Laryngo-rhino-otologie最新文献_第8页

Sinunasales Plattenepithelkarzinom: frühzeitige Operation sichert Überleben. 鼻窦鳞状细胞癌：早期手术确保生存。

IF 0.9 4区医学

Laryngo-rhino-otologie Pub Date : 2024-08-01 DOI: 10.1055/a-2300-3136

引用次数: 0

[After the pandemic is before the pandemic: And how interdisciplinary research can help here]. [大流行之后就是大流行之前：跨学科研究如何在此提供帮助]。

IF 0.9 4区医学

Laryngo-rhino-otologie Pub Date : 2024-08-01 Epub Date: 2024-03-12 DOI: 10.1055/a-2249-4201

Yen-Tran Ly, Franca Arndt, Alessa L Boschert, Bruno Pavletić, Florian Webner, Andreas Kohl, Henrik Grübbel, Julian Soltau, Iman Talai, Mohamed Diaoulé Diallo, Andreas Westhoff, Andreas Schreiber, Tobias Hecking, Frank Duschek, Karin Grünewald, Frank Meller, Jörn Biedermann, Frank Rinderknecht, Werner Kraft, Daniel Schmeling, Jens Jordan, Ralf Moeller

{"title":"[After the pandemic is before the pandemic: And how interdisciplinary research can help here].","authors":"Yen-Tran Ly, Franca Arndt, Alessa L Boschert, Bruno Pavletić, Florian Webner, Andreas Kohl, Henrik Grübbel, Julian Soltau, Iman Talai, Mohamed Diaoulé Diallo, Andreas Westhoff, Andreas Schreiber, Tobias Hecking, Frank Duschek, Karin Grünewald, Frank Meller, Jörn Biedermann, Frank Rinderknecht, Werner Kraft, Daniel Schmeling, Jens Jordan, Ralf Moeller","doi":"10.1055/a-2249-4201","DOIUrl":"10.1055/a-2249-4201","url":null,"abstract":"Aviation is among the social sectors most impacted by the COVID-19 pandemic, and at the same time has contributed to the rapid global spread of the SARS-CoV-2 virus. SARS-CoV-2 is one of the coronaviruses that have led to outbreaks such as MERS-CoV in the past. This group of pathogens, as well as others that may be unknown at this time, will continue to challenge our society in the future. In order to be able to react better, a research training group was established at DLR in cooperation with 6 institutes, which will develop interdisciplinary approaches to researching and combating current and future pandemics. Engineers, physicists, software developers, biologists and physicians are working closely together on new concepts and the development of interdisciplinary knowledge in order to better control and contain future pandemics and to be able to react in a more targeted manner. One focus is the reduction of germ contamination in airplanes but also in other means of public transport such as buses and trains. In this review, we provide an overview of the baseline situation and possible approaches to address future pandemic challenges.","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":" ","pages":"570-577"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140110620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Surgical Treatment of Oropharyngeal Cancer - Recommendations of the Current German S3 Guideline, Part I]. [口咽癌的手术治疗--现行德国 S3 准则的建议，第一部分]。

IF 0.9 4区医学

Laryngo-rhino-otologie Pub Date : 2024-08-01 DOI: 10.1055/a-2223-4083

Andreas Dietz, Markus Pirlich, Matthäus Stöhr, Veit Zebralla, Susanne Wiegand

{"title":"[Surgical Treatment of Oropharyngeal Cancer - Recommendations of the Current German S3 Guideline, Part I].","authors":"Andreas Dietz, Markus Pirlich, Matthäus Stöhr, Veit Zebralla, Susanne Wiegand","doi":"10.1055/a-2223-4083","DOIUrl":"https://doi.org/10.1055/a-2223-4083","url":null,"abstract":"In general, a trend towards transoral resection (as opposed to classic open approaches) + neck dissection + adjuvant radio- (chemo-) therapy has been observed for oropharyngeal carcinoma over the last 20 years. Techniques of transoral surgery (TOS), including transoral laser microsurgery (TLM) and transoral robotic surgery (TORS) have been propagated in retrospective comparisons with conventional surgery or primary radiochemotherapy as gentle, minimally invasive procedures with good late functional results. Meta-analyses of mostly uncontrolled retrospective analyses suggest that TORS may have better disease-free survival (DFS) and a reduced risk of free flap reconstruction compared with open surgery. TORS (TOS) was associated with fewer tumor-positive resection margins (R1), a lower number of recurrences, fewer intraoperative tracheostomies, a shorter inpatient stay and a shorter duration of postoperative nasal tube feeding compared to open surgery. In principle, based on the best evidence currently available from registry studies, stage I-II oropharyngeal carcinomas can be treated either with primary surgery or radiochemotherapy with a comparable chance of survival. With comparable evidence for stage III and IVa, p16neg. oropharyngeal carcinomas, the majority of authors advocate primary surgery followed by adjuvant radiotherapy or radiochemotherapy as the treatment of first choice. For p16pos. patients the results of registry studies are inconsistent, although the largest registry study on 450 HPV-positive stage III patients shows a significant superiority of primary surgery + adjuvant radiochemotherapy. Since all registry studies did not adjust for smoking status, among other factors, the current data situation should be evaluated with the necessary caution.","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":"103 8","pages":"599-612"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adenoidzystisches Karzinom: Fernmetastasierung prognostizieren. 腺样囊性癌：预测远处转移。

IF 0.9 4区医学

Laryngo-rhino-otologie Pub Date : 2024-08-01 DOI: 10.1055/a-2298-8142

引用次数: 0

Kommentar zu: „Sinunasales Plattenepithelkarzinom: frühzeitige Operation sichert Überleben“. 评论："鼻窦鳞状细胞癌：早期手术确保生存"。

IF 0.9 4区医学

Laryngo-rhino-otologie Pub Date : 2024-08-01 DOI: 10.1055/a-2300-3122

引用次数: 0

[Sore throat and hallucinations - an unusual course of EBV- associated tonsillitis]. [喉咙痛和幻觉--与 EB 病毒相关的扁桃体炎的不寻常病程]。

IF 0.9 4区医学

Laryngo-rhino-otologie Pub Date : 2024-08-01 Epub Date: 2024-03-14 DOI: 10.1055/a-2265-2620

Verena Strasser, Teresa Steinbichler, Susanne Dürr

引用次数: 0

[Ultrasound - part 2: closer look at sonography of the thyroid gland]. [超声波 - 第二部分：甲状腺超声波检查的近距离观察]。

IF 0.9 4区医学

Laryngo-rhino-otologie Pub Date : 2024-08-01 Epub Date: 2024-06-20 DOI: 10.1055/a-2251-0620

Veronika Innerhofer, Timo Gottfried, Helen Heppt, Verena Strasser, Charles Schmit, Benedikt Hofauer Mhba, Daniel Dejaco

引用次数: 0

Stellungnahme der Wissenschaftlichen Fachgesellschaft und des Berufsverbandes zur Notfallversorgung in der Hals-Nasen-Ohren-Heilkunde. 耳鼻喉科急诊护理科学协会和专业协会声明。

IF 0.9 4区医学

Laryngo-rhino-otologie Pub Date : 2024-08-01 Epub Date: 2024-06-25 DOI: 10.1055/a-2338-0808

Thomas K Hoffmann, Thomas Deitmer, Burkard M Lippert, Thomas Datzmann, Stefan Drumm, Jan Löhler

{"title":"Stellungnahme der Wissenschaftlichen Fachgesellschaft und des Berufsverbandes zur Notfallversorgung in der Hals-Nasen-Ohren-Heilkunde.","authors":"Thomas K Hoffmann, Thomas Deitmer, Burkard M Lippert, Thomas Datzmann, Stefan Drumm, Jan Löhler","doi":"10.1055/a-2338-0808","DOIUrl":"10.1055/a-2338-0808","url":null,"abstract":"Clinics and practices in the field of ear, nose and throat medicine (ENT) are experiencing a significant increase in the number of emergency patients, which has multiple reasons. There is broad consent that a reform of emergency structures is necessary.The government commission for modern and needs-based hospital care has made recommendations with statements on the reform of emergency and acute care in the areas of \"emergency services and financing\" and \"integrated emergency centers and integrated control centers\". For this purpose a reliable foundation will be created with participation of specialist societies and professional associations, also linked to the hope of initiating the urgently needed relief of medical staff in clinics and practices.The present manuscript describes the health policy history and current problems in emergency care, focusing on proposed solutions with reference to the special features of ENT medicine. This position paper is linked to an appeal to self-administration and politicians to quickly implement a sustainable concept for emergency care, as financing and staff availability are becoming increasingly critical and the unregulated wave of emergency patients must be given a helping hand.","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":" ","pages":"578-585"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Endobronchial Foreign Bodies Telling Readable Stories]. [支气管内异物的可读故事]。

IF 0.9 4区医学

Laryngo-rhino-otologie Pub Date : 2024-07-30 DOI: 10.1055/a-2341-0931

Edgar Haasler, Mohamed Garhy, Stefan Arndt, Bernd Schönhofer

引用次数: 0

[Innovative therapies for treatment of invasive fungal diseases]. [治疗侵袭性真菌疾病的创新疗法]。

IF 0.9 4区医学

Laryngo-rhino-otologie Pub Date : 2024-07-29 DOI: 10.1055/a-2341-0404

Sibylle C Mellinghoff, Oliver A Cornely, Parvin Mammadova, Rosanne Sprute, Jannik Stemler

{"title":"[Innovative therapies for treatment of invasive fungal diseases].","authors":"Sibylle C Mellinghoff, Oliver A Cornely, Parvin Mammadova, Rosanne Sprute, Jannik Stemler","doi":"10.1055/a-2341-0404","DOIUrl":"https://doi.org/10.1055/a-2341-0404","url":null,"abstract":"Invasive fungal diseases (IFD) are difficult to treat and pose a significant threat to immunocompromised individuals. Current antifungal agents face limitations, including antifungal resistance and adverse effects. This review aims to give a comprehensive overview of emerging treatment strategies.Novel drugs in development are Ibrexafungerp, an orally available triterpenoid inhibiting glucan synthesis, and Rezafungin representing the echinocandins with extended half-life and improved tissue penetration, both recently licensed for certain indications. Fosmanogepix targets glycosylphosphatidylinositol biosynthesis, while Olorofim, an orotomide, inhibits fungal nucleic acid synthesis, both currently assessed in advanced clinical trials.Immunotherapeutic approaches include immune checkpoint inhibitors to enhance immune response in immunosuppressed individuals and fungal-specific allogeneic CAR-T cell therapy. For prophylactic purpose in high-risk populations to develop IFD, monoclonal antibodies against different virulence factors of Candida spp. have been discovered but are not yet seen in clinical trials. Vaccines against distinct fungal antigens as well as pan fungal vaccines to prevent IFD are under development in preclinical stages, notably for Candida spp., Cryptococcus spp., and Aspergillus spp., however, their clinical value is still discussed.In summary, major advances to treat IFD have been observed, but challenges for their establishment in the clinical routine persist.","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0