Learning & memory最新文献_第6页

Beyond prediction error: 25 years of modeling the associations formed in the insect mushroom body. 超越预测误差：昆虫蘑菇体内形成的关联建模 25 年。

IF 2.2 4区医学

Learning & memory Pub Date : 2024-06-11 Print Date: 2024-05-01 DOI: 10.1101/lm.053824.123

Barbara Webb

引用次数: 0

Sensory encoding and memory in the mushroom body: signals, noise, and variability. 蘑菇体内的感官编码和记忆：信号、噪音和可变性。

IF 2.2 4区医学

Learning & memory Pub Date : 2024-06-11 Print Date: 2024-05-01 DOI: 10.1101/lm.053825.123

Moshe Parnas, Julia E Manoim, Andrew C Lin

引用次数: 0

Presynaptic regulators in memory formation. 记忆形成过程中的突触前调节器

IF 2.2 4区医学

Learning & memory Pub Date : 2024-06-11 Print Date: 2024-05-01 DOI: 10.1101/lm.054013.124

Oriane Turrel, Lili Gao, Stephan J Sigrist

引用次数: 0

Drosophila learning and memory centers and the actions of drugs of abuse. 果蝇的学习和记忆中枢以及滥用药物的作用。

IF 1.7 4区医学

Learning & memory Pub Date : 2024-06-11 Print Date: 2024-05-01 DOI: 10.1101/lm.053815.123

Caleb Larnerd, Neha Kachewar, Fred W Wolf

{"title":"Drosophila learning and memory centers and the actions of drugs of abuse.","authors":"Caleb Larnerd, Neha Kachewar, Fred W Wolf","doi":"10.1101/lm.053815.123","DOIUrl":"10.1101/lm.053815.123","url":null,"abstract":"Drug addiction and the circuitry for learning and memory are intimately intertwined. Drugs of abuse create strong, inappropriate, and lasting memories that contribute to many of their destructive properties, such as continued use despite negative consequences and exceptionally high rates of relapse. Studies in Drosophila melanogaster are helping us understand how drugs of abuse, especially alcohol, create memories at the level of individual neurons and in the circuits where they function. Drosophila is a premier organism for identifying the mechanisms of learning and memory. Drosophila also respond to drugs of abuse in ways that remarkably parallel humans and rodent models. An emerging consensus is that, for alcohol, the mushroom bodies participate in the circuits that control acute drug sensitivity, not explicitly associative forms of plasticity such as tolerance, and classical associative memories of their rewarding and aversive properties. Moreover, it is becoming clear that drugs of abuse use the mushroom body circuitry differently from other behaviors, potentially providing a basis for their addictive properties.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"31 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glial metabolism versatility regulates mushroom body-driven behavioral output in Drosophila. 神经胶质代谢多功能性调节果蝇蘑菇体驱动的行为输出。

IF 1.7 4区医学

Learning & memory Pub Date : 2024-06-11 Print Date: 2024-05-01 DOI: 10.1101/lm.053823.123

Ruchira Basu, Thomas Preat, Pierre-Yves Plaçais

{"title":"Glial metabolism versatility regulates mushroom body-driven behavioral output in Drosophila.","authors":"Ruchira Basu, Thomas Preat, Pierre-Yves Plaçais","doi":"10.1101/lm.053823.123","DOIUrl":"10.1101/lm.053823.123","url":null,"abstract":"Providing metabolic support to neurons is now recognized as a major function of glial cells that is conserved from invertebrates to vertebrates. However, research in this field has focused for more than two decades on the relevance of lactate and glial glycolysis for neuronal energy metabolism, while overlooking many other facets of glial metabolism and their impact on neuronal physiology, circuit activity, and behavior. Here, we review recent work that has unveiled new features of glial metabolism, especially in Drosophila, in the modulation of behavioral traits involving the mushroom bodies (MBs). These recent findings reveal that spatially and biochemically distinct modes of glucose-derived neuronal fueling are implemented within the MB in a memory type-specific manner. In addition, cortex glia are endowed with several antioxidant functions, whereas astrocytes can serve as pro-oxidant agents that are beneficial to redox signaling underlying long-term memory. Finally, glial fatty acid oxidation seems to play a dual fail-safe role: first, as a mode of energy production upon glucose shortage, and, second, as a factor underlying the clearance of excessive oxidative load during sleep. Altogether, these integrated studies performed in Drosophila indicate that glial metabolism has a deterministic role on behavior.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"31 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Future avenues in Drosophila mushroom body research. 果蝇蘑菇体研究的未来之路。

IF 1.7 4区医学

Learning & memory Pub Date : 2024-06-11 Print Date: 2024-05-01 DOI: 10.1101/lm.053863.123

Ivy Chi Wai Chan, Nannan Chen, John Hernandez, Hagar Meltzer, Annie Park, Aaron Stahl

{"title":"Future avenues in Drosophila mushroom body research.","authors":"Ivy Chi Wai Chan, Nannan Chen, John Hernandez, Hagar Meltzer, Annie Park, Aaron Stahl","doi":"10.1101/lm.053863.123","DOIUrl":"10.1101/lm.053863.123","url":null,"abstract":"How does the brain translate sensory information into complex behaviors? With relatively small neuronal numbers, readable behavioral outputs, and an unparalleled genetic toolkit, the Drosophila mushroom body (MB) offers an excellent model to address this question in the context of associative learning and memory. Recent technological breakthroughs, such as the freshly completed full-brain connectome, multiomics approaches, CRISPR-mediated gene editing, and machine learning techniques, led to major advancements in our understanding of the MB circuit at the molecular, structural, physiological, and functional levels. Despite significant progress in individual MB areas, the field still faces the fundamental challenge of resolving how these different levels combine and interact to ultimately control the behavior of an individual fly. In this review, we discuss various aspects of MB research, with a focus on the current knowledge gaps, and an outlook on the future methodological developments required to reach an overall view of the neurobiological basis of learning and memory.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"31 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diverse memory paradigms in Drosophila reveal diverse neural mechanisms. 果蝇的不同记忆范式揭示了不同的神经机制。

IF 1.7 4区医学

Learning & memory Pub Date : 2024-06-11 Print Date: 2024-05-01 DOI: 10.1101/lm.053810.123

Amoolya Sai Dwijesha, Akhila Eswaran, Jacob A Berry, Anna Phan

{"title":"Diverse memory paradigms in Drosophila reveal diverse neural mechanisms.","authors":"Amoolya Sai Dwijesha, Akhila Eswaran, Jacob A Berry, Anna Phan","doi":"10.1101/lm.053810.123","DOIUrl":"10.1101/lm.053810.123","url":null,"abstract":"In this review, we aggregated the different types of learning and memory paradigms developed in adult Drosophila and attempted to assess the similarities and differences in the neural mechanisms supporting diverse types of memory. The simplest association memory assays are conditioning paradigms (olfactory, visual, and gustatory). A great deal of work has been done on these memories, revealing hundreds of genes and neural circuits supporting this memory. Variations of conditioning assays (reversal learning, trace conditioning, latent inhibition, and extinction) also reveal interesting memory mechanisms, whereas mechanisms supporting spatial memory (thermal maze, orientation memory, and heat box) and the conditioned suppression of innate behaviors (phototaxis, negative geotaxis, anemotaxis, and locomotion) remain largely unexplored. In recent years, there has been an increased interest in multisensory and multicomponent memories (context-dependent and cross-modal memory) and higher-order memory (sensory preconditioning and second-order conditioning). Some of this work has revealed how the intricate mushroom body (MB) neural circuitry can support more complex memories. Finally, the most complex memories are arguably those involving social memory: courtship conditioning and social learning (mate-copying and egg-laying behaviors). Currently, very little is known about the mechanisms supporting social memories. Overall, the MBs are important for association memories of multiple sensory modalities and multisensory integration, whereas the central complex is important for place, orientation, and navigation memories. Interestingly, several different types of memory appear to use similar or variants of the olfactory conditioning neural circuitry, which are repurposed in different ways.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"31 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights from the past: the work of Hans von Alten on the evolution of brain structure, ecological adaptation, and cognition in hymenopteran species. 过去的启示：汉斯-冯-阿尔滕关于膜翅目物种大脑结构、生态适应和认知进化的研究。

IF 1.7 4区医学

Learning & memory Pub Date : 2024-06-11 Print Date: 2024-05-01 DOI: 10.1101/lm.053922.124

Randolf Menzel, Jürgen Rybak

引用次数: 0

The caloric value of food intake structurally adjusts a neuronal mushroom body circuit mediating olfactory learning in Drosophila. 食物摄入的热量价值从结构上调整了果蝇中介导嗅觉学习的神经元蘑菇体回路。

IF 2.2 4区医学

Learning & memory Pub Date : 2024-06-11 Print Date: 2024-05-01 DOI: 10.1101/lm.053997.124

Büşra Çoban, Haiko Poppinga, El Yazid Rachad, Bart Geurten, David Vasmer, Francisco Jesus Rodriguez Jimenez, Yogesh Gadgil, Stephan Hubertus Deimel, Idan Alyagor, Oren Schuldiner, Ilona C Grunwald Kadow, Thomas Dieter Riemensperger, Annekathrin Widmann, André Fiala

{"title":"The caloric value of food intake structurally adjusts a neuronal mushroom body circuit mediating olfactory learning in Drosophila.","authors":"Büşra Çoban, Haiko Poppinga, El Yazid Rachad, Bart Geurten, David Vasmer, Francisco Jesus Rodriguez Jimenez, Yogesh Gadgil, Stephan Hubertus Deimel, Idan Alyagor, Oren Schuldiner, Ilona C Grunwald Kadow, Thomas Dieter Riemensperger, Annekathrin Widmann, André Fiala","doi":"10.1101/lm.053997.124","DOIUrl":"10.1101/lm.053997.124","url":null,"abstract":"Associative learning enables the adaptive adjustment of behavioral decisions based on acquired, predicted outcomes. The valence of what is learned is influenced not only by the learned stimuli and their temporal relations, but also by prior experiences and internal states. In this study, we used the fruit fly Drosophila melanogaster to demonstrate that neuronal circuits involved in associative olfactory learning undergo restructuring during extended periods of low-caloric food intake. Specifically, we observed a decrease in the connections between specific dopaminergic neurons (DANs) and Kenyon cells at distinct compartments of the mushroom body. This structural synaptic plasticity was contingent upon the presence of allatostatin A receptors in specific DANs and could be mimicked optogenetically by expressing a light-activated adenylate cyclase in exactly these DANs. Importantly, we found that this rearrangement in synaptic connections influenced aversive, punishment-induced olfactory learning but did not impact appetitive, reward-based learning. Whether induced by prolonged low-caloric conditions or optogenetic manipulation of cAMP levels, this synaptic rearrangement resulted in a reduction of aversive associative learning. Consequently, the balance between positive and negative reinforcing signals shifted, diminishing the ability to learn to avoid odor cues signaling negative outcomes. These results exemplify how a neuronal circuit required for learning and memory undergoes structural plasticity dependent on prior experiences of the nutritional value of food.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"31 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Phylogeny of the Hymenopteran Brain. 膜翅目动物大脑的系统发育。

IF 2.2 4区医学

Learning & memory Pub Date : 2024-06-11 Print Date: 2024-05-01 DOI: 10.1101/lm.053894.123

Hans V Alten

引用次数: 0