Laboratory medicine最新文献_第9页

Comprehensive Next-Generation Sequencing Testing in a Patient with TEMPI Syndrome. temi综合征患者的全面新一代测序测试。

Laboratory medicine Pub Date : 2023-09-05 DOI: 10.1093/labmed/lmad003

Flavia Guimaraes Nunes Rosado, Danijela Lekovic, Jeffrey Gagan, James Malter, Weina Chen, David B Sykes

引用次数: 0

Effects of the Noise Reduction and Communication Management Headset System SLOS on Noise and Stress of Medical Laboratory Workers. 降噪通信管理耳机系统sls对医务实验室工作人员噪声和应激的影响

Laboratory medicine Pub Date : 2023-09-05 DOI: 10.1093/labmed/lmad033

Jan Lehrke, Sören Lauff, Jan Mücher, Martin G Friedrich, Margarete Boos

{"title":"Effects of the Noise Reduction and Communication Management Headset System SLOS on Noise and Stress of Medical Laboratory Workers.","authors":"Jan Lehrke, Sören Lauff, Jan Mücher, Martin G Friedrich, Margarete Boos","doi":"10.1093/labmed/lmad033","DOIUrl":"https://doi.org/10.1093/labmed/lmad033","url":null,"abstract":"Objective: To investigate the effects of the Silent Laboratory Optimization System (SLOS), a technical-noise reduction and communication-management system, on noise load and stress among medical-laboratory workers.Methods: We conducted a quasiexperimental field study (20 days with SLOS as the experimental condition, and 20 days without SLOS as the control condition) in a within-subjects design. Survey data from 13 workers were collected before and after the shift. Also, a survey was conducted after the control and experimental conditions, respectively. Noise was measured in dBA and as a subjective assessment. Stress was operationalized via a stress composite score (STAI and Perkhofer Stress Scale), the Perceived Stress Scale (PSS), an exhaustion score (Leipziger StimmungsBogen in German [LSB]), and salivary cortisol values in µg/L.Results: SLOS users perceived significantly less noise (V = 76.5; P =.003). Multilevel models revealed a stress reduction with the SLOS on the composite score, compared with a stress increase in the control condition (F[1, 506.99] = 6.00; P = .01). A lower PSS score (F[1,13] = 4.67; P = .05) and a lower exhaustion level (F[1, 508.72] = 9.057; P = .003) in the experimental condition were found, whereas no differences in cortisol (F[1,812.58.6] = 0.093; P = .76) were revealed.Conclusion: The workers showed reduced noise perception and stress across all criteria except cortisol when using SLOS.","PeriodicalId":17951,"journal":{"name":"Laboratory medicine","volume":"54 5","pages":"e161-e169"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10157080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-Term (6 Weeks) Experience of a Modular Workcell for Hemostasis Testing Including an Intelligent Data Manager at a Tertiary Care Hospital. 短期(6周)三级医院止血测试模块化工作单元的经验，包括智能数据管理器。

Laboratory medicine Pub Date : 2023-09-05 DOI: 10.1093/labmed/lmac156

Hwan Tae Lee, So Young Lee, Ja Young Seo, Jeong-Yeal Ahn

{"title":"Short-Term (6 Weeks) Experience of a Modular Workcell for Hemostasis Testing Including an Intelligent Data Manager at a Tertiary Care Hospital.","authors":"Hwan Tae Lee, So Young Lee, Ja Young Seo, Jeong-Yeal Ahn","doi":"10.1093/labmed/lmac156","DOIUrl":"https://doi.org/10.1093/labmed/lmac156","url":null,"abstract":"Objective: Modular workcells could be a better solution than total laboratory automation (TLA) in hemostasis laboratories. Here, we evaluated the impact of implementing a modular workcell (HemoCell) with an intelligent data management facility (HemoHub).Methods: We compared the turnaround times (TATs), numbers of rerun samples, and rerun times pre- and postimplementation of the HemoCell at Gil Medical Center. Prothrombin time (PT), activated partial thromboplastin time (aPTT), D-dimer, and fibrinogen were evaluated.Results: The TAT standard deviations (SDs) and maximum TAT values decreased after HemoCell implementation, although the mean TATs for PT, aPTT, and D-dimer were increased. Numbers of rerun samples were increased (18.1/day vs 44.7/day). However, rerun times were reduced, and SDs were decreased during the post-HemoCell period compared with pre-HemoCell. Additionally, technologists needed smaller working space and less labor.Conclusion: The modular workcell could improve quality and efficiency by providing more consistent TATs and shorter rerun times in the hemostasis laboratory.","PeriodicalId":17951,"journal":{"name":"Laboratory medicine","volume":"54 5","pages":"495-501"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10159281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Importance of Medical Laboratory Scientists and the Number of Doctoral Scientists that Began Their Career by Working on the Front Lines of Laboratory Medicine. 医学检验科学家的重要性和在检验医学第一线开始其职业生涯的博士科学家人数。

Laboratory medicine Pub Date : 2023-09-05 DOI: 10.1093/labmed/lmac143

Rl Sautter, Dc Halstead

{"title":"The Importance of Medical Laboratory Scientists and the Number of Doctoral Scientists that Began Their Career by Working on the Front Lines of Laboratory Medicine.","authors":"Rl Sautter, Dc Halstead","doi":"10.1093/labmed/lmac143","DOIUrl":"https://doi.org/10.1093/labmed/lmac143","url":null,"abstract":"Background: Due to dwindling numbers of medical laboratory scientists (MLS), we are faced with staffing issues due to lack of visibility, recognition, low wages, and perceived lack of opportunities for upward career mobility. A brief survey of doctoral-level clinical microbiologists showed a significant number were certified, worked \"the bench,\" and used this experience as a steppingstone to become a laboratory director or consultant.Objectives: To help dispel the notion working as an MLS is a dead-end job, the authors developed an expanded national survey.Methods: The survey was sent to 815 board-certified microbiologists and chemists to determine their career path. Results indicated that of 243 respondents, 41.3% were MLS certified, 47.1% had worked \"the bench,\" and 51.9% and 63.5% became laboratory or technical directors, respectively.Conclusion: Survey results provide evidence to dispel the notion that MLS and bench working jobs lack upward career mobility and may inspire students for a career in laboratory medicine.","PeriodicalId":17951,"journal":{"name":"Laboratory medicine","volume":"54 5","pages":"e121-e123"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10212901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Laboratory medicine Pub Date : 2023-09-05 DOI: 10.1093/labmed/lmac145

Xinxin Hao, Jue Wang, Tiegang Li, Qiushi Wang

{"title":"Transfusion-Related Acute Lung Injury Caused by HLA-II Antibodies: A Case Report.","authors":"Xinxin Hao, Jue Wang, Tiegang Li, Qiushi Wang","doi":"10.1093/labmed/lmac145","DOIUrl":"https://doi.org/10.1093/labmed/lmac145","url":null,"abstract":"Objective: The aim of this study was to retrospectively analyze the etiology of a case of suspected transfusion-related acute lung injury (TRALI) occurring after blood transfusion.Methods: The clinical symptoms, signs, imaging examinations, and laboratory test results of a patient with suspected TRALI after blood transfusion were retrospectively analyzed, and human leukocyte antigen (HLA) genotyping of the patient and HLA antibodies of the plasma donors were performed.Results: The clinical manifestations of the patient were consistent with those of TRALI after blood transfusion. This TRALI was treated by timely ventilator support. The patient results of high-resolution HLA genotyping were HLA-A* 01:01, 11:01; HLA-B* 15:02, 37:01; HLA-C* 06:02, 08:01; DRB1* 10:01, 12:02; DRB3* 03:01, 03:01; DQA1* 01:05, 06:01; DQB1* 03:01, 05:01; DPA1* 01:03, 02:01; and DPB1* 02:01, 09:01. Of the 6 plasma donors tested, 3 were found to have HLA-II antibodies, which were HLA-DPA1*01:03, HLA-DQB1*03:01, and HLA-DQB1*03:01 antibodies.Conclusion: We described a case of TRALI caused by HLA-DQB1*03:01 antibody and DPA1*01:03 antibody.","PeriodicalId":17951,"journal":{"name":"Laboratory medicine","volume":"54 5","pages":"e117-e120"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10212902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Assessment of Gender Equity and Parity Among "Nontraditional" Pathology Awards. “非传统”病理学奖中性别平等与平等的评估。

Laboratory medicine Pub Date : 2023-09-05 DOI: 10.1093/labmed/lmac166

Jeremy W Jacobs, Brian D Adkins, Elizabeth S Allen, Carlos Parra-Herran, Laura D Stephens, Jennifer S Woo, Garrett S Booth

{"title":"An Assessment of Gender Equity and Parity Among \"Nontraditional\" Pathology Awards.","authors":"Jeremy W Jacobs, Brian D Adkins, Elizabeth S Allen, Carlos Parra-Herran, Laura D Stephens, Jennifer S Woo, Garrett S Booth","doi":"10.1093/labmed/lmac166","DOIUrl":"https://doi.org/10.1093/labmed/lmac166","url":null,"abstract":"Objective: The aim of this study was to assess the gender composition of nontraditional pathology recognition award recipients.Methods: Cross-sectional analysis of American Society for Clinical Pathology (ASCP) Top Five 40 Under Forty and The Pathologist Power List award recipients' gender. Gender was independently analyzed by 2 authors using pronouns. Two analyses were performed: difference in gender parity and difference in gender equity for award recipients.Results: From 2014 through 2022, 618 total awards were conferred. Significantly more men than women received an award overall (57.1% vs 42.9%; P < .001). Compared with population benchmarks, awards conferred to US-based nontrainee pathology physicians (men 56.2%, women 43.8%; P = .091) and US-based pathology physician trainees (men 60.5%, women 39.5%; P = .15) are equitable. Conversely, gender inequities exist among awards conferred to US-based nonphysician laboratory professionals (men 51.7%, women 48.3%; P < .001).Conclusion: The Pathologist Power List and Top Five ASCP 40 Under Forty awards have not completely achieved gender parity, and gender inequities remain among subgroups.","PeriodicalId":17951,"journal":{"name":"Laboratory medicine","volume":"54 5","pages":"519-522"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10510917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autosomal Recessive Renal Hypouricemia Type 2 Presenting with Childhood Stroke in a Sri Lankan Child. 斯里兰卡儿童常染色体隐性2型肾性高尿酸血症伴儿童中风。

Laboratory medicine Pub Date : 2023-09-05 DOI: 10.1093/labmed/lmac165

P Mihika S Fernando, R A Saraji R Gunasekara, Sabine Schröder, Christian Beetz, Anura Jayawardena, Eresha A Jasinge

引用次数: 0

Heparin Concentration in Evacuated Tubes and Its Effect on pH, Ionized Calcium, Lactate, and Potassium in Venous Blood Gas Analysis. 静脉血气分析中肝素浓度及其对pH、离子钙、乳酸、钾的影响。

Laboratory medicine Pub Date : 2023-09-05 DOI: 10.1093/labmed/lmad022

Katherine Mahler, Rae Kerlin, JoAnna Jones, Jieli Li

引用次数: 0

Meteorin-like Protein and Asprosin Levels in Children and Adolescents with Obesity and Their Relationship with Insulin Resistance and Metabolic Syndrome. 儿童和青少年肥胖患者的流星样蛋白和流星蛋白水平及其与胰岛素抵抗和代谢综合征的关系

Laboratory medicine Pub Date : 2023-09-05 DOI: 10.1093/labmed/lmac152

Nariman Moradi, Reza Fadaei, Maryam Roozbehkia, Mitra Nourbakhsh, Mona Nourbakhsh, Maryam Razzaghy-Azar, Bagher Larijani

{"title":"Meteorin-like Protein and Asprosin Levels in Children and Adolescents with Obesity and Their Relationship with Insulin Resistance and Metabolic Syndrome.","authors":"Nariman Moradi, Reza Fadaei, Maryam Roozbehkia, Mitra Nourbakhsh, Mona Nourbakhsh, Maryam Razzaghy-Azar, Bagher Larijani","doi":"10.1093/labmed/lmac152","DOIUrl":"https://doi.org/10.1093/labmed/lmac152","url":null,"abstract":"Objective: Two newly discovered adipokines, including Meteorin-like protein (Metrnl) and asprosin, have been implicated in glucose and insulin metabolism. This study aimed to investigate the associations of these adipokines with obesity in children and adolescents.Methods: This study was performed on 35 normal-weight children and 35 children with obesity. Anthropometric and biochemical parameters were determined. Serum concentrations of Metrnl, asprosin, and insulin were measured using enzyme-linked immunosorbent assay.Results: Metrnl level was significantly lower in obese children than normal-weight children. Additionally, Metrnl was negatively correlated with body mass index (BMI), insulin, waist-to-hip ratio, and homeostatic model assessment of insulin resistance (HOMA-IR). Our results also revealed that circulating asprosin levels were significantly increased in obese children compared to the control subjects and were positively correlated with BMI, insulin, HOMA-IR, cholesterol, and LDL-C.Conclusion: Obesity is accompanied by significant alterations in Metrnl and asprosin and therefore these adipokines, especially Metrnl, are suggested as new promising therapeutic targets for obesity and its associated metabolic imbalances.","PeriodicalId":17951,"journal":{"name":"Laboratory medicine","volume":"54 5","pages":"457-463"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10156578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Analysis of Specificity and Distribution Characteristics of Red Blood Cell Irregular Antibodies. 红细胞不规则抗体特异性及分布特征分析。

Laboratory medicine Pub Date : 2023-09-05 DOI: 10.1093/labmed/lmac160

Hui Ni, Xiaoye Sun, Hui Cong

引用次数: 0