Current smoking is related to severe damage in systemic lupus erythematosus patients.

IF 1.9 4区医学 Q3 RHEUMATOLOGY

Lupus Pub Date : 2024-11-18 DOI:10.1177/09612033241301182

M A Cosatti, S A Muñoz, M T Tamborenea, M García, A Curti, A Cappuccio, O Rillo, P M Imamura, E Schneeberger, F Dal Pra, M Ballent, M L Cousseau, J Velasco Zamora, V Saurit, S Toloza, M C Danielsen, V I Bellomio, C Graf, S Paira, J Cavallasca, B Pons Estel, J L Cristian Moreno, M Díaz, P Alba, M Verando, G Tate, E Mysler, J Sarano, E E Civit, F Risueño, P Álvarez Sepúlveda, M S Larroude, M F Méndez, A Conforti, D Sohn, C A Helling, S Roverano, S Malm-Green, D Medina Bornachera, A Alvarez, A Eimon, G Pendón, M Mayer, J Marin, C N Pisoni

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引用次数: 0

Abstract

Objective: To assess the relationship between smoking exposure and organ damage accrual measured by Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index for Systemic Lupus Erythematosus score (SLICC-SDI) in consecutive patients with systemic lupus erythematosus (SLE) from Argentina.

Methods: 623 consecutive SLE patients (fulfilling ≥4, 1997 ACR criteria) were included in this cross-sectional study. Sociodemographic and disease related variables including SLICC-SDI score and smoking status were collected. Patients currently smoking were considered "smokers", and "non-smokers" those who never smoked and former smokers. SLICC-SDI was divided into two categories: <3 and ≥3 was defined as severe damage.

Results: Six hundred and 23 patients were included in the analysis, 89% women. Eighty-four per cent were non-smokers and 16 % were current smokers 83 percent of patients had SLICC-SDI <3 and 17 % had SLICC-SDI ≥3. Twenty one percent of patients with SLICC-SDI ≥3 and 15% with <3 SLICC-SDI were current smokers (p 0.081). In the multiple regression analysis, current smoking (OR 1.82, CI 95% 1.01-3.31, p 0.046), older age (OR 1.04, CI 95% 1.00-1.05, p 0.034), disease duration (OR 1.03, CI 95% 1.00-1.07, p 0.021) and cyclophosphamide exposure (OR 2.97, CI 95% 1.49-5.88, p 0.002) were related to SLICC-SDI ≥3.

Conclusion: In our sample of patients, current smoking, older age, disease duration and cyclophosphamide were related to severe damage (SLICC-SDI ≥3).

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目前吸烟与系统性红斑狼疮患者的严重损害有关。

目的评估阿根廷系统性红斑狼疮（SLE）连续患者中吸烟与通过系统性红斑狼疮国际合作诊所/美国风湿病学会系统性红斑狼疮损害指数（SLICC-SDI）评分测量的器官损害累积之间的关系。方法：本横断面研究纳入了 623 名连续的系统性红斑狼疮患者（符合 1997 年 ACR 标准，且≥4 分）。研究收集了社会人口学变量和疾病相关变量，包括 SLICC-SDI 评分和吸烟状况。目前吸烟的患者被视为 "吸烟者"，而从未吸烟和曾经吸烟的患者被视为 "非吸烟者"。SLICC-SDI分为两类：结果：分析共纳入 6023 名患者，其中 89% 为女性。84%的患者为非吸烟者，16%为曾经吸烟者，83%的患者有 SLICC-SDI （P 0.081）。在多元回归分析中，当前吸烟（OR 1.82，CI 95% 1.01-3.31，P 0.046）、年龄较大（OR 1.04，CI 95% 1.00-1.05，P 0.034）、病程（OR 1.03，CI 95% 1.00-1.07，P 0.021）和环磷酰胺暴露（OR 2.97，CI 95% 1.49-5.88，P 0.002）与 SLICC-SDI ≥3 有关：在我们的患者样本中，目前吸烟、年龄较大、病程长和环磷酰胺与严重损害（SLICC-SDI ≥3）有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lupus 医学-风湿病学

CiteScore

4.20

自引率

11.50%

发文量

225

审稿时长

1 months

期刊介绍： The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…