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[Cell therapy with tumor infiltrating lymphocytes; a therapeutic alternative for malignant melanoma and soon also other types of cancer]. 肿瘤浸润淋巴细胞的细胞治疗；一种治疗恶性黑色素瘤的替代疗法，很快也会用于其他类型的癌症。
Lakartidningen Pub Date : 2025-05-02
Stina L Wickström, Jonas A Nilsson, Andreas Lundqvist, Hildur Helgadottir, Ana Carneiro, Lars Ny, Rolf Kiessling
{"title":"[Cell therapy with tumor infiltrating lymphocytes; a therapeutic alternative for malignant melanoma and soon also other types of cancer].","authors":"Stina L Wickström, Jonas A Nilsson, Andreas Lundqvist, Hildur Helgadottir, Ana Carneiro, Lars Ny, Rolf Kiessling","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Therapy for advanced cutaneous melanoma with tumor infiltrating lymphocytes (TIL) has shown promising clinical results for 35 years. Owing to advanced production and treatment methods, TIL therapy has only been accessible in a few centers in Europe and the USA. Recently, following a company phase 2 trial and an academic Phase III trial with superior response rate compared to patients treated with the immune checkpoint inhibitor (ICI) ipilimumab, TIL therapy gained FDA approval. Several studies are now ongoing where patients with other tumor diagnoses such as cervical cancer and non-small-cell lung cancer are recruited, some of which are testing combinations with ICI. At Karolinska University Hospital in Stockholm, an academic study combining TIL with a dendritic cell tumor vaccine is ongoing. At Sahlgrenska Academy a TIL study on metastatic uveal melanoma has started. In this review we summarize the recent developments in TIL therapy and provide a discussion about its future.</p>","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"122 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Ethical and clinical recommendations concerning palliative sedation]. [关于姑息性镇静的伦理和临床建议]。
Lakartidningen Pub Date : 2025-04-25
Gunnar Eckerdal, Jenny Lindberg, Anders Birr, Linda Björkhem-Bergman, Ann-Sofie Rehnberg, Madhuri Gogineni, Marit Karlsson, Linnea Schmitz, Sofia Dettmann
{"title":"[Ethical and clinical recommendations concerning palliative sedation].","authors":"Gunnar Eckerdal, Jenny Lindberg, Anders Birr, Linda Björkhem-Bergman, Ann-Sofie Rehnberg, Madhuri Gogineni, Marit Karlsson, Linnea Schmitz, Sofia Dettmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Palliative sedation is a good medical treatment to relieve suffering at the end of life that is judged not to be adequately relieved by other means. The treatment decision should be made by a palliative care physician, preferably in consultation with another palliative care physician and, in some cases, an anesthesiologist. The depth of sedation should be appropriate to the needs of the patient. Informed consent should be obtained from the patient, if possible, and significant others should be informed and cared for during the process. In the case of continuous deep palliative sedation, the medical and ethical risks of reducing the patient's level of consciousness until death should be balanced against the great benefit of the treatment to the patient. The treatment should be thoroughly documented and followed up. The depth of sedation and relief of symptoms should be monitored.</p>","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"122 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Diagnosis and treatment of bile acid diarrhea]. 【胆汁酸腹泻的诊断与治疗】。
Lakartidningen Pub Date : 2025-04-24
Magnus Hansson, Gösta Eggertsen, Elin Paulsson, Stefan Gaunitz, Hans Jacobsson, Greger Lindberg
{"title":"[Diagnosis and treatment of bile acid diarrhea].","authors":"Magnus Hansson, Gösta Eggertsen, Elin Paulsson, Stefan Gaunitz, Hans Jacobsson, Greger Lindberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This review concerns the diagnosis and therapy of bile acid diarrhea, a common type of chronic diarrhea which is considered underdiagnosed with a presumed prevalence of approximately 1%. A simple blood test, S-7-OH-cholestenone/cholesterol ratio, reflecting the bile acid synthesis rate, is a cost-effective analysis to diagnose most patients. Results above 25 nmol/mmol supports the diagnosis, while results <15 nmol/mmol are considered normal. Supplementary 75SeHCAT test may be required for results occurring in the grey zone (15-25 nmol/mmol). The latter investigation is more expensive and utilizes a radioactive isotope. Treatment for bile acid diarrhea consists of bile acid sequestrants that need to be titrated carefully in each patient to achieve lasting results. Future treatment options may include GLP-1 agonists. It is essential to spread information about the condition among general practitioners and physicians in other disciplines who will meet patients with symptoms of diarrhea.</p>","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"122 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risker med hjärt–lungräddning vid larm om misstänkt hjärtstopp.
Lakartidningen Pub Date : 2025-04-22
Joar Björk, Anders Bremer, Fredrik Hessulf, Eva Piscator, Ewa Rosengren
{"title":"Risker med hjärt–lungräddning vid larm om misstänkt hjärtstopp.","authors":"Joar Björk, Anders Bremer, Fredrik Hessulf, Eva Piscator, Ewa Rosengren","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"122 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personcentrerat förhållningssätt krävs.
Lakartidningen Pub Date : 2025-04-10
Ewa-Lena Bratt
{"title":"Personcentrerat förhållningssätt krävs.","authors":"Ewa-Lena Bratt","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"122 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A growing patient group and a shared responsibility. Healthcare providers must have knowledge about adolescents and young adults]. [一个不断增长的病人群体和共同的责任。医疗保健提供者必须有关于青少年和年轻人的知识。
Lakartidningen Pub Date : 2025-04-09
Anna Gutniak, Johanna Forsberg, Charlotte Nylander
{"title":"[A growing patient group and a shared responsibility. Healthcare providers must have knowledge about adolescents and young adults].","authors":"Anna Gutniak, Johanna Forsberg, Charlotte Nylander","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Adolescents and young adults represent a growing patient group in various clinical settings. To effectively address their needs, healthcare providers must have knowledge about the unique developmental aspects of this age group, which includes physical, psychological, social, and sexual maturation. Young people, defined as ages 10 to 24, experience critical changes in identity formation, autonomy, and social relationships, all of which influence diverse parameters such as health behaviours, pain perception, and treatment outcomes. Developmental milestones are divided into early, middle, and late adolescence/young adulthood, each with its specific characteristics regarding bodily changes, identity exploration, and increased independence. The structural and functional maturation of the brain continues into the mid-20s, affecting decision-making and risk perception. Health behaviours in youth are important predictors of long-term well-being, while chronic illness during this period can complicate the biopsychosocial development process. The concept of adolescent-friendly health care emphasizes a tailored approach, including appropriate communication, respect for confidentiality, and support for decision-making autonomy. As health care systems strive to improve care for young people, there is a need for integrated, youth-centered services that account for both medical and psychosocial factors. This approach has been shown to enhance patient satisfaction and improve long-term health outcomes for young patients.</p>","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"122 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The transition from child to adult health care for youths with neurodevelopmental conditions - a challenge]. [对有神经发育问题的青少年从儿童保健过渡到成人保健——一个挑战]。
Lakartidningen Pub Date : 2025-04-09
Sven Bölte, Tatja Hirvikoski, Ulf Jonsson, Johan Nyrenius, Eric Zander
{"title":"[The transition from child to adult health care for youths with neurodevelopmental conditions - a challenge].","authors":"Sven Bölte, Tatja Hirvikoski, Ulf Jonsson, Johan Nyrenius, Eric Zander","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The transition from child to adult health care is particularly challenging for youths with neurodevelopmental conditions, and there is a considerable risk of not receiving sufficient care. In Sweden, national and regional guidelines on the transition process for psychiatry and habilitation services exist, describing the important steps. Still, there is a lack of explicit quality indicators and evaluation, making it difficult to know explicit results. The role of physicians in this process is sparsely described in the guidelines. Youths, especially those with autism, express dissatisfaction with the transition to adult health care and with the care itself. Further development of person-centered care, evaluation, and follow-up of the transition process as well as cooperation between different care providers and support systems is recommended. Existing research evidence regarding specific transition interventions for this age group needs to be applied.</p>","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"122 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[All childhood cancer survivors get at least one visit at follow-up clinics for adults]. [所有儿童癌症幸存者都会在成人随访诊所接受至少一次随访]。
Lakartidningen Pub Date : 2025-04-08
Marianne Jarfelt, Lars Hjorth, Cecilia Petersen, Karin Enskär, Maria Olsson, Mattias Mattson, Samantha Nath, Micaela Herslow
{"title":"[All childhood cancer survivors get at least one visit at follow-up clinics for adults].","authors":"Marianne Jarfelt, Lars Hjorth, Cecilia Petersen, Karin Enskär, Maria Olsson, Mattias Mattson, Samantha Nath, Micaela Herslow","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Childhood cancer survivors (CCS) are at increased risk of developing several late complications, often in adulthood. It is therefore essential that accurate information is provided to both the CCS and healthcare providers when transitioning to adult healthcare. Since the first publication of the Swedish national guidelines for long-term follow-up in 2016, long-term follow-up clinics for adult CCS have been established at all six university hospitals, offering at least one visit at the age of twenty-five. Dedicated transition clinics at paediatric cancer centres offer two to three visits during adolescence in preparation for the transition, including an individual dialogue between the young person and the paediatric oncologist or nurse. Further developments are ongoing, including the introduction of specialised transition nurses and a more structured element into the visits.</p>","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"122 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Stepstones - transition project for young people with chronic conditions. Coordinator plays a central role, empowerment is a key goal]. [阶梯-为患有慢性疾病的年轻人提供的过渡项目。协调者起着核心作用，授权是一个关键目标]。
Lakartidningen Pub Date : 2025-04-08
Carina Sparud Lundin, Markus Saarijärvi, Sandra Skogby, Mariela Acuna Mora, Åsa Burström, Anna Lena Brorsson, Ewa-Lena Bratt
{"title":"[Stepstones - transition project for young people with chronic conditions. Coordinator plays a central role, empowerment is a key goal].","authors":"Carina Sparud Lundin, Markus Saarijärvi, Sandra Skogby, Mariela Acuna Mora, Åsa Burström, Anna Lena Brorsson, Ewa-Lena Bratt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The Stepstones transition project began in 2014 to improve care for young people with chronic conditions transitioning from pediatric to adult healthcare. Based on a Belgian transition program, it was adapted to Swedish settings through preparatory studies and literature reviews. Findings highlighted that early planning and parental involvement are crucial for a successful transition. Empowerment, aiming at increasing adolescents' winvolvement and responsibility in their care, is a key goal of the program. Stepstones implements person-centered care through eight components, with the transition coordinator playing a central role. The program focuses on empowering adolescents through goal setting, learning about their illness and implications for their daily lives. It has shown positive effects, such as increased empowerment and disease-specific knowledge, and has been tested in adolescents with congenital heart disease.</p>","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"122 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[»Ungdomsenheten« at Sachsska Children and Youth Hospital, a unique unit for adolescent comprehensive care]. [萨赫斯卡儿童和青年医院的 "Ungdomsenheten"，一个独特的青少年综合护理单位]。
Lakartidningen Pub Date : 2025-04-07
Iris Treutiger, Josephine Haas, Susanna Klevebro, Petter Malmborg, Sofia Paulsson, Karin Rosenborg, Camilla Rahm
{"title":"[»Ungdomsenheten« at Sachsska Children and Youth Hospital, a unique unit for adolescent comprehensive care].","authors":"Iris Treutiger, Josephine Haas, Susanna Klevebro, Petter Malmborg, Sofia Paulsson, Karin Rosenborg, Camilla Rahm","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>»Ungdomsenheten« at Södersjukhuset in Stockholm started as a project in 2000, focusing on adolescents aged 13 to 20 with chronic illnesses and complex health problems. The aim is to provide tailored medical care for adolescents within a youth-friendly environment. The unit employs a multidisciplinary team, including pediatricians, gynecologists, a pain specialist, nurses, physiotherapists, and an occupational therapist. A close collaboration with social counsellors and psychologists further ensures comprehensive adolescent care at the unit. Transitioning from pediatric to adult care is a key focus, empowering youth in managing their health as they approach adulthood.</p>","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"122 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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