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Letters in Applied NanoBioScience最新文献

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Extraction and Purification of Lectin from Soybean Seeds (Glycine max) 大豆种子凝集素(Glycine max)的提取纯化
Letters in Applied NanoBioScience Pub Date : 2022-09-17 DOI: 10.33263/lianbs124.100
{"title":"Extraction and Purification of Lectin from Soybean Seeds (Glycine max)","authors":"","doi":"10.33263/lianbs124.100","DOIUrl":"https://doi.org/10.33263/lianbs124.100","url":null,"abstract":"In this study, the effectiveness of the ion exchange column packed with anionic resin DEAE-Sephadex®-A-50 in purifying lectin isolated by conventional saline buffer method was investigated. After the lectin extraction, the purification efficacy of ion exchange cationic and anionic resins was compared. The purified lectin was freeze-dried to a solid state to characterize its physiochemical properties. The characterization included the presence and content of protein, sulfur, and carbohydrate, hemagglutination test, gel electrophoresis for molecular weight determination, and metal photometry for sodium content determination. The physiochemical characterization was carried out by Fourier-transfer infrared spectroscopy and X-ray diffraction studies. The test results were compared with the standard sample of soybean lectin. The purified lectin was amorphous, basic in nature, tetramer, galactose binding/N-acetylgalactosamine molecule in its sodium salt form, with a molecular weight of 120 kiloDaltons. Based on the results, the anionic resin DEAE-Sephadex®-A-50 can effectively purify lectin isolated from soybean seeds.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83894208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-Vivo Pharmacokinetics Study of Exemestane Hydrochloride Self-nanoemulsifying Drug Delivery Systems via Oral Route 盐酸依西美坦自纳米乳化给药系统的体内药代动力学研究
Letters in Applied NanoBioScience Pub Date : 2022-09-17 DOI: 10.33263/lianbs124.098
{"title":"In-Vivo Pharmacokinetics Study of Exemestane Hydrochloride Self-nanoemulsifying Drug Delivery Systems via Oral Route","authors":"","doi":"10.33263/lianbs124.098","DOIUrl":"https://doi.org/10.33263/lianbs124.098","url":null,"abstract":"Exemestane HCl (EXM) is a novel irreversible steroidal aromatase inhibitor for the adjuvant treatment of hormonally responsive breast cancer in postmenopausal women. Poor aqueous solubility of EXM is the biggest hurdle for developing solid oral dosage forms. That’s why the current study aims to evaluate the pharmacokinetics of formulating the EXM loaded self nano emulsifying drug delivery (SNEDDs) system. SNEDDs were formulated using Labrafac CC (20% w/v), Tween 80 (27%w/v), and Triacetin (54%w/v) as oil, surfactant, and co-surfactant, respectively, by water titration method. A comparative Pharmacokinetics study of EXM suspension and EXM SNEDDS was performed using a female waster rate. The developed formulation had a 37.65± 5.08 nm size and a 21.57±0.73 sec of self-emulsification time. Cmax of EXM suspension and EXM SNEDDS was found to be 122.49±8.27 and 194.86 ± 14.75 ng/mL, respectively. AUC0-720 of EMX SNEDDS was 1.71 times higher compared to EXM suspension, indicating that lipid nanoparticles improve the drug concentration in the plasma. So we conclude that SNEDDS improves the pharmacokinetic of EXM, which subsequently improves oral bioavailability.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75045104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Structure, Reactivity and Spectroscopic Properties of Hallucinogens Psilocybin, Mescaline and their Derivatives – A Computational Study 致幻剂裸盖菇素、美斯卡灵及其衍生物的分子结构、反应性和光谱性质的计算研究
Letters in Applied NanoBioScience Pub Date : 2022-09-17 DOI: 10.33263/lianbs124.105
{"title":"Molecular Structure, Reactivity and Spectroscopic Properties of Hallucinogens Psilocybin, Mescaline and their Derivatives – A Computational Study","authors":"","doi":"10.33263/lianbs124.105","DOIUrl":"https://doi.org/10.33263/lianbs124.105","url":null,"abstract":"Medical hallucinogens have been important compounds of research interest in recent years. Computational chemistry methods like Density Functional Theory (DFT) calculations at BP86/Def2-TZVP level are carried out to get more insight into the structural preferences and mechanism of hallucinogens like psilocybin and mescaline derivatives at the molecular level. The molecular structure, reactivity, spectroscopic properties, and mechanism in hallucination confirm that the geometry of the molecules is crucial in their preferred action. The results show the ability of these compounds and their derivatives to act as drugs for different problems. Among the 13 compounds studied, all the compounds, except tin and lead derivatives, show considerable stability in synthesizing them in the laboratories. The geometry and the reactivity descriptors are important tools in deciding the activity of magic mushrooms.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80198056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photocatalytic Degradation of Textile Dye Using Green Synthesized Nanoparticles 绿色合成纳米颗粒光催化降解纺织染料
Letters in Applied NanoBioScience Pub Date : 2022-09-17 DOI: 10.33263/lianbs124.102
{"title":"Photocatalytic Degradation of Textile Dye Using Green Synthesized Nanoparticles","authors":"","doi":"10.33263/lianbs124.102","DOIUrl":"https://doi.org/10.33263/lianbs124.102","url":null,"abstract":"In recent years, plants have been used as reducing agents for the synthesis of nanoparticles in a short time, and it consists of low cost, and there is no harmful effect on the environment; In this study, silver nanoparticles are synthesized from AgNO3 using leaf extract of Solena amplexicaulis (Lam.) Gandhi. The leaf extract is mixed with AgNO3 solution, and color change occurs from whitish-yellow to dark brown at room temperature within a few minutes. After incubation, the suspension was centrifuged, and particles were separated and dried. The green synthesized AgNPs were characterized by UV-visible spectroscopy in a maximum wavelength of 393 nm, FTIR, SEM, EDAX, DLS, XRD, and ZETA POTENTIAL; Photocatalytic degradation of Victoria blue or basic blue dye was investigated by green synthesized Ag nanoparticles with solar irradiation technique by biometrically at different time intervals. The UV-visible characteristic peak absorption of Victoria blue solution was 250 nm. The photocatalytic activity at different time intervals [control, treated controls, 30 min, (1, 2, 3, 5, 8, 12, 24, 48, 60, 72) hrs] was collected and decreased the peak intensity and was measured using UV-visible spectroscopy and Fourier Transform Infrared Spectroscopy. Green synthesized Ag nanoparticles effectively degraded the Victoria blue dye solution in total exposure time.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89940422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methods of Chitosan Identification: History and Trends 壳聚糖的鉴定方法:历史与趋势
Letters in Applied NanoBioScience Pub Date : 2022-09-17 DOI: 10.33263/lianbs124.094
{"title":"Methods of Chitosan Identification: History and Trends","authors":"","doi":"10.33263/lianbs124.094","DOIUrl":"https://doi.org/10.33263/lianbs124.094","url":null,"abstract":"Chitosan, discovered in 1859 and named in 1894, has long attracted the attention of scientists. However, endless possibilities for the chemical engineering of chitosan still offer inspiration for various innovative applications. The highly biocompatible and antimicrobial features of chitosan enable its multi-disciplinary applications, such as in medical engineering, food science, environmental science, and cosmetics; this is evident from the significantly increasing number of chitosan articles in the last two decades. This article presents methods for identifying chitosan using various analytical techniques and summarizes the findings from such techniques throughout the literature. The summary of the key analytical data presented in this review article could be used as a quick reference for a researcher who intends to analyze chitinous content by the method of their choice.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87488926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Greener Synthesis of Jasminaldehyde via Cross Aldol Condensation Reaction Using Recyclable Phase Transfer Catalysis and its Cosmetic Application 可循环相转移催化交叉醛缩合反应绿色合成茉莉醛及其化妆品应用
Letters in Applied NanoBioScience Pub Date : 2022-09-17 DOI: 10.33263/lianbs124.104
{"title":"Greener Synthesis of Jasminaldehyde via Cross Aldol Condensation Reaction Using Recyclable Phase Transfer Catalysis and its Cosmetic Application","authors":"","doi":"10.33263/lianbs124.104","DOIUrl":"https://doi.org/10.33263/lianbs124.104","url":null,"abstract":"Jasminaldehyde or alpha amyl cinnamic aldehyde is a commonly used aroma molecule in perfume formulationsThe aldol condensation of equimolar n-heptanal and benzaldehyde in NaOH using a surfactant catalyst cetyltrimethylammonium bromide to achieve high cross aldol product Jasminaldehyde selectivity was studied. The process is highly efficient due to the recyclability of the catalyst. The process was studied for four cycles of catalyst reusability. The selectivity of the cross product was dependent on the temperature, surfactant concentration, and mixing. The olfactive profile of Jasminaldehyde obtained with 0.1 M surfactant solution was identical to the standard. Jasminaldehyde formulation was created and applied to in-home care applications.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87519601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Comparative Pharmacognostical and Phytochemical Account of the Peel and Pulp of the Fruit of C. pepo 山茱萸果皮和果肉的比较生药学和植物化学研究
Letters in Applied NanoBioScience Pub Date : 2022-09-17 DOI: 10.33263/lianbs124.093
{"title":"Comparative Pharmacognostical and Phytochemical Account of the Peel and Pulp of the Fruit of C. pepo","authors":"","doi":"10.33263/lianbs124.093","DOIUrl":"https://doi.org/10.33263/lianbs124.093","url":null,"abstract":"The current investigation was performed to explore the phytochemicals and pharmacognostic activity in the pulp and peel part of the fruit of Cucurbita pepo. The most important stage in determining the identification of a crude medicine and assessing its quality and purity is pharmacognostic assessment. The parameters such as acid-insoluble, water-soluble, total ash value, extractive value, and moisture content were determined. Fluorescence characterization and phytochemical screening were also done to know the presence of various phytocompounds. The phytochemical investigation revealed therapeutic components in the peel and pulp extracts of C. pepo. The ash value of peel and pulp was 6.9 ± 0.17 and 5.8 ± 0.07, the insoluble acid value was 2.9 ± 0.10 and 1.7 ± 0.05, and the water-insoluble value was 3.6 ± 0.41 and 2.4 ± 0.10 respectively. The moisture content of peel and pulp was determined to be 0.249±0.022gm and 0.256±0.025 gm, respectively, while the extractive values were observed as 23.71±1.25 in methanolic extract of peel whereas 55.44±2.019 in aqueous extract of pulp.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88231586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional Enhancement of Wheat Bread by Probiotic Lactobacillus consortium 益生菌乳酸菌群对小麦面包营养的增强作用
Letters in Applied NanoBioScience Pub Date : 2022-09-17 DOI: 10.33263/lianbs124.101
{"title":"Nutritional Enhancement of Wheat Bread by Probiotic Lactobacillus consortium","authors":"","doi":"10.33263/lianbs124.101","DOIUrl":"https://doi.org/10.33263/lianbs124.101","url":null,"abstract":"The Lactobacillus acidophilus and L. rhamnosus are used as probiotic strains, supplement food for better human health. Initially, the wheat flour was fermented for 1 to 3 days. A higher increase in carbohydrates, proteins, and lipids was observed in flour fermented for 48 hours. It was compared both in the presence and the absence of Lactobacillus strains. Elevated levels of proteins, carbohydrates, and fats were noted in bread with probiotic strains. Lactobacillus spp. proved to be deficient in fat as the fat content was found to have decreased in bread made with the same—selenium and folate, “vitamin B9,” the essential vitamins for all (pregnancy) women. Bread with the probiotic strains is notably enriched with it. Selenium possesses an antioxidant property estimated using the FRAP assay technique. Bread with and without the Lactobacillus spp. was given for assessment via sensory analysis. The bread with the Lactobacillus was further tested and compared with normal wheat bread, with enhanced flavor and texture. This study shows that a combination of LAB (lactic acid bacteria) with wheat bread can be produced; it exists without any fungus for more than 10 days, while the wheat bread made without LAB wouldn’t attain its staleness period.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86102075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sesquiterpene lactones from Inula confertiflora A. Rich (Asteraceae) Leaf 菖蒲叶中的倍半萜内酯类化合物
Letters in Applied NanoBioScience Pub Date : 2022-09-17 DOI: 10.33263/lianbs124.095
{"title":"Sesquiterpene lactones from Inula confertiflora A. Rich (Asteraceae) Leaf","authors":"","doi":"10.33263/lianbs124.095","DOIUrl":"https://doi.org/10.33263/lianbs124.095","url":null,"abstract":"This study was aimed at the isolation of compounds present in the methanol extract of the leaves of the Ethiopian endemic plant Inula confertiflora A. Rich (Asteraceae). Phytochemical study on this extract led to first-time isolation and structural elucidations of reportedly bioactive sesquiterpene lactones, namely 4α, 5α-epoxyinuviscolide, graveolide, and carabrone, using spectroscopic methods.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86819937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Curcumin and Nanocurcumin in the Treatment of Photodynamic Therapy for Skincare 姜黄素和纳米姜黄素在光动力疗法护肤中的作用
Letters in Applied NanoBioScience Pub Date : 2022-09-17 DOI: 10.33263/lianbs124.092
{"title":"Curcumin and Nanocurcumin in the Treatment of Photodynamic Therapy for Skincare","authors":"","doi":"10.33263/lianbs124.092","DOIUrl":"https://doi.org/10.33263/lianbs124.092","url":null,"abstract":"Can photodynamic therapy be suitable for skincare? Do curcumin and nano-curcumin as photosensitizer for this photodynamic therapy? What are the differences between them? Is it a possible choice for photorejuvenation? There are still many questions on this topic. Let’s discuss the photodynamic therapy in skincare, curcumin, and its research progress for skin, as well as the difference between curcumin and nano-curcumin in the treatment of photodynamic therapy for skincare.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79522174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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