Laryngo-rhino-otologie最新文献_第8页

Teprotumumab: Risiko von Hörstörungen unter der Behandlung. Teprotumumab治疗听力障碍的风险。

IF 1.4 4区医学

Laryngo-rhino-otologie Pub Date : 2026-06-01 Epub Date: 2026-06-05 DOI: 10.1055/a-2824-0159

引用次数: 0

[Facial palsy after basaloid sinonasal carcinoma of the left nose - an unusual way of metastasis]. [左侧鼻基底样窦鼻癌后面瘫-一种不寻常的转移方式]。

IF 1.4 4区医学

Laryngo-rhino-otologie Pub Date : 2026-06-01 Epub Date: 2025-09-18 DOI: 10.1055/a-2689-7161

Atur Ilie, Lars-Uwe Scholtz, Ingo Todt

引用次数: 0

[Twist1 und Snail/Slug: epithelial-mesenchymal transition in juvenilen Angiofibrom]. [twist]和蜗牛/蛞蝓：幼年血管纤维瘤的上皮-间质转化[j]。

IF 1.4 4区医学

Laryngo-rhino-otologie Pub Date : 2026-06-01 Epub Date: 2026-01-13 DOI: 10.1055/a-2762-4675

Bernhard Schick, Lukas Pillong, Rafail Ebner, Silke Wemmert

{"title":"[Twist1 und Snail/Slug: epithelial-mesenchymal transition in juvenilen Angiofibrom].","authors":"Bernhard Schick, Lukas Pillong, Rafail Ebner, Silke Wemmert","doi":"10.1055/a-2762-4675","DOIUrl":"10.1055/a-2762-4675","url":null,"abstract":"Objective: Juvenile angiofibroma (JA) is an intriguing fibrovascular neoplasm that has prompted diverse theories of origin since 1853. While approaches focusing on isolated features of JA have not gained broad acceptance, the current explanation of JA tumorigenesis based on embryologic vascular remnants is gaining prominence. In the core embryologic process of epithelial-mesenchymal transition (EMT), the transcription factors Twist1 and Snail/Slug play key roles; their expression in JA is therefore of particular interest within this embryologic framework.Material and methods: In a cohort of 19 JAs, quantitative real-time PCR (qRT-PCR) analyses and immunohistochemical investigations were performed for the transcription factors Twist1 and Snail/Slug, as well as for CD31 (Pecam1) and vimentin.Results: Twist1 and Snail2 were detectable by RT-PCR in all JAs examined (n=11). No correlation was observed with vessel-rich (CD31-positive) or fibrous (vimentin-positive) tumor regions. Immunohistochemistry for Twist1 and Snail/Sslug confirmed protein-level expression (n=19), with inter- and intratumoral heterogeneity of EMT markers.Conclusions: Demonstration of Twist1 and Snail/Slug expression in JA indicates involvement of the embryologic process of EMT in JA and supports the embryologic explanatory model, which accounts for the clinical characteristics of this unique fibrovascular neoplasm.","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":" ","pages":"373-379"},"PeriodicalIF":1.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Newborn Hearing Screening]. [新生儿听力筛查]。

IF 1.4 4区医学

Laryngo-rhino-otologie Pub Date : 2026-06-01 Epub Date: 2026-06-05 DOI: 10.1055/a-2623-3100

Katharina Geißler, Orlando Guntinas-Lichius

{"title":"[Newborn Hearing Screening].","authors":"Katharina Geißler, Orlando Guntinas-Lichius","doi":"10.1055/a-2623-3100","DOIUrl":"10.1055/a-2623-3100","url":null,"abstract":"Abstract: In Germany, approximately 1-3 per 1000 newborns are affected by a bilateral hearing impairment requiring treatment. Early diagnosis through newborn hearing screening and rapid initiation of therapy are crucial for age-appropriate language, motor, and social development and are therefore the focus of this \"Facharztwissen HNO\" educational article. Delayed diagnosis leads to persistent developmental disadvantages even when rehabilitation is initiated later. As around half of affected children have no identifiable risk factors, newborn hearing screening was introduced nationwide as a standard service in 2009 and anchored in the Children's Health Screening Guidelines. Newborn hearing screening is a voluntary preventive measure funded by statutory health insurance. Its aim is to detect bilateral hearing loss of 35 dB or greater by the third month of life and to initiate appropriate therapy by the sixth month at the latest. The multi-step screening process uses transient evoked otoacoustic emissions (TEOAE) and automated auditory brainstem response (AABR); abnormal findings are followed by repeat measurements and pediatric audiological confirmatory diagnostics. However, mild, frequency-specific, or slowly progressive hearing losses are not reliably detected. Despite long-standing implementation, substantial regional differences in screening rates and process quality persist, and the defined quality targets are not consistently achieved nationwide. In particular, there is a lack of uniform and mandatory tracking structures across Germany. Regional models demonstrate that systematic tracking can improve early detection and timely initiation of therapy.","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":"105 6","pages":"388-398"},"PeriodicalIF":1.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148176386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fall Ösophaguskarzinom.

IF 1.4 4区医学

Laryngo-rhino-otologie Pub Date : 2026-06-01 Epub Date: 2026-06-05 DOI: 10.1055/a-2820-2095

Gerlind Schneider

引用次数: 0

Sehr geehrte Leserinnen und Leser der LRO, liebe Kolleginnen und Kollegen. 亲爱的LRO读者，同事们。

IF 1.4 4区医学

Laryngo-rhino-otologie Pub Date : 2026-06-01 Epub Date: 2026-06-05 DOI: 10.1055/a-2820-2303

引用次数: 0

[Acquired neurogenic stuttering]. [获得性神经性口吃]。

IF 1.4 4区医学

Laryngo-rhino-otologie Pub Date : 2026-06-01 Epub Date: 2026-06-05 DOI: 10.1055/a-2723-3818

Stefanie Brühl, Beate Janusch, Silja Schramm

引用次数: 0

Fall Schilddrüsenkarzinom. 案子Schilddrüsenkarzinom .

IF 1.4 4区医学

Laryngo-rhino-otologie Pub Date : 2026-06-01 Epub Date: 2026-06-05 DOI: 10.1055/a-2820-2257

Gerlind Schneider

引用次数: 0

[Casuistic of traumatic phonophobia]. [创伤性语音恐惧症的诡辩者]。

IF 1.4 4区医学

Laryngo-rhino-otologie Pub Date : 2026-06-01 Epub Date: 2025-09-19 DOI: 10.1055/a-2699-8615

Helmut Schaaf

引用次数: 0

Scoping Review Protocol: Quality of Life in Children with Active Middle Ear Implants. 范围审查方案：使用主动中耳植入物的儿童的生活质量。

IF 1.4 4区医学

Laryngo-rhino-otologie Pub Date : 2026-06-01 Epub Date: 2025-10-28 DOI: 10.1055/a-2699-9028

Vanessa Hoffmann, Anke Leichtle, Karl-Ludwig Bruchhage

{"title":"Scoping Review Protocol: Quality of Life in Children with Active Middle Ear Implants.","authors":"Vanessa Hoffmann, Anke Leichtle, Karl-Ludwig Bruchhage","doi":"10.1055/a-2699-9028","DOIUrl":"10.1055/a-2699-9028","url":null,"abstract":"Abstract: Active middle ear implants, particularly the Vibrant Soundbridge (VSB), represent an established audiological treatment option for children with conductive, sensorineural, or mixed hearing loss when conventional hearing aids are insufficient or cannot be worn. In addition to functional improvements, the assessment of health-related quality of life (HRQoL) is gaining increasing importance. While extensive data on quality of life exist for adults with cochlear implants, only a few methodologically heterogeneous studies have examined HRQoL in children with active middle ear implants. This protocol outlines the methodology for conducting a scoping review based on the Joanna Briggs Institute (JBI) guidelines, aiming to identify, systematically collect, and analyze the international evidence. Empirical studies published since 2012 will be included without restrictions regarding study design or quality. The results aim to provide a comprehensive understanding of the multidimensional aspects of quality of life in affected children and to serve as a foundation for future research as well as the development of needs-based clinical and educational interventions.","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":" ","pages":"367-372"},"PeriodicalIF":1.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145390711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0