic SLE cohort in Malaysia.</p><p><strong>Methodology: </strong>This was a cross-sectional study involving SLE patients who visited our institute between January 2020 and June 2021. A review of the medical records and face-to-face interviews were conducted to obtain sociodemographics, SLE disease characteristics and the intervals from the first symptoms to the diagnosis. Health-seeking behaviours were assessed by asking about the patients' first action during the initial symptoms and were divided into: (i) seeking professional health personnel; (ii) self-treatment; and (iii) the use of the internet as a primary source of information. Diagnostic delays were defined as the interval between initial symptoms and SLE diagnosis of more than 6 months. Low-level disease activity state (LLDAS) at 12 months was assessed from the medical records. Univariate and multivariate logistic regression analysis was subsequently conducted to determine factors associated with diagnostic delays.</p><p><strong>Results: </strong>Among the 154 patients included in the study, 24% (<i>n</i> = 37) had delayed diagnosis. The delay was significantly higher among the Indian versus Malay versus Chinese (42.9% vs 28% vs 10.8%, <i>p</i> = 0.037). Patients with rash tend to have delayed diagnosis (37.8% vs 22.2%, <i>p</i> = 0.08) while fewer patients with frothy urine had delayed diagnosis (8.1% vs 21.4%, <i>p</i> = 0.09). No significant association was found between health-seeking behaviours and diagnostic delays. The rate of LLDAS at 12 months was significantly lower among patients with delayed diagnosis (43.2% vs 70.0%, <i>p</i> = 0.006). Chinese ethnicity remained the only significant factor associated with lesser diagnostic delays in the multivariate analysis, with OR 0.30 (CI 0.09-0.93), <i>p</i> = 0.037.</p><p><strong>Conclusion: </strong>There were ethnic disparities in the early diagnosis of SLE in Malaysia, with Indian patients having a longer interval between the first symptom and diagnosis while the Chinese were associated with lower diagnostic delays. Early diagnosis predicted early attainment of LLDAS, suggesting that prompt recognition of the initial SLE symptoms is important.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1645-1653"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rituximab in lupus anticoagulant hypoprothrombinemia syndrome: A case report.","authors":"Jacopo Agnelli Giacchello, Nicol Francesca Trincheri, Patrizia Sciancalepore, Laura Contino, Roberto Mario Santi, Vittorio Pengo","doi":"10.1177/09612033241299619","DOIUrl":"10.1177/09612033241299619","url":null,"abstract":"<p><strong>Background: </strong>Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare autoimmune condition characterized by acquired prothrombin (FII) deficiency associated with antiphospholipid syndrome (APS) and life-threatening bleeding. We present the case of a 34-year-old woman with heavy menstrual bleeding (HMB), positive Lupus anticoagulant (LA) test, and high titer anticardiolipin antibodies Immunoglobulin G (ACA IgG) and anti-β2 glycoprotein I antibodies IgG (antiB2GPI IgG). Severe iron deficiency anemia necessitated recurrent blood transfusions and intravenous iron infusions from 2018 to 2021.</p><p><strong>Results: </strong>In January 2022, she was admitted to our clinic. Von Willebrand disease screening and platelet function analysis (PFA100) were normal. FII and FIX deficiencies were detected, without factor IX inhibitors. Anti-phosphatidylserine/prothrombin antibodies were confirmed by Padua University lab. To reduce antibody titers and menstrual bleeding, immunosuppressive therapy (Rituximab 375 mg/m2 weekly ×4 weeks) and hormonal therapy (desogestrel 75 mcg/day) were initiated.</p><p><strong>Conclusion: </strong>After 1-year, complete remission of clinical symptoms was achieved, with normalization of FII and FIX values and moderate reduction of aPS/PT titers, especially IgM isotype.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1611-1614"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA NRIR serves as a biomarker for systemic lupus erythematosus and participates in the disease progression.","authors":"Qingfeng Ma, Li Li, Youzhong Xing","doi":"10.1177/09612033241294032","DOIUrl":"10.1177/09612033241294032","url":null,"abstract":"<p><strong>Background: </strong>Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by a malfunction of the body's immune defense system.</p><p><strong>Objective: </strong>The objective of the present investigation was to examine the expression and diagnostic significance of NRIR in SLE and to prove whether it is involved in the progression of SLE.</p><p><strong>Methods: </strong>The study involved 110 participants, including 55 healthy individuals and 55 SLE patients. The expression levels of NRIR, miR-31-5p, and ICAM-1 were measured using qRT-PCR. The ROC curve was performed to assess the diagnostic significance of NRIR in SLE patients. Pearson correlation analysis was utilized to explore the relationship between NRIR and other indicators. Cytokines including IL-4, IL-6, and IL-21, along with IgG levels, were assessed using ELISA. The interaction between NRIR and miR-31-5p was validated using a dual-luciferase reporter assay.</p><p><strong>Result: </strong>Upregulated expression of NRIR was observed in individuals with SLE, serving a diagnostic function for SLE. Additionally, abnormal expression of NRIR impacted the viability of CD4⁺ T cells within SLE patients. NRIR could negatively modulate the expression of miR-31-5p.</p><p><strong>Conclusion: </strong>LncRNA NRIR may be a potential biomarker for SLE and is likely involved in the progression of SLE.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1538-1546"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibromyalgia, mood disorders and chronic damage are the main determinants of worse quality of life in systemic lupus erythematosus patients: Results from a cross-sectional analysis.","authors":"Fulvia Ceccarelli, Claudia Ciancarella, Carmelo Pirone, Francesco Natalucci, Licia Picciariello, Cristina Garufi, Silvia Mancuso, Simona Truglia, Francesca Romana Spinelli, Cristiano Alessandri, Fabrizio Cont","doi":"10.1177/09612033241299978","DOIUrl":"10.1177/09612033241299978","url":null,"abstract":"<p><strong>Objective: </strong>As suggested by the EULAR recommendations, a comprehensive management of Systemic Lupus Erythematosus (SLE) should include the evaluation of disease activity, chronic damage, and quality of life (QoL). QoL is significantly impaired in SLE patients, even in those achieving a state of remission, suggesting the possible contribution of other factors. Thus, in the present study we aimed at analyzing QoL in a large SLE cohort by using LupusQoL, and at identifying the main determinant of poorer QoL.</p><p><strong>Methods: </strong>We conducted a cross-sectional study by including consecutive SLE patients diagnosed according to the 2019 ACR/EULAR criteria. Clinical, laboratory and therapeutical data were collected. Disease activity was assessed by SLEDAI-2k, while chronic damage by the SLICC Damage Index (SDI). The diagnosis of fibromyalgia was made in accordance with the ACR criteria (2016). At the time of the enrollment, all patients completed the following questionnaires: LupusQoL to assess quality of life and hospital anxiety and depression scale (HADS) for anxiety and depression.</p><p><strong>Results: </strong>Our analysis included 237 SLE patients [92.4% female, median age 46 years (IQR 19.5), median disease duration 156.8 months (IQR 180.6)]. At the time of enrollment, we found a mean SLEDAI-2k of 1.7 (DS 2.4); 104 patients (43.9%) had chronic damage, with a mean SDI value of 0.8 (DS 1.3). Patients diagnosed with fibromyalgia were 69 (29.1%); moreover, HADS questionnaire identified a condition of anxiety and depression in 112 (47.3%) and 94 (39.7%) patients, respectively. The most compromised domain in the LupusQoL resulted \"fatigue\", followed by \"burden to others\". Patients with SDI ≥ 1 showed lower quality of life than patients without chronic damage, as demonstrated by significantly lower values in all items of the LupusQoL (<i>p</i> < .01). Furthermore, significantly lower values in all the LupusQoL domains were observed in patients with fibromyalgia, anxiety and depression, in comparison to those patients without these manifestations (<i>p</i> < .0001). No association was demonstrated between QoL and disease activity. Finally, the linear regression analysis confirmed mood disorders, in particular depression, and fibromyalgia as the main determinants of worse quality of life in our cohort.</p><p><strong>Conclusions: </strong>The present study demonstrated the influence of different factors in the quality of life of SLE patients. In particular, the presence of mood disorders, fibromyalgia and chronic damage resulted the main determinants of poorer QoL. This evidence reinforces the need for a comprehensive patient care.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1584-1593"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}