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[GOLD 2026: implications for COPD care in Sweden]. [GOLD 2026：瑞典COPD护理的意义]。
Lakartidningen Pub Date : 2026-10-21 DOI: 10.65868/IQJD6944
Nikolaos Lazarinis, Hamid Akbarshahi, Anne Lindberg, Andrei Malinovschi, Magnus Nisell, Lowie E G W Vanfleteren, Magnus Sköld
{"title":"[GOLD 2026: implications for COPD care in Sweden].","authors":"Nikolaos Lazarinis, Hamid Akbarshahi, Anne Lindberg, Andrei Malinovschi, Magnus Nisell, Lowie E G W Vanfleteren, Magnus Sköld","doi":"10.65868/IQJD6944","DOIUrl":"https://doi.org/10.65868/IQJD6944","url":null,"abstract":"<p><p>The 2026 update of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) report introduces major changes with likely implications for the treatment of chronic obstructive pulmonary disease (COPD) in Sweden. Disease stability and disease control are defined as treatment goals for all patients, irrespective of disease severity. The document highlights underdiagnosis of COPD and places greater emphasis on early detection through active case-finding, structured follow-up of disease activity, and systematic assessment of multimorbidity. Extended risk-assessment criteria at diagnosis mean that a single moderate exacerbation is now sufficient to place a patient in GOLD group E. The treatment strategies outlined in GOLD 2026 largely align with the Swedish Medical Products Agency recommendations from 2023, but to fully implement GOLD 2026 in Swedish clinical practice, the current recommendations need to be revised in light of the new evidence.</p>","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"123 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Autism, selective mutism and mild intellectual disability explained by 17q12 microdeletion syndrome]. [由17q12微缺失综合征解释的自闭症、选择性缄默症和轻度智力残疾]。
Lakartidningen Pub Date : 2026-10-20 DOI: 10.65868/VBWE4409
Elisabeth Fernell, Linda Bulmer, Christopher Gillberg
{"title":"[Autism, selective mutism and mild intellectual disability explained by 17q12 microdeletion syndrome].","authors":"Elisabeth Fernell, Linda Bulmer, Christopher Gillberg","doi":"10.65868/VBWE4409","DOIUrl":"10.65868/VBWE4409","url":null,"abstract":"<p><p>The patient had presented symptoms during preschool years with motor coordination difficulties, deviant reactions to sensory stimuli and separation anxiety. A language stagnation had occurred at the age of 1.5 to 2 years. At school start, she became completely mute during school hours but spoke at home. At assessment at the Child Neuropsychiatric Clinic at the age of 10, autism, selective mutism and ADHD/ADD were diagnosed. Her intellectual level corresponded to borderline intellectual functioning, and a similar test result was evident also at the age of 14 years. When transition to upper secondary school was planned, the cognitive assessment showed a mild intellectual disability. Then, medical investigations, including genetic SNP array, was carried out. This analysis showed a 17q12 microdeletion syndrome. Then, specific medical investigations were carried out due to the various medical conditions that need to be checked and followed up in patients with 17q12 microdeletion syndrome.</p>","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"123 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Idiopathic systemic capillary leak syndrome - a rare but serious differential diagnosis in the hypovolemic patient]. 特发性全身毛细血管渗漏综合征-低血容量患者罕见但严重的鉴别诊断。
Lakartidningen Pub Date : 2026-10-19 DOI: 10.65868/URRP6393
Johan Hylander, Hanna Andersson, Magnus von Seth
{"title":"[Idiopathic systemic capillary leak syndrome - a rare but serious differential diagnosis in the hypovolemic patient].","authors":"Johan Hylander, Hanna Andersson, Magnus von Seth","doi":"10.65868/URRP6393","DOIUrl":"10.65868/URRP6393","url":null,"abstract":"<p><p>Idiopathic systemic capillary leak syndrome (SCLS) is a rare, life-threatening cause of hypovolemic shock characterized by hemoconcentration, hypoalbuminemia, and acute hypovolemia due to plasma extravasation. It should be suspected in patients presenting with unexplained hypotension and markedly elevated hemoglobin levels, often following nonspecific prodromal symptoms such as malaise. Management is supportive and includes aggressive crystalloid resuscitation, vasopressor therapy, corticosteroids, and intravenous immunoglobulins. Owing to the risk of rapid hemodynamic deterioration and multi--organ failure, intensive care monitoring is essential. We report a previously healthy middle-aged man with recent upper respiratory tract infection and syncope who developed fulminant SCLS with refractory shock and died despite intensive care treatment.</p>","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"123 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Patients with papillary craniopharyngioma successfully treated with BRAF and MEK inhibitors]. 【BRAF和MEK抑制剂成功治疗乳头状颅咽管瘤患者】。
Lakartidningen Pub Date : 2026-10-16 DOI: 10.65868/SYFF9630
Eva Marie Erfurth, Peter Siesjö, Pia C Sundgren, Björn Hammar, Sara Kinhult
{"title":"[Patients with papillary craniopharyngioma successfully treated with BRAF and MEK inhibitors].","authors":"Eva Marie Erfurth, Peter Siesjö, Pia C Sundgren, Björn Hammar, Sara Kinhult","doi":"10.65868/SYFF9630","DOIUrl":"10.65868/SYFF9630","url":null,"abstract":"<p><p>Craniopharyngioma is a rare brain epithelial tumor infiltrating the hypothalamus causing visual loss, panhypopituitarism, cognitive deficits and obesity. 94% of papillary craniopharyngiomas harbour a BRAF mutation. Two patients with PCP and BRAF V600E mutation, with different tumor status, were treated with BRAF and MEK inhibitors. Case I is a male diagnosed with biopsy and treated for 16 months with BRAF and MEK inhibitors. After 12 months of treatment the tumor volume decreased from 2 220 mm3 to 90 mm3. The patient was treated with fractionated cranial irradiation (54 Gy) and has been without recurrence during two years' follow-up. Case II is a female patient with four surgeries due to recurrent papillar craniopharyngioma with BRAF V600E mutation. Due to further recurrence she received BRAF and MEK inhibitors for 31 months, and evaluation with MRI demonstrated a volume reduction from 633 mm3 to 483 mm3. The visual acuity in her left eye improved from 0.05 to 0.3. She is currently off treatment without recurrence.</p>","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"123 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Modern evolutionary medicine offers a deeper understanding of psychiatric symptoms]. [现代进化医学对精神症状有了更深的理解]。
Lakartidningen Pub Date : 2026-10-14 DOI: 10.65868/HOCB4063
Matti Cervin, Simon Cervenka
{"title":"[Modern evolutionary medicine offers a deeper understanding of psychiatric symptoms].","authors":"Matti Cervin, Simon Cervenka","doi":"10.65868/HOCB4063","DOIUrl":"10.65868/HOCB4063","url":null,"abstract":"<p><p>Psychiatric diagnoses are important classifications but should not be understood as discrete disease entities.Genetic and longitudinal studies suggest that vulnerabilities, symptoms, and trajectories cut across diagnostic boundaries. Modern evolutionary medicine can deepen our understanding of why overlap, heterogeneity, and shifting trajectories are so pervasive in psychiatry.This perspective preserves the practical value of diagnoses while offering a broader basis for clinical understanding, research and prevention.</p>","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"123 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Swedish Renal Registry - from diagnostic prodedures and treatment to dialysis and transplantation]. [瑞典肾脏登记-从诊断程序和治疗到透析和移植]。
Lakartidningen Pub Date : 2026-10-08 DOI: 10.65868/SKOI7162
Helena Rydell, Ursa Bonnevier, Gunilla Welander, Torbjörn Lundgren, Marie Evans, Maria Stendahl
{"title":"[Swedish Renal Registry - from diagnostic prodedures and treatment to dialysis and transplantation].","authors":"Helena Rydell, Ursa Bonnevier, Gunilla Welander, Torbjörn Lundgren, Marie Evans, Maria Stendahl","doi":"10.65868/SKOI7162","DOIUrl":"https://doi.org/10.65868/SKOI7162","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) is a common disorder, affecting approximately 10-15% of the population. The Swedish Renal Registry (SRR) is a comprehensive national registry that follows patients throughout the entire disease trajectory, from diagnostic procedures and medical treatment to dialysis and renal transplantation. More than 90 000 patients are included in the registry, and all Swedish nephrology units contribute data. The coverage is high for the most important variables. Medical treatments to slow CKD progression, as well as therapies targeting specific diagnoses, are developing rapidly. The SRR plays a central role in monitoring and evaluating developments in nephrology care.</p>","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"123 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hur tillförlitlig är den medicinska informationen i sjukintygen?
Lakartidningen Pub Date : 2026-10-07 DOI: 10.65868/WJMS4203
Magnus Falk, Cecilia Rosander, Elin Karlsson, Hanna Israelsson Larsen
{"title":"Hur tillförlitlig är den medicinska informationen i sjukintygen?","authors":"Magnus Falk, Cecilia Rosander, Elin Karlsson, Hanna Israelsson Larsen","doi":"10.65868/WJMS4203","DOIUrl":"https://doi.org/10.65868/WJMS4203","url":null,"abstract":"","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"123 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Longer medical certificates do not improve the quality of physicians' assessments]. [较长的医疗证明不能提高医生评估的质量]。
Lakartidningen Pub Date : 2026-10-07 DOI: 10.65868/GOLT7613
Sandra Af Winklerfelt Hammarberg, Anna Finnes, Alice Giöstad
{"title":"[Longer medical certificates do not improve the quality of physicians' assessments].","authors":"Sandra Af Winklerfelt Hammarberg, Anna Finnes, Alice Giöstad","doi":"10.65868/GOLT7613","DOIUrl":"https://doi.org/10.65868/GOLT7613","url":null,"abstract":"<p><p>Sickness certification is a common and demanding task in Swedish primary care, particularly for patients with mental health conditions, for whom assessments of work ability and functional impairment are often associated with considerable uncertainty. Drawing on the findings of Falk et al., the authors argue that longer or more detailed sickness certificates do not improve the consistency or quality of physicians' assessments but do increase the administrative burden. The authors advocate shifting the focus from documentation towards active rehabilitation. Suggested strategies include earlier access to evidence-based treatment, greater use of part-time sickness absence, stronger workplace involvement, and closer collaboration among healthcare services,occupational health services, employers, the Social Insurance Agency, and the Public Employment Service. Behavioural medicine approaches may also help strengthen patients' problem-solving skills and reduce the risk of prolonged dependence on sickness absence.</p>","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"123 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hur tillförlitlig är den medicinska informationen i sjukintygen?
Lakartidningen Pub Date : 2026-10-07 DOI: 10.65868/WJMS4203
Magnus Falk, Cecilia Rosander, Elin Karlsson, Hanna Israelsson Larsen
{"title":"Hur tillförlitlig är den medicinska informationen i sjukintygen?","authors":"Magnus Falk, Cecilia Rosander, Elin Karlsson, Hanna Israelsson Larsen","doi":"10.65868/WJMS4203","DOIUrl":"https://doi.org/10.65868/WJMS4203","url":null,"abstract":"","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"123 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tarmjäsningssyndrom – kliniska och forensiska aspekter.
Lakartidningen Pub Date : 2026-09-11 DOI: 10.65868/NVMP4067
Anders Helander, Alan Wayne Jones
{"title":"Tarmjäsningssyndrom – kliniska och forensiska aspekter.","authors":"Anders Helander, Alan Wayne Jones","doi":"10.65868/NVMP4067","DOIUrl":"10.65868/NVMP4067","url":null,"abstract":"","PeriodicalId":17988,"journal":{"name":"Lakartidningen","volume":"123 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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