Lupus最新文献

{"title":"Association of serum levels of galectin-9 and IP-10 with disease activation in lupus nephritis.","authors":"Sibel Varelci, Suzan Cinar, Erdem Gürel, Safak Mirioglu, Omer Uludag, Ege Sinan Torun, Yasemin Yalcinkaya, Ahmet Gul, Murat Inanc, Bahar Artim-Esen","doi":"10.1177/09612033261493837","DOIUrl":"https://doi.org/10.1177/09612033261493837","url":null,"abstract":"<p><p>ObjectivesGalectin-9 and IP-10 are downstream effectors of the type I interferon (IFN) pathway and have been proposed as surrogate biomarkers of IFN signature in systemic lupus erythematosus (SLE). This study aimed to investigate the association of serum Galectin-9 and IP-10 levels with disease activity in lupus nephritis (LN) and to compare them with those in disease controls, including antiphospholipid syndrome (APS) and primary Sjögren's disease (pSD), and healthy controls.MethodsFifty-nine patients with biopsy-proven LN (31 active, 28 inactive), 36 patients with APS, 17 patients with pSD, and 61 healthy volunteers were enrolled. All SLE patients fulfilled both the SLICC and the 2019 EULAR/ACR classification criteria. Serum Galectin-9 and IP-10 levels were measured by enzyme-linked immunosorbent assay (ELISA) in samples obtained at the same visit as the disease activity assessment. In patients with active LN, kidney biopsy was performed as part of the same clinical evaluation, whereas patients with inactive LN had a previously established biopsy-proven diagnosis of LN.ResultsAmong 59 LN patients (74.6% female; mean age 37.9 ± 12 years), serum levels of both biomarkers were significantly higher in the active LN group compared with inactive LN, APS, pSD, and healthy controls (p ≤ 0.05). Biomarker levels did not differ significantly among the inactive LN, APS, and pSD groups (p > 0.05); however, all three groups showed significantly higher levels compared to healthy controls (p ≤ 0.05). Both biomarkers showed weak but statistically significant correlations with SLEDAI scores (Galectin-9: r = 0.36, p = 0.004; IP-10: r = 0.33, p = 0.009). ROC analysis demonstrated moderate discriminatory ability for distinguishing active from inactive LN (AUC: 0.695 for Galectin-9; 0.658 for IP-10).ConclusionSerum Galectin-9 and IP-10 are elevated in active LN and show weak but statistically significant correlations with SLEDAI scores. However, elevated levels are not specific to LN, as similar values are observed in inactive LN, APS, and pSD, suggesting these markers reflect a shared IFN-driven inflammatory state rather than LN-specific pathology.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"9612033261493837"},"PeriodicalIF":1.8,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of herpes zoster and recombinant zoster vaccine willingness in systemic lupus erythematosus: A single-center cohort study.","authors":"Yuhei Fujisawa, Ryu Watanabe, Ryuhei Ishihara, Yuya Fujita, Masao Katsushima, Kazuo Fukumoto, Shinsuke Yamada, Motomu Hashimoto","doi":"10.1177/09612033261493819","DOIUrl":"https://doi.org/10.1177/09612033261493819","url":null,"abstract":"<p><p>ObjectiveTo characterize the burden of herpes zoster (HZ) in systemic lupus erythematosus (SLE) and to examine clinical correlates of HZ and patients' attitudes toward the recombinant zoster vaccine (RZV).MethodsWe conducted a single-center retrospective cohort study combined with a cross-sectional survey among consecutive adult outpatients with SLE between December 2024 and June 2025. HZ episodes after SLE diagnosis were ascertained via structured interviews. Incidence rates were calculated as the number of HZ episodes per 1000 person-years from SLE diagnosis to enrollment. Participants were classified into three groups according to the number of HZ episodes: HZ⁰, HZ¹, and HZ^≥2 groups. Factors associated with HZ development were assessed using multivariable logistic regression. Patients were asked about willingness to receive RZV (\"yes\", \"no\", or \"not sure\") and reasons for the response.ResultsAmong 170 patients with SLE, 73 (43%) reported at least one HZ episode after SLE diagnosis, and 29 (40% of those with HZ) reported recurrent HZ. During 3138 person-years of follow-up, at least 102 HZ episodes were reported, yielding a minimum incidence of 32.5 per 1000 person-years. In multivariable analysis, ever use of azathioprine (OR 2.74, 95% CI 1.03-7.29) and renal dysfunction (OR 2.59, 95% CI 1.04-6.48) were associated with HZ development. Attitude data were available for 159 patients: 31 (20%) were willing to receive RZV, 47 (30%) were unwilling, and 81 (50%) were unsure.ConclusionsHZ was common and frequently recurrent in this Japanese SLE cohort. Ever use of azathioprine and renal dysfunction were associated with HZ development, while willingness to receive RZV was low. Risk-stratified clinician counselling and shared decision-making may improve acceptance of HZ prevention strategies in high-risk patients with SLE.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"9612033261493819"},"PeriodicalIF":1.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lupus nephritis at systemic lupus erythematosus onset and kidney outcomes in a Latin American biopsy-proven cohort.","authors":"José Alejandro Galeano-Toro, Tomás Urrego-Callejas, Joaquín Roberto Rodelo-Ceballos, Mauricio Restrepo-Escobar, Luis Alonso González-Naranjo, Janine Andrea Orejuela-Erazo, José Manuel Ustariz-Durán, Lina Marcela Aguirre-Hernández","doi":"10.1177/09612033261493844","DOIUrl":"https://doi.org/10.1177/09612033261493844","url":null,"abstract":"<p><p>BackgroundThe prognostic relevance of lupus nephritis (LN) occurring at systemic lupus erythematosus (SLE) onset versus later remains uncertain, particularly in Hispanic populations.MethodsWe conducted a retrospective cohort study of adults (≥18 years) with biopsy-proven LN from tertiary centers in Colombia (2011-2024). The exposure was LN at SLE onset (LNSO), defined as LN diagnosed concurrently with SLE or with kidney biopsy within 30 days of SLE onset, versus LN occurring later (non-LNSO). The primary outcome was end-stage kidney disease (ESKD), defined as sustained eGFR <15 mL/min/1.73 m² for ≥3 months, chronic dialysis, or kidney transplantation. Secondary outcomes were all-cause mortality and a composite of ESKD, death, or doubling of creatinine. Associations were estimated using cause-specific Cox and Fine-Gray models. A 180-day landmark analysis assessed the impact of no remission at 6 months.ResultsAmong 428 patients, 281 (65.7%) had LNSO and 147 (34.3%) non-LNSO. Median follow-up was 5.3 years. ESKD occurred in 72 patients (16.8%) and did not differ by LNSO status (log-rank <i>p</i> = 0.278). LNSO was not associated with ESKD (adjusted HR 0.87; 95% CI 0.48-1.60) or in competing-risk models (sHR 0.85; 95% CI 0.19-3.84). Lower baseline eGFR, higher NIH chronicity index, and higher non-renal damage were associated with ESKD. The composite outcome occurred in 156 patients and was not associated with LNSO. No remission at 6 months strongly predicted adverse outcomes.ConclusionsLNSO was not independently associated with kidney or survival outcomes. Baseline function, chronicity, non-renal damage, and early response were the main prognostic factors.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"9612033261493844"},"PeriodicalIF":1.8,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Views on pregnancy and related concerns among women with systemic lupus erythematosus: A cross-sectional study.","authors":"Dionysia Mandilara, Spyridon Katechis, Konstantinos Drougkas, Maria Pappa, Konstantina Zoupidou, Konstantina Kouna, Eleni Sampatakaki, Georgios Demirtzoglou, Dimitrios T Boumpas, Antonis Fanouriakis","doi":"10.1177/09612033261486353","DOIUrl":"https://doi.org/10.1177/09612033261486353","url":null,"abstract":"<p><p>ObjectivesTo explore pregnancy-related concerns among women with systemic lupus erythematosus (SLE) and impact of the disease on desired family size.MethodCross-sectional, single-center study, including women with SLE diagnosed before menopause. Data were collected via questionnaires and medical records. Participants were classified into three groups: (i) those who never conceived (Group 1); (ii) those who had conceived before SLE diagnosis (Group 2), and (iii) those who had conceived at least once after disease diagnosis (Group 3). Continuous variables were analyzed using Kruskal-Wallis with Mann-Whitney U <i>post-hoc</i> tests; categorical variables using Chi-square or Fisher's exact tests.Results152 patients were included and 75% had received information from their treating physician on reproductive health. Most common pregnancy-related concerns were the need to receive medication during pregnancy (56.6%), followed by concerns about pregnancy complications (53.9%). Women in Group 1 were younger and mainly attributed not having children to personal choice and not to SLE (56.4%). In contrast, women in Groups 2 and 3 frequently reported having fewer children than desired (35.3% and 44.6%, respectively), mostly due to SLE-related concerns (83.3% and 86.2%, respectively). In Group 3, deviation from desired family size was smaller among women who conceived in more recent periods (2015-2024, 32%), although attribution of deviations to SLE remained high.ConclusionsSLE affects women's reproductive decisions, underscoring the importance of tailored counseling.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"9612033261486353"},"PeriodicalIF":1.8,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective registration of systematic reviews and meta-analyses: A step toward greater research transparency.","authors":"Aditya K Panda","doi":"10.1177/09612033261486363","DOIUrl":"https://doi.org/10.1177/09612033261486363","url":null,"abstract":"","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"9612033261486363"},"PeriodicalIF":1.8,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From clinical to immunologic remission in lupus nephritis: Toward MRD-grade B-cell depletion.","authors":"Lucas Maciel de Almeida Corrêa, Luiggi Kevin Virgino Brandão, Clara Belo Gamon Santiago, Alexandre de Assis Barbosa, Gabriel Rian Mazur, Gabriel Costa de Santana, Yan Roberth Delmiro Silva, Letícia Esteves Dante, Ivan Felipe Dutra Júnior","doi":"10.1177/09612033261458553","DOIUrl":"10.1177/09612033261458553","url":null,"abstract":"<p><p>Current B-cell depletion strategies in lupus nephritis (LN) may encounter a mechanistic \"glass ceiling.\" While rituximab remains an important therapeutic option, its activity can be constrained by CD20 internalization, antigenic modulation, and greater reliance on complement-dependent mechanisms, which may be less efficient in complement-consuming inflammatory states. Type II anti-CD20 antibodies, particularly obinutuzumab, offer a biologically distinct approach by favoring stronger effector-cell recruitment and direct cell-death programs while reducing target internalization. In this perspective, we examine whether these properties may support deeper B-cell depletion in proliferative LN. Drawing conceptually from hematologic oncology, we propose that minimal residual disease (MRD) may serve as a useful analogue for thinking about depletion depth in nephrology; however, MRD-like peripheral depletion should not be interpreted as a validated renal endpoint or as direct proof of intrarenal immune quiescence. High-sensitivity flow cytometry may refine quantification of residual circulating B cells, whereas biomarkers such as uCD163 may provide complementary information on ongoing intrarenal inflammatory activity rather than tissue B-cell depletion per se. At present, surveillance-based retreatment and fixed peripheral thresholds remain investigational. Overall, obinutuzumab expands the mechanistic and clinical horizon of LN therapy, while underscoring the need for studies linking depletion depth, tissue biology, safety, and durability of response.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"997-1002"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney outcomes in pure membranous versus proliferative lupus nephritis: A 14-year Latin American cohort study.","authors":"Joaquín Rodelo-Ceballos, Mauricio Restrepo-Escobar, Jose Ustariz, Alejandra Taborda, Luis Alonso González","doi":"10.1177/09612033261458574","DOIUrl":"10.1177/09612033261458574","url":null,"abstract":"<p><p>BackgroundPure membranous lupus nephritis (MLN) generally has a better kidney prognosis than proliferative lupus nephritis (PLN), but comparative data from Latin America remain limited. We evaluated clinical features and kidney outcomes of MLN in a Colombian cohort and compared them with proliferative forms.MethodsWe retrospectively included adults (≥18 years) with first biopsy-proven MLN or PLN at a Colombian tertiary center. Clinical and histopathological features were compared between pure MLN (Class V) and PLN (Class III/IV ± V). Factors associated with MLN were analyzed using logistic regression. Kidney survival was estimated using Kaplan-Meier analysis, and predictors of end-stage kidney disease (ESKD) were assessed using Cox proportional hazards regression analyses. Because death could preclude observation of ESKD, competing-risks analyses were performed using cumulative incidence functions and Fine-Gray subdistribution hazard models with death treated as a competing event.ResultsOf 371 patients, 54 (14.6%) had MLN and 317 (85.4%) had PLN. Compared with PLN, patients with MLN have lower immunological activity, better kidney function, less active urinary sediment at biopsy, and lower modified NIH activity and chronicity indices scores. In multivariable logistic regression, higher eGFR was independently associated with MLN (OR 1.02, 95% CI 1.01-1.03), whereas anti-dsDNA positivity was inversely associated (OR 0.33, 95% CI 0.15-0.71). In univariable Cox analysis, MLN was associated with lower ESKD risk (HR 0.12, 95% CI 0.03-0.48); but this association was not confirmed in multivariable analysis, which was underpowered because only 2 ESKD events occurred in the MLN group. In competing-risks analysis, MLN was associated with a lower unadjusted subdistribution hazard of ESKD (SHR 0.13, 95% CI 0.03-0.51), but not after adjustment for baseline eGFR and modified NIH indices (adjusted SHR 0.46, 95% CI 0.11-2.00). Kaplan-Meier analysis showed higher crude renal survival in MLN than in PLN.ConclusionIn this Latin American cohort, MLN exhibited a distinct baseline profile characterized by lower inflammatory activity and better-preserved kidney function at presentation. Although crude and competing-risk analyses suggested a more favorable renal trajectory for MLN, the study was underpowered to confirm an independent effect of MLN on ESKD after adjustment.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1019-1029"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148176455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and histopathological predictors of systemic lupus erythematosus in a South American cohort of patients with full-house glomerulonephritis.","authors":"Romina Tanten Zabaleta, Estefania Espejo, Valeria Scaglioni, Silvia Christiansen, Griselda Bratti, Carlos Federico Varela, Javier E Rosa, Enrique R Soriano, Gustavo Greloni, Marina Scolnik","doi":"10.1177/09612033261463575","DOIUrl":"10.1177/09612033261463575","url":null,"abstract":"<p><p>ObjectivesOur aim was to evaluate clinical and renal histopathological variables associated with the diagnosis of Systemic Lupus Erythematosus (SLE) in a South American cohort with Full-House (FH) glomerulonephritis (GN) in order to distinguish it from other causes of FHGN.MethodsObservational retrospective study. Kidney biopsies performed in our hospital between 2000 and 2019 were reviewed, identifying those with a FH pattern. Clinical, analytical, and histopathological data were collected. Patients were classified as SLE with Lupus - FHGN (if they met ACR 1997 and/or SLICC 2012 and/or ACR-EULAR 2019 SLE criteria) and as non-Lupus FH GN (idiopathic or secondary). Descriptive statistics, univariate and multivariate logistic regression analysis were performed to identify factors associated with Lupus- FHGN, and Kaplan-Meier survival curves were used to compare renal survival between both groups.Results181 patients with FHGN were included, 124 women (68.5%), with a mean age of 41.1 years (SD 16.0) and a median post-biopsy follow-up time of 2.9 years (IQR 0.4-6.8 years). 116 patients (64.1%) met SLE criteria (103 with extrarenal manifestations and 13 with renal-limited lupus), 52 patients presented identifiable secondary causes of FHGN and 13 remained idiopathic FHGN. Renal biopsies in Lupus - FHGN presented more frequently 3 or 4 crosses of IgG, C3 and C1q deposits (<i>p</i> < 0.001) and had less moderate/severe involvement of the tubulointerstitial compartment (<i>p</i> < 0.001), when compared with non-Lupus FHGN. In the multivariate analysis, the factors that remained associated with Lupus - FHGN were: female sex, younger age, positive ANA, anti-DNA, and 3 or 4 crosses of C1q deposits. Lupus - FHGN showed a protective effect for the development of End-Stage Renal Disease (ESRD) in the univariate analysis (HR 0.34, 95% CI 0.13-0.89) but this association was not significant in the multivariate analysis.ConclusionsIn this South American cohort, 35.9% of FHGN were not associated with SLE diagnosis. Female sex, younger age, positive ANA or anti-DNA antibodies and marked C1q deposits at renal biopsy were associated with SLE diagnosis.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1058-1065"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148302050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The lived experiences of woman navigating university with lupus and their primary support persons.","authors":"Hailey A O'Neil, Misha Behi, Paula C Fletcher","doi":"10.1177/09612033261461992","DOIUrl":"10.1177/09612033261461992","url":null,"abstract":"<p><p>ObjectiveThis study examined the lived experiences of women with lupus and their primary support persons to better understand the effects associated with navigating university/college with lupus.MethodsFive women with lupus and five primary support persons (<i>n</i> = 10) were recruited from Southern Ontario. One-on-one semi-structured interviews were conducted with participants. Reflexive thematic analysis was used to analyze verbatim transcripts.ResultsTwo salient themes, (1) <i>Lupus is a part of me</i>, and (2) <i>Lupus does not exist in a bubble</i>, were identified, each with associated sub-themes. <i>Lupus is a part of me</i> discussed how lupus was part of participants everyday lives and how it became their new normal following symptom onset. <i>Lupus does not exist in a bubble</i> explored the ongoing challenges individuals and support persons experienced due to the lack of knowledge within healthcare, education, and society.ConclusionsWomen with lupus who are navigating university endure unique challenges in addition to school-related demands. Similarly, primary support persons who assisted throughout this navigation period encountered several individual and situational hardships due to the nature of lupus. Education for healthcare professionals, universities, and individuals with lived experience is warranted, along with more support services, to help navigate university/college more effectively.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1048-1057"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual triad in systemic lupus erythematosus: Alopecia, pigmentation, and keratoderma.","authors":"Inês Tribolet de Abreu, Inês Pereira-Amaral, Leonor Lopes","doi":"10.1177/09612033261465930","DOIUrl":"10.1177/09612033261465930","url":null,"abstract":"","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1099-1100"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148330567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}