Langenbeck's Archives of Surgery最新文献

{"title":"Value and relevance of routine postoperative blood sample analysis after general surgery-a single centre analysis of 1198 patients.","authors":"Dalil Ali, Claudius Juergens, Markus Unnewehr, Maximilian Schmeding","doi":"10.1007/s00423-025-03726-4","DOIUrl":"10.1007/s00423-025-03726-4","url":null,"abstract":"<p><strong>Background: </strong>Routine blood sample analysis is performed in most surgical institutions after general surgery on the first postoperative day. Substantial economical impact is thereby generated in addition to patient distress caused by venous puncture.</p><p><strong>Aim: </strong>The presented study was designed to analyse the relevance of postoperative routine blood sampling with special focus on patient safety.</p><p><strong>Methods: </strong>1198 patients undergoing minor general surgical procedures (appendectomy, cholecystectomy, groin hernia repair) at our institution were retrospectively analysed. Data was gathered and forwarded to statistical evaluation with respect to patient safety and economical impact / cost-saving potential.</p><p><strong>Results: </strong>In 5,3% of our patients there was clinical impact of postoperative blood sampling. Relevant medical treatment consequences were derived for complicated appendectomy cases only.</p><p><strong>Discussion: </strong>Our data suggests that routine postoperative blood sample analysis after minor general surgery has very little impact on the further clinical course. Patient safety is not at risk. Regarding the economical and distressing impacts of routine blood-drawing post-operatively it should be evaluated if routine sampling may be limited to special interest cases.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"169"},"PeriodicalIF":2.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic resection with perioperative drug repurposing of propranolol and etodolac - the phase II randomized controlled PROSPER trial.","authors":"Felix J Hüttner, Rosa Klotz, Nathalia A Giese, Bo Kong, Azaz Ahmed, Daniela Merz, Alexandra Pöchmann, Ina Burghaus, Thilo Hackert, Oliver Strobel, André L Mihaljevic, Christoph W Michalski, Markus W Büchler, Markus K Diener","doi":"10.1007/s00423-025-03735-3","DOIUrl":"10.1007/s00423-025-03735-3","url":null,"abstract":"<p><strong>Purpose: </strong>The perioperative period is characterized by psychological stress and inflammatory reactions that can contribute to disease recurrence or metastatic spread. These reactions are mediated particularly by catecholamines and prostaglandins. The PROSPER trial aimed to evaluate whether a perioperative drug repurposing with a non-selective betablocker (propranolol) and a COX-2 inhibitor (etodolac) is feasible and safe in the setting of pancreatic cancer surgery.</p><p><strong>Methods: </strong>Patients undergoing partial pancreatoduodenectomy for pancreatic cancer were randomized to perioperative treatment with propranolol and etodolac or placebo. Main safety endpoint was the rate of serious adverse events (SAE) and the main feasibility endpoint was adherence. Overall and disease-free survival (DFS) as well as recurrences were assessed as efficacy parameters and the trial was accompanied by a translational study.</p><p><strong>Results: </strong>The trial was prematurely closed due to slow recruitment. 26 patients were randomized, but 6 never started trial medication. Finally, 9 patients received the trial medication and 11 patients placebo. There were 6 SAE in the treatment vs. 14 in the placebo group. Adherence was lower in the treatment group, but without statistically significance. Median DFS was 16.36 months (95%-CI 1.18 - not reached) in verum vs. 11.25 (95%-CI 2.2 - 17.25) in placebo group. The rate of distant recurrences was 11.1% in verum vs. 54.5% in placebo group.</p><p><strong>Conclusion: </strong>There were no safety concerns, but the trial intervention was not feasible given slow recruitment and limited adherence. However, the translational study and preliminary efficacy data revealed some promising findings, warranting further investigation.</p><p><strong>Registration: </strong>DRKS00014054.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"168"},"PeriodicalIF":2.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direction of perforation predicts the failure of non-operative management in patients with acute diverticulitis.","authors":"I Iesalnieks, M Beyer, A Agha, D Hofmann, Maximilian Sohn","doi":"10.1007/s00423-025-03733-5","DOIUrl":"10.1007/s00423-025-03733-5","url":null,"abstract":"<p><strong>Aim: </strong>To identify factors predicting the failure of non-operative treatment in acute complicated colonic diverticulitis.</p><p><strong>Material and methods: </strong>Consecutive patients hospitalized for non-operative treatment of acute complicated diverticulitis of the sigmoid colon between 2009 and 2015 were included in this retrospective analysis. Complicated disease was defined as the presence of extraluminal air or fluid collection within a computed tomography (CT) scan. The primary endpoint of the study was the need for emergent sigmoidectomy. The direction of perforation was assessed by CT scan and divided into 2 main groups: perforation towards the small bowel and perforation in other directions (abdominal wall, pelvic wall, retroperitoneum, urogenital organs).</p><p><strong>Results: </strong>A total of 140 patients were included. Of these patients, 25 patients did not respond to non-operative treatment and underwent rescue surgery (18%). CT revealed perforations towards the small bowel in 28 patients, 19 of whom did not respond to non-operative treatment (68%); in contrast, 6 of 112 (5%) patients with perforation in other directions experienced treatment failure. By multivariate analysis, perforation towards the small bowel (hazard ratio 75.0; 95% CI, 13.7-409.7, p < 0.001) was associated with a significantly increased risk for a failure of non-operative management. The only other risk factor was the presence of an intra-abdominal abscess. Diverticular perforation towards the small bowel is associated with a very high risk for emergency sigmoidectomy due to failed non-operative treatment.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"167"},"PeriodicalIF":2.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of robot-assisted laparoscopic surgery for rectal cancer: a retrospective propensity score matching analysis.","authors":"Masayuki Ando, Takeru Matsuda, Kimihiro Yamashita, Hiroshi Hasegawa, Ryuichiro Sawada, Yasufumi Koterazawa, Naoki Urakawa, Hironobu Goto, Shingo Kanaji, Yoshihiro Kakeji","doi":"10.1007/s00423-025-03734-4","DOIUrl":"10.1007/s00423-025-03734-4","url":null,"abstract":"<p><strong>Purpose: </strong>Conventional laparoscopic surgery (CLS) for rectal cancer may sometimes be difficult. Robot-assisted laparoscopic surgery (RALS) is expected to overcome these technical challenges of CLS and provide better short-term outcomes. However, previous randomized controlled trials indicated that the safety and feasibility of RALS compared to CLS remain controversial; therefore, we assessed the safety and feasibility of RALS for rectal cancer compared with CLS.</p><p><strong>Methods: </strong>This study retrospectively reviewed 702 patients who had undergone anterior resection by CLS or RALS for rectal malignancies from January 2009 to December 2023. Among the patients, 313 and 75 were included in the CLS and RALS groups, respectively. Short- and midterm outcomes of the two groups were compared after performing propensity score matching analysis (PSM) to adjust for patient and tumor characteristics.</p><p><strong>Results: </strong>A total of 140 and 70 patients in the CLS and RALS groups, respectively, were matched using PSM. The bleeding amount and C-reactive protein (CRP) levels on postoperative days 1 and 3 were significantly lower, the operation time was longer, and the postoperative hospital stay was significantly shorter in the RALS group than in the CLS group. The Kaplan-Meier curves for cause-specific survival, relapse-free survival, and the cumulative incidence of local recurrence demonstrated no difference between the two groups.</p><p><strong>Conclusion: </strong>RALS for rectal cancer provided superior outcomes to CLS in terms of the bleeding amount, postoperative CRP levels, and postoperative hospital stay. The midterm oncological outcomes in RALS were comparable to those in CLS.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"165"},"PeriodicalIF":2.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of serum ferritin on overall survival following resection in patients with intrahepatic cholangiocarcinoma.","authors":"Laura Schwenk, Carlos Wolf, Felix Dondorf, Oliver Rohland, Aladdin Ali-Deeb, Utz Settmacher, Falk Rauchfuß","doi":"10.1007/s00423-025-03737-1","DOIUrl":"10.1007/s00423-025-03737-1","url":null,"abstract":"<p><strong>Purpose: </strong>The global incidence of intrahepatic cholangiocarcinoma is increasing. Surgical resection remains the gold standard treatment. However, the long-term prognosis remains dismal. The role of serum ferritin in malignant diseases has not been fully elucidated. This study aimed to evaluate the relationship between preoperative serum ferritin levels and patient outcomes.</p><p><strong>Methods: </strong>In our retrospective study, we analyzed data from 95 patients who underwent liver resection for intrahepatic cholangiocarcinoma at Jena University Hospital between 2009 and 2023. Comprehensive clinical and pathological data, along with the correlation between Serum ferritin and clinicopathological parameters, were systematically analyzed and compared. Survival rates were determined using the Kaplan-Meier method.</p><p><strong>Results: </strong>The optimal preoperative serum ferritin cut-off value for overall survival was 303.1 µg/L, with an area under the curve of 0.697 (95% CI (0.592-0.801; P < 0.001). The 1-, 3-, and 5-year survival rates were 74.7%, 50.5%, and 43.2%, respectively. Patients with elevated preoperative SF levels demonstrated significantly worse overall survival compared to the low SF group (50.9% vs. 4.5%; P < 0.001). SF had a significant impact on recurrence rates (P < 0.001). The overall recurrence rate in the high-SF group was 67,3%, compared to 43,5% in the low-SF group.</p><p><strong>Conclusion: </strong>Elevated preoperative serum ferritin levels are associated with significantly worse overall and recurrence-free survival in patients with intrahepatic cholangiocarcinoma. Serum ferritin could serve as a valuable adjunct to the tumor marker CA 19 - 9.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"166"},"PeriodicalIF":2.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of postoperative epileptic seizures after microsurgical treatment in supratentorial single cerebral cavernous malformations: a retrospective study.","authors":"Qihang Zou, Yaqian Zhang, Runfang Hu, Jiakun Xu, Jia Yang, Hongxing Tang, Yibing Yang, Xixi Li, Weijie Su","doi":"10.1007/s00423-025-03741-5","DOIUrl":"10.1007/s00423-025-03741-5","url":null,"abstract":"<p><strong>Purpose: </strong>Seizures are the most common symptom of supratentorial cerebral cavernous malformations (CCMs). This study aimed to investigate the predictors of seizure freedom in patients with single supratentorial CCMs after microsurgical treatment.</p><p><strong>Methods: </strong>Clinical data were retrospectively obtained from 164 patients with CCM (including 98 patients with preoperative seizures, and 66 patients without preoperative seizures) who underwent microsurgical treatment between January 2016 and December 2023 at the First Affiliated Hospital of Sun Yat-sen University.</p><p><strong>Results: </strong>After microsurgical treatment, early postoperative seizures (≤ 1 week) occurred in 2 of 98 (2.04%) and 2 of 66 (3.03%) CCM patients with and without preoperative seizures, respectively. The mean length of follow-up for all the patients was 44.70 ± 2.04 months (range: 1-98 months). Sixty-four of the 66 (96.97%) patients without preoperative seizures were seizure free during the follow-up period. Among the patients with preoperative seizures, 77 of 98 (78.57%) patients achieved followed-up seizure remission, including 18 of 28 (64.29%) patients with drug-resistant epilepsy and 59 of 70 (84.29%) patients with drug-controlled epilepsy. Univariate analysis indicated that preoperative seizure duration, drug-resistant epilepsy, tailored resection and the application of intraoperative electrocorticography (ECoG) were important risk factors that affected followed-up seizure remission among patients with preoperative seizures. However, according to multivariate regression, only the use of intraoperative ECoG was an independent predictor related to the followed-up seizure remission.</p><p><strong>Conclusion: </strong>For CCM patients with preoperative seizures, intraoperative ECoG was an independent predictor of followed-up seizure remission. The application of intraoperative ECoG is beneficial for improving seizure outcome among CCM patients after microsurgical treatment, especially among patients with preoperative drug-resistant epilepsy.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"164"},"PeriodicalIF":2.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simplified stent-bridging pancreaticogastrostomy during pancreaticoduodenectomy: How I do it.","authors":"Yan Sun, Zheng Wang, Kaixuan Li, Longchang Chen, Junpeng Wang, Liuxin Duan, Quanda Liu","doi":"10.1007/s00423-025-03738-0","DOIUrl":"10.1007/s00423-025-03738-0","url":null,"abstract":"<p><strong>Background: </strong>Pancreaticoduodenectomy (PD) remains the standard approach for benign or malignant disease in the pancreatic head and periampullary regions. Despite attempts of diverse pancreatic anastomosis, no reliable pancreatic anastomosis has been recommended.</p><p><strong>Methods: </strong>Between July 2023 to December 2023, a novel method of pancreaticogastrostomy (PG) using a stent bridging the remnant pancreas and the stomach were applied to drain the pancreatic juice into the gastric cavity in 12 consecutive open and laparoscopic cases. The surgical details and postoperative outcomes were analyzed to evaluate this method.</p><p><strong>Results: </strong>The mean operation time was 318 ± 51.60 min. The mean time for the stent-bridging PG was 25.90 ± 4.86 min. No incidence of grades B or C postoperative pancreatic fistula (POPF) or anastomotic failure was occurred during the median follow-up period of 10.20 ± 1.55 months.</p><p><strong>Conclusion: </strong>The stent-bridging PG had the advantages of safety, simplicity and promising efficacy by complete diversion of pancreatic juice and minimal manipulation of the pancreatic remnant under open or laparoscopic PD, proving its value as an alternative technique for mitigating the risk of POPF. By understanding the standardized procedures, surgeons can achieve consistent and reproducible results in complex pancreatic anastomosis. However, further evaluation with clinical trials is required to validate its real benefits.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"163"},"PeriodicalIF":2.1,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of health literacy and general self-efficacy with emergency department visits for unclear abdominal pain after bariatric surgery.","authors":"Jenny Angerås-Kraftling, Maria Jaensson, Karuna Dahlberg, Erik Stenberg","doi":"10.1007/s00423-025-03736-2","DOIUrl":"10.1007/s00423-025-03736-2","url":null,"abstract":"<p><strong>Introduction: </strong>Emergency department visits are common following bariatric surgery and may be partially preventable. Health literacy and general self-efficacy are factors that may influence health-seeking behaviors in these patients. This study aimed to assess whether health literacy and general self-efficacy are associated with an increased frequency of emergency department visits after bariatric surgery.</p><p><strong>Methods: </strong>Patients who underwent bariatric surgery at a single hospital from 2018 to 2020 were evaluated for their health literacy and general self-efficacy levels before surgery. Data on emergency department visits within the patient's residential region were evaluated over a three-year period, with repeated emergency department visits for abdominal pain as the primary outcome.</p><p><strong>Results: </strong>During the follow-up period, 69 of 231 patients (29.9%) had at least one emergency department visit for abdominal pain, and 20 patients (8.7%) had three or more visits. Inadequate functional health literacy (OR 5.56, 95% CI 1.80-17.19, p = 0.003) and inadequate communicative and critical health literacy (OR 10.48, 95% CI 3.13-35.08, p < 0.001) were both significantly associated with an increased risk of repeated emergency department visits over the three-year period. No significant association was found between low general self-efficacy and the frequency of emergency department visits.</p><p><strong>Conclusions: </strong>Inadequate health literacy is associated with an increased risk of repeated emergency department visits for abdominal pain following bariatric surgery.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"162"},"PeriodicalIF":2.1,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncologic effect of preoperative endoscopic sphincterotomy in patients undergoing pancreaticoduodenectomy for ampulla of vater cancer.","authors":"Su Min Jeon, Yoo Jin Choi, Hye-Sung Jo, Sae Byeol Choi, Wan-Bae Kim, Hyung-Joon Han, Tae Jin Song, Dong-Sik Kim, Young-Dong Yu","doi":"10.1007/s00423-025-03730-8","DOIUrl":"10.1007/s00423-025-03730-8","url":null,"abstract":"<p><strong>Purpose: </strong>Ampulla of Vater (AoV) cancer often presents with bile flow obstruction requiring bile drainage. Endoscopic sphincterotomy (EST) for AoV cancer may result in inflammation and spread of the tumor due to the abundant lymphatic channels and microvascular structures around the AoV, which may impact the postoperative and oncologic outcomes. This study aimed to evaluate the postoperative and oncological effects of EST on AoV cancer.</p><p><strong>Methods: </strong>Medical records of 131 patients with AoV cancer who underwent pancreaticoduodeenectomy between 2011 and 2020 were reviewed. We compared the perioperative outcomes, overall survival, and disease recurrence in the patients.</p><p><strong>Results: </strong>Approximately 71 patients underwent EST for preoperative biliary drainage, whereas 60 did not receive any procedure or underwent percutaneous transhepatic biliary drainage. No significant differences were observed in the 5-year overall survival rate (EST 69.9% vs. no EST 75.1%, P = 0.804) or the 5-year cumulative recurrence rate (EST 49.1% vs. no EST 56.8%, P = 0.855). However, in subgroup analysis using the T stage, EST was associated with reduced 5-year overall survival in the T3 and T4 stages (EST 34.8% vs. no EST 78.0%: P = 0.038).</p><p><strong>Conclusion and discussion: </strong>Preoperative endoscopic intervention for AoV cancer did not affect oncologic outcomes. However, in the advanced stage, direct manipulation of cancer may result in lower overall survival, requiring careful consideration for preoperative biliary drainage.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"161"},"PeriodicalIF":2.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporary abdominal closure in trauma surgery: a comparative cohort study between open abdomen techniques with negative pressure therapy.","authors":"Yuri Thomé Machado Petrillo, Gabrieli Flesch da Silva, Vitor Steffens Bracht, Neiva Baldissera, Mariana Kumaira Fonseca, Leandro Totti Cavazzola","doi":"10.1007/s00423-025-03725-5","DOIUrl":"10.1007/s00423-025-03725-5","url":null,"abstract":"<p><strong>Background: </strong>The use of negative pressure therapy (NPT) to maintain an open abdomen (OA) is a well-established practice in trauma surgery. The aim of this study was to compare two techniques for temporary closure of the OA using negative pressure therapy NPT with regard to the outcome of definitive closure of the abdominal wall, the incidence of complications and mortality.</p><p><strong>Methodology: </strong>Controlled retrospective cohort study with trauma patients submitted to NPT as a method of maintaining OA. The groups were divided into \"Group B\", referring to the use of NPT by Barker dressing, and \"Group V\", referring to the use of NPT by RENASYS™ AB abdominal dressing.</p><p><strong>Results: </strong>A total of 76 patients were analyzed (Group B, n = 48; Group V, n = 28), with mean age of 34 years, and 92% male. The groups were equivalent in their trauma severity scores. The overall rate of abdominal cavity closure was 38%, higher in Group V than in Group B (46%, n = 13 vs. 33%, n = 16, p = 0.374). The peritoneostomy outcome was significantly higher in group B (48%, n = 23 vs. 21%, n = 6, p = 0.028). Moderate negative correlation was observed between the duration of OA therapy and the rate of definitive closure of the abdominal cavity (ρ -0.637; p < 0.0001). Damage control surgery (DCS) and shorter duration of OA were identified as predictors of closure.</p><p><strong>Conclusion: </strong>OA with NPT by industrial abdominal dressing decreases the rate of peritoniostomy as abdominal wall outcome compared to Barker dressing.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"159"},"PeriodicalIF":2.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}